CA1339103C - Stable creatine amidinohydrolase mutants - Google Patents

Stable creatine amidinohydrolase mutants

Info

Publication number
CA1339103C
CA1339103C CA000565576A CA565576A CA1339103C CA 1339103 C CA1339103 C CA 1339103C CA 000565576 A CA000565576 A CA 000565576A CA 565576 A CA565576 A CA 565576A CA 1339103 C CA1339103 C CA 1339103C
Authority
CA
Canada
Prior art keywords
creatine amidinohydrolase
dsm
enzyme
gene
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000565576A
Other languages
English (en)
French (fr)
Inventor
Peter Buckel
Gunther Schumacher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of CA1339103C publication Critical patent/CA1339103C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/874Pseudomonas
    • Y10S435/877Pseudomonas putida

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA000565576A 1987-05-12 1988-04-29 Stable creatine amidinohydrolase mutants Expired - Fee Related CA1339103C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3715841 1987-05-12
DEP3715841.4 1987-05-12
DE3803175A DE3803175A1 (de) 1987-05-12 1988-02-03 Stabile creatinamidinohydrolase-mutanten
DEP3803175.2 1988-02-03

Publications (1)

Publication Number Publication Date
CA1339103C true CA1339103C (en) 1997-07-29

Family

ID=25855502

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000565576A Expired - Fee Related CA1339103C (en) 1987-05-12 1988-04-29 Stable creatine amidinohydrolase mutants

Country Status (12)

Country Link
US (1) US4990453A (de)
EP (1) EP0291055B1 (de)
JP (1) JPS63287484A (de)
KR (1) KR900007648B1 (de)
AU (1) AU593438B2 (de)
CA (1) CA1339103C (de)
CZ (1) CZ279006B6 (de)
DE (2) DE3803175A1 (de)
DK (1) DK251788A (de)
ES (1) ES2059431T3 (de)
HU (1) HU204093B (de)
IE (1) IE60307B1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6437292A (en) * 1987-08-04 1989-02-07 Toyo Jozo Kk Dna having genetic information of creatinase and use thereof
JP2000157279A (ja) 1998-11-25 2000-06-13 Kikkoman Corp クレアチンアミジノハイドロラーゼ及びその製造法
JP3773160B2 (ja) * 1999-01-01 2006-05-10 キッコーマン株式会社 耐熱性クレアチンアミジノハイドロラーゼ及びその製造法
CA2404293C (en) 2001-09-20 2007-05-15 F. Hoffmann-La Roche Ag Variants of an erwinia-type creatinase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2122255B2 (de) * 1971-05-05 1979-01-11 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur spezifischen Bestimmung von Creatinin
US4039384A (en) * 1975-04-05 1977-08-02 Noda Institute For Scientific Research Creatinine amidohydrolase and creatine amidinohydrolase and process for producing them
JPS5736985A (ja) * 1980-08-14 1982-02-27 Toyobo Co Ltd Kosoanteikaho
JPS59232088A (ja) * 1983-06-15 1984-12-26 Tanabe Seiyaku Co Ltd L−アスパラギン酸の製法
DE3500184A1 (de) * 1985-01-04 1986-08-14 Boehringer Mannheim Gmbh, 6800 Mannheim Mikroorganismus und plasmid fuer konstitutive creatinamidinohydrolase-bildung sowie verfahren zur herstellung derselben
DE3707172C2 (de) * 1986-03-07 1995-09-21 Kikkoman Corp Rekombiniertes DNA-Molekül, das ein Kreatinasegen codiert, rekombinanter Vektor, der diese DNA-Sequenz umfaßt, sowie Verfahren zur Herstellung von Kreatinase unter Verwendung eines Stammes vom Genus Escherichia, der diesen rekombinanten DNA Vektor enthält

Also Published As

Publication number Publication date
EP0291055A2 (de) 1988-11-17
HU204093B (en) 1991-11-28
ES2059431T3 (es) 1994-11-16
IE881016L (en) 1988-11-12
CZ279006B6 (en) 1994-11-16
AU593438B2 (en) 1990-02-08
EP0291055A3 (en) 1989-11-29
KR900007648B1 (ko) 1990-10-17
DE3884045D1 (de) 1993-10-21
DK251788D0 (da) 1988-05-06
DK251788A (da) 1988-11-13
DE3803175A1 (de) 1988-11-24
JPS63287484A (ja) 1988-11-24
JPH0336514B2 (de) 1991-05-31
HUT46942A (en) 1988-12-28
EP0291055B1 (de) 1993-09-15
IE60307B1 (en) 1994-06-29
AU1518688A (en) 1988-11-17
CZ311888A3 (en) 1994-04-13
US4990453A (en) 1991-02-05
KR880014106A (ko) 1988-12-22

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