GR3023130T3 - Phosphotriester-type biologically active compounds. - Google Patents

Phosphotriester-type biologically active compounds.

Info

Publication number
GR3023130T3
GR3023130T3 GR970400791T GR970400791T GR3023130T3 GR 3023130 T3 GR3023130 T3 GR 3023130T3 GR 970400791 T GR970400791 T GR 970400791T GR 970400791 T GR970400791 T GR 970400791T GR 3023130 T3 GR3023130 T3 GR 3023130T3
Authority
GR
Greece
Prior art keywords
biologically active
phosphotriester
active compounds
radical
type biologically
Prior art date
Application number
GR970400791T
Other languages
Greek (el)
Inventor
Gilles Gosselin
Jean-Louis Imbach
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9206383A external-priority patent/FR2691463A1/en
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Publication of GR3023130T3 publication Critical patent/GR3023130T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Abstract

Compounds of formula RS-P(=O)(QR)-Nu where: R is a radical -(CH2)n-W-X; X is a radical -C(=Z) (Y) or -S-U; Z is O or S; W is O or S; Q is O or S; Y and U are an alkyl, aryl or saccharide radical which is optionally substituted with, for example, an OH, SH or NH group; n is equal to 1 to 4, preferably 1 or 2; and Nu is a radical consisting of a residue of a biologically active compound or the dephosphorylated residue of a compound which is biologically active when it bears a phosphate or phosphonate group.
GR970400791T 1992-05-25 1997-04-14 Phosphotriester-type biologically active compounds. GR3023130T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9206383A FR2691463A1 (en) 1992-05-25 1992-05-25 Phospho:tri:ester derivs. of nucleoside(s)
FR9304117A FR2692265B1 (en) 1992-05-25 1993-04-07 BIOLOGICALLY ACTIVE COMPOUNDS OF THE PHOSPHOTRIESTER TYPE.
PCT/FR1993/000498 WO1993024510A1 (en) 1992-05-25 1993-05-24 Phosphotriester-type biologically active compounds

Publications (1)

Publication Number Publication Date
GR3023130T3 true GR3023130T3 (en) 1997-07-30

Family

ID=26229484

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970400791T GR3023130T3 (en) 1992-05-25 1997-04-14 Phosphotriester-type biologically active compounds.

Country Status (11)

Country Link
US (2) US6399589B1 (en)
EP (1) EP0642528B1 (en)
JP (1) JP3628324B2 (en)
AT (1) ATE147750T1 (en)
CA (1) CA2136622C (en)
DE (1) DE69307506T2 (en)
DK (1) DK0642528T3 (en)
ES (1) ES2099436T3 (en)
FR (1) FR2692265B1 (en)
GR (1) GR3023130T3 (en)
WO (1) WO1993024510A1 (en)

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CA2136622C (en) 2006-01-03
WO1993024510A1 (en) 1993-12-09
EP0642528A1 (en) 1995-03-15
ATE147750T1 (en) 1997-02-15
FR2692265B1 (en) 1996-11-08
DE69307506T2 (en) 1997-07-03
JPH07507068A (en) 1995-08-03
CA2136622A1 (en) 1993-12-09
US20020037873A1 (en) 2002-03-28
DK0642528T3 (en) 1997-07-21
ES2099436T3 (en) 1997-05-16
JP3628324B2 (en) 2005-03-09
DE69307506D1 (en) 1997-02-27
EP0642528B1 (en) 1997-01-15
FR2692265A1 (en) 1993-12-17
US6399589B1 (en) 2002-06-04
US6555676B2 (en) 2003-04-29

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