CA2140662A1 - Tetracyclic compounds, process and intermediates for their preparation and their use as antitumour agents - Google Patents
Tetracyclic compounds, process and intermediates for their preparation and their use as antitumour agentsInfo
- Publication number
- CA2140662A1 CA2140662A1 CA002140662A CA2140662A CA2140662A1 CA 2140662 A1 CA2140662 A1 CA 2140662A1 CA 002140662 A CA002140662 A CA 002140662A CA 2140662 A CA2140662 A CA 2140662A CA 2140662 A1 CA2140662 A1 CA 2140662A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- carbon atoms
- carbazole
- optionally substituted
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929215361A GB9215361D0 (en) | 1992-07-20 | 1992-07-20 | Heterocyclic compounds |
| GB9215361.8 | 1992-07-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2140662A1 true CA2140662A1 (en) | 1994-02-03 |
Family
ID=10718981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002140662A Abandoned CA2140662A1 (en) | 1992-07-20 | 1993-07-19 | Tetracyclic compounds, process and intermediates for their preparation and their use as antitumour agents |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0651750A1 (es) |
| JP (1) | JPH08502037A (es) |
| KR (1) | KR950702563A (es) |
| CN (1) | CN1088209A (es) |
| AU (1) | AU4579593A (es) |
| BG (1) | BG99359A (es) |
| CA (1) | CA2140662A1 (es) |
| CZ (1) | CZ14995A3 (es) |
| FI (1) | FI950229A (es) |
| GB (1) | GB9215361D0 (es) |
| HR (1) | HRP931066A2 (es) |
| HU (1) | HUT76787A (es) |
| IL (1) | IL106385A0 (es) |
| MX (1) | MX9304355A (es) |
| NO (1) | NO950202D0 (es) |
| NZ (1) | NZ254207A (es) |
| PL (1) | PL307169A1 (es) |
| RU (1) | RU95104939A (es) |
| SI (1) | SI9300390A (es) |
| SK (1) | SK7595A3 (es) |
| WO (1) | WO1994002483A1 (es) |
| YU (1) | YU50293A (es) |
| ZA (1) | ZA935213B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9401921D0 (en) * | 1994-02-01 | 1994-03-30 | Wellcome Found | Heterocyclic compounds |
| GB9413758D0 (en) * | 1994-07-07 | 1994-08-24 | Wellcome Found | Heterocyclic compounds |
| GB9804343D0 (en) * | 1998-02-27 | 1998-04-22 | Univ Cardiff | Chemical compounds |
| US7419992B2 (en) | 2001-02-14 | 2008-09-02 | Wisconsin Alumni Research Foundation | Use of aryl hydrocarbon receptor ligand as a therapeutic intervention in angiogenesis-implicated disorders |
| ATE431823T1 (de) * | 2001-02-14 | 2009-06-15 | Wisconsin Alumni Res Found | Zubereitungen und verwendung eines ah-rezeptor- liganden, 2-(1'h-indol-3'-carbonyl)-thiazol-4- carbonsäure-methylester |
| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| WO2008051523A2 (en) * | 2006-10-23 | 2008-05-02 | Georgetown University | Carbazole derivatives useful as medicaments in cancer therapy |
| JP2012500197A (ja) | 2008-08-15 | 2012-01-05 | ジョージタウン ユニバーシティー | Ｒａｓｓｆ１ａ発現およびヒト癌細胞増殖の蛍光調節剤 |
| JP2012051804A (ja) * | 2008-12-26 | 2012-03-15 | Kyoto Univ | Ｅｇ５阻害剤 |
| KR20160066490A (ko) * | 2014-12-02 | 2016-06-10 | 주식회사 씨앤드씨신약연구소 | 헤테로사이클 유도체 및 그의 용도 |
| US11053255B2 (en) | 2015-06-22 | 2021-07-06 | Georgetown University | Synthesis of mahanine and related compounds |
| CN109776550B (zh) * | 2019-01-17 | 2021-08-10 | 广东轻工职业技术学院 | 一种海洋真菌来源的生物碱化合物及其在制备食品防腐剂中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0300688A1 (en) * | 1987-07-21 | 1989-01-25 | FISONS plc | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them |
| US5166204A (en) * | 1989-11-01 | 1992-11-24 | Toyama Chemical Co., Ltd. | Isoindole derivatives and salts thereof and antitumor agent comprising the same |
| MC2251A1 (fr) * | 1990-03-20 | 1993-03-25 | Wellcome Found | Composes heterocycliques biocides,leur synthese et leurs internediaires,compositions les contenant et leur utilisation en medecine |
-
1992
- 1992-07-20 GB GB929215361A patent/GB9215361D0/en active Pending
-
1993
- 1993-07-19 SI SI9300390A patent/SI9300390A/sl unknown
- 1993-07-19 HU HU9500171A patent/HUT76787A/hu unknown
- 1993-07-19 WO PCT/GB1993/001512 patent/WO1994002483A1/en not_active Application Discontinuation
- 1993-07-19 IL IL106385A patent/IL106385A0/xx unknown
- 1993-07-19 CN CN93116598A patent/CN1088209A/zh active Pending
- 1993-07-19 CA CA002140662A patent/CA2140662A1/en not_active Abandoned
- 1993-07-19 ZA ZA935213A patent/ZA935213B/xx unknown
- 1993-07-19 CZ CZ95149A patent/CZ14995A3/cs unknown
- 1993-07-19 MX MX9304355A patent/MX9304355A/es not_active IP Right Cessation
- 1993-07-19 PL PL93307169A patent/PL307169A1/xx unknown
- 1993-07-19 NZ NZ254207A patent/NZ254207A/en unknown
- 1993-07-19 HR HR931066A patent/HRP931066A2/hr not_active Application Discontinuation
- 1993-07-19 EP EP93916105A patent/EP0651750A1/en not_active Withdrawn
- 1993-07-19 JP JP6504272A patent/JPH08502037A/ja active Pending
- 1993-07-19 SK SK75-95A patent/SK7595A3/sk unknown
- 1993-07-19 RU RU95104939/04A patent/RU95104939A/ru unknown
- 1993-07-19 AU AU45795/93A patent/AU4579593A/en not_active Abandoned
- 1993-07-19 KR KR1019950700226A patent/KR950702563A/ko not_active Application Discontinuation
- 1993-07-20 YU YU50293A patent/YU50293A/sh unknown
-
1995
- 1995-01-18 BG BG99359A patent/BG99359A/bg unknown
- 1995-01-19 FI FI950229A patent/FI950229A/fi unknown
- 1995-01-19 NO NO950202A patent/NO950202D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1088209A (zh) | 1994-06-22 |
| YU50293A (sh) | 1997-01-08 |
| NO950202L (no) | 1995-01-19 |
| GB9215361D0 (en) | 1992-09-02 |
| NO950202D0 (no) | 1995-01-19 |
| FI950229A0 (fi) | 1995-01-19 |
| HRP931066A2 (en) | 1995-12-31 |
| CZ14995A3 (en) | 1995-10-18 |
| HU9500171D0 (en) | 1995-03-28 |
| SK7595A3 (en) | 1995-07-11 |
| PL307169A1 (en) | 1995-05-15 |
| JPH08502037A (ja) | 1996-03-05 |
| MX9304355A (es) | 1994-04-29 |
| SI9300390A (en) | 1994-03-31 |
| RU95104939A (ru) | 1996-10-27 |
| WO1994002483A1 (en) | 1994-02-03 |
| FI950229A (fi) | 1995-03-10 |
| ZA935213B (en) | 1995-01-19 |
| AU4579593A (en) | 1994-02-14 |
| KR950702563A (ko) | 1995-07-29 |
| NZ254207A (en) | 1997-03-24 |
| HUT76787A (en) | 1997-11-28 |
| BG99359A (bg) | 1995-11-30 |
| EP0651750A1 (en) | 1995-05-10 |
| IL106385A0 (en) | 1993-11-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0432040B2 (fr) | Dérivés hétérocycliques d'acylaminothiazoles, leur préparation et compositions pharmaceutiques en contenant | |
| CA2140662A1 (en) | Tetracyclic compounds, process and intermediates for their preparation and their use as antitumour agents | |
| CN107556244B (zh) | 并环化合物、其药物组合物及应用 | |
| CA2140440A1 (en) | 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and which have antitumor properties | |
| EP0397060A2 (de) | Maleinimid-Derivate und deren Verwendung als Arzneimittel | |
| US20040048915A1 (en) | Methods and compounds for treating proliferative diseases | |
| CA2459879A1 (en) | 3-(4,5,6,7-tetrahydroindol-2-ylmethylidiene)-2-indolinone derivatives as kinase inhibitors | |
| RU2162089C2 (ru) | Новые пирролокарбазолы | |
| Tholander et al. | Syntheses of 6, 12-disubstituted 5, 11-dihydroindolo [3, 2-b] carbazoles, including 5, 11-dihydroindolo [3, 2-b] carbazole-6, 12-dicarbaldehyde, an extremely efficient ligand for the TCDD (Ah) receptor | |
| FI79319B (fi) | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tricykliska oxindolkarboxamidderivat. | |
| Naveen et al. | Concise total synthesis of water soluble metatacarboline A, C, D, E and F and its anticancer activity | |
| Tholander et al. | Syntheses of 6-substituted indolo [3, 2-b] carbazoles, including 6-formylindolo [3, 2-b] carbazole, an extremely efficient ligand for the TCDD (Ah) receptor | |
| EP0591058B1 (fr) | Dérivés d'Ellipticine à activité antitumorale | |
| US5679694A (en) | Tetracyclic compounds, intermediates for their preparation and their use as antitumor agents | |
| KR101752932B1 (ko) | 4-(아세틸아미노))-3-［(4-클로로-페닐)티오］-2-메틸-1ｈ-인돌-1-아세트산의 중간체 및 그의 제조 방법 | |
| WO2001009129A2 (en) | 1h-pirido[3, 4-b]indol-1-one derivatives | |
| CA2443585A1 (fr) | Nouveaux derives de (3,4-a:3,4-c) carbazole, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent | |
| FR2933983A1 (fr) | Nouveaux derives tricycliques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. | |
| AU701025B2 (en) | Heterocyclic compounds | |
| EP2379549B1 (en) | 7-azaindirubins, 7'-azaindirubins, 7-7'-diazaindirubin and the corresponding 3'-oxime ether derivates: production thereof, their production and use as a medicament | |
| SU1268586A1 (ru) | Способ получени незамещенного 4-оксо-1,2,3,3а-тетрагидропирамидо-(1,2,3,3 @ )- @ -карболина или его 5,6-алкил (арил)производных | |
| JP2003506376A (ja) | １，２−ジヒドロ−１−オキソ−ピラジノ［１，２−ａ］インドール誘導体 | |
| EP2199292A1 (en) | 7-azaindirubins, 7'-azaindirubins, 7-7'-diazaindirubin and the corresponding 3'-oxime ether derivates: production thereof, their production and use as a medicament | |
| WO2004035582A1 (fr) | Derives de pyrrolo (3,4-c) carbazole et de pyrido (2,3-b) pyrrolo (3,4-e) indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| SU1468902A1 (ru) | Способ получени пирано @ 3,4-в @ индолов |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |