CA2090981C - Immunological method for the determination of a haemoglobin derivative - Google Patents
Immunological method for the determination of a haemoglobin derivativeInfo
- Publication number
- CA2090981C CA2090981C CA002090981A CA2090981A CA2090981C CA 2090981 C CA2090981 C CA 2090981C CA 002090981 A CA002090981 A CA 002090981A CA 2090981 A CA2090981 A CA 2090981A CA 2090981 C CA2090981 C CA 2090981C
- Authority
- CA
- Canada
- Prior art keywords
- haemoglobin
- reagent
- blood sample
- determination
- glycated haemoglobin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 45
- 230000001900 immune effect Effects 0.000 title claims description 24
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 84
- 210000004369 blood Anatomy 0.000 claims abstract description 66
- 239000008280 blood Substances 0.000 claims abstract description 66
- 206010018910 Haemolysis Diseases 0.000 claims abstract description 60
- 230000008588 hemolysis Effects 0.000 claims abstract description 53
- 239000003599 detergent Substances 0.000 claims description 56
- 238000012360 testing method Methods 0.000 claims description 50
- 239000000203 mixture Substances 0.000 claims description 19
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 14
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 14
- 229940083575 sodium dodecyl sulfate Drugs 0.000 claims description 11
- 239000000872 buffer Substances 0.000 claims description 10
- CXRFDZFCGOPDTD-UHFFFAOYSA-M Cetrimide Chemical compound [Br-].CCCCCCCCCCCCCC[N+](C)(C)C CXRFDZFCGOPDTD-UHFFFAOYSA-M 0.000 claims description 8
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 6
- 230000027455 binding Effects 0.000 claims description 6
- 239000007800 oxidant agent Substances 0.000 claims description 6
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims description 2
- YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 claims description 2
- 239000011535 reaction buffer Substances 0.000 description 26
- 238000002835 absorbance Methods 0.000 description 18
- 239000000243 solution Substances 0.000 description 16
- IEQAICDLOKRSRL-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO IEQAICDLOKRSRL-UHFFFAOYSA-N 0.000 description 13
- 238000006243 chemical reaction Methods 0.000 description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
- 238000005259 measurement Methods 0.000 description 10
- 238000011088 calibration curve Methods 0.000 description 8
- 239000007987 MES buffer Substances 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 238000011534 incubation Methods 0.000 description 7
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 6
- YAGKRVSRTSUGEY-UHFFFAOYSA-N ferricyanide Chemical compound [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- AWDBHOZBRXWRKS-UHFFFAOYSA-N tetrapotassium;iron(6+);hexacyanide Chemical compound [K+].[K+].[K+].[K+].[Fe+6].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] AWDBHOZBRXWRKS-UHFFFAOYSA-N 0.000 description 6
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
- 230000008105 immune reaction Effects 0.000 description 5
- 238000001556 precipitation Methods 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- 239000008118 PEG 6000 Substances 0.000 description 4
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 4
- BHATUINFZWUDIX-UHFFFAOYSA-N Zwittergent 3-14 Chemical compound CCCCCCCCCCCCCC[N+](C)(C)CCCS([O-])(=O)=O BHATUINFZWUDIX-UHFFFAOYSA-N 0.000 description 4
- 229940098773 bovine serum albumin Drugs 0.000 description 4
- 125000002091 cationic group Chemical group 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000006911 enzymatic reaction Methods 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 230000004520 agglutination Effects 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 102000035122 glycosylated proteins Human genes 0.000 description 3
- 108091005608 glycosylated proteins Proteins 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 238000005375 photometry Methods 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 239000012064 sodium phosphate buffer Substances 0.000 description 3
- CKRJGDYKYQUNIM-UHFFFAOYSA-N 3-fluoro-2,2-dimethylpropanoic acid Chemical compound FCC(C)(C)C(O)=O CKRJGDYKYQUNIM-UHFFFAOYSA-N 0.000 description 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 239000007995 HEPES buffer Substances 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 238000000862 absorption spectrum Methods 0.000 description 2
- 239000012491 analyte Substances 0.000 description 2
- 230000008033 biological extinction Effects 0.000 description 2
- XVBRCOKDZVQYAY-UHFFFAOYSA-N bronidox Chemical compound [O-][N+](=O)C1(Br)COCOC1 XVBRCOKDZVQYAY-UHFFFAOYSA-N 0.000 description 2
- 239000012876 carrier material Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- -1 polyoxyethylene Polymers 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 230000008092 positive effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 2
- KFGWEMFTDGCYSK-UHFFFAOYSA-N 3-methyl-1,2-thiazole 1-oxide Chemical compound CC=1C=CS(=O)N=1 KFGWEMFTDGCYSK-UHFFFAOYSA-N 0.000 description 1
- RCLDHCIEAUJSBD-UHFFFAOYSA-N 6-(6-sulfonaphthalen-2-yl)oxynaphthalene-2-sulfonic acid Chemical compound C1=C(S(O)(=O)=O)C=CC2=CC(OC3=CC4=CC=C(C=C4C=C3)S(=O)(=O)O)=CC=C21 RCLDHCIEAUJSBD-UHFFFAOYSA-N 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 238000003691 Amadori rearrangement reaction Methods 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 206010018913 Haemolyses Diseases 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
- 150000004753 Schiff bases Chemical class 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000003196 chaotropic effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 108060003196 globin Proteins 0.000 description 1
- 102000018146 globin Human genes 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 108010036302 hemoglobin AS Proteins 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000001155 isoelectric focusing Methods 0.000 description 1
- IZWSFJTYBVKZNK-UHFFFAOYSA-N lauryl sulfobetaine Chemical compound CCCCCCCCCCCC[N+](C)(C)CCCS([O-])(=O)=O IZWSFJTYBVKZNK-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910003002 lithium salt Inorganic materials 0.000 description 1
- 159000000002 lithium salts Chemical class 0.000 description 1
- ZJZXSOKJEJFHCP-UHFFFAOYSA-M lithium;thiocyanate Chemical compound [Li+].[S-]C#N ZJZXSOKJEJFHCP-UHFFFAOYSA-M 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical group O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 238000006462 rearrangement reaction Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 125000004149 thio group Chemical group *S* 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- G01N33/723—Glycosylated haemoglobin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP4206932.7 | 1992-03-05 | ||
| DE4206932A DE4206932A1 (de) | 1992-03-05 | 1992-03-05 | Immunologische methode zur bestimmung eines haemoglobinderivates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2090981A1 CA2090981A1 (en) | 1993-09-06 |
| CA2090981C true CA2090981C (en) | 1999-11-16 |
Family
ID=6453281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002090981A Expired - Lifetime CA2090981C (en) | 1992-03-05 | 1993-03-04 | Immunological method for the determination of a haemoglobin derivative |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5541117A (enExample) |
| EP (1) | EP0559164B1 (enExample) |
| JP (1) | JP2637677B2 (enExample) |
| KR (1) | KR930020162A (enExample) |
| CN (1) | CN1081765A (enExample) |
| AT (1) | ATE193378T1 (enExample) |
| AU (1) | AU652092B2 (enExample) |
| CA (1) | CA2090981C (enExample) |
| CZ (1) | CZ29193A3 (enExample) |
| DE (2) | DE4206932A1 (enExample) |
| DK (1) | DK0559164T3 (enExample) |
| ES (1) | ES2148190T3 (enExample) |
| FI (1) | FI930975A7 (enExample) |
| HR (1) | HRP930253A2 (enExample) |
| HU (1) | HUT70463A (enExample) |
| IL (1) | IL104902A0 (enExample) |
| NO (1) | NO930770L (enExample) |
| NZ (1) | NZ247054A (enExample) |
| PL (1) | PL297915A1 (enExample) |
| PT (1) | PT559164E (enExample) |
| SI (1) | SI9300108A (enExample) |
| SK (1) | SK14993A3 (enExample) |
| ZA (1) | ZA931533B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5739037A (en) * | 1992-09-29 | 1998-04-14 | Drew Scientific Limited | Process for eliminating labile glycohaemoglobin from a sample |
| US5610076A (en) * | 1994-04-29 | 1997-03-11 | Alteon Inc. | Method for detecting hemoglobin advanced glycosylation endproducts |
| FR2721112B1 (fr) * | 1994-06-13 | 1996-08-14 | Gks Technologies | Dispositif de diagnostic rapide de toute molécule glyquée et procédé de mise en Óoeuvre. |
| JP3150857B2 (ja) * | 1994-10-19 | 2001-03-26 | 富士写真フイルム株式会社 | グリコヘモグロビン含有比測定用分析要素及び分析方法 |
| EP0729031A1 (en) * | 1995-02-24 | 1996-08-28 | F. Hoffmann-La Roche Ag | Set of reagents determining the content of total haemoglobin |
| JP3269765B2 (ja) | 1995-12-14 | 2002-04-02 | 富士写真フイルム株式会社 | ヘモグロビン誘導体の免疫学的測定方法及びその方法に用いる処理試薬 |
| JP3551678B2 (ja) * | 1996-03-14 | 2004-08-11 | 東ソー株式会社 | ヘモグロビンＡ１ｃの測定法及びキット |
| JP3249919B2 (ja) * | 1996-07-30 | 2002-01-28 | 株式会社堀場製作所 | 免疫測定方法 |
| US6855562B1 (en) * | 1996-07-30 | 2005-02-15 | Horiba, Ltd. | Immunoassay method for lyzed whole blood |
| US5858794A (en) * | 1997-05-13 | 1999-01-12 | Bayer Corporation | Cyanide-containing hemoglobin reagent composition and method providing acceptable precision, accuracy and freedom from white cell interference on automated hematology analyzers |
| EP0905514B1 (en) * | 1997-09-27 | 2003-11-26 | Horiba, Ltd. | Blood cell count/immunoassay apparatus using whole blood |
| US6485923B1 (en) * | 2000-02-02 | 2002-11-26 | Lifescan, Inc. | Reagent test strip for analyte determination having hemolyzing agent |
| WO2002021142A1 (en) * | 2000-09-07 | 2002-03-14 | Wako Pure Chemical Industries, Ltd. | Method of quantifying total hemoglobin and glycohemoglobin |
| AU2003291250A1 (en) * | 2002-11-05 | 2004-06-07 | Therasense, Inc. | Assay device, system and method |
| CA2527199C (en) * | 2003-05-27 | 2011-11-22 | Mitsubishi Kagaku Iatron, Inc. | Immunochromatographic method |
| ATE509275T1 (de) * | 2003-09-23 | 2011-05-15 | Epinex Diagnostic Inc | Schnelltest für glykiertes albumin |
| AU2004286284B2 (en) * | 2003-10-29 | 2011-08-25 | Mec Dynamics Corp. | Micro mechanical methods and systems for performing assays |
| US7150995B2 (en) | 2004-01-16 | 2006-12-19 | Metrika, Inc. | Methods and systems for point of care bodily fluid analysis |
| US7541190B2 (en) * | 2005-02-07 | 2009-06-02 | Beckman Coulter, Inc. | Method of measurement of cellular hemoglobin |
| JP4957547B2 (ja) * | 2005-04-14 | 2012-06-20 | パナソニック株式会社 | ヘモグロビン誘導体の測定方法、それに用いる試薬組成物、測定キット、分析デバイス、及び分析システム |
| EP2012111B1 (en) * | 2006-03-24 | 2014-07-16 | ARKRAY, Inc. | Method of measuring glycohemoglobin concentration and apparatus for concentration measurement |
| JP4989628B2 (ja) * | 2006-03-24 | 2012-08-01 | アークレイ株式会社 | グリコヘモグロビン濃度測定方法および濃度測定装置 |
| WO2007127616A2 (en) * | 2006-04-12 | 2007-11-08 | Benjamin Pless | Cavitation heating system and method |
| WO2008016193A1 (en) | 2006-07-29 | 2008-02-07 | I-Sens, Inc. | Electrochemical determination system of glycated proteins |
| WO2008093722A1 (ja) * | 2007-01-30 | 2008-08-07 | Arkray, Inc. | フェノチアジン誘導体色素の検出方法およびそれに用いる発色剤試薬 |
| JP5465008B2 (ja) * | 2007-10-30 | 2014-04-09 | パナソニック株式会社 | ヘモグロビン及びヘモグロビン誘導体の測定方法、測定キット |
| CN101493467A (zh) * | 2008-01-25 | 2009-07-29 | 上海伊思柏生物科技有限公司 | 定量测定糖化蛋白质的方法 |
| KR101005559B1 (ko) | 2008-07-15 | 2011-01-05 | 주식회사 아이센스 | 바이오센서를 이용한 단백질 측정 장치 |
| US20110269147A1 (en) * | 2008-07-18 | 2011-11-03 | Bayer Healthcare Llc | Methods, Devices, and Systems for Glycated Hemoglobin Analysis |
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| RU2683773C2 (ru) | 2014-05-06 | 2019-04-02 | Дайасис Дайагностик Системз Гмбх | Ферментативное определение hba1c |
| CN104062430B (zh) * | 2014-06-30 | 2016-03-30 | 洛阳普莱柯万泰生物技术有限公司 | 一种用于检测样品中流感病毒的试剂盒及其检测方法和应用 |
| EP3397971B1 (en) * | 2015-12-30 | 2021-08-04 | W. Health L.P. | Method for determining the quantity of an hba1c in a blood sample |
| WO2020054572A1 (ja) * | 2018-09-12 | 2020-03-19 | 積水メディカル株式会社 | ヘモグロビン類測定用試薬及びヘモグロビン類の測定方法 |
| CN110702894A (zh) * | 2019-10-10 | 2020-01-17 | 南京欧凯生物科技有限公司 | 一种直接测定糖化血红蛋白含量的检测方法 |
| CA3173418A1 (en) * | 2020-03-31 | 2021-10-07 | Pravansu S. Mohanty | Device and methods for rapid detection of target analytes in a biological sample |
| CN112067566A (zh) * | 2020-08-28 | 2020-12-11 | 南开大学 | 一种用于糖化血红蛋白定量分析的比色传感器 |
| CN114441750B (zh) * | 2020-10-30 | 2025-03-28 | 深圳市瑞图生物技术有限公司 | 用于全血样本免疫五项测定的试剂、试剂盒、方法和装置 |
| CN113984689B (zh) * | 2021-10-25 | 2023-11-03 | 中元汇吉生物技术股份有限公司 | 一种测定谷胱甘肽还原酶的试剂盒 |
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1992
- 1992-03-05 DE DE4206932A patent/DE4206932A1/de not_active Withdrawn
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1993
- 1993-02-26 CZ CZ93291A patent/CZ29193A3/cs unknown
- 1993-03-01 SK SK14993A patent/SK14993A3/sk unknown
- 1993-03-01 AU AU33871/93A patent/AU652092B2/en not_active Ceased
- 1993-03-01 IL IL104902A patent/IL104902A0/xx unknown
- 1993-03-02 PL PL29791593A patent/PL297915A1/xx unknown
- 1993-03-03 AT AT93103349T patent/ATE193378T1/de active
- 1993-03-03 DE DE59310046T patent/DE59310046D1/de not_active Expired - Lifetime
- 1993-03-03 NO NO93930770A patent/NO930770L/no unknown
- 1993-03-03 DK DK93103349T patent/DK0559164T3/da active
- 1993-03-03 EP EP93103349A patent/EP0559164B1/de not_active Expired - Lifetime
- 1993-03-03 ES ES93103349T patent/ES2148190T3/es not_active Expired - Lifetime
- 1993-03-03 NZ NZ247054A patent/NZ247054A/en not_active IP Right Cessation
- 1993-03-03 HR HR930253A patent/HRP930253A2/hr not_active Application Discontinuation
- 1993-03-03 PT PT93103349T patent/PT559164E/pt unknown
- 1993-03-04 ZA ZA931533A patent/ZA931533B/xx unknown
- 1993-03-04 CA CA002090981A patent/CA2090981C/en not_active Expired - Lifetime
- 1993-03-04 HU HU9300596A patent/HUT70463A/hu unknown
- 1993-03-04 US US08/026,464 patent/US5541117A/en not_active Expired - Lifetime
- 1993-03-04 CN CN93104037A patent/CN1081765A/zh active Pending
- 1993-03-04 FI FI930975A patent/FI930975A7/fi unknown
- 1993-03-05 JP JP5045130A patent/JP2637677B2/ja not_active Expired - Fee Related
- 1993-03-05 KR KR1019930003336A patent/KR930020162A/ko not_active Ceased
- 1993-03-05 SI SI9300108A patent/SI9300108A/sl unknown
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| US5541117A (en) | 1996-07-30 |
| IL104902A0 (en) | 1993-07-08 |
| CN1081765A (zh) | 1994-02-09 |
| JPH0611510A (ja) | 1994-01-21 |
| DK0559164T3 (da) | 2000-10-30 |
| FI930975L (fi) | 1993-09-06 |
| HU9300596D0 (en) | 1993-05-28 |
| NO930770D0 (no) | 1993-03-03 |
| SI9300108A (en) | 1993-09-30 |
| FI930975A0 (fi) | 1993-03-04 |
| DE4206932A1 (de) | 1993-09-09 |
| AU652092B2 (en) | 1994-08-11 |
| SK14993A3 (en) | 1993-10-06 |
| ES2148190T3 (es) | 2000-10-16 |
| EP0559164B1 (de) | 2000-05-24 |
| JP2637677B2 (ja) | 1997-08-06 |
| CZ29193A3 (en) | 1994-01-19 |
| AU3387193A (en) | 1993-09-16 |
| NZ247054A (en) | 1995-02-24 |
| EP0559164A2 (de) | 1993-09-08 |
| EP0559164A3 (enExample) | 1994-01-26 |
| HRP930253A2 (en) | 1995-10-31 |
| DE59310046D1 (de) | 2000-06-29 |
| PL297915A1 (en) | 1993-09-06 |
| FI930975A7 (fi) | 1993-09-06 |
| ZA931533B (en) | 1994-09-04 |
| ATE193378T1 (de) | 2000-06-15 |
| CA2090981A1 (en) | 1993-09-06 |
| HUT70463A (en) | 1995-10-30 |
| NO930770L (no) | 1993-09-06 |
| KR930020162A (ko) | 1993-10-19 |
| PT559164E (pt) | 2000-10-31 |
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