ATE521697T1 - Verfahren zum wachstum von menschlichen bindehautgewebeäquivalenten für die forschung, die klinische augenoberflächentransplantation und die geweberekonstruktion - Google Patents

Verfahren zum wachstum von menschlichen bindehautgewebeäquivalenten für die forschung, die klinische augenoberflächentransplantation und die geweberekonstruktion

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Publication number
ATE521697T1
ATE521697T1 AT03721475T AT03721475T ATE521697T1 AT E521697 T1 ATE521697 T1 AT E521697T1 AT 03721475 T AT03721475 T AT 03721475T AT 03721475 T AT03721475 T AT 03721475T AT E521697 T1 ATE521697 T1 AT E521697T1
Authority
AT
Austria
Prior art keywords
tissue
equivalents
research
eye surface
human connective
Prior art date
Application number
AT03721475T
Other languages
English (en)
Inventor
Donald Tan
Leonard Ang
Roger Beuermann
Original Assignee
Singapore Eye Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Singapore Eye Res Inst filed Critical Singapore Eye Res Inst
Application granted granted Critical
Publication of ATE521697T1 publication Critical patent/ATE521697T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
    • C12N2500/14—Calcium; Ca chelators; Calcitonin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/80—Undefined extracts from animals
    • C12N2500/84—Undefined extracts from animals from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
    • C12N2533/92—Amnion; Decellularised dermis or mucosa
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Prostheses (AREA)
AT03721475T 2002-03-29 2003-03-28 Verfahren zum wachstum von menschlichen bindehautgewebeäquivalenten für die forschung, die klinische augenoberflächentransplantation und die geweberekonstruktion ATE521697T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36815802P 2002-03-29 2002-03-29
PCT/US2003/009392 WO2003084431A2 (en) 2002-03-29 2003-03-28 Method for growth of human conjunctival tissue equivalents for research, clinical ocular surface transplantation and tissue engineering

Publications (1)

Publication Number Publication Date
ATE521697T1 true ATE521697T1 (de) 2011-09-15

Family

ID=28791886

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03721475T ATE521697T1 (de) 2002-03-29 2003-03-28 Verfahren zum wachstum von menschlichen bindehautgewebeäquivalenten für die forschung, die klinische augenoberflächentransplantation und die geweberekonstruktion

Country Status (7)

Country Link
US (2) US7049139B2 (de)
EP (1) EP1499710B1 (de)
CN (1) CN1649998A (de)
AT (1) ATE521697T1 (de)
AU (1) AU2003224785B2 (de)
HK (1) HK1080111A1 (de)
WO (1) WO2003084431A2 (de)

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WO2003084431A2 (en) * 2002-03-29 2003-10-16 Singapore Eye Research Institute Method for growth of human conjunctival tissue equivalents for research, clinical ocular surface transplantation and tissue engineering
US7824671B2 (en) * 2002-10-04 2010-11-02 Tissuetech, Inc. Retinal pigment epithelial cell cultures on amniotic membrane and transplantation
DE102005027355A1 (de) * 2005-06-13 2006-12-14 Femtotechnologies Gmbh Verfahren zum Bearbeiten eines organischen Materials
AU2007220122B2 (en) * 2006-02-24 2014-01-16 Reliance Life Sciences Pvt Ltd. Conjunctival tissue system
US8372437B2 (en) 2006-08-17 2013-02-12 Mimedx Group, Inc. Placental tissue grafts
WO2008105454A1 (ja) 2007-02-28 2008-09-04 Senju Pharmaceutical Co., Ltd. ラクリチン高発現細胞
US8574567B2 (en) 2007-05-03 2013-11-05 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
EP2607477B1 (de) 2007-05-03 2020-09-23 The Brigham and Women's Hospital, Inc. Multipotente stammzellen und ihre verwendung
EP2151492B1 (de) * 2007-05-11 2015-03-04 Dai Nippon Printing Co., Ltd. Zellschicht mit guter dimensionaler stabilität, verfahren zu ihrer herstellung und zellkulturträger zur verwendung für das verfahren
EP2197270B8 (de) 2007-09-07 2020-03-04 Surgical Biologics, LLC Plazentagewebetransplantate und verbesserte verfahren zu ihrer herstellung und verwendung
MX2010005791A (es) * 2007-11-28 2010-08-10 Organogenesis Inc Construcciones de tejido hechas mediante bio-ingenieria y metodos para produccion y uso.
CN104263699A (zh) * 2014-09-19 2015-01-07 江苏华亿细胞组织工程有限公司 细胞移植用临床治疗级真皮多能干细胞规模化制备培养方法
CN104312970A (zh) * 2014-09-19 2015-01-28 朱宁文 一种细胞治疗用临床治疗级表皮干细胞应用人类细胞外基质筛选及规模化培养制备方法
KR102583179B1 (ko) * 2020-11-27 2023-09-26 (주)엑셀세라퓨틱스 칼슘, 상피세포성장인자 및 알부민을 포함하는 각질형성세포 수립 또는 배양용 배지 조성물

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Also Published As

Publication number Publication date
EP1499710B1 (de) 2011-08-24
WO2003084431A2 (en) 2003-10-16
EP1499710A4 (de) 2005-08-31
US7049139B2 (en) 2006-05-23
WO2003084431A3 (en) 2004-04-15
AU2003224785A1 (en) 2003-10-20
AU2003224785B2 (en) 2008-12-11
HK1080111A1 (zh) 2006-04-21
EP1499710A2 (de) 2005-01-26
US7611895B2 (en) 2009-11-03
CN1649998A (zh) 2005-08-03
US20060177927A1 (en) 2006-08-10
US20040009590A1 (en) 2004-01-15

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