NZ247031A - Poly-n-methylated undeca cyclosporoids - Google Patents
Poly-n-methylated undeca cyclosporoidsInfo
- Publication number
- NZ247031A NZ247031A NZ247031A NZ24703193A NZ247031A NZ 247031 A NZ247031 A NZ 247031A NZ 247031 A NZ247031 A NZ 247031A NZ 24703193 A NZ24703193 A NZ 24703193A NZ 247031 A NZ247031 A NZ 247031A
- Authority
- NZ
- New Zealand
- Prior art keywords
- cyclosporin
- formula
- ser
- residue
- hydroxy
- Prior art date
Links
- 229930182912 cyclosporin Natural products 0.000 claims abstract 21
- 239000001257 hydrogen Substances 0.000 claims abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 3
- 238000011200 topical administration Methods 0.000 claims abstract 3
- 208000006673 asthma Diseases 0.000 claims abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 2
- 229960001265 ciclosporin Drugs 0.000 claims 21
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 20
- 229930105110 Cyclosporin A Natural products 0.000 claims 20
- 108010036949 Cyclosporine Proteins 0.000 claims 20
- 238000000034 method Methods 0.000 claims 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 5
- 239000001301 oxygen Substances 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 210000004072 lung Anatomy 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- AHQFCPOIMVMDEZ-UNISNWAASA-N (e,2s,3r,4r)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoic acid Chemical compound CN[C@H](C(O)=O)[C@H](O)[C@H](C)C\C=C\C AHQFCPOIMVMDEZ-UNISNWAASA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000005864 Sulphur Chemical group 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 238000011861 anti-inflammatory therapy Methods 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- -1 dimethylamino, hydroxymethyl Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000003979 eosinophil Anatomy 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 238000002650 immunosuppressive therapy Methods 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 abstract 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 108010036941 Cyclosporins Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Gasification And Melting Of Waste (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929204466A GB9204466D0 (en) | 1992-03-02 | 1992-03-02 | Improvements in or relating to organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ247031A true NZ247031A (en) | 1995-05-26 |
Family
ID=10711333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ247031A NZ247031A (en) | 1992-03-02 | 1993-03-01 | Poly-n-methylated undeca cyclosporoids |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5643870A (show.php) |
| EP (1) | EP0577544B1 (show.php) |
| JP (1) | JP3382656B2 (show.php) |
| KR (1) | KR100256988B1 (show.php) |
| CN (1) | CN1037104C (show.php) |
| AT (1) | ATE146484T1 (show.php) |
| AU (1) | AU667072B2 (show.php) |
| CA (1) | CA2090634C (show.php) |
| CZ (1) | CZ285421B6 (show.php) |
| DE (1) | DE69306670T2 (show.php) |
| DK (1) | DK0577544T3 (show.php) |
| ES (1) | ES2096262T3 (show.php) |
| FI (1) | FI111729B (show.php) |
| GB (1) | GB9204466D0 (show.php) |
| GR (1) | GR3022539T3 (show.php) |
| HU (1) | HU214028B (show.php) |
| IL (1) | IL104891A (show.php) |
| MX (1) | MX9301129A (show.php) |
| MY (1) | MY106921A (show.php) |
| NO (1) | NO310685B1 (show.php) |
| NZ (1) | NZ247031A (show.php) |
| PL (1) | PL174816B1 (show.php) |
| RU (1) | RU2131883C1 (show.php) |
| SK (1) | SK279529B6 (show.php) |
| TW (1) | TW264472B (show.php) |
| ZA (1) | ZA931491B (show.php) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639852A (en) * | 1994-09-01 | 1997-06-17 | Wisconsin Alumni Research Foundation | Immunostimulatory agents |
| CN1130373C (zh) * | 1996-09-13 | 2003-12-10 | 诺瓦蒂斯有限公司 | [3'－脱氧－3'－氧代－MeBmt]'环孢菌素制备方法 |
| ZA9711732B (en) | 1996-12-31 | 1998-12-28 | Quadrant Holdings Cambridge | Methods and compositions for improvement bioavailability of bioactive agents for mucosal delivery |
| US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| JP4261049B2 (ja) | 1997-10-08 | 2009-04-30 | アイソテクニカ インコーポレイテッド | 重水素化シクロスポリンアナログおよび免疫調節剤としてのそれらの使用 |
| RU2235554C2 (ru) * | 1998-03-06 | 2004-09-10 | Новартис Аг | Предварительно приготовленные эмульсионные концентраты, содержащие циклоспорин или макролид |
| US6784156B2 (en) * | 2001-03-05 | 2004-08-31 | Enanta Pharmaceuticals, Inc. | Cyclosporins for the treatment of respiratory diseases |
| EP1379547B1 (fr) * | 2001-04-20 | 2005-12-21 | Debiopharm S.A. | Cyclosporine modifiee utilisable en tant que pro-drogue et son utilisation |
| US20030087813A1 (en) * | 2001-10-12 | 2003-05-08 | Or Yat Sun | Cyclosporin analogs for the treatment of lung diseases |
| US6809077B2 (en) * | 2001-10-12 | 2004-10-26 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogs for the treatment of autoimmune diseases |
| PL210697B1 (pl) * | 2001-10-19 | 2012-02-29 | Isotechnika Inc | Kompozycja zawierająca mieszaninę izomerów analogu cyklosporyny i zastosowanie tej mieszaniny |
| EP1436321B9 (en) * | 2001-10-19 | 2008-11-12 | Isotechnika Inc. | Synthesis of cyclosporin analogs |
| US7012065B2 (en) * | 2003-02-07 | 2006-03-14 | Enanta Pharmaceuticals, Inc. | Cyclosporins for the treatment of immune disorders |
| JP2006524232A (ja) * | 2003-03-17 | 2006-10-26 | アルバニー モレキュラー リサーチ インコーポレーティッド | 新規サイクロスポリン |
| US20040266669A1 (en) * | 2003-06-20 | 2004-12-30 | Wu Frank X. H. | Cyclosporin derivatives for the treatment of immune disorders |
| JP2006014722A (ja) * | 2004-06-02 | 2006-01-19 | Keio Gijuku | 遺伝子マーカー及びその利用 |
| WO2006039164A2 (en) * | 2004-09-29 | 2006-04-13 | Amr Technology, Inc. | Novel cyclosporin analogues and their pharmaceutical uses |
| WO2006039163A2 (en) * | 2004-09-29 | 2006-04-13 | Amr Technology, Inc. | Cyclosporin alkyne analogues and their pharmaceutical uses |
| EP1812037A4 (en) * | 2004-10-06 | 2009-11-11 | Amr Technology Inc | ALKYNES OF CYCLOSPORINE AND THEIR USEFUL AS PHARMACEUTICAL AGENTS |
| US7696167B2 (en) * | 2004-11-22 | 2010-04-13 | Astellas Pharma Inc. | Cyclic peptide compound |
| US7696165B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| US7696166B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| CA3014633C (en) | 2007-10-08 | 2022-05-17 | Aurinia Pharmaceuticals Inc. | Ophthalmic compositions comprising calcineurin inhibitors or mtor inhibitors |
| BRPI0911709A2 (pt) * | 2008-07-30 | 2017-06-20 | Isotechnika Labs Inc | composto, processo para a produção de um composto, composição farmacêutica e método de tratar uma doença mediada a ciclofilina em um mamífero |
| WO2010144194A1 (en) | 2009-06-09 | 2010-12-16 | Lux Biosciences, Inc. | Topical drug delivery systems for ophthalmic use |
| US20130267460A1 (en) * | 2010-09-16 | 2013-10-10 | The Johns Hopkins University | Methods of Inhibiting Alphavirus Replication and Treating Alphavirus Infection |
| AU2011342284C1 (en) | 2010-12-15 | 2017-07-13 | Contravir Pharmaceuticals, Inc. | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
| CN105076117B (zh) * | 2014-10-31 | 2017-08-25 | 北京林业大学 | 一种种子抗老化剂及其制备方法 |
| KR20170000243U (ko) | 2015-07-09 | 2017-01-18 | (주)하나피앤씨 | 배관연결용 플랜지 기구 |
| US9981041B2 (en) * | 2016-08-23 | 2018-05-29 | Ira Jason Salzman | Ophthalmic lubricating spray |
| US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2819094A1 (de) * | 1977-05-10 | 1978-11-23 | Sandoz Ag | Cyclosporin-derivate, ihre verwendung und herstellung |
| EP0194972B1 (en) * | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
| US4649047A (en) * | 1985-03-19 | 1987-03-10 | University Of Georgia Research Foundation, Inc. | Ophthalmic treatment by topical administration of cyclosporin |
| US4764503A (en) * | 1986-11-19 | 1988-08-16 | Sandoz Ltd. | Novel cyclosporins |
| EP0283801A3 (en) * | 1987-03-27 | 1990-05-30 | Abbott Laboratories | Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies |
| US4798823A (en) * | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
| ATE95193T1 (de) * | 1987-06-17 | 1993-10-15 | Sandoz Ag | Cyclosporine und deren benutzung als arzneimittel. |
| GB8717300D0 (en) * | 1987-07-22 | 1987-08-26 | Nat Res Dev | Cyclosporins |
| US4839342A (en) * | 1987-09-03 | 1989-06-13 | University Of Georgia Research Foundation, Inc. | Method of increasing tear production by topical administration of cyclosporin |
| DE3840354A1 (de) * | 1988-11-30 | 1990-06-07 | Hoechst Ag | Benzolsulfonamid-derivate und verfahren zu ihrer herstellung |
| WO1990006763A1 (en) * | 1988-12-05 | 1990-06-28 | The Trustees Of Columbia University In The City Of New York | Novel derivatives of cyclosporine a, antibodies directed thereto and uses thereof |
| US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
| GB8916901D0 (en) * | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5202310A (en) * | 1990-06-06 | 1993-04-13 | Levy Gary A | Cyclosporine metabolites |
| FI111730B (fi) * | 1990-11-02 | 2003-09-15 | Novartis Ag | Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi |
-
1992
- 1992-03-02 GB GB929204466A patent/GB9204466D0/en active Pending
-
1993
- 1993-02-16 HU HU9300418A patent/HU214028B/hu not_active IP Right Cessation
- 1993-02-22 ES ES93810113T patent/ES2096262T3/es not_active Expired - Lifetime
- 1993-02-22 EP EP93810113A patent/EP0577544B1/en not_active Expired - Lifetime
- 1993-02-22 DE DE69306670T patent/DE69306670T2/de not_active Expired - Fee Related
- 1993-02-22 DK DK93810113.6T patent/DK0577544T3/da active
- 1993-02-22 AT AT93810113T patent/ATE146484T1/de not_active IP Right Cessation
- 1993-02-26 MY MYPI93000352A patent/MY106921A/en unknown
- 1993-02-26 US US08/023,525 patent/US5643870A/en not_active Expired - Lifetime
- 1993-02-26 SK SK140-93A patent/SK279529B6/sk not_active IP Right Cessation
- 1993-02-27 KR KR1019930002881A patent/KR100256988B1/ko not_active Expired - Fee Related
- 1993-03-01 JP JP03983793A patent/JP3382656B2/ja not_active Expired - Fee Related
- 1993-03-01 NZ NZ247031A patent/NZ247031A/en not_active IP Right Cessation
- 1993-03-01 MX MX9301129A patent/MX9301129A/es unknown
- 1993-03-01 RU RU93004574A patent/RU2131883C1/ru active
- 1993-03-01 AU AU33872/93A patent/AU667072B2/en not_active Ceased
- 1993-03-01 CA CA002090634A patent/CA2090634C/en not_active Expired - Fee Related
- 1993-03-01 NO NO19930738A patent/NO310685B1/no not_active IP Right Cessation
- 1993-03-01 FI FI930912A patent/FI111729B/fi active
- 1993-03-01 PL PL93297902A patent/PL174816B1/pl not_active IP Right Cessation
- 1993-03-01 CN CN93102101A patent/CN1037104C/zh not_active Expired - Fee Related
- 1993-03-01 CZ CZ93303A patent/CZ285421B6/cs not_active IP Right Cessation
- 1993-03-01 IL IL104891A patent/IL104891A/xx not_active IP Right Cessation
- 1993-03-02 ZA ZA931491A patent/ZA931491B/xx unknown
- 1993-03-03 TW TW082101559A patent/TW264472B/zh active
-
1997
- 1997-02-12 GR GR970400227T patent/GR3022539T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| EXPY | Patent expired | ||
| ERR | Error or correction |
Free format text: THE OWNER HAS BEEN CORRECTED TO 890887, NOVARTIS AG, LICHTSTRASSE 35, CH-4056 BASEL, CH Effective date: 20140409 |