CA2008616A1 - Composes d'acide aryl- ou htroaryl-l-alkyl-pyrrole-2-carboxylique utiles pour le traitement des affections a l'interleukine-1 - Google Patents

Composes d'acide aryl- ou htroaryl-l-alkyl-pyrrole-2-carboxylique utiles pour le traitement des affections a l'interleukine-1

Info

Publication number
CA2008616A1
CA2008616A1 CA2008616A CA2008616A CA2008616A1 CA 2008616 A1 CA2008616 A1 CA 2008616A1 CA 2008616 A CA2008616 A CA 2008616A CA 2008616 A CA2008616 A CA 2008616A CA 2008616 A1 CA2008616 A1 CA 2008616A1
Authority
CA
Canada
Prior art keywords
alkyl
pyrrole
heteroaryl
carboxylic acid
acid compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2008616A
Other languages
English (en)
Other versions
CA2008616C (fr
Inventor
Roger A. Parker
George Ku
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2008616A1 publication Critical patent/CA2008616A1/fr
Application granted granted Critical
Publication of CA2008616C publication Critical patent/CA2008616C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CA002008616A 1989-01-31 1990-01-25 Composes d'acide aryl- ou htroaryl-l-alkyl-pyrrole-2-carboxylique utiles pour le traitement des affections a l'interleukine-1 Expired - Fee Related CA2008616C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30414189A 1989-01-31 1989-01-31
US304,141 1989-01-31

Publications (2)

Publication Number Publication Date
CA2008616A1 true CA2008616A1 (fr) 1990-07-31
CA2008616C CA2008616C (fr) 2000-07-18

Family

ID=23175237

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002008616A Expired - Fee Related CA2008616C (fr) 1989-01-31 1990-01-25 Composes d'acide aryl- ou htroaryl-l-alkyl-pyrrole-2-carboxylique utiles pour le traitement des affections a l'interleukine-1

Country Status (17)

Country Link
EP (1) EP0381141B1 (fr)
JP (1) JP2841305B2 (fr)
KR (1) KR0139288B1 (fr)
CN (1) CN1022754C (fr)
AR (1) AR245694A1 (fr)
AT (1) ATE135702T1 (fr)
AU (1) AU629290B2 (fr)
CA (1) CA2008616C (fr)
DE (1) DE69025967T2 (fr)
ES (1) ES2087093T3 (fr)
FI (1) FI900464A0 (fr)
HU (1) HU209290B (fr)
IL (1) IL93187A (fr)
NO (1) NO174887C (fr)
NZ (1) NZ232278A (fr)
PT (1) PT93009A (fr)
ZA (1) ZA90554B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
AU625688B2 (en) * 1989-01-31 1992-07-16 Merrell Dow Pharmaceuticals Inc. Method of using aryl- or heteroaryl-1-alkyl-pyrrole-2- carboxylic acid compounds in the treatment of interleukin-1 mediated conditions
EP2451779B1 (fr) * 2009-07-10 2014-09-03 The General Hospital Corporation Analogues de l'étomidate qui n'inhibent pas la synthèse de stéroïdes corticosurrénaux
CN102114430B (zh) * 2009-12-30 2013-06-05 上海睿智化学研究有限公司 催化剂、其制备方法及n-烷基吡咯衍生物的制备方法
DK2802325T3 (en) 2012-01-13 2017-03-13 Massachusetts Gen Hospital ANESTHETIC RELATIONS AND RELATED APPLICATIONS THEREOF

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4112112A (en) * 1976-06-29 1978-09-05 Merck & Co., Inc. Pyrrolo[2,1-b] [3]benzazepines useful for producing a skeletal muscle relaxing or tranquilizing effect
JPS54128567A (en) * 1978-03-28 1979-10-05 Teijin Ltd 1-substituted-4-acyl-2-pyrrolecarboxylic acid derivative

Also Published As

Publication number Publication date
DE69025967T2 (de) 1996-08-29
HU209290B (en) 1994-04-28
CN1022754C (zh) 1993-11-17
NO900432D0 (no) 1990-01-30
EP0381141A3 (fr) 1991-11-21
JPH02247165A (ja) 1990-10-02
EP0381141A2 (fr) 1990-08-08
NO900432L (no) 1990-08-01
NO174887C (no) 1994-07-27
HU900592D0 (en) 1990-04-28
ZA90554B (en) 1990-10-31
ATE135702T1 (de) 1996-04-15
NZ232278A (en) 1992-07-28
CN1044653A (zh) 1990-08-15
AU4875990A (en) 1990-08-09
AU629290B2 (en) 1992-10-01
IL93187A (en) 1994-12-29
DE69025967D1 (de) 1996-04-25
ES2087093T3 (es) 1996-07-16
NO174887B (no) 1994-04-18
HUT53868A (en) 1990-12-28
FI900464A0 (fi) 1990-01-30
KR0139288B1 (ko) 1998-05-15
IL93187A0 (en) 1990-11-05
KR900011725A (ko) 1990-08-02
EP0381141B1 (fr) 1996-03-20
PT93009A (pt) 1990-07-31
AR245694A1 (es) 1994-02-28
JP2841305B2 (ja) 1998-12-24
CA2008616C (fr) 2000-07-18

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKLA Lapsed

Effective date: 20050125