CA2018228A1 - Systemes et milieu de culture cellulaire - Google Patents
Systemes et milieu de culture cellulaireInfo
- Publication number
- CA2018228A1 CA2018228A1 CA2018228A CA2018228A CA2018228A1 CA 2018228 A1 CA2018228 A1 CA 2018228A1 CA 2018228 A CA2018228 A CA 2018228A CA 2018228 A CA2018228 A CA 2018228A CA 2018228 A1 CA2018228 A1 CA 2018228A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- media
- cell culture
- culture systems
- population
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004113 cell culture Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
- 229910052791 calcium Inorganic materials 0.000 abstract 2
- 239000011575 calcium Substances 0.000 abstract 2
- 230000001332 colony forming effect Effects 0.000 abstract 1
- 210000002919 epithelial cell Anatomy 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0629—Keratinocytes; Whole skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
- C12N5/0075—General culture methods using substrates using microcarriers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
- C12N2500/14—Calcium; Ca chelators; Calcitonin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
- C12N2501/392—Sexual steroids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/395—Thyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36104189A | 1989-06-05 | 1989-06-05 | |
US361,041 | 1989-06-05 | ||
US53225790A | 1990-06-01 | 1990-06-01 | |
USC.I.P.532,257 | 1990-06-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2018228A1 true CA2018228A1 (fr) | 1990-12-05 |
CA2018228C CA2018228C (fr) | 1996-02-27 |
Family
ID=27001138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002018228A Expired - Lifetime CA2018228C (fr) | 1989-06-05 | 1990-06-04 | Systemes et milieu de culture cellulaire |
Country Status (9)
Country | Link |
---|---|
US (1) | US5712163A (fr) |
EP (1) | EP0403139B1 (fr) |
JP (1) | JP2577114B2 (fr) |
AT (1) | ATE169670T1 (fr) |
CA (1) | CA2018228C (fr) |
DE (1) | DE69032549T2 (fr) |
DK (1) | DK0403139T3 (fr) |
ES (1) | ES2120946T3 (fr) |
IL (1) | IL94611A (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5610007A (en) * | 1993-01-21 | 1997-03-11 | Universite Laval | Chimeric sheets of epithelial cells |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69231063T2 (de) * | 1991-11-20 | 2001-01-11 | Innogenetics Nv | Lysate von keratinozyten zur verwendung als heilmittel für wunden. |
US6585969B1 (en) | 1991-11-20 | 2003-07-01 | N. V. Innogenetics S.A. | Non-viable keratinocyte cell composition or lysate for promoting wound healing |
US6326194B1 (en) | 1993-03-11 | 2001-12-04 | Geoffrey Michael Curtin | Method for providing cell growth |
CA2119064A1 (fr) * | 1993-03-17 | 1994-09-18 | Richard A. Berg | Systeme d'analyse dermo-epidermique in vitro |
DE69527141T2 (de) | 1994-04-29 | 2002-11-07 | Scimed Life Systems Inc | Stent mit kollagen |
DE4438015A1 (de) * | 1994-10-25 | 1996-05-02 | Boehringer Mannheim Gmbh | Epithelzellenhaltiges Biomaterial und dessen Verwendung als Transplantat |
JP3660026B2 (ja) * | 1995-09-04 | 2005-06-15 | 扶桑薬品工業株式会社 | 体外受精用培地組成物 |
FR2747395B1 (fr) * | 1996-04-16 | 1998-06-26 | Univ Nantes | Procede de primoculture in vitro de cellules epitheliales gastro-intestinales, composition cellulaire obtenue notamment par la mise en oeuvre du procede et applications de ladite composition en tant que systeme de production |
FR2757536B1 (fr) * | 1996-12-24 | 1999-03-05 | Univ Nantes | Procede et milieu de culture de cellules, composition cellul aire obtenue et ses applications en tant que systeme de production et de modele d'etude |
EP0904353B1 (fr) * | 1996-04-16 | 2003-07-02 | Universite De Nantes | Procede et milieu de culture de cellules, composition cellulaire obtenue et ses applications en tant que systeme de production et de modele d'etude |
EP2218775B1 (fr) * | 1996-08-30 | 2015-01-28 | Life Technologies Corporation | Méthode de production d'un polypeptide in vitro dans une cellule de mammifère dans un milieu de culture sans sérum and sans protéines |
US6692961B1 (en) * | 1996-10-11 | 2004-02-17 | Invitrogen Corporation | Defined systems for epithelial cell culture and use thereof |
US5972332A (en) * | 1997-04-16 | 1999-10-26 | The Regents Of The University Of Michigan | Wound treatment with keratinocytes on a solid support enclosed in a porous material |
AU3077299A (en) | 1998-03-11 | 1999-09-27 | University Of Southern California | Method of promoting production of living tissue equivalents |
PT1612265E (pt) * | 1998-11-19 | 2013-03-14 | Organogenesis Inc | Construções de tecidos por bioengenharia e métodos de produção e utilização das mesmas |
US6248725B1 (en) * | 1999-02-23 | 2001-06-19 | Amgen, Inc. | Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction |
US7056503B2 (en) * | 1999-08-19 | 2006-06-06 | Regents Of The University Of Michigan | Enclosures housing cell-coated supports for treating tumors |
CA2383398C (fr) * | 1999-08-23 | 2013-06-11 | Organogenesis, Inc. | Compositions et traitements pour soins cutanes |
FR2812004B1 (fr) * | 2000-07-24 | 2002-12-27 | Ccd Lab | Milieux de culture pour fecondation in vitro, ou pour la culture de follicules, cellules germinales males ou embryons |
CA2439899C (fr) * | 2001-03-02 | 2015-09-29 | Stratatech Corporation | Substituts de peau ameliores et utilisations correspondantes |
US6506576B2 (en) | 2001-03-14 | 2003-01-14 | Board Of Trustees Of The University Of Arkansas | Serum-and steroid-free culture media for cerebellar granule neurons |
JP3728750B2 (ja) * | 2001-11-22 | 2005-12-21 | ニプロ株式会社 | 培養皮膚及びその製造方法 |
JP2005511046A (ja) | 2001-12-04 | 2005-04-28 | オーガノジェネシス インコーポレーテッド | 膵島由来の培養細胞 |
AU2003219830A1 (en) * | 2002-02-22 | 2003-09-09 | Ebi, L.P. | Methods and compositions for treating bone or cartilage defects |
US7741116B2 (en) * | 2002-03-06 | 2010-06-22 | University Of Cincinnati | Surgical device for skin therapy or testing |
JP2005521401A (ja) * | 2002-03-27 | 2005-07-21 | イミュネックス・コーポレーション | ポリペプチド産生を増加させる方法 |
ATE521697T1 (de) | 2002-03-29 | 2011-09-15 | Singapore Eye Res Inst | Verfahren zum wachstum von menschlichen bindehautgewebeäquivalenten für die forschung, die klinische augenoberflächentransplantation und die geweberekonstruktion |
JP2006516408A (ja) | 2003-02-01 | 2006-07-06 | タノックス インコーポレーテッド | 高親和性抗体の生成方法 |
GB0304799D0 (en) * | 2003-03-03 | 2003-04-09 | Glaxosmithkline Biolog Sa | Novel method |
JP4756816B2 (ja) * | 2003-03-10 | 2011-08-24 | 株式会社アドバンス | 骨再生補綴物の製造方法 |
WO2004083384A2 (fr) * | 2003-03-17 | 2004-09-30 | Shire Laboratories, Inc. | Systeme de culture accelere pour monocouches de cellules epitheliales intestinales |
US20040185561A1 (en) * | 2003-03-18 | 2004-09-23 | Cascade Biologics, Inc. | Animal product-free cell culture media extracts, supplements and culture media supplement systems |
EP1475434A1 (fr) * | 2003-05-09 | 2004-11-10 | Oncoscience AG | Procédé de stockage de cellules tumorales |
CA2528115A1 (fr) * | 2003-06-03 | 2004-12-16 | Nancy L. Parenteau | Selection et propagation de cellules progenitrices |
KR100567655B1 (ko) * | 2004-04-26 | 2006-04-04 | 사회복지법인 삼성생명공익재단 | 섬유아세포 배양용 배지, 상기 배지를 이용하여 진피대체물을 제조하는 방법 및 그에 의하여 제조되는 진피대체물, 상기 진피 대체물을 이용하여 피부 대체물을제조하는 방법 및 그에 의하여 제조되는 피부 대체물 |
US8252591B2 (en) * | 2004-05-07 | 2012-08-28 | Whitehead Institute For Biomedical Research | Hormone responsive tissue culture system and uses thereof |
US20060121512A1 (en) * | 2004-12-02 | 2006-06-08 | Organ Recovery Systems, Inc. | Biological pathways in progenitor cells |
US20070003541A1 (en) * | 2005-07-01 | 2007-01-04 | Rodolfo Faudoa | Methods and compositions for therapeutics |
US20070004036A1 (en) * | 2005-07-01 | 2007-01-04 | Rodolfo Faudoa | Methods and compositions for keratinocyte culture |
US20070128685A1 (en) * | 2005-07-01 | 2007-06-07 | Rodolfo Faudoa | Methods and compositions for cell culture |
KR100771171B1 (ko) * | 2006-07-05 | 2007-10-29 | 재단법인서울대학교산학협력재단 | 모낭 줄기세포의 분리, 증식 및 분화 방법 및 대머리치료용 조성물 |
CN105085682A (zh) | 2006-11-02 | 2015-11-25 | 健泰科生物技术公司 | 人源化的抗-d因子抗体 |
JP5386364B2 (ja) | 2006-12-18 | 2014-01-15 | ジェネンテック, インコーポレイテッド | 抗Notch3アンタゴニスト抗体とNotch3関連疾患の予防及び治療におけるその使用 |
EP2599791A1 (fr) | 2007-04-27 | 2013-06-05 | Genentech, Inc. | Anticorps anti-CD4 puissants, stables et non immunosuppresseurs |
US20110244502A1 (en) | 2007-08-10 | 2011-10-06 | Whitehead Institute For Biomedical Research | Hormone responsive tissue culture system and uses thereof |
SI2195023T1 (en) | 2007-08-29 | 2018-07-31 | Sanofi | Humanized anti-CXCR5 antibodies, their derivatives and their uses |
EP2050764A1 (fr) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Nouveau format d'anticorps bispécifique polyvalent |
CR20170001A (es) | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
MX2011002478A (es) | 2008-09-07 | 2011-04-05 | Glyconex Inc | Anticuerpo anti-glucoesfingolipido tipo i extendido, derivados del mismo y su uso. |
US20110207175A1 (en) * | 2008-10-06 | 2011-08-25 | Mc2 Cell Aps | Multi-culture bioreactor system |
CN102892880A (zh) | 2010-01-14 | 2013-01-23 | 奥加诺吉尼西斯公司 | 生物工程化组织构建物及其制备和使用方法 |
WO2012048298A2 (fr) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Procédés et systèmes de culture et de récolte de cellules dans un système de bioréacteur à fibres creuses avec conditions de régulation |
BR112013021514A2 (pt) * | 2011-02-25 | 2020-09-29 | Riken | método de produção de camada de célula epitelial de pigmento retinal |
WO2012125775A1 (fr) | 2011-03-16 | 2012-09-20 | Sanofi | Utilisations d'une protéine de type anticorps à région v double |
JP6216318B2 (ja) * | 2011-09-30 | 2017-10-18 | 株式会社アモーレパシフィックAmorepacific Corporation | 角化細胞に適応したメラニン形成細胞又はその前駆細胞 |
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JP6292557B2 (ja) | 2012-08-24 | 2018-03-14 | 国立研究開発法人理化学研究所 | 網膜色素上皮細胞シートの製造方法 |
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US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
CN106715676A (zh) | 2014-09-26 | 2017-05-24 | 泰尔茂比司特公司 | 按计划供养 |
WO2016080732A1 (fr) * | 2014-11-17 | 2016-05-26 | 주식회사 바이오코즈글로벌코리아 | Composition cosmétique pour améliorer l'état de la peau, contenant du milieu de culture de cellules, du facteur de croissance épidermique et de la sérum-albumine bovine |
WO2017004592A1 (fr) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Croissance cellulaire à l'aide de stimuli mécaniques |
US10119117B2 (en) | 2016-01-28 | 2018-11-06 | Nanogen Pharmaceutical Biotechnology Co., Ltd | Universal, glycosylation enhancer, completely chemically defined medium formulation |
CN109415696A (zh) | 2016-05-25 | 2019-03-01 | 泰尔茂比司特公司 | 细胞扩增 |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
EP3601521A2 (fr) | 2017-03-31 | 2020-02-05 | Terumo BCT, Inc. | Expansion cellulaire |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
WO2019006127A1 (fr) * | 2017-06-28 | 2019-01-03 | Rutgers, The State University Of New Jersey | Organoïdes dérivés d'une cellule rénale unique |
KR102583179B1 (ko) * | 2020-11-27 | 2023-09-26 | (주)엑셀세라퓨틱스 | 칼슘, 상피세포성장인자 및 알부민을 포함하는 각질형성세포 수립 또는 배양용 배지 조성물 |
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US4769317A (en) * | 1983-06-14 | 1988-09-06 | Hefton John M | Process for growing human epidermis, product thereof |
US4673649A (en) * | 1983-07-15 | 1987-06-16 | University Patents, Inc. | Process and defined medium for growth of human epidermal keratinocyte cells |
US4940666A (en) * | 1983-07-15 | 1990-07-10 | University Patents, Inc. | Process and defined medium for growth of human epidermal keratinocyte cells |
FR2612938B1 (fr) * | 1987-03-26 | 1989-06-23 | Cird | Procede d'obtention d'un equivalent de peau et equivalent de peau correspondant |
FR2612939B1 (fr) * | 1987-03-26 | 1989-06-23 | Cird | Equivalent de peau |
US4885238A (en) * | 1987-10-30 | 1989-12-05 | The United States Of America As Represented By The Department Of Health And Human Services | Immortalized human bronchial epitherial mesothelial cell lines |
JPS6434282A (en) * | 1987-07-31 | 1989-02-03 | Meguro Kenkyusho Kk | Synthetic culture medium for producing monoclonal antibody |
WO1989009258A1 (fr) * | 1988-03-30 | 1989-10-05 | Trustees Of Tufts College | Procedes d'augmentation de teneur en melanine et induisant la proliferation de melanocytes in vivo et in vitro |
JPH03504330A (ja) * | 1988-12-14 | 1991-09-26 | アメリカ合衆国 | ヒト肝上皮細胞系のための細胞培地 |
US5292655A (en) * | 1990-01-29 | 1994-03-08 | Wille Jr John J | Method for the formation of a histologically-complete skin substitute |
-
1990
- 1990-06-04 CA CA002018228A patent/CA2018228C/fr not_active Expired - Lifetime
- 1990-06-04 IL IL9461190A patent/IL94611A/en not_active IP Right Cessation
- 1990-06-05 AT AT90306084T patent/ATE169670T1/de not_active IP Right Cessation
- 1990-06-05 DE DE69032549T patent/DE69032549T2/de not_active Expired - Fee Related
- 1990-06-05 DK DK90306084T patent/DK0403139T3/da active
- 1990-06-05 EP EP90306084A patent/EP0403139B1/fr not_active Expired - Lifetime
- 1990-06-05 ES ES90306084T patent/ES2120946T3/es not_active Expired - Lifetime
- 1990-06-05 JP JP2147191A patent/JP2577114B2/ja not_active Expired - Fee Related
-
1995
- 1995-03-28 US US08/412,982 patent/US5712163A/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5610007A (en) * | 1993-01-21 | 1997-03-11 | Universite Laval | Chimeric sheets of epithelial cells |
Also Published As
Publication number | Publication date |
---|---|
ES2120946T3 (es) | 1998-11-16 |
EP0403139B1 (fr) | 1998-08-12 |
IL94611A0 (en) | 1991-04-15 |
CA2018228C (fr) | 1996-02-27 |
EP0403139A1 (fr) | 1990-12-19 |
DE69032549T2 (de) | 1999-02-04 |
JPH0387174A (ja) | 1991-04-11 |
ATE169670T1 (de) | 1998-08-15 |
DE69032549D1 (de) | 1998-09-17 |
IL94611A (en) | 1994-12-29 |
US5712163A (en) | 1998-01-27 |
JP2577114B2 (ja) | 1997-01-29 |
DK0403139T3 (da) | 1999-05-10 |
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