CA2146348A1

CA2146348A1 - Cosmetic composition

Cosmetic composition

Info

Publication number: CA2146348A1
Authority: CA; Canada
Prior art keywords: arginine; metabolic intermediate; hair; derivatives; composition
Prior art date: 1992-10-30
Legal status : Abandoned

Application number

CA002146348A

Other languages

English (en)

French (fr)

Inventor

Walter Thomas Gibson

Terence George Evelyn Kealey

Gillian Elizabeth Westgate

Current Assignee

Unilever PLC

Original Assignee

Individual

Priority date

1992-10-30

Filing date

1993-10-27

Publication date

1994-05-11

1993-10-27 Application filed by Individual filed Critical Individual

1994-05-11 Publication of CA2146348A1 publication Critical patent/CA2146348A1/en

Status Abandoned legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 104
239000002537 cosmetic Substances 0.000 title abstract description 8
230000004143 urea cycle Effects 0.000 claims abstract description 37
230000002503 metabolic effect Effects 0.000 claims abstract description 29
210000004761 scalp Anatomy 0.000 claims abstract description 29
230000000699 topical effect Effects 0.000 claims abstract description 21
230000036621 balding Effects 0.000 claims abstract description 5
-1 L-tyrosinylarginine L-arginylmethionine L-ornithylmethionine Chemical compound 0.000 claims description 76
230000003779 hair growth Effects 0.000 claims description 36
150000003839 salts Chemical class 0.000 claims description 19
RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims description 18
KDZOASGQNOPSCU-WDSKDSINSA-N Argininosuccinic acid Chemical compound OC(=O)[C@@H](N)CCC\N=C(/N)N[C@H](C(O)=O)CC(O)=O KDZOASGQNOPSCU-WDSKDSINSA-N 0.000 claims description 17
125000000217 alkyl group Chemical group 0.000 claims description 16
239000004475 Arginine Substances 0.000 claims description 15
229960003121 arginine Drugs 0.000 claims description 15
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 15
235000009697 arginine Nutrition 0.000 claims description 15
239000004094 surface-active agent Substances 0.000 claims description 15
AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims description 14
229960002173 citrulline Drugs 0.000 claims description 14
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 13
RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims description 13
235000013477 citrulline Nutrition 0.000 claims description 13
AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims description 11
UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims description 11
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229960003104 ornithine Drugs 0.000 claims description 11
125000002252 acyl group Chemical group 0.000 claims description 7
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OMLWNBVRVJYMBQ-YUMQZZPRSA-N Arg-Arg Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O OMLWNBVRVJYMBQ-YUMQZZPRSA-N 0.000 claims description 5
OPINTGHFESTVAX-BQBZGAKWSA-N Gln-Arg Chemical compound NC(=O)CC[C@H](N)C(=O)N[C@H](C(O)=O)CCCN=C(N)N OPINTGHFESTVAX-BQBZGAKWSA-N 0.000 claims description 5
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VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 3
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ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
150000001483 arginine derivatives Chemical class 0.000 claims description 3
CCTIOCVIZPCTGO-BYPYZUCNSA-N phosphoarginine Chemical compound OC(=O)[C@@H](N)CCCNC(=N)NP(O)(O)=O CCTIOCVIZPCTGO-BYPYZUCNSA-N 0.000 claims description 3
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DEQQDEIRBQYEFZ-FHNDMYTFSA-N (2s)-2,5-diaminopentanoic acid;sodium;hydrochloride Chemical compound [Na].Cl.NCCC[C@H](N)C(O)=O DEQQDEIRBQYEFZ-FHNDMYTFSA-N 0.000 claims 2
KWTQSFXGGICVPE-UHFFFAOYSA-N 2-amino-5-(diaminomethylideneamino)pentanoic acid;hydron;chloride Chemical compound Cl.OC(=O)C(N)CCCN=C(N)N KWTQSFXGGICVPE-UHFFFAOYSA-N 0.000 claims 2
KWTQSFXGGICVPE-WCCKRBBISA-N Arginine hydrochloride Chemical compound Cl.OC(=O)[C@@H](N)CCCN=C(N)N KWTQSFXGGICVPE-WCCKRBBISA-N 0.000 claims 2
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125000002059 L-arginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 claims 2
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