CA2162463C - Azolylamine derivative - Google Patents
Azolylamine derivative Download PDFInfo
- Publication number
- CA2162463C CA2162463C CA002162463A CA2162463A CA2162463C CA 2162463 C CA2162463 C CA 2162463C CA 002162463 A CA002162463 A CA 002162463A CA 2162463 A CA2162463 A CA 2162463A CA 2162463 C CA2162463 C CA 2162463C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- group
- acid addition
- addition salt
- butane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polymerization Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP132931/1993 | 1993-05-10 | ||
| JP13293193 | 1993-05-10 | ||
| PCT/JP1994/000737 WO1994026734A1 (fr) | 1993-05-10 | 1994-05-02 | Derive d'azolylamine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2162463A1 CA2162463A1 (en) | 1994-11-24 |
| CA2162463C true CA2162463C (en) | 2006-01-03 |
Family
ID=15092851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002162463A Expired - Lifetime CA2162463C (en) | 1993-05-10 | 1994-05-02 | Azolylamine derivative |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US5620994A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0698606B1 (cg-RX-API-DMAC7.html) |
| KR (1) | KR100339166B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1046278C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE161257T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU685116B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2162463C (cg-RX-API-DMAC7.html) |
| DE (1) | DE69407409T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0698606T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2110749T3 (cg-RX-API-DMAC7.html) |
| GR (1) | GR3025715T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HU225416B1 (cg-RX-API-DMAC7.html) |
| TW (1) | TW325473B (cg-RX-API-DMAC7.html) |
| UA (1) | UA41365C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1994026734A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69407409T2 (de) * | 1993-05-10 | 1998-04-09 | Kaken Pharma Co Ltd | Azolylamin-derivat |
| EP0881215B1 (en) * | 1995-09-28 | 2001-09-05 | Kaken Pharmaceutical Co., Ltd. | Process for the preparation of 4-methylenepiperidines |
| WO2001007643A1 (en) * | 1999-07-28 | 2001-02-01 | Kaken Pharmaceutical Co., Ltd. | Method for detecting pathogenic microorganism and antimicrobial agent, method for evaluating the drug effect of antimicrobial agent, and antimicrobial agents |
| US20090162419A1 (en) * | 2004-05-25 | 2009-06-25 | Watson James B | Live bacteria product |
| US20100080869A1 (en) * | 2004-05-25 | 2010-04-01 | Watson James B | Live Bacteria product |
| US20090162481A1 (en) * | 2004-05-25 | 2009-06-25 | Watson James B | Live bacteria product |
| WO2007101204A1 (en) * | 2006-02-27 | 2007-09-07 | Alcon Research, Ltd. | Method of treating glaucoma |
| ATE482703T1 (de) * | 2006-12-28 | 2010-10-15 | Kaken Pharma Co Ltd | Gelzusammensetzung zur behandlung von mykose |
| US20090175810A1 (en) | 2008-01-03 | 2009-07-09 | Gareth Winckle | Compositions and methods for treating diseases of the nail |
| US8039494B1 (en) | 2010-07-08 | 2011-10-18 | Dow Pharmaceutical Sciences, Inc. | Compositions and methods for treating diseases of the nail |
| TWI518081B (zh) | 2010-08-31 | 2016-01-21 | Kaken Pharma Co Ltd | 1-triazole-2-butanol derivative |
| EP3052487B1 (en) | 2013-10-03 | 2018-09-05 | Dow Pharmaceutical Sciences, Inc. | Stabilized efinaconazole compositions |
| US10245257B2 (en) | 2013-11-22 | 2019-04-02 | Dow Pharmaceutical Sciences, Inc. | Anti-infective methods, compositions, and devices |
| CN104292214B (zh) * | 2014-09-24 | 2017-04-05 | 南京华威医药科技开发有限公司 | 艾氟康唑及其中间体的合成方法 |
| CN104327047B (zh) * | 2014-10-17 | 2016-04-06 | 苏州明锐医药科技有限公司 | 艾菲康唑的制备方法 |
| US9617241B2 (en) | 2014-11-23 | 2017-04-11 | Mapi Pharma Ltd. | Intermediate compounds and process for the preparation of efinaconazole |
| AU2015379251A1 (en) * | 2015-01-20 | 2017-07-27 | Wavelength Enterprises Ltd | Crystalline forms of efinaconazole |
| ITUB20150417A1 (it) | 2015-05-08 | 2016-11-08 | Dipharma Francis Srl | Procedimento per la preparazione di composti piperidinici |
| WO2016181306A1 (en) * | 2015-05-12 | 2016-11-17 | Lupin Limited | Process for the preparation of efinaconazole |
| EP3112360A1 (en) * | 2015-06-29 | 2017-01-04 | Dipharma Francis S.r.l. | Process for the preparation of efinaconazole |
| CN106565672A (zh) * | 2015-10-08 | 2017-04-19 | 中美华世通生物医药科技（武汉）有限公司 | 制备艾氟康唑的方法 |
| US20170129874A1 (en) * | 2015-11-10 | 2017-05-11 | Virupaksha Organics Limited | Novel improved process for preparing a triazole antifungal agent |
| CN106810534A (zh) * | 2015-11-30 | 2017-06-09 | 中美华世通生物医药科技（武汉）有限公司 | 艾氟康唑晶型及其制备方法 |
| CN106928186A (zh) * | 2015-12-29 | 2017-07-07 | 中美华世通生物医药科技（武汉）有限公司 | 化合物及其制备方法和用途 |
| ITUB20159795A1 (it) * | 2015-12-30 | 2017-06-30 | Procos Spa | Processo per la sintesi di efinaconazolo |
| ITUA20162545A1 (it) | 2016-04-13 | 2017-10-13 | Laboratorio Chimico Int S P A | Procedimento per la preparazione di intermedi utili nella sintesi di farmaci |
| US11185548B2 (en) | 2016-12-23 | 2021-11-30 | Helmholtz Zentrum Munchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Inhibitors of cytochrome P450 family 7 subfamily B member 1 (CYP7B1) for use in treating diseases |
| IT201700048270A1 (it) | 2017-05-04 | 2018-11-04 | Seegpharm Sa | Procedimento per la preparazione di un derivato azolico. |
| WO2018212333A1 (ja) | 2017-05-19 | 2018-11-22 | 科研製薬株式会社 | エフィナコナゾールの製造及び精製方法 |
| ES2915582T3 (es) | 2017-08-10 | 2022-06-23 | Sumitomo Chemical Co | Método para producir un compuesto de alcohol epoxi |
| EP3885341A4 (en) * | 2018-12-29 | 2022-08-10 | Viwit Pharmaceutical Co., Ltd. | METHOD FOR THE PREPARATION OF EFINACONAZOLE |
| KR102181155B1 (ko) | 2019-09-26 | 2020-11-20 | 대봉엘에스 주식회사 | 이온성 액체를 매개로 한 에피나코나졸의 신규 제조방법 |
| JP2021054781A (ja) | 2019-09-26 | 2021-04-08 | デボン エルエス，リミテッド | 共結晶形エフィナコナゾール、及びその製造方法 |
| KR102301743B1 (ko) | 2020-12-29 | 2021-09-13 | 대봉엘에스 주식회사 | 에피나코나졸 경구용 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1162540A (en) * | 1980-12-24 | 1984-02-21 | Ikutaro Saji | Imidazolylpropanol compounds and their acid addition salts, and production and use thereof |
| US4507484A (en) * | 1982-07-24 | 1985-03-26 | Pfizer Inc. | Triazole antifungal agents |
| GB8412750D0 (en) * | 1984-05-18 | 1984-06-27 | Ici Plc | Heterocyclic compounds |
| DE69407409T2 (de) * | 1993-05-10 | 1998-04-09 | Kaken Pharma Co Ltd | Azolylamin-derivat |
-
1994
- 1994-05-02 DE DE69407409T patent/DE69407409T2/de not_active Expired - Lifetime
- 1994-05-02 ES ES94914585T patent/ES2110749T3/es not_active Expired - Lifetime
- 1994-05-02 AU AU66896/94A patent/AU685116B2/en not_active Expired
- 1994-05-02 HU HU9503217A patent/HU225416B1/hu unknown
- 1994-05-02 KR KR1019950704971A patent/KR100339166B1/ko not_active Expired - Lifetime
- 1994-05-02 DK DK94914585T patent/DK0698606T3/da active
- 1994-05-02 AT AT94914585T patent/ATE161257T1/de active
- 1994-05-02 UA UA95125159A patent/UA41365C2/uk unknown
- 1994-05-02 EP EP94914585A patent/EP0698606B1/en not_active Expired - Lifetime
- 1994-05-02 WO PCT/JP1994/000737 patent/WO1994026734A1/ja not_active Ceased
- 1994-05-02 CN CN94192041A patent/CN1046278C/zh not_active Expired - Lifetime
- 1994-05-02 CA CA002162463A patent/CA2162463C/en not_active Expired - Lifetime
- 1994-05-11 TW TW083104253A patent/TW325473B/zh not_active IP Right Cessation
-
1995
- 1995-11-07 US US08/532,800 patent/US5620994A/en not_active Expired - Lifetime
-
1997
- 1997-01-09 US US08/781,204 patent/US5716969A/en not_active Expired - Lifetime
- 1997-11-10 US US08/966,527 patent/US5962476A/en not_active Expired - Lifetime
- 1997-12-18 GR GR970403105T patent/GR3025715T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3025715T3 (en) | 1998-03-31 |
| EP0698606A1 (en) | 1996-02-28 |
| EP0698606A4 (cg-RX-API-DMAC7.html) | 1996-04-10 |
| US5620994A (en) | 1997-04-15 |
| AU685116B2 (en) | 1998-01-15 |
| UA41365C2 (uk) | 2001-09-17 |
| HU225416B1 (en) | 2006-11-28 |
| US5962476A (en) | 1999-10-05 |
| HU9503217D0 (en) | 1996-01-29 |
| DE69407409T2 (de) | 1998-04-09 |
| TW325473B (en) | 1998-01-21 |
| EP0698606B1 (en) | 1997-12-17 |
| ATE161257T1 (de) | 1998-01-15 |
| US5716969A (en) | 1998-02-10 |
| ES2110749T3 (es) | 1998-02-16 |
| WO1994026734A1 (fr) | 1994-11-24 |
| AU6689694A (en) | 1994-12-12 |
| CN1046278C (zh) | 1999-11-10 |
| DK0698606T3 (da) | 1998-08-24 |
| CN1122598A (zh) | 1996-05-15 |
| DE69407409D1 (de) | 1998-01-29 |
| HUT75031A (en) | 1997-03-28 |
| KR100339166B1 (ko) | 2004-04-30 |
| CA2162463A1 (en) | 1994-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20140502 |
|
| MKEX | Expiry |
Effective date: 20140502 |