CA2176043A1 - 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents - Google Patents

5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents

Info

Publication number
CA2176043A1
CA2176043A1 CA002176043A CA2176043A CA2176043A1 CA 2176043 A1 CA2176043 A1 CA 2176043A1 CA 002176043 A CA002176043 A CA 002176043A CA 2176043 A CA2176043 A CA 2176043A CA 2176043 A1 CA2176043 A1 CA 2176043A1
Authority
CA
Canada
Prior art keywords
dihydro
pyran
phenyl
mmol
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002176043A
Other languages
English (en)
French (fr)
Inventor
Edmund Lee Ellsworth
Bradley Dean Tait
Elizabeth Lunney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/319,820 external-priority patent/US5840751A/en
Application filed by Individual filed Critical Individual
Publication of CA2176043A1 publication Critical patent/CA2176043A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA002176043A 1993-11-19 1994-10-26 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents Abandoned CA2176043A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15544393A 1993-11-19 1993-11-19
US155,443 1993-11-19
US319,820 1994-10-12
US08/319,820 US5840751A (en) 1993-11-19 1994-10-12 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents

Publications (1)

Publication Number Publication Date
CA2176043A1 true CA2176043A1 (en) 1995-05-26

Family

ID=26852338

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002176043A Abandoned CA2176043A1 (en) 1993-11-19 1994-10-26 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents

Country Status (18)

Country Link
EP (1) EP0729464A1 (ja)
JP (1) JP3684426B2 (ja)
AT (1) ATE263761T1 (ja)
AU (1) AU689158B2 (ja)
CA (1) CA2176043A1 (ja)
DE (1) DE69433705T2 (ja)
DK (1) DK1142887T3 (ja)
ES (1) ES2219457T3 (ja)
FI (1) FI962022A (ja)
HR (1) HRP940935B1 (ja)
HU (1) HUT77668A (ja)
IL (1) IL111674A0 (ja)
NO (1) NO316172B1 (ja)
NZ (1) NZ275961A (ja)
PT (1) PT1142887E (ja)
RU (1) RU2140917C1 (ja)
SI (1) SI1142887T1 (ja)
WO (1) WO1995014012A1 (ja)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69636357T2 (de) * 1995-08-11 2007-08-09 Zenon Environmental Inc., Oakville Membranmodul mit frei schwingenden Hohlfasermembranen
US5834506A (en) * 1996-11-01 1998-11-10 Warner-Lambert Company Dihydropyrones with improved antiviral activity
NZ503338A (en) * 1997-09-11 2002-03-01 Upjohn Co Process to produce 4-hydroxy-2-oxo-pyrane derivatives
KR20010085780A (ko) * 1998-09-11 2001-09-07 로즈 암스트롱, 크리스틴 에이. 트러트웨인 Ｈｉｖ 프로테아제 억제제
US6288235B1 (en) 1999-04-14 2001-09-11 Ortho-Mcneil Pharmaceutical, Inc. Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries
DE10030094A1 (de) * 2000-06-19 2001-12-20 Bayer Ag Phenylsubstituierte 5,6-Dihydro-pyron-Derivate
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
US6500963B2 (en) 2001-02-22 2002-12-31 Boehringer Ingelheim Pharma Kg Process for preparing optically active dihydropyrones
DE10108471C1 (de) 2001-02-22 2002-11-21 Boehringer Ingelheim Pharma Kontinuierliches Verfahren zur Herstellung von 5,6-Dihydro-4-hydroxy-2-pyronen
US7141681B2 (en) 2001-02-22 2006-11-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Continuous process for preparing dihydropyrones
DE10108470A1 (de) * 2001-02-22 2002-09-05 Boehringer Ingelheim Pharma Verfahren zur Herstellung optisch aktiver Dihydropyrone
TW200307667A (en) 2002-05-06 2003-12-16 Bristol Myers Squibb Co Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
DOP2003000641A (es) 2002-05-10 2003-11-15 Pfizer Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan
US7148226B2 (en) 2003-02-21 2006-12-12 Agouron Pharmaceuticals, Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
AU2005273619B2 (en) 2004-08-18 2009-05-28 Pfizer Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
DE102005059469A1 (de) 2005-12-13 2007-06-14 Bayer Cropscience Ag Insektizide Zusammensetzungen mit verbesserter Wirkung
DE102006007882A1 (de) 2006-02-21 2007-08-30 Bayer Cropscience Ag Cycloalkyl-phenylsubstituierte cyclische Ketoenole
AU2007259257B8 (en) * 2006-06-16 2012-04-05 Pharma Mar, S.A. Antitumoral dihydropyran-2-one compounds
MX2011009188A (es) 2009-03-11 2011-09-26 Bayer Cropscience Ag Cetoenoles sustituidos con haloalquilmetilenoxi-fenilo.
DE102010008644A1 (de) 2010-02-15 2011-08-18 Bayer Schering Pharma Aktiengesellschaft, 13353 Zyklische Ketoenole zur Therapie
RU2461555C1 (ru) * 2011-07-07 2012-09-20 Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" Способ получения 5-арил-3-фенил-2-оксаспиро[5,6]додец-3-ен-1-онов, проявляющих анальгетическую активность
AU2013211636B2 (en) 2012-01-26 2016-09-29 Bayer Intellectual Property Gmbh Phenyl-substituted ketoenols for controlling fish parasites
EP2925736B1 (en) 2012-11-28 2017-01-04 Sumitomo Chemical Co., Ltd Dihydropyrone compounds and herbicides comprising the same
SE539512C2 (sv) 2015-12-02 2017-10-03 Ultupharma Ab Compounds and methods of treating bacterial infections

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3818046A (en) * 1972-12-18 1974-06-18 Dow Chemical Co Sulfur-containing hydroxy pyrones and alkali metal salts thereof
ZA938019B (en) * 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses

Also Published As

Publication number Publication date
HRP940935A2 (en) 1997-04-30
NO316172B1 (no) 2003-12-22
HU9601348D0 (en) 1996-07-29
DE69433705D1 (de) 2004-05-13
DK1142887T3 (da) 2004-06-21
AU689158B2 (en) 1998-03-26
HUT77668A (hu) 1998-07-28
FI962022A (fi) 1996-07-12
JP3684426B2 (ja) 2005-08-17
RU2140917C1 (ru) 1999-11-10
DE69433705T2 (de) 2005-03-10
ES2219457T3 (es) 2004-12-01
NZ275961A (en) 2001-11-30
IL111674A0 (en) 1995-01-24
HRP940935B1 (en) 2004-08-31
NO962017D0 (no) 1996-05-15
AU8125694A (en) 1995-06-06
FI962022A0 (fi) 1996-05-13
SI1142887T1 (en) 2004-08-31
PT1142887E (pt) 2004-08-31
JPH09505294A (ja) 1997-05-27
ATE263761T1 (de) 2004-04-15
NO962017L (no) 1996-07-08
WO1995014012A1 (en) 1995-05-26
EP0729464A1 (en) 1996-09-04

Similar Documents

Publication Publication Date Title
CA2176043A1 (en) 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
US5789440A (en) 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
JP3698435B2 (ja) プロテアーゼ阻害剤および抗ウイルス剤としての５，６−ジヒドロピロン誘導体
RU2136674C1 (ru) Производные пирона, фармацевтическая композиция с антибактериальной и антивирусной активностью, способ лечения вызванных ретровирусом инфекции или заболевания
KR100441361B1 (ko) 프로테아제억제제및항바이러스제로서의5,6-디히드로피론유도체
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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued