CA2136622A1 - Composes biologiquement actifs de type phosphotriesters - Google Patents

Composes biologiquement actifs de type phosphotriesters

Info

Publication number
CA2136622A1
CA2136622A1 CA002136622A CA2136622A CA2136622A1 CA 2136622 A1 CA2136622 A1 CA 2136622A1 CA 002136622 A CA002136622 A CA 002136622A CA 2136622 A CA2136622 A CA 2136622A CA 2136622 A1 CA2136622 A1 CA 2136622A1
Authority
CA
Canada
Prior art keywords
biologically active
phosphotriester
active compounds
radical
type biologically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002136622A
Other languages
English (en)
Other versions
CA2136622C (fr
Inventor
Gilles Gosselin
Jean-Louis Imbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Gilles Gosselin
Jean-Louis Imbach
Centre National De La Recherche Scientifique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9206383A external-priority patent/FR2691463A1/fr
Application filed by Gilles Gosselin, Jean-Louis Imbach, Centre National De La Recherche Scientifique filed Critical Gilles Gosselin
Publication of CA2136622A1 publication Critical patent/CA2136622A1/fr
Application granted granted Critical
Publication of CA2136622C publication Critical patent/CA2136622C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention a pour objet un composé phosphotriester répondant à la formule générale (I) dans laquelle: R est un radical -(CH2)n - S - X où X représente un radical (a) ou -S-U, Z étant O ou S et, Y et U représentant un radical alkyle, aryle ou osidique, éventuellement substitué notamment par un groupe OH, SH ou NH2 et, n est égal à 1 à 4 de préférence 1 ou 2 et, Nu est un radical consistant en un reste d'un composé biologiquement actif ou le reste déphosphorylé d'un composé qui est biologiquement actif lorsqu'il porte un groupe phosphate ou phosphonate.
CA002136622A 1992-05-25 1993-05-24 Composes biologiquement actifs de type phosphotriesters Expired - Lifetime CA2136622C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR9206383A FR2691463A1 (fr) 1992-05-25 1992-05-25 Dérivés nucléotidiques, leur préparation et leur application en thérapeutique.
FR92/06383 1992-05-25
FR9304117A FR2692265B1 (fr) 1992-05-25 1993-04-07 Composes biologiquement actifs de type phosphotriesters.
FR93/04117 1993-04-07
PCT/FR1993/000498 WO1993024510A1 (fr) 1992-05-25 1993-05-24 Composes biologiquement actifs de type phosphotriesters

Publications (2)

Publication Number Publication Date
CA2136622A1 true CA2136622A1 (fr) 1993-12-09
CA2136622C CA2136622C (fr) 2006-01-03

Family

ID=26229484

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002136622A Expired - Lifetime CA2136622C (fr) 1992-05-25 1993-05-24 Composes biologiquement actifs de type phosphotriesters

Country Status (11)

Country Link
US (2) US6399589B1 (fr)
EP (1) EP0642528B1 (fr)
JP (1) JP3628324B2 (fr)
AT (1) ATE147750T1 (fr)
CA (1) CA2136622C (fr)
DE (1) DE69307506T2 (fr)
DK (1) DK0642528T3 (fr)
ES (1) ES2099436T3 (fr)
FR (1) FR2692265B1 (fr)
GR (1) GR3023130T3 (fr)
WO (1) WO1993024510A1 (fr)

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ATE147750T1 (de) 1997-02-15
FR2692265A1 (fr) 1993-12-17
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WO1993024510A1 (fr) 1993-12-09
US20020037873A1 (en) 2002-03-28
CA2136622C (fr) 2006-01-03
US6555676B2 (en) 2003-04-29
US6399589B1 (en) 2002-06-04
DE69307506D1 (de) 1997-02-27
GR3023130T3 (en) 1997-07-30
ES2099436T3 (es) 1997-05-16
EP0642528B1 (fr) 1997-01-15
DE69307506T2 (de) 1997-07-03
EP0642528A1 (fr) 1995-03-15
FR2692265B1 (fr) 1996-11-08
JP3628324B2 (ja) 2005-03-09
DK0642528T3 (da) 1997-07-21

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