DE69433705D1 - 5,6-Dihydropyronderivate als Proteaseinhibitoren und Antiviralmittel - Google Patents
5,6-Dihydropyronderivate als Proteaseinhibitoren und AntiviralmittelInfo
- Publication number
- DE69433705D1 DE69433705D1 DE69433705T DE69433705T DE69433705D1 DE 69433705 D1 DE69433705 D1 DE 69433705D1 DE 69433705 T DE69433705 T DE 69433705T DE 69433705 T DE69433705 T DE 69433705T DE 69433705 D1 DE69433705 D1 DE 69433705D1
- Authority
- DE
- Germany
- Prior art keywords
- dihydropyrone derivatives
- protease inhibitors
- antiviral agents
- dihydropyrone
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15544393A | 1993-11-19 | 1993-11-19 | |
| US155443 | 1993-11-19 | ||
| US08/319,820 US5840751A (en) | 1993-11-19 | 1994-10-12 | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents |
| US319820 | 1994-10-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69433705D1 true DE69433705D1 (de) | 2004-05-13 |
| DE69433705T2 DE69433705T2 (de) | 2005-03-10 |
Family
ID=26852338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69433705T Expired - Fee Related DE69433705T2 (de) | 1993-11-19 | 1994-10-26 | 5,6-Dihydropyronderivate als Proteaseinhibitoren und Antiviralmittel |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0729464A1 (de) |
| JP (1) | JP3684426B2 (de) |
| AT (1) | ATE263761T1 (de) |
| AU (1) | AU689158B2 (de) |
| CA (1) | CA2176043A1 (de) |
| DE (1) | DE69433705T2 (de) |
| DK (1) | DK1142887T3 (de) |
| ES (1) | ES2219457T3 (de) |
| FI (1) | FI962022A (de) |
| HR (1) | HRP940935B1 (de) |
| HU (1) | HUT77668A (de) |
| IL (1) | IL111674A0 (de) |
| NO (1) | NO316172B1 (de) |
| NZ (1) | NZ275961A (de) |
| PT (1) | PT1142887E (de) |
| RU (1) | RU2140917C1 (de) |
| SI (1) | SI1142887T1 (de) |
| WO (1) | WO1995014012A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69632422T2 (de) * | 1995-08-11 | 2005-05-19 | Zenon Environmental Inc., Oakville | Verfahren zum Einbetten von Hohlfaser-Membranen |
| US5834506A (en) * | 1996-11-01 | 1998-11-10 | Warner-Lambert Company | Dihydropyrones with improved antiviral activity |
| CN1284763C (zh) * | 1997-09-11 | 2006-11-15 | 法玛西雅厄普约翰美国公司 | 用于制备蛋白酶抑制剂的化合物 |
| NZ510013A (en) * | 1998-09-11 | 2003-11-28 | Warner Lambert Co | Dihydropyrones with selected heterocycles replacing the phenyls bearing polar substituents used as HIV protease inhibitors |
| US6288235B1 (en) | 1999-04-14 | 2001-09-11 | Ortho-Mcneil Pharmaceutical, Inc. | Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries |
| DE10030094A1 (de) * | 2000-06-19 | 2001-12-20 | Bayer Ag | Phenylsubstituierte 5,6-Dihydro-pyron-Derivate |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| DE10108471C1 (de) | 2001-02-22 | 2002-11-21 | Boehringer Ingelheim Pharma | Kontinuierliches Verfahren zur Herstellung von 5,6-Dihydro-4-hydroxy-2-pyronen |
| US6500963B2 (en) | 2001-02-22 | 2002-12-31 | Boehringer Ingelheim Pharma Kg | Process for preparing optically active dihydropyrones |
| US7141681B2 (en) | 2001-02-22 | 2006-11-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Continuous process for preparing dihydropyrones |
| DE10108470A1 (de) * | 2001-02-22 | 2002-09-05 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung optisch aktiver Dihydropyrone |
| TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
| DOP2003000641A (es) | 2002-05-10 | 2003-11-15 | Pfizer | Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan |
| US7148226B2 (en) | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
| EP1781662B1 (de) | 2004-08-18 | 2011-04-20 | Pfizer, Inc. | Inhibitoren der rna-abhängigen rna-polymerase des hepatitis-c-virus und zusammensetzungen und behandlungen, bei denen diese verwendet werden |
| DE102005059469A1 (de) | 2005-12-13 | 2007-06-14 | Bayer Cropscience Ag | Insektizide Zusammensetzungen mit verbesserter Wirkung |
| DE102006007882A1 (de) | 2006-02-21 | 2007-08-30 | Bayer Cropscience Ag | Cycloalkyl-phenylsubstituierte cyclische Ketoenole |
| EP2032551B9 (de) * | 2006-06-16 | 2012-02-29 | Pharma Mar, S.A. | Dihydropyran-2-onverbindungen mit antitumorwirkung |
| WO2010102758A2 (de) | 2009-03-11 | 2010-09-16 | Bayer Cropscience Ag | Halogenalkylmethylenoxy-phenyl-substituierte ketoenole |
| DE102010008644A1 (de) | 2010-02-15 | 2011-08-18 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Zyklische Ketoenole zur Therapie |
| RU2461555C1 (ru) * | 2011-07-07 | 2012-09-20 | Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" | Способ получения 5-арил-3-фенил-2-оксаспиро[5,6]додец-3-ен-1-онов, проявляющих анальгетическую активность |
| CN104066332B (zh) | 2012-01-26 | 2016-10-26 | 拜耳知识产权有限责任公司 | 用于控制鱼类寄生虫的苯基取代的酮烯醇 |
| WO2014084407A1 (en) | 2012-11-28 | 2014-06-05 | Sumitomo Chemical Company, Limited | Dihydropyrone compounds and herbicides comprising the same |
| SE539512C2 (sv) | 2015-12-02 | 2017-10-03 | Ultupharma Ab | Compounds and methods of treating bacterial infections |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3818046A (en) * | 1972-12-18 | 1974-06-18 | Dow Chemical Co | Sulfur-containing hydroxy pyrones and alkali metal salts thereof |
| ZA938019B (en) * | 1992-11-13 | 1995-04-28 | Upjohn Co | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses |
-
1994
- 1994-10-26 AU AU81256/94A patent/AU689158B2/en not_active Ceased
- 1994-10-26 DK DK01114943T patent/DK1142887T3/da active
- 1994-10-26 JP JP51445895A patent/JP3684426B2/ja not_active Expired - Fee Related
- 1994-10-26 WO PCT/US1994/012269 patent/WO1995014012A1/en not_active Application Discontinuation
- 1994-10-26 ES ES01114943T patent/ES2219457T3/es not_active Expired - Lifetime
- 1994-10-26 EP EP95900429A patent/EP0729464A1/de not_active Withdrawn
- 1994-10-26 PT PT01114943T patent/PT1142887E/pt unknown
- 1994-10-26 DE DE69433705T patent/DE69433705T2/de not_active Expired - Fee Related
- 1994-10-26 HU HU9601348A patent/HUT77668A/hu not_active Application Discontinuation
- 1994-10-26 AT AT01114943T patent/ATE263761T1/de not_active IP Right Cessation
- 1994-10-26 NZ NZ275961A patent/NZ275961A/en unknown
- 1994-10-26 RU RU96113098/04A patent/RU2140917C1/ru not_active IP Right Cessation
- 1994-10-26 SI SI9430463T patent/SI1142887T1/xx unknown
- 1994-10-26 CA CA002176043A patent/CA2176043A1/en not_active Abandoned
- 1994-11-17 HR HR940935A patent/HRP940935B1/xx not_active IP Right Cessation
- 1994-11-17 IL IL11167494A patent/IL111674A0/xx unknown
-
1996
- 1996-05-13 FI FI962022A patent/FI962022A/fi unknown
- 1996-05-15 NO NO19962017A patent/NO316172B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0729464A1 (de) | 1996-09-04 |
| HU9601348D0 (en) | 1996-07-29 |
| HUT77668A (hu) | 1998-07-28 |
| HRP940935A2 (en) | 1997-04-30 |
| NZ275961A (en) | 2001-11-30 |
| NO316172B1 (no) | 2003-12-22 |
| DK1142887T3 (da) | 2004-06-21 |
| CA2176043A1 (en) | 1995-05-26 |
| FI962022A (fi) | 1996-07-12 |
| IL111674A0 (en) | 1995-01-24 |
| JPH09505294A (ja) | 1997-05-27 |
| DE69433705T2 (de) | 2005-03-10 |
| RU2140917C1 (ru) | 1999-11-10 |
| SI1142887T1 (en) | 2004-08-31 |
| FI962022A0 (fi) | 1996-05-13 |
| JP3684426B2 (ja) | 2005-08-17 |
| HRP940935B1 (en) | 2004-08-31 |
| ES2219457T3 (es) | 2004-12-01 |
| NO962017D0 (no) | 1996-05-15 |
| PT1142887E (pt) | 2004-08-31 |
| ATE263761T1 (de) | 2004-04-15 |
| WO1995014012A1 (en) | 1995-05-26 |
| NO962017L (no) | 1996-07-08 |
| AU8125694A (en) | 1995-06-06 |
| AU689158B2 (en) | 1998-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69433705D1 (de) | 5,6-Dihydropyronderivate als Proteaseinhibitoren und Antiviralmittel | |
| PT729463E (pt) | Derivados de 5,6-dihidropirona como inibidores de protease e agentes antivirais | |
| MD960171A (ro) | Derivaţi ai pironei folosiţi ca inhibitori ai proteazei şi agenţi antivirali | |
| FI962020A0 (fi) | Pyronijohdannaiset proteaasi-inhibiittoreina ja antiviraalisina aineina | |
| WO1995014014A3 (en) | Pyrone derivatives as protease inhibitors and antiviral agents |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |