CA2135440A1 - Heterocyclic compounds, their production and use - Google Patents

Heterocyclic compounds, their production and use

Info

Publication number
CA2135440A1
CA2135440A1 CA002135440A CA2135440A CA2135440A1 CA 2135440 A1 CA2135440 A1 CA 2135440A1 CA 002135440 A CA002135440 A CA 002135440A CA 2135440 A CA2135440 A CA 2135440A CA 2135440 A1 CA2135440 A1 CA 2135440A1
Authority
CA
Canada
Prior art keywords
group
compound
ring
oxo
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002135440A
Other languages
English (en)
French (fr)
Inventor
Hideaki Natsugari
Takenori Ishimaru
Takayuki Doi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2135440A1 publication Critical patent/CA2135440A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002135440A 1993-11-10 1994-11-09 Heterocyclic compounds, their production and use Abandoned CA2135440A1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP28117893 1993-11-10
JP281178-1993 1993-11-10
JP33748893 1993-12-28
JP337488-1993 1993-12-28
JP3363794 1994-03-03
JP033637-1994 1994-03-03
JP138551-1994 1994-06-21
JP13855194 1994-06-21

Publications (1)

Publication Number Publication Date
CA2135440A1 true CA2135440A1 (en) 1995-05-11

Family

ID=27459814

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002135440A Abandoned CA2135440A1 (en) 1993-11-10 1994-11-09 Heterocyclic compounds, their production and use

Country Status (16)

Country Link
US (1) US5585385A (cg-RX-API-DMAC10.html)
EP (1) EP0652218B1 (cg-RX-API-DMAC10.html)
KR (1) KR950014108A (cg-RX-API-DMAC10.html)
CN (1) CN1052004C (cg-RX-API-DMAC10.html)
AT (1) ATE203024T1 (cg-RX-API-DMAC10.html)
AU (1) AU678295B2 (cg-RX-API-DMAC10.html)
BR (1) BR9404403A (cg-RX-API-DMAC10.html)
CA (1) CA2135440A1 (cg-RX-API-DMAC10.html)
DE (1) DE69427675T2 (cg-RX-API-DMAC10.html)
FI (1) FI945281L (cg-RX-API-DMAC10.html)
HU (1) HUT68810A (cg-RX-API-DMAC10.html)
IL (1) IL111590A0 (cg-RX-API-DMAC10.html)
NO (1) NO301764B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ264887A (cg-RX-API-DMAC10.html)
RU (1) RU2135471C1 (cg-RX-API-DMAC10.html)
TW (1) TW263498B (cg-RX-API-DMAC10.html)

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EP0733632B1 (en) * 1995-03-24 2003-06-04 Takeda Chemical Industries, Ltd. Cyclic compounds, their production and use as tachykinin receptor antagonists
FR2732221B1 (fr) * 1995-03-28 1997-04-25 Oreal Utilisation d'un antagoniste de cgrp pour traiter les rougeurs cutanees d'origine neurogene et composition obtenue
GB9524104D0 (en) * 1995-11-24 1996-01-24 Smithkline Beecham Spa Novel compounds
US6087373A (en) * 1997-09-23 2000-07-11 Merck & Co., Inc. Thrombin inhibitors
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US6727258B2 (en) 1997-10-29 2004-04-27 King Pharmaceutical Research & Development, Inc. Allosteric adenosine receptor modulators
US6323214B1 (en) 1997-10-29 2001-11-27 Medco Research, Inc Allosteric adenosine receptor modulators
US5939432A (en) * 1997-10-29 1999-08-17 Medco Research, Inc. Thiophenes useful for modulating the adenosine receptor
AU5305299A (en) * 1998-08-26 2000-03-21 Tanabe Seiyaku Co., Ltd. Naphthyridine derivatives and process for the preparation thereof
AU6228499A (en) * 1998-10-22 2000-05-08 Akzo Nobel N.V. Tetrahydropyridopyridine derivatives and intermediates for producing the same
US6239132B1 (en) 1999-04-23 2001-05-29 Merck & Co., Inc. Thrombin inhibitors
EP1189618A4 (en) 1999-06-04 2002-06-19 Merck & Co Inc thrombin
US20040152727A1 (en) * 2001-05-18 2004-08-05 Hay Douglas William Pierre Novel use
US7030107B2 (en) 2001-12-10 2006-04-18 Kyorin Pharmaceutical.Co., Ltd. Fused bicyclic pyridine derivatives as tachykinin receptor antagonists
KR100887471B1 (ko) * 2002-01-18 2009-03-10 교린 세이야꾸 가부시키 가이샤 축합 바이사이클릭 피리미딘 유도체
CA2476162A1 (en) * 2002-02-13 2003-08-21 Takeda Chemical Industries, Ltd. Jnk inhibitor
JP4494020B2 (ja) 2002-03-15 2010-06-30 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖインテグラーゼ阻害剤として有用なｎ−（置換ベンジル）−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミド
CN1310922C (zh) * 2002-03-26 2007-04-18 杏林制药株式会社 作为速激肽受体拮抗剂的稠合双环吡啶衍生物
EP1569925A1 (en) 2002-12-13 2005-09-07 Neurogen Corporation 2-substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators
RU2229475C1 (ru) * 2003-03-06 2004-05-27 ООО "Исследовательский институт химического разнообразия 6-сульфамоилхинолин-4-карбоновые кислоты, их производные и комбинаторная библиотека
AU2004276267B2 (en) 2003-09-23 2010-08-19 Merck Sharp & Dohme Corp. Isoquinolinone potassium channel inhibitors
EP1667973B1 (en) * 2003-09-23 2013-12-04 Merck Sharp & Dohme Corp. Quinoline potassium channel inhibitors
CA2552965A1 (en) * 2004-01-14 2005-07-28 Takeda Pharmaceutical Company Limited Carboxamide derivative and use thereof
KR100781704B1 (ko) * 2005-04-20 2007-12-03 에스케이케미칼주식회사 피리딘 유도체와 이의 제조방법, 및 이를 포함하는약제조성물
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR056048A1 (es) * 2005-09-01 2007-09-12 Tanabe Seiyaku Co Compuesto tiomorfolina y procedimiento para preparar el mismo
RU2359962C1 (ru) * 2007-12-13 2009-06-27 Общество с ограниченной ответственностью "Консорциум-ПИК" (ООО "Консорциум-ПИК") Нейротропное средство и способ его получения
RU2429230C1 (ru) * 2010-05-27 2011-09-20 Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) Способ получения n-метил-4-бензилкарбамидопиридиния йодида
EP2681200A4 (en) * 2011-03-03 2015-05-27 Zalicus Pharmaceuticals Ltd INHIBITORS OF BENZIMIDAZOLE TYPE OF SODIUM CHANNEL
CN102358730A (zh) * 2011-08-24 2012-02-22 济南赛文医药技术有限公司 一种小分子mek蛋白激酶抑制剂
WO2013097052A1 (en) 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
ES2625945T3 (es) 2012-11-14 2017-07-21 Glaxosmithkline Llc Tieno[3,2-c]piridin-4(5H)-onas como inhibidores de bet
MX2015017963A (es) * 2013-06-28 2016-11-10 Abbvie Inc Inhibidores de bromodominio.
WO2016141341A1 (en) * 2015-03-04 2016-09-09 Vanda Pharmaceuticals Inc. Method of treatment with tradipitant
EP3133065A1 (en) 2015-08-21 2017-02-22 Merck Patent GmbH Compounds for optically active devices
MX379459B (es) 2016-04-15 2025-03-10 Abbvie Inc Inhibidores de bromodominios.
EP3363793A1 (en) 2017-02-15 2018-08-22 Merck Patent GmbH Hydrophobic compounds for optically active devices
EP3363786A1 (en) 2017-02-15 2018-08-22 Merck Patent GmbH Compounds for optically active devices
KR20200054232A (ko) 2017-09-13 2020-05-19 반다 파마슈티칼즈, 인코퍼레이티드. 트라디피탄트를 이용한 아토피 피부염의 개선된 치료
WO2021233800A1 (en) 2020-05-20 2021-11-25 Merck Patent Gmbh Azacoumarin and azathiocoumarin derivatives for use in optically active devices
WO2021257857A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Naphthyridinone compounds as jak2 v617f inhibitors
US11753413B2 (en) 2020-06-19 2023-09-12 Incyte Corporation Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors
WO2022006456A1 (en) 2020-07-02 2022-01-06 Incyte Corporation Tricyclic pyridone compounds as jak2 v617f inhibitors
AU2021300429A1 (en) 2020-07-02 2023-02-16 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
WO2022046989A1 (en) 2020-08-27 2022-03-03 Incyte Corporation Tricyclic urea compounds as jak2 v617f inhibitors
WO2022140231A1 (en) 2020-12-21 2022-06-30 Incyte Corporation Deazaguaine compounds as jak2 v617f inhibitors
WO2022182839A1 (en) 2021-02-25 2022-09-01 Incyte Corporation Spirocyclic lactams as jak2 v617f inhibitors
CN119173514A (zh) 2022-03-17 2024-12-20 因赛特公司 作为jak2 v617f抑制剂的三环脲化合物

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Also Published As

Publication number Publication date
RU2135471C1 (ru) 1999-08-27
FI945281A0 (fi) 1994-11-09
NZ264887A (en) 1996-12-20
HU9403230D0 (en) 1995-01-30
IL111590A0 (en) 1995-01-24
CN1107476A (zh) 1995-08-30
RU94040174A (ru) 1996-10-10
HUT68810A (en) 1995-05-19
FI945281A7 (fi) 1995-05-11
US5585385A (en) 1996-12-17
DE69427675D1 (de) 2001-08-16
EP0652218B1 (en) 2001-07-11
NO944252L (no) 1995-05-11
ATE203024T1 (de) 2001-07-15
AU7773894A (en) 1995-05-18
EP0652218A1 (en) 1995-05-10
TW263498B (cg-RX-API-DMAC10.html) 1995-11-21
BR9404403A (pt) 1995-07-18
AU678295B2 (en) 1997-05-22
KR950014108A (ko) 1995-06-15
CN1052004C (zh) 2000-05-03
NO944252D0 (no) 1994-11-08
DE69427675T2 (de) 2002-05-16
NO301764B1 (no) 1997-12-08
FI945281L (fi) 1995-05-11

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued