CA2093798A1 - Derives pyridine et n-oxyde de pyridine de diaryle methyle piperidines ou piperazines; compositions et methodes de preparation - Google Patents

Derives pyridine et n-oxyde de pyridine de diaryle methyle piperidines ou piperazines; compositions et methodes de preparation

Info

Publication number
CA2093798A1
CA2093798A1 CA2093798A CA2093798A CA2093798A1 CA 2093798 A1 CA2093798 A1 CA 2093798A1 CA 2093798 A CA2093798 A CA 2093798A CA 2093798 A CA2093798 A CA 2093798A CA 2093798 A1 CA2093798 A1 CA 2093798A1
Authority
CA
Canada
Prior art keywords
pyridine
piperazines
methods
pct
oxide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2093798A
Other languages
English (en)
Other versions
CA2093798C (fr
Inventor
John J. Piwinski
Jesse Wong
Michael J. Green
Vera Seidl
Richard Friary
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2093798A1 publication Critical patent/CA2093798A1/fr
Application granted granted Critical
Publication of CA2093798C publication Critical patent/CA2093798C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Pyridine et dérivés de N-oxyde de pyridine de pipéridines ou de pipérazines de méthyle diaryle correspondant à la formule structurelle (1.0), et sels pharmaceutiquement acceptables de ces composés. Ces substances présentent une activité anti-allergique et anti-inflammatoire. L'invention concerne en outre des compositions pharmaceutiques renfermant ces composés et des procédés d'utilisation de ces dernières.
CA002093798A 1990-10-10 1991-10-08 Derives pyridine et n-oxyde de pyridine de diaryle methyle piperidines ou piperazines; compositions et methodes de preparation Expired - Fee Related CA2093798C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59533090A 1990-10-10 1990-10-10
US595,330 1990-10-10
PCT/US1991/007169 WO1992006971A1 (fr) 1990-10-10 1991-10-08 Pyridine et derives de n-oxyde de pyridine, de piperidines ou de piperazines de methyle diaryle, compositions et procedes d'utilisation de ces dernieres

Publications (2)

Publication Number Publication Date
CA2093798A1 true CA2093798A1 (fr) 1992-04-11
CA2093798C CA2093798C (fr) 2000-02-01

Family

ID=24382813

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002093798A Expired - Fee Related CA2093798C (fr) 1990-10-10 1991-10-08 Derives pyridine et n-oxyde de pyridine de diaryle methyle piperidines ou piperazines; compositions et methodes de preparation

Country Status (22)

Country Link
US (1) US5432175A (fr)
EP (1) EP0553191B1 (fr)
JP (1) JPH089596B2 (fr)
KR (1) KR970005927B1 (fr)
AT (1) ATE122673T1 (fr)
AU (1) AU646519B2 (fr)
CA (1) CA2093798C (fr)
CZ (1) CZ280532B6 (fr)
DE (1) DE69109871T2 (fr)
DK (1) DK0553191T3 (fr)
ES (1) ES2072627T3 (fr)
FI (1) FI931600A (fr)
HK (1) HK186596A (fr)
HU (1) HUT66081A (fr)
IE (1) IE67808B1 (fr)
IL (1) IL99676A (fr)
MY (1) MY108616A (fr)
NO (1) NO305028B1 (fr)
PH (1) PH31566A (fr)
SK (1) SK31793A3 (fr)
WO (1) WO1992006971A1 (fr)
ZA (1) ZA918044B (fr)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3357879B2 (ja) * 1992-02-13 2002-12-16 メレルダウファーマス−ティカルズ インコーポレイテッド ピペリジニルチア環状誘導体類
CA2132848A1 (fr) * 1992-03-27 1993-10-14 Richard Friary Derives bis-arylcarbinol non pontes, compositions de ceux-ci et methodes d'utilisation
ES2117264T3 (es) * 1993-03-17 1998-08-01 Meiji Seika Co Nuevo compuesto con actividad inhibitoria de la agregacion plaquetaria.
CN1042228C (zh) * 1993-07-13 1999-02-24 詹森药业有限公司 抗过敏咪唑并吖庚因
US5886186A (en) * 1995-10-25 1999-03-23 Versicor, Inc. Synthesis of substituted N-heteroaromatic compounds and methods of use thereof
ZA200300255B (en) 2000-07-20 2004-09-28 Bristol Myers Squibb Pharma Co Tricyclic 2-pyridone compounds useful as HIV reverse transcriptase inhibitors.
DE10035928A1 (de) 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
AU2002259147A1 (en) 2001-05-08 2002-11-18 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
BR0209678A (pt) 2001-05-18 2004-09-14 Astrazeneca Ab Composto, processo para preparar e uso do mesmo, composição farmacêutica, e, métodos para o tratamento da dor e de distúrbios gastrintestinais funcionais
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
CN1551878B (zh) * 2001-09-06 2011-08-10 先灵公司 用于治疗雄激素依赖性疾病的3型17β-羟基类固醇脱氢酶抑制剂
EP1436281B1 (fr) * 2001-10-17 2010-06-16 Schering Corporation Piperidine- et piperazineacetamines en tant qu'inhibiteurs de 17 beta hydroxysteroide deshydrogenase de type 3 servant a traiter des maladies dependantes des androgenes
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7198606B2 (en) 2002-04-19 2007-04-03 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with analyte sensing
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US6874499B2 (en) * 2002-09-23 2005-04-05 3M Innovative Properties Company Filter element that has a thermo-formed housing around filter material
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
WO2006001797A1 (fr) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Element penetrant peu douloureux
DE10333671A1 (de) * 2003-07-24 2005-08-04 Alstom Technology Ltd Verfahren zur Reduktion der Nox-Emissionen einer mehrere Brenner umfassenden Brenneranordnung sowie Brenneranordnung zur Durchführung des Verfahrens
EP1667955A2 (fr) 2003-07-28 2006-06-14 SmithKline Beecham Corporation Composes cycloalhylidene comme modulateurs de recepteur d'oestrogene
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
WO2005065414A2 (fr) 2003-12-31 2005-07-21 Pelikan Technologies, Inc. Procede et appareil permettant d'ameliorer le flux fluidique et le prelevement d'echantillons
EP1751546A2 (fr) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Hydrogel imprimable pour biocapteurs
US9820684B2 (en) 2004-06-03 2017-11-21 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
DK1781631T3 (da) 2004-08-02 2012-05-14 Astrazeneca Ab Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf
US7419526B2 (en) * 2005-03-03 2008-09-02 3M Innovative Properties Company Conformal filter cartridges and methods
DE102005012049A1 (de) * 2005-03-16 2006-09-28 Cognis Ip Management Gmbh Verfahren zur Dehydratisierung von Fettalkoholen
EP2125750B1 (fr) * 2007-02-26 2014-05-21 Vitae Pharmaceuticals, Inc. Inhibiteurs d'urée et de carbamate de 11beta-hydroxystéroïde déshydrogénase 1 cycliques
JP5451611B2 (ja) * 2007-07-26 2014-03-26 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックインヒビター
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
JP5490014B2 (ja) 2007-12-11 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (fr) * 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Carbazate cyclique et inhibiteurs du type semi-carbazide de la 11β-hydroxystéroïde déshydrogénase 1
JP5734666B2 (ja) * 2008-02-11 2015-06-17 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の１，３−オキサアゼパン−２−オン及び１，３−ジアゼパン−２−オン阻害剤
EP2254872A2 (fr) * 2008-02-15 2010-12-01 Vitae Pharmaceuticals, Inc. Inhibiteurs de 11beta-hydroxystéroïde deshydrogénase 1
EP2274287B1 (fr) * 2008-03-18 2016-03-09 Vitae Pharmaceuticals, Inc. Inhibiteurs de la 11-bêta-hydroxystéroïde déshydrogénase de type 1
EP2265324B1 (fr) 2008-04-11 2015-01-28 Sanofi-Aventis Deutschland GmbH Système intégré de mesure d'analytes
JP5301563B2 (ja) 2008-05-01 2013-09-25 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
US8569292B2 (en) 2008-05-01 2013-10-29 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
EP2291370B1 (fr) 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déhydrogénase 1
EP2291373B1 (fr) * 2008-05-01 2013-09-11 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déhydrogénase 1
JP5379160B2 (ja) 2008-07-25 2013-12-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
JP5777030B2 (ja) 2008-07-25 2015-09-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
EP2393807B1 (fr) 2009-02-04 2013-08-14 Boehringer Ingelheim International GmbH Inhibiteurs cycliques de la 11beta -hydroxystéroïde déshydrogénase 1
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
US20100331320A1 (en) * 2009-04-30 2010-12-30 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
WO2011011123A1 (fr) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déshydrogénase 1 basée sur la structure 1,3-oxazinan-2-one
JP5749263B2 (ja) 2009-07-01 2015-07-15 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
JP5813106B2 (ja) 2010-06-25 2015-11-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン
AU2011325286B2 (en) 2010-11-02 2015-04-16 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders
US9212180B2 (en) * 2013-06-12 2015-12-15 The Regents Of The University Of Michigan Menin-MLL inhibitors and methods of use thereof
CN103755626A (zh) * 2014-01-23 2014-04-30 安徽安腾药业有限责任公司 一种贝托斯汀关键中间体的合成方法
CN111000844B (zh) * 2019-12-19 2022-06-28 浙江立恩生物科技有限公司 一种治疗流感病毒感染的药物

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL88063C (fr) * 1950-12-05
US2898339A (en) * 1957-07-29 1959-08-04 Wm S Merrell Co N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
US4105849A (en) * 1974-09-30 1978-08-08 G. D. Searle & Co. [(Substituted )phenyl]phenylmethyl-1-(dialkylaminoalkyl)piperidines
US4032642A (en) * 1974-12-11 1977-06-28 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
JPS59118765A (ja) * 1982-12-24 1984-07-09 Fujisawa Pharmaceut Co Ltd ピペラジン誘導体
US4540780A (en) * 1983-06-02 1985-09-10 Warner-Lambert Company Diphenylmethylene piperidines
US4632925A (en) * 1985-10-07 1986-12-30 Hoffmann-La Roche Inc. N-substituted diphenylpiperidines and antiobesity use thereof
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
EP0235463A3 (fr) * 1985-12-20 1990-01-17 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Arylalkyl et arylalkylène piperidines substitués sur l'azote utilisés comme agents antihistaminiques cardiovasculaires et antisécrétion
IL78939A (en) * 1986-01-17 1990-04-29 Robins Co Inc A H Pharmaceutical compositions containing n-substituted arylalkyl-and arylalkylene-piperidines and tetrahydropyridines and certain such novel compounds
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5028610A (en) * 1987-03-18 1991-07-02 Sankyo Company Limited N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use
US4797489A (en) * 1987-12-02 1989-01-10 American Home Products Corp. Adamantyl- and fluorenyl-arylpiperazines and -arylpiperidines
KR890012971A (ko) * 1988-02-10 1989-09-20 원본미기재 심장혈관 항히스타민제 및 분비억제제로서의 n-치환된-아릴알킬 및 아릴알킬렌 아미노헤테로사이클릭 화합물
US4835157A (en) * 1988-03-15 1989-05-30 Ortho Pharmaceutical Corporation Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents
US5104876A (en) * 1988-04-28 1992-04-14 Schering Corporation Benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use
US4994456A (en) * 1989-03-01 1991-02-19 Nisshin Flour Milling Co., Ltd. Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same
GB9000304D0 (en) * 1990-01-06 1990-03-07 Pfizer Ltd Muscarinic receptor antagonists
FR2665160A1 (fr) * 1990-07-26 1992-01-31 Esteve Labor Dr Nouveaux derives de 1-diphenylmethylpiperazine, leur preparation et leur application en tant que medicaments.

Also Published As

Publication number Publication date
CA2093798C (fr) 2000-02-01
DE69109871T2 (de) 1995-09-14
IE913571A1 (en) 1992-04-22
WO1992006971A1 (fr) 1992-04-30
DK0553191T3 (da) 1995-08-07
JPH089596B2 (ja) 1996-01-31
ES2072627T3 (es) 1995-07-16
NO931312L (no) 1993-06-10
CZ280532B6 (cs) 1996-02-14
MY108616A (en) 1996-10-31
SK31793A3 (en) 1993-09-09
ATE122673T1 (de) 1995-06-15
AU646519B2 (en) 1994-02-24
HK186596A (en) 1996-10-11
NO931312D0 (no) 1993-04-06
HUT66081A (en) 1994-09-28
AU8849091A (en) 1992-05-20
CZ62293A3 (en) 1994-02-16
US5432175A (en) 1995-07-11
IL99676A0 (en) 1992-08-18
EP0553191A1 (fr) 1993-08-04
EP0553191B1 (fr) 1995-05-17
FI931600A0 (fi) 1993-04-08
ZA918044B (en) 1992-07-29
FI931600A (fi) 1993-05-17
IE67808B1 (en) 1996-05-01
HU9301051D0 (en) 1993-07-28
PH31566A (en) 1998-11-03
JPH05508660A (ja) 1993-12-02
NO305028B1 (no) 1999-03-22
KR970005927B1 (ko) 1997-04-22
DE69109871D1 (de) 1995-06-22
IL99676A (en) 1995-11-27

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