DE69032549T2 - Zellkultursysteme und Medien - Google Patents
Zellkultursysteme und MedienInfo
- Publication number
- DE69032549T2 DE69032549T2 DE69032549T DE69032549T DE69032549T2 DE 69032549 T2 DE69032549 T2 DE 69032549T2 DE 69032549 T DE69032549 T DE 69032549T DE 69032549 T DE69032549 T DE 69032549T DE 69032549 T2 DE69032549 T2 DE 69032549T2
- Authority
- DE
- Germany
- Prior art keywords
- cells
- media
- cell culture
- culture systems
- population
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0629—Keratinocytes; Whole skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
- C12N5/0075—General culture methods using substrates using microcarriers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
- C12N2500/14—Calcium; Ca chelators; Calcitonin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
- C12N2501/392—Sexual steroids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/395—Thyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36104189A | 1989-06-05 | 1989-06-05 | |
US53225790A | 1990-06-01 | 1990-06-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69032549D1 DE69032549D1 (de) | 1998-09-17 |
DE69032549T2 true DE69032549T2 (de) | 1999-02-04 |
Family
ID=27001138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69032549T Expired - Fee Related DE69032549T2 (de) | 1989-06-05 | 1990-06-05 | Zellkultursysteme und Medien |
Country Status (9)
Country | Link |
---|---|
US (1) | US5712163A (de) |
EP (1) | EP0403139B1 (de) |
JP (1) | JP2577114B2 (de) |
AT (1) | ATE169670T1 (de) |
CA (1) | CA2018228C (de) |
DE (1) | DE69032549T2 (de) |
DK (1) | DK0403139T3 (de) |
ES (1) | ES2120946T3 (de) |
IL (1) | IL94611A (de) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0970701B1 (de) * | 1991-11-20 | 2005-10-26 | Innogenetics N.V. | Keratinozyt-abstammende Granulate zur Verwendung als wundheilendes Mittel |
US6585969B1 (en) | 1991-11-20 | 2003-07-01 | N. V. Innogenetics S.A. | Non-viable keratinocyte cell composition or lysate for promoting wound healing |
US5610007A (en) * | 1993-01-21 | 1997-03-11 | Universite Laval | Chimeric sheets of epithelial cells |
US6326194B1 (en) | 1993-03-11 | 2001-12-04 | Geoffrey Michael Curtin | Method for providing cell growth |
CA2119064A1 (en) * | 1993-03-17 | 1994-09-18 | Richard A. Berg | Dermal-epidermal in vitro test system |
EP0754017B1 (de) * | 1994-04-29 | 2002-06-19 | SciMed Life Systems, Inc. | Stent mit kollagen |
DE4438015A1 (de) * | 1994-10-25 | 1996-05-02 | Boehringer Mannheim Gmbh | Epithelzellenhaltiges Biomaterial und dessen Verwendung als Transplantat |
JP3660026B2 (ja) * | 1995-09-04 | 2005-06-15 | 扶桑薬品工業株式会社 | 体外受精用培地組成物 |
AU2642897A (en) * | 1996-04-16 | 1997-11-07 | Universite De Nantes | Cell culture process and medium, cellular composition obtained and its application as production system and study model |
FR2747395B1 (fr) * | 1996-04-16 | 1998-06-26 | Univ Nantes | Procede de primoculture in vitro de cellules epitheliales gastro-intestinales, composition cellulaire obtenue notamment par la mise en oeuvre du procede et applications de ladite composition en tant que systeme de production |
FR2757536B1 (fr) * | 1996-12-24 | 1999-03-05 | Univ Nantes | Procede et milieu de culture de cellules, composition cellul aire obtenue et ses applications en tant que systeme de production et de modele d'etude |
EP2243827B2 (de) * | 1996-08-30 | 2017-11-22 | Life Technologies Corporation | Serumfreies kulturmedium für säugerzellen und seine verwendung |
US6692961B1 (en) * | 1996-10-11 | 2004-02-17 | Invitrogen Corporation | Defined systems for epithelial cell culture and use thereof |
US5972332A (en) | 1997-04-16 | 1999-10-26 | The Regents Of The University Of Michigan | Wound treatment with keratinocytes on a solid support enclosed in a porous material |
AU3077299A (en) | 1998-03-11 | 1999-09-27 | University Of Southern California | Method of promoting production of living tissue equivalents |
DE69927600T2 (de) * | 1998-11-19 | 2006-07-06 | Organogenesis, Inc., Canton | Biotechnisch konstruiertes gewebe und verfahren zu dessen produktion und benutzung |
US6248725B1 (en) * | 1999-02-23 | 2001-06-19 | Amgen, Inc. | Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction |
US7056503B2 (en) * | 1999-08-19 | 2006-06-06 | Regents Of The University Of Michigan | Enclosures housing cell-coated supports for treating tumors |
CA2383398C (en) * | 1999-08-23 | 2013-06-11 | Organogenesis, Inc. | Skin care compositions and treatments |
FR2812004B1 (fr) * | 2000-07-24 | 2002-12-27 | Ccd Lab | Milieux de culture pour fecondation in vitro, ou pour la culture de follicules, cellules germinales males ou embryons |
US6846675B2 (en) * | 2001-03-02 | 2005-01-25 | Stratech Corporation | Skin substitutes and uses thereof |
US6506576B2 (en) | 2001-03-14 | 2003-01-14 | Board Of Trustees Of The University Of Arkansas | Serum-and steroid-free culture media for cerebellar granule neurons |
JP3728750B2 (ja) * | 2001-11-22 | 2005-12-21 | ニプロ株式会社 | 培養皮膚及びその製造方法 |
WO2003048336A2 (en) | 2001-12-04 | 2003-06-12 | Organogenesis Inc. | Cultured cells from pancreatic islets |
AU2003219830A1 (en) * | 2002-02-22 | 2003-09-09 | Ebi, L.P. | Methods and compositions for treating bone or cartilage defects |
US7741116B2 (en) * | 2002-03-06 | 2010-06-22 | University Of Cincinnati | Surgical device for skin therapy or testing |
JP2005521401A (ja) * | 2002-03-27 | 2005-07-21 | イミュネックス・コーポレーション | ポリペプチド産生を増加させる方法 |
EP1499710B1 (de) * | 2002-03-29 | 2011-08-24 | Singapore Eye Research Institute | Verfahren zum wachstum von menschlichen bindehautgewebeäquivalenten für die forschung, die klinische augenoberflächentransplantation und die geweberekonstruktion |
US7531169B2 (en) | 2003-02-01 | 2009-05-12 | Tanox, Inc. | High affinity anti-human IgE antibodies |
GB0304799D0 (en) * | 2003-03-03 | 2003-04-09 | Glaxosmithkline Biolog Sa | Novel method |
JP4756816B2 (ja) * | 2003-03-10 | 2011-08-24 | 株式会社アドバンス | 骨再生補綴物の製造方法 |
EP1606395A4 (de) * | 2003-03-17 | 2006-06-14 | Shire Lab Inc | Beschleunigtes kultivierungssystem für monolayer von darmepithelzellen |
US20040185561A1 (en) * | 2003-03-18 | 2004-09-23 | Cascade Biologics, Inc. | Animal product-free cell culture media extracts, supplements and culture media supplement systems |
EP1475434A1 (de) * | 2003-05-09 | 2004-11-10 | Oncoscience AG | Verfahren zur Lagerung von Tumorzellen |
KR20060032958A (ko) * | 2003-06-03 | 2006-04-18 | 올간 리커버리 시스템즈, 인코포레이티드 | 전구 세포의 분리 및 증식 |
KR100567655B1 (ko) * | 2004-04-26 | 2006-04-04 | 사회복지법인 삼성생명공익재단 | 섬유아세포 배양용 배지, 상기 배지를 이용하여 진피대체물을 제조하는 방법 및 그에 의하여 제조되는 진피대체물, 상기 진피 대체물을 이용하여 피부 대체물을제조하는 방법 및 그에 의하여 제조되는 피부 대체물 |
US8252591B2 (en) * | 2004-05-07 | 2012-08-28 | Whitehead Institute For Biomedical Research | Hormone responsive tissue culture system and uses thereof |
US20060121512A1 (en) * | 2004-12-02 | 2006-06-08 | Organ Recovery Systems, Inc. | Biological pathways in progenitor cells |
US20070004036A1 (en) * | 2005-07-01 | 2007-01-04 | Rodolfo Faudoa | Methods and compositions for keratinocyte culture |
US20070128685A1 (en) * | 2005-07-01 | 2007-06-07 | Rodolfo Faudoa | Methods and compositions for cell culture |
US20070003541A1 (en) * | 2005-07-01 | 2007-01-04 | Rodolfo Faudoa | Methods and compositions for therapeutics |
KR100771171B1 (ko) * | 2006-07-05 | 2007-10-29 | 재단법인서울대학교산학협력재단 | 모낭 줄기세포의 분리, 증식 및 분화 방법 및 대머리치료용 조성물 |
CA2667997C (en) | 2006-11-02 | 2016-10-11 | Genentech, Inc. | Humanized anti-factor d antibodies and uses thereof |
AR064388A1 (es) | 2006-12-18 | 2009-04-01 | Genentech Inc | Anticuerpos antagonistas anti- notch3 y su uso en la prevencion y el tratamiento de enfermedades relacionadas con el receptor notch3 |
EP3067368A1 (de) | 2007-04-27 | 2016-09-14 | Genentech, Inc. | Starke, stabile und nicht immunsuppressive anti-cd4-antikörper |
EP2188367A4 (de) * | 2007-08-10 | 2010-10-27 | Whitehead Biomedical Inst | Auf hormon ansprechendes gewebekultursystem und verwendungen davon |
KR101599704B1 (ko) | 2007-08-29 | 2016-03-07 | 사노피 | 인간화된 항-cxcr5 항체, 이의 유도체 및 이들의 용도 |
EP2050764A1 (de) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Neues polyvalentes bispezifisches Antikörperformat und Verwendung |
CR20170001A (es) | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
ES2549877T3 (es) | 2008-09-07 | 2015-11-02 | Glyconex Inc. | Anticuerpo antiglucoesfingolípido de tipo I extendido, derivados del mismo y utilización |
US20110207175A1 (en) * | 2008-10-06 | 2011-08-25 | Mc2 Cell Aps | Multi-culture bioreactor system |
WO2011088365A1 (en) | 2010-01-14 | 2011-07-21 | Organogenesis, Inc. | Bioengineered tissue constructs and methods for producing and using thereof |
US8895291B2 (en) | 2010-10-08 | 2014-11-25 | Terumo Bct, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
AU2012222255B2 (en) * | 2011-02-25 | 2017-04-13 | Riken | Method of producing retinal pigment epithelial cell sheet |
PL3235508T3 (pl) | 2011-03-16 | 2021-07-12 | Sanofi | Kompozycje zawierające białko podobne do przeciwciała z podwójnym regionem v |
EP2762559B1 (de) | 2011-09-30 | 2019-03-13 | Amorepacific Corporation | An keratinozyten angepasste melanozyten oder vorläuferzellen davon und herstellungsverfahren dafür |
US9592289B2 (en) | 2012-03-26 | 2017-03-14 | Sanofi | Stable IgG4 based binding agent formulations |
US11033586B2 (en) | 2012-08-24 | 2021-06-15 | Riken | Method for producing retinal pigment epithelial cell sheet |
CN105992816B (zh) | 2013-11-16 | 2018-04-17 | 泰尔茂比司特公司 | 生物反应器中的细胞扩增 |
EP3613841B1 (de) | 2014-03-25 | 2022-04-20 | Terumo BCT, Inc. | Passives ersetzen von medien |
JP6830059B2 (ja) | 2014-09-26 | 2021-02-17 | テルモ ビーシーティー、インコーポレーテッド | スケジュール化された細胞フィーディング |
WO2016080732A1 (ko) * | 2014-11-17 | 2016-05-26 | 주식회사 바이오코즈글로벌코리아 | 세포 배양 배지, 표피성장인자 및 소혈청알부민을 포함하는 피부 상태 개선용 화장료 조성물 |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
US10119117B2 (en) | 2016-01-28 | 2018-11-06 | Nanogen Pharmaceutical Biotechnology Co., Ltd | Universal, glycosylation enhancer, completely chemically defined medium formulation |
WO2017205667A1 (en) | 2016-05-25 | 2017-11-30 | Terumo Bct, Inc. | Cell expansion |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
CN117247899A (zh) | 2017-03-31 | 2023-12-19 | 泰尔茂比司特公司 | 细胞扩增 |
US11834680B2 (en) | 2017-06-28 | 2023-12-05 | Rutgers, The State University Of New Jersey | Single kidney cell-derived organoids |
KR102583179B1 (ko) * | 2020-11-27 | 2023-09-26 | (주)엑셀세라퓨틱스 | 칼슘, 상피세포성장인자 및 알부민을 포함하는 각질형성세포 수립 또는 배양용 배지 조성물 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4456687A (en) * | 1978-11-16 | 1984-06-26 | President And Fellows Of Harvard College | Agents for promoting growth of epithelial cells |
US4254226A (en) * | 1979-09-13 | 1981-03-03 | Sloan Kettering Institute For Cancer Research | Process for growing human epidermal cells in tissue culture |
US4443546A (en) * | 1980-07-07 | 1984-04-17 | The Beth Israel Hospital Association | Process and composition for propagating mammalian cells |
IL69664A0 (en) * | 1982-09-15 | 1983-12-30 | Collaborative Res Inc | Medium supplement and method for growing cells in vitro |
US4560655A (en) * | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4769317A (en) * | 1983-06-14 | 1988-09-06 | Hefton John M | Process for growing human epidermis, product thereof |
US4673649A (en) * | 1983-07-15 | 1987-06-16 | University Patents, Inc. | Process and defined medium for growth of human epidermal keratinocyte cells |
US4940666A (en) * | 1983-07-15 | 1990-07-10 | University Patents, Inc. | Process and defined medium for growth of human epidermal keratinocyte cells |
FR2612939B1 (fr) * | 1987-03-26 | 1989-06-23 | Cird | Equivalent de peau |
FR2612938B1 (fr) * | 1987-03-26 | 1989-06-23 | Cird | Procede d'obtention d'un equivalent de peau et equivalent de peau correspondant |
US4885238A (en) * | 1987-10-30 | 1989-12-05 | The United States Of America As Represented By The Department Of Health And Human Services | Immortalized human bronchial epitherial mesothelial cell lines |
JPS6434282A (en) * | 1987-07-31 | 1989-02-03 | Meguro Kenkyusho Kk | Synthetic culture medium for producing monoclonal antibody |
DE68916197T2 (de) * | 1988-03-30 | 1994-09-29 | Univ Boston | Zusammensetzung zur in-vivo bzw. in-vitro steigerung des melaningehaltes der melanocyten und deren in-vitro verwendung. |
JPH03504330A (ja) * | 1988-12-14 | 1991-09-26 | アメリカ合衆国 | ヒト肝上皮細胞系のための細胞培地 |
US5292655A (en) * | 1990-01-29 | 1994-03-08 | Wille Jr John J | Method for the formation of a histologically-complete skin substitute |
-
1990
- 1990-06-04 CA CA002018228A patent/CA2018228C/en not_active Expired - Lifetime
- 1990-06-04 IL IL9461190A patent/IL94611A/en not_active IP Right Cessation
- 1990-06-05 EP EP90306084A patent/EP0403139B1/de not_active Expired - Lifetime
- 1990-06-05 ES ES90306084T patent/ES2120946T3/es not_active Expired - Lifetime
- 1990-06-05 DE DE69032549T patent/DE69032549T2/de not_active Expired - Fee Related
- 1990-06-05 DK DK90306084T patent/DK0403139T3/da active
- 1990-06-05 JP JP2147191A patent/JP2577114B2/ja not_active Expired - Fee Related
- 1990-06-05 AT AT90306084T patent/ATE169670T1/de not_active IP Right Cessation
-
1995
- 1995-03-28 US US08/412,982 patent/US5712163A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
IL94611A (en) | 1994-12-29 |
EP0403139B1 (de) | 1998-08-12 |
CA2018228A1 (en) | 1990-12-05 |
EP0403139A1 (de) | 1990-12-19 |
JP2577114B2 (ja) | 1997-01-29 |
CA2018228C (en) | 1996-02-27 |
JPH0387174A (ja) | 1991-04-11 |
DE69032549D1 (de) | 1998-09-17 |
IL94611A0 (en) | 1991-04-15 |
ES2120946T3 (es) | 1998-11-16 |
US5712163A (en) | 1998-01-27 |
DK0403139T3 (da) | 1999-05-10 |
ATE169670T1 (de) | 1998-08-15 |
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