RU2140917C1 - Производные 5,6-дигидропирона и фармацевтическая композиция на их основе - Google Patents

Производные 5,6-дигидропирона и фармацевтическая композиция на их основе Download PDF

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Publication number
RU2140917C1
RU2140917C1 RU96113098/04A RU96113098A RU2140917C1 RU 2140917 C1 RU2140917 C1 RU 2140917C1 RU 96113098/04 A RU96113098/04 A RU 96113098/04A RU 96113098 A RU96113098 A RU 96113098A RU 2140917 C1 RU2140917 C1 RU 2140917C1
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Russia
Prior art keywords
mmol
dihydro
pyran
hydroxy
phenyl
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RU96113098/04A
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English (en)
Russian (ru)
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RU96113098A (ru
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Ли Эльсворс Эдмунд (US)
Ли Эльсворс Эдмунд
Ланни Элизабет (US)
Ланни Элизабет
Дин Тайт Бредли (US)
Дин Тайт Бредли
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Парк, Дэвис энд Компани
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Priority claimed from US08/319,820 external-priority patent/US5840751A/en
Application filed by Парк, Дэвис энд Компани filed Critical Парк, Дэвис энд Компани
Publication of RU96113098A publication Critical patent/RU96113098A/ru
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Publication of RU2140917C1 publication Critical patent/RU2140917C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
RU96113098/04A 1993-11-19 1994-10-26 Производные 5,6-дигидропирона и фармацевтическая композиция на их основе RU2140917C1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15544393A 1993-11-19 1993-11-19
US08/155,443 1993-11-19
US08/319,820 1994-10-12
US08/319,820 US5840751A (en) 1993-11-19 1994-10-12 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
PCT/US1994/012269 WO1995014012A1 (en) 1993-11-19 1994-10-26 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents

Publications (2)

Publication Number Publication Date
RU96113098A RU96113098A (ru) 1998-09-27
RU2140917C1 true RU2140917C1 (ru) 1999-11-10

Family

ID=26852338

Family Applications (1)

Application Number Title Priority Date Filing Date
RU96113098/04A RU2140917C1 (ru) 1993-11-19 1994-10-26 Производные 5,6-дигидропирона и фармацевтическая композиция на их основе

Country Status (18)

Country Link
EP (1) EP0729464A1 (ja)
JP (1) JP3684426B2 (ja)
AT (1) ATE263761T1 (ja)
AU (1) AU689158B2 (ja)
CA (1) CA2176043A1 (ja)
DE (1) DE69433705T2 (ja)
DK (1) DK1142887T3 (ja)
ES (1) ES2219457T3 (ja)
FI (1) FI962022A (ja)
HR (1) HRP940935B1 (ja)
HU (1) HUT77668A (ja)
IL (1) IL111674A0 (ja)
NO (1) NO316172B1 (ja)
NZ (1) NZ275961A (ja)
PT (1) PT1142887E (ja)
RU (1) RU2140917C1 (ja)
SI (1) SI1142887T1 (ja)
WO (1) WO1995014012A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2461555C1 (ru) * 2011-07-07 2012-09-20 Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" Способ получения 5-арил-3-фенил-2-оксаспиро[5,6]додец-3-ен-1-онов, проявляющих анальгетическую активность
RU2809158C1 (ru) * 2023-03-31 2023-12-07 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" Применение n-(2-оксо-6-(3,4,5-триметоксифенил)-2h-пиран-3-ил)бензамида в качестве противомикробного средства

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0846023B1 (en) * 1995-08-11 2002-10-23 Zenon Environmental Inc. Vertical skein of hollow fiber membranes and method of maintaining clean fiber surfaces
US5834506A (en) * 1996-11-01 1998-11-10 Warner-Lambert Company Dihydropyrones with improved antiviral activity
PL193240B1 (pl) * 1997-09-11 2007-01-31 Upjohn Co Sposób wytwarzania hydroksylaktonu i związki pośrednie stosowane w tym sposobie
EP1112269A2 (en) * 1998-09-11 2001-07-04 Warner-Lambert Company Hiv protease inhibitors
US6288235B1 (en) 1999-04-14 2001-09-11 Ortho-Mcneil Pharmaceutical, Inc. Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries
DE10030094A1 (de) * 2000-06-19 2001-12-20 Bayer Ag Phenylsubstituierte 5,6-Dihydro-pyron-Derivate
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
DE10108471C1 (de) 2001-02-22 2002-11-21 Boehringer Ingelheim Pharma Kontinuierliches Verfahren zur Herstellung von 5,6-Dihydro-4-hydroxy-2-pyronen
US6500963B2 (en) 2001-02-22 2002-12-31 Boehringer Ingelheim Pharma Kg Process for preparing optically active dihydropyrones
US7141681B2 (en) 2001-02-22 2006-11-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Continuous process for preparing dihydropyrones
DE10108470A1 (de) * 2001-02-22 2002-09-05 Boehringer Ingelheim Pharma Verfahren zur Herstellung optisch aktiver Dihydropyrone
TW200307667A (en) 2002-05-06 2003-12-16 Bristol Myers Squibb Co Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
DOP2003000641A (es) 2002-05-10 2003-11-15 Pfizer Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan
US7148226B2 (en) 2003-02-21 2006-12-12 Agouron Pharmaceuticals, Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
RS51794B (en) 2004-08-18 2011-12-31 Pfizer Inc. RNA SUBSTITUTE RNA POLYMERASE INHIBITORS OF HEPATITIS C VIRUS AND COMPOSITIONS AND TREATMENTS USING THEM
DE102005059469A1 (de) 2005-12-13 2007-06-14 Bayer Cropscience Ag Insektizide Zusammensetzungen mit verbesserter Wirkung
DE102006007882A1 (de) 2006-02-21 2007-08-30 Bayer Cropscience Ag Cycloalkyl-phenylsubstituierte cyclische Ketoenole
SI2032551T1 (sl) * 2006-06-16 2012-01-31 Pharma Mar Sa Antitumorne dihidropiran-2-on spojine
MX338802B (es) 2009-03-11 2016-05-02 Bayer Cropscience Ag Cetoenoles sustituidos con haloalquilmetilenoxi-fenilo.
DE102010008644A1 (de) 2010-02-15 2011-08-18 Bayer Schering Pharma Aktiengesellschaft, 13353 Zyklische Ketoenole zur Therapie
CN104066332B (zh) 2012-01-26 2016-10-26 拜耳知识产权有限责任公司 用于控制鱼类寄生虫的苯基取代的酮烯醇
BR112015010873A2 (pt) 2012-11-28 2017-07-11 Sumitomo Chemical Co compostos à base de di-hidropirona e herbicidas compreendendo os mesmos
SE539512C2 (sv) 2015-12-02 2017-10-03 Ultupharma Ab Compounds and methods of treating bacterial infections

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3818046A (en) * 1972-12-18 1974-06-18 Dow Chemical Co Sulfur-containing hydroxy pyrones and alkali metal salts thereof
ZA938019B (en) * 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2461555C1 (ru) * 2011-07-07 2012-09-20 Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" Способ получения 5-арил-3-фенил-2-оксаспиро[5,6]додец-3-ен-1-онов, проявляющих анальгетическую активность
RU2809158C1 (ru) * 2023-03-31 2023-12-07 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" Применение n-(2-оксо-6-(3,4,5-триметоксифенил)-2h-пиран-3-ил)бензамида в качестве противомикробного средства

Also Published As

Publication number Publication date
NO962017L (no) 1996-07-08
JP3684426B2 (ja) 2005-08-17
EP0729464A1 (en) 1996-09-04
CA2176043A1 (en) 1995-05-26
NO316172B1 (no) 2003-12-22
WO1995014012A1 (en) 1995-05-26
FI962022A (fi) 1996-07-12
DE69433705T2 (de) 2005-03-10
HRP940935A2 (en) 1997-04-30
NZ275961A (en) 2001-11-30
SI1142887T1 (en) 2004-08-31
DE69433705D1 (de) 2004-05-13
HRP940935B1 (en) 2004-08-31
JPH09505294A (ja) 1997-05-27
AU689158B2 (en) 1998-03-26
IL111674A0 (en) 1995-01-24
ES2219457T3 (es) 2004-12-01
DK1142887T3 (da) 2004-06-21
NO962017D0 (no) 1996-05-15
AU8125694A (en) 1995-06-06
ATE263761T1 (de) 2004-04-15
PT1142887E (pt) 2004-08-31
FI962022A0 (fi) 1996-05-13
HU9601348D0 (en) 1996-07-29
HUT77668A (hu) 1998-07-28

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Effective date: 20051027