CA2090876A1 - Apoptosis regulating composition - Google Patents

Apoptosis regulating composition

Info

Publication number
CA2090876A1
CA2090876A1 CA002090876A CA2090876A CA2090876A1 CA 2090876 A1 CA2090876 A1 CA 2090876A1 CA 002090876 A CA002090876 A CA 002090876A CA 2090876 A CA2090876 A CA 2090876A CA 2090876 A1 CA2090876 A1 CA 2090876A1
Authority
CA
Canada
Prior art keywords
cells
compound
apoptosis
cell
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002090876A
Other languages
English (en)
French (fr)
Inventor
Satoru Nakai
Koutoku Aihara
Hitomi Mori
Michiaki Tominaga
Masakazu Adachi
Hiroyuki Ichikawa
Seiji Akamatsu
Fumio Saito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of CA2090876A1 publication Critical patent/CA2090876A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002090876A 1991-07-03 1992-07-02 Apoptosis regulating composition Abandoned CA2090876A1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP162587/1991 1991-07-03
JP16258791 1991-07-03
JP33469/1992 1992-02-20
JP3346992 1992-02-20
JP45718/1992 1992-03-03
JP4571892 1992-03-03
JP100585/1992 1992-03-25
JP10058592 1992-03-25

Publications (1)

Publication Number Publication Date
CA2090876A1 true CA2090876A1 (en) 1993-01-04

Family

ID=27459795

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002090876A Abandoned CA2090876A1 (en) 1991-07-03 1992-07-02 Apoptosis regulating composition

Country Status (11)

Country Link
US (5) US5672603A (enExample)
EP (1) EP0552373B1 (enExample)
KR (1) KR100196368B1 (enExample)
AU (1) AU648690B2 (enExample)
CA (1) CA2090876A1 (enExample)
DE (1) DE69230131T2 (enExample)
DK (1) DK0552373T3 (enExample)
ES (1) ES2138971T3 (enExample)
MX (1) MX9203950A (enExample)
TW (1) TW229157B (enExample)
WO (1) WO1993000902A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2121148A1 (en) * 1992-08-19 1994-03-03 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulator
US5521185A (en) * 1993-03-02 1996-05-28 Otsuka Pharmaceutical Co., Ltd. Methods for inhibiting graft rejection and IL-1 production
GB9311132D0 (en) 1993-05-28 1993-07-14 Eisai London Res Lab Ltd Control of cell death
WO1995011026A1 (en) * 1993-10-21 1995-04-27 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative for inhibiting production of interleukin-8
US5504093A (en) * 1994-08-01 1996-04-02 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting nucleoside and nucleobase transport in mammalian cells, and method for inhibition of DNA virus replication
EP0749311A1 (en) * 1995-01-11 1996-12-27 Otsuka Pharmaceutical Co., Ltd. Pharmaceutical composition of indene derivatives for regulating apoptosis
WO1998046229A1 (en) * 1995-06-21 1998-10-22 Otsuka Pharmaceutical Co., Ltd. Il-8 and mcaf production inhibitors
JPH0971532A (ja) * 1995-09-06 1997-03-18 Otsuka Pharmaceut Co Ltd 発癌抑制剤
US5700803A (en) * 1995-12-12 1997-12-23 Otsuka Pharmaceutical Co., Ltd. Method for reducing infarct size in subjects afflicted with ischemic heart disease
AU6854398A (en) * 1997-04-25 1998-11-24 Otsuka Pharmaceutical Co., Ltd. Hyaluronate synthesis inhibitors
US6008209A (en) * 1997-04-28 1999-12-28 Hoffmann-La Roche Inc. Method of using vitamin D3 analogs with bis C-20 side chains
WO1999015179A1 (en) * 1997-09-25 1999-04-01 Regents Of The University Of Minnesota Methods of limiting apoptosis of cells
US6281191B1 (en) 1997-12-29 2001-08-28 Vladimir I. Slesarev Compositions and methods for treating hepatitis-C
FR2774289B1 (fr) * 1998-02-03 2002-05-24 Goemar Lab Sa Medicament pour le traitement des dereglements de l'apoptose
IL140701A0 (en) 1998-07-13 2002-02-10 Univ Texas Cancer treatment methods using antibodies to aminophospholipids
SI1107795T1 (en) 1998-09-04 2003-06-30 The Regents Of The University Of Michigan Thiomolybdate associated with at least one carbohydrate, and its use for preventing or treating diseases characterized by aberrant vascularization, such as cancer, wet type macular degeneration, rheumatoid arthritis
US6277974B1 (en) 1999-12-14 2001-08-21 Cogent Neuroscience, Inc. Compositions and methods for diagnosing and treating conditions, disorders, or diseases involving cell death
US20030044413A1 (en) * 2000-08-15 2003-03-06 Regents Of The University Of Minnesota Methods of limiting apoptosis of cells
EP1467767A2 (en) * 2001-12-20 2004-10-20 Cogent Neuroscience, Inc. Methods for treating conditions,disorders,or diseases involving cell death
EP2283868B1 (en) 2002-07-15 2016-03-30 Board of Regents, The University of Texas System Peptides binding to phosphatidylethanolamine and their use in treating viral infections and cancer
US20060135494A1 (en) * 2002-11-07 2006-06-22 Steer Clifford J Methods of treating injuries of the nervous system associated with hemorrhage
US8431396B2 (en) 2003-03-21 2013-04-30 The Cleveland Clinic Foundation Anti-angiogenic peptides
US20060204481A1 (en) * 2003-04-02 2006-09-14 Steer Clifford J Methods of promoting cell viability
CA3031283A1 (en) 2004-01-22 2005-08-04 University Of Miami Topical co-enzyme q10 formulations and methods of use
WO2006086452A1 (en) * 2005-02-10 2006-08-17 Regents Of The University Of Minnesota Methods for treating visual disorders
MX2010005104A (es) 2007-11-09 2010-08-04 Peregrine Pharmaceuticals Inc Composiciones de anticuerpo anti-factor de crecimiento endotelial vascular y metodos.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5430184A (en) * 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative
JPS6038384B2 (ja) * 1978-03-24 1985-08-31 大塚製薬株式会社 チオセミカルバゾン誘導体
JPS5777676A (en) * 1980-10-31 1982-05-15 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5793962A (en) * 1980-12-01 1982-06-11 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS62135423A (ja) * 1985-12-09 1987-06-18 Otsuka Pharmaceut Co Ltd 低酸素症改善剤

Also Published As

Publication number Publication date
TW229157B (enExample) 1994-09-01
US5916890A (en) 1999-06-29
KR930702002A (ko) 1993-09-08
EP0552373A1 (en) 1993-07-28
WO1993000902A1 (fr) 1993-01-21
MX9203950A (es) 1993-05-01
ES2138971T3 (es) 2000-02-01
DE69230131T2 (de) 2000-03-02
AU648690B2 (en) 1994-04-28
AU2231792A (en) 1993-02-11
US5925640A (en) 1999-07-20
US5872120A (en) 1999-02-16
KR100196368B1 (ko) 1999-06-15
US5672603A (en) 1997-09-30
EP0552373A4 (en) 1993-09-22
DE69230131D1 (de) 1999-11-18
DK0552373T3 (da) 1999-12-27
US5798358A (en) 1998-08-25
HK1004469A1 (en) 1998-11-27
EP0552373B1 (en) 1999-10-13

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued