CA1317300C - Procede pour la preparation d'acide 2-(2-¬4-¬(4-chlorophenyl)phenylmethyl|-1-piperazinyl| ethoxy) acetique et de son dichlorhydrate - Google Patents

Procede pour la preparation d'acide 2-(2-¬4-¬(4-chlorophenyl)phenylmethyl|-1-piperazinyl| ethoxy) acetique et de son dichlorhydrate

Info

Publication number
CA1317300C
CA1317300C CA000614709A CA614709A CA1317300C CA 1317300 C CA1317300 C CA 1317300C CA 000614709 A CA000614709 A CA 000614709A CA 614709 A CA614709 A CA 614709A CA 1317300 C CA1317300 C CA 1317300C
Authority
CA
Canada
Prior art keywords
chlorophenyl
phenylmethyl
piperazinyl
ethoxy
dihydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000614709A
Other languages
English (en)
Inventor
Eric Cossement
Genevieve Motte
Guy Bodson
Jean Gobert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Application granted granted Critical
Publication of CA1317300C publication Critical patent/CA1317300C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA000614709A 1988-11-23 1989-09-29 Procede pour la preparation d'acide 2-(2-¬4-¬(4-chlorophenyl)phenylmethyl|-1-piperazinyl| ethoxy) acetique et de son dichlorhydrate Expired - Fee Related CA1317300C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888827391A GB8827391D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB8827391 1988-11-23

Publications (1)

Publication Number Publication Date
CA1317300C true CA1317300C (fr) 1993-05-04

Family

ID=10647347

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000614709A Expired - Fee Related CA1317300C (fr) 1988-11-23 1989-09-29 Procede pour la preparation d'acide 2-(2-¬4-¬(4-chlorophenyl)phenylmethyl|-1-piperazinyl| ethoxy) acetique et de son dichlorhydrate

Country Status (16)

Country Link
KR (1) KR970009728B1 (fr)
AT (1) AT398971B (fr)
CA (1) CA1317300C (fr)
CY (1) CY1671A (fr)
DK (1) DK174543B1 (fr)
ES (1) ES2021907A6 (fr)
FI (1) FI91862C (fr)
GB (2) GB8827391D0 (fr)
GR (1) GR1000553B (fr)
HK (1) HK95892A (fr)
HU (1) HU205094B (fr)
NO (1) NO172342C (fr)
PH (1) PH25982A (fr)
PL (1) PL161379B1 (fr)
PT (1) PT92364B (fr)
SG (1) SG89492G (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1072661C (zh) * 1996-04-10 2001-10-10 Ucb公司 新的取代[2－(1－哌嗪基)乙氧基]甲基化合物

Families Citing this family (37)

* Cited by examiner, † Cited by third party
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EP0950412A3 (fr) * 1992-09-24 2001-05-16 Sepracor, Inc. Compositions pour traiter des affections allergiques à l'aide de (-) cétirizine
AU703690B2 (en) * 1992-09-24 1999-04-01 Sepracor, Inc. Methods for treating allergic disorders using optically pure (+)cetirizine
AU5136193A (en) * 1992-09-24 1994-04-12 Sepracor, Inc. Methods and compositions for treating allergic disorders using optically pure (+) cetirizine
GB9305282D0 (en) 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
US6469009B1 (en) 1996-04-08 2002-10-22 Ucb, S.A. Pharmaceutical compositions for the treatment of rhinitis
BE1010095A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.
AU7455798A (en) 1997-06-04 1998-12-21 Nippon Shoji Kaisha, Ltd. Process for producing piperazinesulfonamide derivatives and salts thereof
EP0919550A1 (fr) 1997-11-26 1999-06-02 Ucb, S.A. Formes pseudopolymorphiques de l'acide 2-2-4-bis(4-fluorophényl)méthyl -1-pipérazinyl-éthoxy acétique dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
GR990100135A (el) * 1999-04-22 2000-12-29 Genepharm �.�. Μεθοδος παρασκευης του 2-(2-[4-[4-χλωροφαινυλο)(φαινυλο)μεθυλο]πιπεραζινο]αιθοξυ) οξικου οξεος και του διυδροχλωρικου αλατος αυτου
JP2002249487A (ja) * 2001-02-22 2002-09-06 Sumitomo Chem Co Ltd ４−（ｔｅｒｔ−ブトキシカルボニル）ピペラジン誘導体、その光学活性な酸付加塩、それらの製造法、およびそれらを用いる光学活性な１−［（置換フェニル）フェニルメチル］ピペラジンの製造法。
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7381821B2 (en) 2003-01-23 2008-06-03 Ucb, S.A. Piperazine derivatives and their use as synthesis intermediates
KR100503443B1 (ko) 2004-02-02 2005-07-22 한림제약(주) 광학적으로 활성인 세티리진 또는 그의 염의 제조방법
CA2599498C (fr) * 2005-03-03 2011-06-21 Ucb Farchim Sa Sels de pyroglutamate et utilisation de ceux-ci dans la resolution optique d'intermediaires pour la synthese de la dextro-cetirizine et de la levo-cetirizine
HU227325B1 (en) * 2005-12-08 2011-03-28 Egis Gyogyszergyar Nyrt Process for the production of an intermediate of (dextro- and levo)- cetirizine
US8049011B2 (en) 2007-03-12 2011-11-01 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of levocetirizine and intermediates thereof
SI22489A (sl) * 2007-03-12 2008-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek za pripravo levocetirizina in njegovih intermediatov
EP2167479B1 (fr) 2007-06-15 2013-09-11 Symed Labs Limited Procédé de préparation d'énantiomères lévogyres et dextrogyres sensiblement optiquement purs de cétirizine à l'aide de nouveaux intermédiaires
WO2009062036A2 (fr) * 2007-11-09 2009-05-14 Dr. Reddy's Laboratories Ltd. Procédés de préparation de lévocétirizine et de ses sels pharmaceutiquement acceptables
ATE499352T1 (de) 2007-11-21 2011-03-15 Synthon Bv Verfahren zur herstellung von n- (diphenylmethyl)piperazinen
US7989623B2 (en) 2007-11-21 2011-08-02 Synthon Bv Process for making n-(diphenylmethyl)piperazines
WO2009147389A2 (fr) 2008-06-02 2009-12-10 Cipla Limited Procédés de synthèse de lévocétirizine et intermédiaires pour une utilisation dans ceux-ci
WO2009150147A1 (fr) * 2008-06-11 2009-12-17 Krka, Tovarna Zdravil, D.D., Novo Mesto Nouveau procédé pour la préparation de la lévocétirizine et de ses intermédiaires
KR100998067B1 (ko) 2008-09-08 2010-12-03 주식회사 삼오제약 비스(1-[(4-클로로페닐)페닐메틸]피페라진)-2,3-디벤조일 타르타르산 신규 중간체 염 및 이를 이용한 광학 활성적으로 순수한 1-[(4-클로로페닐)페닐메틸]피페라진을 분리하는 분리방법
US20110172425A1 (en) 2008-09-17 2011-07-14 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
WO2010107404A1 (fr) 2009-03-16 2010-09-23 Mahmut Bilgic Combinaisons pharmaceutiques stables
TR201007652A2 (tr) 2010-09-20 2012-04-24 Bi̇lgi̇ç Mahmut Sinerjik etki.
TR201009398A2 (tr) 2010-11-11 2012-05-21 Bi̇lgi̇ç Mahmut Fiziksel özellikleri geliştirilmiş tablet formülasyonları
WO2012101475A1 (fr) 2011-01-27 2012-08-02 Jubilant Life Sciences Limited Procédé de préparation amélioré d'antihistaminiques faisant appel à un nouvel intermédiaire carbamate
CN103044355A (zh) * 2011-10-13 2013-04-17 湖南九典制药有限公司 合成左西替利嗪的关键中间体及其制备方法
KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형
CN104045607B (zh) * 2014-05-21 2016-04-13 丽珠医药集团股份有限公司 一种盐酸西替利嗪的纯化方法
CN105924409B (zh) * 2016-05-12 2019-01-08 浙江永宁药业股份有限公司 一种(r)-1-((2-氯苯基)-(苯基)-甲基)-哌嗪的拆分方法
CN111205247B (zh) * 2020-04-22 2020-08-14 湖南九典宏阳制药有限公司 左旋西替利嗪的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO155805C (no) * 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1072661C (zh) * 1996-04-10 2001-10-10 Ucb公司 新的取代[2－(1－哌嗪基)乙氧基]甲基化合物

Also Published As

Publication number Publication date
NO894651L (no) 1990-05-25
DK586789D0 (da) 1989-11-22
KR970009728B1 (ko) 1997-06-17
PT92364A (pt) 1990-05-31
NO172342B (no) 1993-03-29
GB8827391D0 (en) 1988-12-29
SG89492G (en) 1992-12-04
FI895564A0 (fi) 1989-11-22
GB2225321B (en) 1992-04-08
GB2225321A (en) 1990-05-30
ATA266589A (de) 1994-07-15
ES2021907A6 (es) 1991-11-16
PT92364B (pt) 1995-07-18
NO172342C (no) 1993-07-07
FI91862B (fi) 1994-05-13
GR1000553B (el) 1992-08-26
HU896131D0 (en) 1990-02-28
FI91862C (fi) 1994-08-25
PL161379B1 (pl) 1993-06-30
KR900007825A (ko) 1990-06-02
NO894651D0 (no) 1989-11-22
GR890100770A (en) 1990-12-31
DK174543B1 (da) 2003-05-19
HU205094B (en) 1992-03-30
GB8926243D0 (en) 1990-01-10
HUT53627A (en) 1990-11-28
CY1671A (en) 1993-05-14
PH25982A (en) 1992-01-13
DK586789A (da) 1990-05-24
AT398971B (de) 1995-02-27
HK95892A (en) 1992-12-11

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