CA2156194C - New a83543 compounds and process for production thereof - Google Patents
New a83543 compounds and process for production thereof Download PDFInfo
- Publication number
- CA2156194C CA2156194C CA002156194A CA2156194A CA2156194C CA 2156194 C CA2156194 C CA 2156194C CA 002156194 A CA002156194 A CA 002156194A CA 2156194 A CA2156194 A CA 2156194A CA 2156194 C CA2156194 C CA 2156194C
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/08—Systemic pesticides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/10—Insect repellent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dentistry (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Devices That Are Associated With Refrigeration Equipment (AREA)
- Manufacturing Of Printed Wiring (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3052293A | 1993-03-12 | 1993-03-12 | |
| US08/030,522 | 1993-03-12 | ||
| PCT/US1994/002674 WO1994020518A1 (en) | 1993-03-12 | 1994-03-11 | New a83543 compounds and process for production thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2156194A1 CA2156194A1 (en) | 1994-09-15 |
| CA2156194C true CA2156194C (en) | 2008-01-08 |
Family
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|---|---|---|---|
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| JP (1) | JP4258575B2 (enExample) |
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| IL (1) | IL108979A (enExample) |
| TW (1) | TW294672B (enExample) |
| WO (1) | WO1994020518A1 (enExample) |
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| AU711185B2 (en) * | 1995-06-14 | 1999-10-07 | Dow Agrosciences Llc | Synthetic modification to spinosyn compounds |
| DE19823396A1 (de) * | 1998-05-26 | 1999-12-02 | Bayer Ag | Synergistische insektizide Mischungen |
| DE19823397B4 (de) | 1998-05-26 | 2011-07-28 | Bayer CropScience AG, 40789 | Verwendung von Spinosynen zum Einsatz als Bodeninsektizide |
| ID29130A (id) * | 1998-07-02 | 2001-08-02 | Lilly Co Eli | Formulasi pengendali kutu pada manusia |
| US6927210B1 (en) | 1999-08-12 | 2005-08-09 | Eli Lilly And Company | Ectoparasiticidal aqueous suspension formulations of spinosyns |
| MXPA02001505A (es) | 1999-08-12 | 2002-07-02 | Lilly Co Eli | Tratamiento oral de animales de compania con spinosyns actoparasiticida. |
| AU6606400A (en) * | 1999-08-12 | 2001-03-13 | Eli Lilly And Company | Topical treatment for insect pests in companion animals |
| US6933318B1 (en) | 1999-08-12 | 2005-08-23 | Eli Lilly And Company | Topical organic ectoparasiticidal formulations |
| AU6839300A (en) | 1999-08-27 | 2001-03-26 | Bayer Aktiengesellschaft | Nucleic acids which code for the enzyme activities of the spinosyn biosynthesis |
| JP4666861B2 (ja) * | 1999-09-13 | 2011-04-06 | ダウ・アグロサイエンス・エル・エル・シー | 有害生物防除性マクロライド |
| AUPQ441699A0 (en) | 1999-12-02 | 2000-01-06 | Eli Lilly And Company | Pour-on formulations |
| AUPQ634300A0 (en) * | 2000-03-20 | 2000-04-15 | Eli Lilly And Company | Synergistic formulations |
| US6585990B1 (en) | 2001-03-05 | 2003-07-01 | Dow Agrosciences, Llc | Compositions and devices using a spinosyn compound for control of insects |
| ES2496940T3 (es) | 2001-03-21 | 2014-09-22 | Dow Agrosciences, Llc | Derivados plaguicidas de las espinosinas |
| ES2276929T3 (es) * | 2001-03-29 | 2007-07-01 | Bayer Cropscience Ag | Compuestos intermedios para la obtencion de espinosinas. |
| AR033022A1 (es) | 2001-03-30 | 2003-12-03 | Dow Agrosciences Llc | Genes biosinteticos para la produccion de insecticida de butenilespinosina |
| US6727228B2 (en) * | 2001-04-25 | 2004-04-27 | Johnson & Johnson Consumer Companies, Inc. | Pediculicidal and ovacidal treatment compositions and methods for killing head lice and their eggs |
| DE10135550A1 (de) * | 2001-07-20 | 2003-01-30 | Bayer Cropscience Ag | Verfahren zum Herstellen von neuen Spinosyn-Derivaten |
| EP2347654B1 (en) | 2001-09-17 | 2019-02-27 | Elanco US Inc. | Formulation for controlling lice or ticks in catlle |
| TWI330183B (enExample) * | 2001-10-22 | 2010-09-11 | Eisai R&D Man Co Ltd | |
| KR101016561B1 (ko) | 2002-02-19 | 2011-02-22 | 다우 아그로사이언시즈 엘엘씨 | 신규한 스피노신 생산 폴리케타이드 신타제 |
| EP1682118B1 (en) * | 2003-11-04 | 2008-10-22 | Intervet International BV | Ectoparasiticidal formulations of spinosyns and azole pesticides |
| EP1849363A1 (en) * | 2006-03-09 | 2007-10-31 | Cheminova A/S | Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin |
| RU2513723C2 (ru) * | 2008-02-12 | 2014-04-20 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Пестицидные композиции |
| CN101560477B (zh) * | 2008-04-16 | 2012-04-25 | 上海医药工业研究院 | 发酵多杀菌素产生菌的培养基 |
| US9514283B2 (en) | 2008-07-09 | 2016-12-06 | Baxter International Inc. | Dialysis system having inventory management including online dextrose mixing |
| DK2343975T3 (da) | 2008-09-22 | 2012-12-03 | Entarco Sa | Spinosyn-antibegroningssammensætninger, fremgangsmåder til deres anvendelse samt genstande beskyttet mod vedhæftning af biobegroningsorganismer |
| US8268975B2 (en) | 2009-04-03 | 2012-09-18 | Dow Agrosciences Llc | Demulsification compositions, systems and methods for demulsifying and separating aqueous emulsions |
| TW201041508A (en) | 2009-04-30 | 2010-12-01 | Dow Agrosciences Llc | Pesticide compositions exhibiting enhanced activity |
| TW201041510A (en) | 2009-04-30 | 2010-12-01 | Dow Agrosciences Llc | Pesticide compositions exhibiting enhanced activity |
| TW201041509A (en) * | 2009-04-30 | 2010-12-01 | Dow Agrosciences Llc | Pesticide compositions exhibiting enhanced activity |
| TW201041507A (en) * | 2009-04-30 | 2010-12-01 | Dow Agrosciences Llc | Pesticide compositions exhibiting enhanced activity and methods for preparing same |
| WO2010150100A1 (en) | 2009-06-24 | 2010-12-29 | Entarco Sa | The use of spinosyns and spinosyn compositions against diseases caused by protozoans, viral infections and cancer |
| AU2011250904A1 (en) | 2010-05-11 | 2012-11-08 | Dow Agrosciences Llc | spnK strains |
| EP2654757A1 (en) | 2010-12-22 | 2013-10-30 | Entarco SA | The use of spinosyns and spinosyn compositions as local anesthetics and as antiarrhythmic agents |
| KR101960110B1 (ko) | 2010-12-29 | 2019-03-19 | 다우 아그로사이언시즈 엘엘씨 | 곤충 방제 방법 |
| EP2998399A1 (en) | 2011-05-03 | 2016-03-23 | Dow AgroSciences LLC | Enhancing spinosyn production with oxygen binding proteins |
| US9404107B2 (en) | 2011-05-03 | 2016-08-02 | Dow Agrosciences Llc | Integration of genes into the chromosome of Saccharopolyspora spinosa |
| US8741603B2 (en) | 2011-05-03 | 2014-06-03 | Agrigenetics Inc. | Enhancing spinosyn production with oxygen binding proteins |
| US9631195B2 (en) | 2011-12-28 | 2017-04-25 | Dow Agrosciences Llc | Identification and characterization of the spinactin biosysnthesis gene cluster from spinosyn producing saccharopolyspora spinosa |
| NZ731588A (en) | 2012-02-06 | 2018-11-30 | Boehringer Ingelheim Animal Health Usa Inc | Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| AU2012233000B2 (en) * | 2012-09-28 | 2016-01-21 | Elanco New Zealand | Ectoparasitic Treatment Method and Composition |
| EP3131398B1 (en) | 2014-04-17 | 2019-10-23 | Boehringer Ingelheim Animal Health USA Inc. | Use of malononitrile compounds for protecting animals from parasites |
| MX361606B (es) | 2014-05-19 | 2018-12-11 | Merial Inc | Compuestos antihelmínticos. |
| BR112016029888B1 (pt) | 2014-06-19 | 2021-05-18 | Merial, Inc | composições parasiticidas compreendendo derivados de indol, métodos e usos dos mesmos |
| US10306887B2 (en) | 2014-08-05 | 2019-06-04 | The Board Of Regents Of The University Of Texas Systems | Composition and methods for modulation of the octopamine receptor and its homologs |
| UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| DK3298027T3 (da) | 2015-05-20 | 2021-08-09 | Boehringer Ingelheim Animal Health Usa Inc | Anthelmintiske depsipeptidforbindelser |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| EP3541789A1 (en) | 2016-11-16 | 2019-09-25 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| WO2018226893A2 (en) | 2017-06-06 | 2018-12-13 | Zymergen Inc. | A high-throughput (htp) genomic engineering platform for improving saccharopolyspora spinosa |
| KR102785432B1 (ko) | 2018-07-09 | 2025-03-21 | 베링거잉겔하임베트메디카게엠베하 | 구충성 헤테로시클릭 화합물 |
| KR20210061336A (ko) | 2018-07-27 | 2021-05-27 | 아페르타 바이오사이언시스 엘엘씨 | 모낭충으로 유발된 안구 및 안면 증상의 치료를 위한 스피노신 제제 |
| CN113260419A (zh) | 2018-11-20 | 2021-08-13 | 勃林格殷格翰动物保健美国公司 | 吲唑基氰基乙基氨基化合物、其组合物、其制备方法和其使用方法 |
| AU2020208145B2 (en) | 2019-01-16 | 2023-02-02 | Boehringer Ingelheim Vetmedica Gmbh | Topical compositions comprising a neonicotinoid and a macrocyclic lactone, methods and uses thereof |
| CN113825543B (zh) | 2019-03-19 | 2024-09-06 | 勃林格殷格翰动物保健有限公司 | 驱虫的氮杂-苯并噻吩和氮杂-苯并呋喃化合物 |
| CN110734467B (zh) * | 2019-09-10 | 2021-08-27 | 北大方正集团有限公司 | 一种从发酵液中提取纯化多杀霉素的方法 |
| KR20230028268A (ko) | 2020-05-29 | 2023-02-28 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 헤테로시클릭 화합물 |
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| DE3162169D1 (en) * | 1980-07-15 | 1984-03-15 | Kowa Co | Process for production of antibiotics, and novel antibiotics produced thereby |
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| IT1195299B (it) * | 1981-11-27 | 1988-10-12 | Pierrel Spa | Procedimento chimico di sintesi per la preparazione di antibiotici macrolidici |
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| IT1194181B (it) * | 1983-03-30 | 1988-09-14 | Erba Farmitalia | Procedimento migliorato per la purificazione della tilosina |
| US4530835A (en) * | 1983-07-08 | 1985-07-23 | Warner-Lambert Company | CL-1577 Antibiotic compounds and their production |
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1994
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- 1994-03-11 ES ES94912774T patent/ES2099604T3/es not_active Expired - Lifetime
- 1994-03-11 DE DE69402308T patent/DE69402308T2/de not_active Expired - Lifetime
- 1994-03-11 DK DK94912774.0T patent/DK0688332T3/da active
- 1994-03-11 JP JP52034194A patent/JP4258575B2/ja not_active Expired - Lifetime
- 1994-03-11 AU AU65187/94A patent/AU685107B2/en not_active Expired
- 1994-03-11 WO PCT/US1994/002674 patent/WO1994020518A1/en not_active Ceased
- 1994-03-11 BR BR9406587A patent/BR9406587A/pt not_active IP Right Cessation
- 1994-03-11 CA CA002156194A patent/CA2156194C/en not_active Expired - Lifetime
- 1994-03-11 AT AT94912774T patent/ATE150758T1/de active
- 1994-03-15 IL IL10897994A patent/IL108979A/en not_active IP Right Cessation
- 1994-03-21 TW TW083102553A patent/TW294672B/zh not_active IP Right Cessation
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1995
- 1995-02-08 US US08/385,497 patent/US5840861A/en not_active Expired - Lifetime
- 1995-06-07 US US08/474,026 patent/US5670364A/en not_active Expired - Lifetime
- 1995-06-07 US US08/483,440 patent/US5670486A/en not_active Expired - Lifetime
- 1995-09-11 FI FI954246A patent/FI107266B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08507533A (ja) | 1996-08-13 |
| AU6518794A (en) | 1994-09-26 |
| EP0688332B1 (en) | 1997-03-26 |
| ATE150758T1 (de) | 1997-04-15 |
| US5670486A (en) | 1997-09-23 |
| DE69402308D1 (de) | 1997-04-30 |
| JP4258575B2 (ja) | 2009-04-30 |
| US5670364A (en) | 1997-09-23 |
| IL108979A0 (en) | 1994-06-24 |
| ES2099604T3 (es) | 1997-05-16 |
| CA2156194A1 (en) | 1994-09-15 |
| EP0688332A1 (en) | 1995-12-27 |
| IL108979A (en) | 1999-09-22 |
| WO1994020518A1 (en) | 1994-09-15 |
| FI107266B (fi) | 2001-06-29 |
| FI954246A0 (fi) | 1995-09-11 |
| US5840861A (en) | 1998-11-24 |
| FI954246L (fi) | 1995-09-11 |
| AU685107B2 (en) | 1998-01-15 |
| BR9406587A (pt) | 1996-01-02 |
| TW294672B (enExample) | 1997-01-01 |
| DE69402308T2 (de) | 1997-10-23 |
| DK0688332T3 (da) | 1997-10-13 |
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