CA2090634C - Novel cyclosporins - Google Patents

Novel cyclosporins Download PDF

Info

Publication number
CA2090634C
CA2090634C CA002090634A CA2090634A CA2090634C CA 2090634 C CA2090634 C CA 2090634C CA 002090634 A CA002090634 A CA 002090634A CA 2090634 A CA2090634 A CA 2090634A CA 2090634 C CA2090634 C CA 2090634C
Authority
CA
Canada
Prior art keywords
cyclosporin
cyclosporins
formula
ser
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002090634A
Other languages
English (en)
French (fr)
Other versions
CA2090634A1 (en
Inventor
Johann Jakob Boelsterli
Marcel Karl Eberle
Reto Naef
Trevor Glyn Payne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CA2090634A1 publication Critical patent/CA2090634A1/en
Application granted granted Critical
Publication of CA2090634C publication Critical patent/CA2090634C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Gasification And Melting Of Waste (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA002090634A 1992-03-02 1993-03-01 Novel cyclosporins Expired - Fee Related CA2090634C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929204466A GB9204466D0 (en) 1992-03-02 1992-03-02 Improvements in or relating to organic compounds
GB9204466.8 1992-03-02

Publications (2)

Publication Number Publication Date
CA2090634A1 CA2090634A1 (en) 1993-09-03
CA2090634C true CA2090634C (en) 2005-12-13

Family

ID=10711333

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002090634A Expired - Fee Related CA2090634C (en) 1992-03-02 1993-03-01 Novel cyclosporins

Country Status (26)

Country Link
US (1) US5643870A (show.php)
EP (1) EP0577544B1 (show.php)
JP (1) JP3382656B2 (show.php)
KR (1) KR100256988B1 (show.php)
CN (1) CN1037104C (show.php)
AT (1) ATE146484T1 (show.php)
AU (1) AU667072B2 (show.php)
CA (1) CA2090634C (show.php)
CZ (1) CZ285421B6 (show.php)
DE (1) DE69306670T2 (show.php)
DK (1) DK0577544T3 (show.php)
ES (1) ES2096262T3 (show.php)
FI (1) FI111729B (show.php)
GB (1) GB9204466D0 (show.php)
GR (1) GR3022539T3 (show.php)
HU (1) HU214028B (show.php)
IL (1) IL104891A (show.php)
MX (1) MX9301129A (show.php)
MY (1) MY106921A (show.php)
NO (1) NO310685B1 (show.php)
NZ (1) NZ247031A (show.php)
PL (1) PL174816B1 (show.php)
RU (1) RU2131883C1 (show.php)
SK (1) SK279529B6 (show.php)
TW (1) TW264472B (show.php)
ZA (1) ZA931491B (show.php)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639852A (en) * 1994-09-01 1997-06-17 Wisconsin Alumni Research Foundation Immunostimulatory agents
CN1130373C (zh) * 1996-09-13 2003-12-10 诺瓦蒂斯有限公司 [3'－脱氧－3'－氧代－MeBmt]'环孢菌素制备方法
ZA9711732B (en) 1996-12-31 1998-12-28 Quadrant Holdings Cambridge Methods and compositions for improvement bioavailability of bioactive agents for mucosal delivery
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
JP4261049B2 (ja) 1997-10-08 2009-04-30 アイソテクニカ インコーポレイテッド 重水素化シクロスポリンアナログおよび免疫調節剤としてのそれらの使用
RU2235554C2 (ru) * 1998-03-06 2004-09-10 Новартис Аг Предварительно приготовленные эмульсионные концентраты, содержащие циклоспорин или макролид
US6784156B2 (en) * 2001-03-05 2004-08-31 Enanta Pharmaceuticals, Inc. Cyclosporins for the treatment of respiratory diseases
EP1379547B1 (fr) * 2001-04-20 2005-12-21 Debiopharm S.A. Cyclosporine modifiee utilisable en tant que pro-drogue et son utilisation
US20030087813A1 (en) * 2001-10-12 2003-05-08 Or Yat Sun Cyclosporin analogs for the treatment of lung diseases
US6809077B2 (en) * 2001-10-12 2004-10-26 Enanta Pharmaceuticals, Inc. Cyclosporin analogs for the treatment of autoimmune diseases
PL210697B1 (pl) * 2001-10-19 2012-02-29 Isotechnika Inc Kompozycja zawierająca mieszaninę izomerów analogu cyklosporyny i zastosowanie tej mieszaniny
EP1436321B9 (en) * 2001-10-19 2008-11-12 Isotechnika Inc. Synthesis of cyclosporin analogs
US7012065B2 (en) * 2003-02-07 2006-03-14 Enanta Pharmaceuticals, Inc. Cyclosporins for the treatment of immune disorders
JP2006524232A (ja) * 2003-03-17 2006-10-26 アルバニー モレキュラー リサーチ インコーポレーティッド 新規サイクロスポリン
US20040266669A1 (en) * 2003-06-20 2004-12-30 Wu Frank X. H. Cyclosporin derivatives for the treatment of immune disorders
JP2006014722A (ja) * 2004-06-02 2006-01-19 Keio Gijuku 遺伝子マーカー及びその利用
WO2006039164A2 (en) * 2004-09-29 2006-04-13 Amr Technology, Inc. Novel cyclosporin analogues and their pharmaceutical uses
WO2006039163A2 (en) * 2004-09-29 2006-04-13 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
EP1812037A4 (en) * 2004-10-06 2009-11-11 Amr Technology Inc ALKYNES OF CYCLOSPORINE AND THEIR USEFUL AS PHARMACEUTICAL AGENTS
US7696167B2 (en) * 2004-11-22 2010-04-13 Astellas Pharma Inc. Cyclic peptide compound
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
CA3014633C (en) 2007-10-08 2022-05-17 Aurinia Pharmaceuticals Inc. Ophthalmic compositions comprising calcineurin inhibitors or mtor inhibitors
BRPI0911709A2 (pt) * 2008-07-30 2017-06-20 Isotechnika Labs Inc composto, processo para a produção de um composto, composição farmacêutica e método de tratar uma doença mediada a ciclofilina em um mamífero
WO2010144194A1 (en) 2009-06-09 2010-12-16 Lux Biosciences, Inc. Topical drug delivery systems for ophthalmic use
US20130267460A1 (en) * 2010-09-16 2013-10-10 The Johns Hopkins University Methods of Inhibiting Alphavirus Replication and Treating Alphavirus Infection
AU2011342284C1 (en) 2010-12-15 2017-07-13 Contravir Pharmaceuticals, Inc. Cyclosporine analogue molecules modified at amino acid 1 and 3
CN105076117B (zh) * 2014-10-31 2017-08-25 北京林业大学 一种种子抗老化剂及其制备方法
KR20170000243U (ko) 2015-07-09 2017-01-18 (주)하나피앤씨 배관연결용 플랜지 기구
US9981041B2 (en) * 2016-08-23 2018-05-29 Ira Jason Salzman Ophthalmic lubricating spray
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
EP0194972B1 (en) * 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
US4764503A (en) * 1986-11-19 1988-08-16 Sandoz Ltd. Novel cyclosporins
EP0283801A3 (en) * 1987-03-27 1990-05-30 Abbott Laboratories Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
ATE95193T1 (de) * 1987-06-17 1993-10-15 Sandoz Ag Cyclosporine und deren benutzung als arzneimittel.
GB8717300D0 (en) * 1987-07-22 1987-08-26 Nat Res Dev Cyclosporins
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
DE3840354A1 (de) * 1988-11-30 1990-06-07 Hoechst Ag Benzolsulfonamid-derivate und verfahren zu ihrer herstellung
WO1990006763A1 (en) * 1988-12-05 1990-06-28 The Trustees Of Columbia University In The City Of New York Novel derivatives of cyclosporine a, antibodies directed thereto and uses thereof
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
GB8916901D0 (en) * 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5202310A (en) * 1990-06-06 1993-04-13 Levy Gary A Cyclosporine metabolites
FI111730B (fi) * 1990-11-02 2003-09-15 Novartis Ag Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi

Also Published As

Publication number Publication date
JPH07252296A (ja) 1995-10-03
DE69306670D1 (de) 1997-01-30
ATE146484T1 (de) 1997-01-15
CZ285421B6 (cs) 1999-08-11
PL297902A1 (en) 1993-09-06
CN1037104C (zh) 1998-01-21
GB9204466D0 (en) 1992-04-15
KR930019692A (ko) 1993-10-18
IL104891A (en) 1997-04-15
SK14093A3 (en) 1993-10-06
FI111729B (fi) 2003-09-15
AU3387293A (en) 1993-09-09
NO310685B1 (no) 2001-08-13
TW264472B (show.php) 1995-12-01
CN1076453A (zh) 1993-09-22
ZA931491B (en) 1994-09-02
MY106921A (en) 1995-08-30
EP0577544B1 (en) 1996-12-18
MX9301129A (es) 1994-07-29
AU667072B2 (en) 1996-03-07
NO930738D0 (no) 1993-03-01
DE69306670T2 (de) 1997-07-03
JP3382656B2 (ja) 2003-03-04
DK0577544T3 (da) 1997-04-01
US5643870A (en) 1997-07-01
ES2096262T3 (es) 1997-03-01
CZ30393A3 (en) 1994-02-16
NZ247031A (en) 1995-05-26
RU2131883C1 (ru) 1999-06-20
EP0577544A1 (en) 1994-01-05
HU214028B (en) 1997-12-29
FI930912A0 (fi) 1993-03-01
HU9300418D0 (en) 1993-05-28
HUT64567A (en) 1994-01-28
PL174816B1 (pl) 1998-09-30
GR3022539T3 (en) 1997-05-31
SK279529B6 (sk) 1998-12-02
NO930738L (no) 1993-09-03
KR100256988B1 (ko) 2000-05-15
CA2090634A1 (en) 1993-09-03
FI930912L (fi) 1993-09-03
IL104891A0 (en) 1993-07-08

Similar Documents

Publication Publication Date Title
CA2090634C (en) Novel cyclosporins
US6784156B2 (en) Cyclosporins for the treatment of respiratory diseases
US20030109425A1 (en) Cyclosporin analogs for the treatment of lung diseases
CA1274346A (en) Amino acid ester and amide renin inhibitors
CA1338319C (en) Cyclosporin derivative with modified "8-amino acid"
US4764503A (en) Novel cyclosporins
JPH08838B2 (ja) 新規シクロスポリン類
EP1434594A1 (en) Cyclosporin analogs for the treatment of autoimmune diseases
EP0373260B1 (en) Cyclosporin derivatives with modified "8-amino acid"
JPH01151600A (ja) シクロスポリン
WO2004050687A2 (en) Cyclosporins for the treatment of autoimmune diseases
WO1996022305A2 (en) Modified peptides
JPH0232095A (ja) 免疫機構の機能を仰制する新規ペプチド、それらを含む医薬組成物、並びに前記ペプチド及び医薬組成物の調製方法
JPH06329552A (ja) 腫瘍疾患を処置するための組成物
JP2006515563A (ja) 抗インテグリン活性を有するフルオロ−アルキル−シクロペプチド誘導体
AU2002245567A1 (en) Cyclosporins for the treatment of respiratory diseases
GB2227244A (en) Immunosuppressive fluorinated cyclosporin analogs
JPH0717677B2 (ja) “８−アミノ酸”に改良のある新規シクロスポリン誘導体
KR20020063932A (ko) 신규 환식 화합물

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed