IL111674A0 - 5,6-Dihydropyrone derivatives and pharmaceutical compositions containing them - Google Patents
5,6-Dihydropyrone derivatives and pharmaceutical compositions containing themInfo
- Publication number
- IL111674A0 IL111674A0 IL11167494A IL11167494A IL111674A0 IL 111674 A0 IL111674 A0 IL 111674A0 IL 11167494 A IL11167494 A IL 11167494A IL 11167494 A IL11167494 A IL 11167494A IL 111674 A0 IL111674 A0 IL 111674A0
- Authority
- IL
- Israel
- Prior art keywords
- dihydropyrone derivatives
- pharmaceutical compositions
- compositions containing
- dihydropyrone
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Abstract
The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized 5,6-dihydropyrones and of related structures.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15544393A | 1993-11-19 | 1993-11-19 | |
US08/319,820 US5840751A (en) | 1993-11-19 | 1994-10-12 | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents |
Publications (1)
Publication Number | Publication Date |
---|---|
IL111674A0 true IL111674A0 (en) | 1995-01-24 |
Family
ID=26852338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11167494A IL111674A0 (en) | 1993-11-19 | 1994-11-17 | 5,6-Dihydropyrone derivatives and pharmaceutical compositions containing them |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0729464A1 (en) |
JP (1) | JP3684426B2 (en) |
AT (1) | ATE263761T1 (en) |
AU (1) | AU689158B2 (en) |
CA (1) | CA2176043A1 (en) |
DE (1) | DE69433705T2 (en) |
DK (1) | DK1142887T3 (en) |
ES (1) | ES2219457T3 (en) |
FI (1) | FI962022A (en) |
HR (1) | HRP940935B1 (en) |
HU (1) | HUT77668A (en) |
IL (1) | IL111674A0 (en) |
NO (1) | NO316172B1 (en) |
NZ (1) | NZ275961A (en) |
PT (1) | PT1142887E (en) |
RU (1) | RU2140917C1 (en) |
SI (1) | SI1142887T1 (en) |
WO (1) | WO1995014012A1 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997006880A2 (en) * | 1995-08-11 | 1997-02-27 | Zenon Environmental Inc. | Vertical skein of hollow fiber membranes and method of maintaining clean fiber surfaces |
US5834506A (en) * | 1996-11-01 | 1998-11-10 | Warner-Lambert Company | Dihydropyrones with improved antiviral activity |
JP4462760B2 (en) * | 1997-09-11 | 2010-05-12 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | Method for producing 4-hydroxy-2-oxo-pyran derivatives useful as protease inhibitors |
KR20010085780A (en) * | 1998-09-11 | 2001-09-07 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | HIV Protease Inhibitors |
US6288235B1 (en) | 1999-04-14 | 2001-09-11 | Ortho-Mcneil Pharmaceutical, Inc. | Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries |
DE10030094A1 (en) * | 2000-06-19 | 2001-12-20 | Bayer Ag | New phenyl-substituted 5,6-dihydro-pyrone derivatives, useful as total or selective herbicides, insecticides, acaricides, nematocides, ectoparasiticides or antifouling agents |
US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
DE10108471C1 (en) | 2001-02-22 | 2002-11-21 | Boehringer Ingelheim Pharma | Continuous process for the preparation of 5,6-dihydro-4-hydroxy-2-pyrones |
DE10108470A1 (en) * | 2001-02-22 | 2002-09-05 | Boehringer Ingelheim Pharma | Process for the production of optically active dihydropyrones |
US6500963B2 (en) | 2001-02-22 | 2002-12-31 | Boehringer Ingelheim Pharma Kg | Process for preparing optically active dihydropyrones |
US7141681B2 (en) | 2001-02-22 | 2006-11-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Continuous process for preparing dihydropyrones |
TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
DOP2003000641A (en) | 2002-05-10 | 2003-11-15 | Pfizer | INHIBITORS OF RNA-DEPENDENT RNA POLYMERASE OF HEPATITIS C VIRUSES AND COMPOSITIONS AND TREATMENT USED |
US7148226B2 (en) | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
BRPI0514425A (en) | 2004-08-18 | 2008-06-10 | Pfizer | hepatitis c virus-dependent rna polymerase inhibitors, and compositions and treatments using the same |
DE102005059469A1 (en) | 2005-12-13 | 2007-06-14 | Bayer Cropscience Ag | Insecticidal compositions having improved activity |
DE102006007882A1 (en) | 2006-02-21 | 2007-08-30 | Bayer Cropscience Ag | New cyclic keto enol derivatives useful for controlling animal pests and/or unwanted plant growth |
WO2007144423A1 (en) * | 2006-06-16 | 2007-12-21 | Pharma Mar, S.A. | Antitumoral dihydropyran-2-one compounds |
BRPI1008949B1 (en) | 2009-03-11 | 2018-07-10 | Bayer Intellectual Property Gmbh | HALOALKYLMETHYLENEXY-PHENYL-SUBSTITUTED KETOENOLS AND THEIR USE, COMPOSITION, USE AND METHOD OF PRODUCTION, METHODS FOR COMBATING ANIMAL PEST AND / OR GROWTH OF UNWANTED PLANTS |
DE102010008644A1 (en) | 2010-02-15 | 2011-08-18 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Cyclic ketoenols for therapy |
RU2461555C1 (en) * | 2011-07-07 | 2012-09-20 | Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" | Method of producing 5-aryl-3-phenyl-2-oxaspiro[5,6]dodec-3-en-1-ones, exhibiting analgesic activity |
US9089137B2 (en) | 2012-01-26 | 2015-07-28 | Bayer Intellectual Property Gmbh | Phenyl-substituted ketoenols for controlling fish parasites |
CA2889200A1 (en) | 2012-11-28 | 2014-06-05 | Sumitomo Chemical Company, Limited | Dihydropyrone compounds and herbicides comprising the same |
SE539512C2 (en) * | 2015-12-02 | 2017-10-03 | Ultupharma Ab | Compounds and methods of treating bacterial infections |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3818046A (en) * | 1972-12-18 | 1974-06-18 | Dow Chemical Co | Sulfur-containing hydroxy pyrones and alkali metal salts thereof |
ZA938019B (en) * | 1992-11-13 | 1995-04-28 | Upjohn Co | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses |
-
1994
- 1994-10-26 CA CA002176043A patent/CA2176043A1/en not_active Abandoned
- 1994-10-26 PT PT01114943T patent/PT1142887E/en unknown
- 1994-10-26 JP JP51445895A patent/JP3684426B2/en not_active Expired - Fee Related
- 1994-10-26 DE DE69433705T patent/DE69433705T2/en not_active Expired - Fee Related
- 1994-10-26 AU AU81256/94A patent/AU689158B2/en not_active Ceased
- 1994-10-26 WO PCT/US1994/012269 patent/WO1995014012A1/en not_active Application Discontinuation
- 1994-10-26 AT AT01114943T patent/ATE263761T1/en not_active IP Right Cessation
- 1994-10-26 HU HU9601348A patent/HUT77668A/en not_active Application Discontinuation
- 1994-10-26 DK DK01114943T patent/DK1142887T3/en active
- 1994-10-26 SI SI9430463T patent/SI1142887T1/en unknown
- 1994-10-26 RU RU96113098/04A patent/RU2140917C1/en not_active IP Right Cessation
- 1994-10-26 EP EP95900429A patent/EP0729464A1/en not_active Withdrawn
- 1994-10-26 NZ NZ275961A patent/NZ275961A/en unknown
- 1994-10-26 ES ES01114943T patent/ES2219457T3/en not_active Expired - Lifetime
- 1994-11-17 HR HR940935A patent/HRP940935B1/en not_active IP Right Cessation
- 1994-11-17 IL IL11167494A patent/IL111674A0/en unknown
-
1996
- 1996-05-13 FI FI962022A patent/FI962022A/en unknown
- 1996-05-15 NO NO19962017A patent/NO316172B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2219457T3 (en) | 2004-12-01 |
AU689158B2 (en) | 1998-03-26 |
NZ275961A (en) | 2001-11-30 |
HRP940935B1 (en) | 2004-08-31 |
DK1142887T3 (en) | 2004-06-21 |
JP3684426B2 (en) | 2005-08-17 |
PT1142887E (en) | 2004-08-31 |
HUT77668A (en) | 1998-07-28 |
WO1995014012A1 (en) | 1995-05-26 |
NO316172B1 (en) | 2003-12-22 |
EP0729464A1 (en) | 1996-09-04 |
NO962017D0 (en) | 1996-05-15 |
DE69433705T2 (en) | 2005-03-10 |
ATE263761T1 (en) | 2004-04-15 |
JPH09505294A (en) | 1997-05-27 |
SI1142887T1 (en) | 2004-08-31 |
HU9601348D0 (en) | 1996-07-29 |
RU2140917C1 (en) | 1999-11-10 |
NO962017L (en) | 1996-07-08 |
HRP940935A2 (en) | 1997-04-30 |
CA2176043A1 (en) | 1995-05-26 |
FI962022A0 (en) | 1996-05-13 |
DE69433705D1 (en) | 2004-05-13 |
AU8125694A (en) | 1995-06-06 |
FI962022A (en) | 1996-07-12 |
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