CA2140229A1 - Derives de la n-cycloalkylpiperazine, methodes pour leur obtention et compositions pharmaceutiques qui en contiennent - Google Patents
Derives de la n-cycloalkylpiperazine, methodes pour leur obtention et compositions pharmaceutiques qui en contiennentInfo
- Publication number
- CA2140229A1 CA2140229A1 CA002140229A CA2140229A CA2140229A1 CA 2140229 A1 CA2140229 A1 CA 2140229A1 CA 002140229 A CA002140229 A CA 002140229A CA 2140229 A CA2140229 A CA 2140229A CA 2140229 A1 CA2140229 A1 CA 2140229A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- derivatives
- pharmaceutically acceptable
- acid addition
- addition salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9208808A FR2693722B1 (fr) | 1992-07-16 | 1992-07-16 | Dérivés de la N-cycloalkylpipérazine, procédé d'obtention et compositions pharmaceutiques les contenant. |
FR9208808 | 1992-07-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2140229A1 true CA2140229A1 (fr) | 1994-02-03 |
Family
ID=9431966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002140229A Abandoned CA2140229A1 (fr) | 1992-07-16 | 1993-07-15 | Derives de la n-cycloalkylpiperazine, methodes pour leur obtention et compositions pharmaceutiques qui en contiennent |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0649419A1 (fr) |
JP (1) | JPH08501285A (fr) |
AU (1) | AU4573793A (fr) |
CA (1) | CA2140229A1 (fr) |
FR (1) | FR2693722B1 (fr) |
WO (1) | WO1994002473A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6281215B1 (en) | 1996-12-18 | 2001-08-28 | Merck Patent Gmbh | 4-(1-piperazinyl) benzoic acid derivatives, process for preparing them and their therapeutic applications |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5395835A (en) * | 1994-03-24 | 1995-03-07 | Warner-Lambert Company | Naphthalamides as central nervous system agents |
US5472966A (en) * | 1995-03-29 | 1995-12-05 | Bristol-Myers Squibb Company | Antidepressant heteroarylaminoalkyl derivatives of naphthyl-monazines |
CA2175395A1 (fr) * | 1995-06-02 | 1996-12-03 | Ronald J. Mattson | Indanylpiperazines ou homopiperazines, agents melatonergiques |
FR2763334A1 (fr) * | 1997-05-13 | 1998-11-20 | Lipha | Derives anthraniliques |
RU2216549C2 (ru) | 1997-11-07 | 2003-11-20 | Дайити Фармасьютикал Ко., Лтд. | Пиперазин-циклодекстриновый комплекс и лекарственное средство, содержащее указанный комплекс |
JP2004520347A (ja) * | 2001-01-15 | 2004-07-08 | グラクソ グループ リミテッド | Ldl−受容体発現のインデューサーとしてのアリールピペリジンおよびピペラジン誘導体 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR6452M (fr) * | 1967-03-10 | 1968-11-12 | ||
ES8308553A1 (es) * | 1982-06-17 | 1983-09-01 | Ferrer Int | "procedimiento de obtencion de nuevos derivados de piperazina". |
US5028610A (en) * | 1987-03-18 | 1991-07-02 | Sankyo Company Limited | N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use |
NZ231631A (en) * | 1988-12-08 | 1992-07-28 | Duphar Int Res | Heterocyclically-substituted piperazine and diazepine derivatives and anxiolytic compositions |
FR2655988B1 (fr) * | 1989-12-20 | 1994-05-20 | Adir Cie | Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2664592B1 (fr) * | 1990-07-10 | 1994-09-02 | Adir | Nouveaux derives de la piperidine, de la tetrahydropyridine et de la pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
-
1992
- 1992-07-16 FR FR9208808A patent/FR2693722B1/fr not_active Expired - Fee Related
-
1993
- 1993-07-15 WO PCT/FR1993/000723 patent/WO1994002473A1/fr not_active Application Discontinuation
- 1993-07-15 EP EP93916003A patent/EP0649419A1/fr not_active Withdrawn
- 1993-07-15 CA CA002140229A patent/CA2140229A1/fr not_active Abandoned
- 1993-07-15 AU AU45737/93A patent/AU4573793A/en not_active Abandoned
- 1993-07-15 JP JP6503935A patent/JPH08501285A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6281215B1 (en) | 1996-12-18 | 2001-08-28 | Merck Patent Gmbh | 4-(1-piperazinyl) benzoic acid derivatives, process for preparing them and their therapeutic applications |
Also Published As
Publication number | Publication date |
---|---|
AU4573793A (en) | 1994-02-14 |
WO1994002473A1 (fr) | 1994-02-03 |
JPH08501285A (ja) | 1996-02-13 |
FR2693722A1 (fr) | 1994-01-21 |
FR2693722B1 (fr) | 1994-10-14 |
EP0649419A1 (fr) | 1995-04-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2436225C (fr) | Derives de n-(arylsulfonyl)beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant | |
AU657799B2 (en) | Novel 4-arylpiperazines and 4-arylpiperidines | |
FI91862C (fi) | 2-/2-/4-/(4-kloorifenyyli)fenyylimetyyli/-1-piperatsinyyli/etoksi/-etikkahapon ja sen dihydrokloridin valmistusmenetelmä | |
US4605655A (en) | Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives | |
CA2015473C (fr) | Derives de triphenylmethane | |
CS381991A3 (en) | Novel n-arylpiperazine alkane amides, process of their preparation and pharmaceuticals based thereon | |
JP2006342190A (ja) | 1−〔(4−クロロフェニル)フェニルメチル〕ピペラジンの鏡像体およびその製造法 | |
JPH0518830B2 (fr) | ||
CA2541066C (fr) | Derives d'indanyl-piperazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
EP1608635B1 (fr) | Derives de phenyl-sulfone et leur utilisation dans le traitement de troubles du systeme nerveux central (snc) | |
US4604392A (en) | 2-substituted benzofuran derivatives useful in treating cardiac arrhythmic, histaminic and tussive conditions | |
HU190827B (en) | Process for preparing 2-/4/-/4,4-dialkyl-1,2,6-piperidindion-1-yl/-butyl/-1-piperazinyl/-pyridines | |
CA1084490A (fr) | Synthese de composes tetracycliques | |
NO311615B1 (no) | Nye substituerte [2-(1-piperazinyl)etoksy]metylforbindelser, fremgangsmåte for fremstilling og anvendelse av slike | |
JP2000086603A (ja) | 桂皮酸アミド誘導体および3―フェニルプロピオン酸アミド誘導体 | |
CA2140229A1 (fr) | Derives de la n-cycloalkylpiperazine, methodes pour leur obtention et compositions pharmaceutiques qui en contiennent | |
NO311515B1 (no) | Tetrahydrobenzindolforbindelser, og farmasöytiske preparater inneholdende slike forbindelser | |
US4882329A (en) | Alkoxyphenylindolinone derivatives, medicaments containing them and their use | |
NO323401B1 (no) | Halogensubstituerte 4-fenyl-piperazinderivater, farmasoytiske sammensetninger inneholdende dem og deres anvendelse. | |
CA2053709C (fr) | Derives de la piperazine | |
US4957927A (en) | (Diarylmethoxy alkyl)-1-pyrrolidines and piperidines having cardiovascular activity | |
US3000892A (en) | 1-aroylalkyl-4-aroylpiperazines | |
US5364849A (en) | 1-[3 or 4-[1-[4-piperazinyl]]-2 arylpropionyl or butryl]-heterocyclic derivatives | |
JP2004537531A (ja) | 新規フェニルアルキルジアミンおよびアミド類似体 | |
CA2000060A1 (fr) | Composes aromatiques substitues ayant un effet sur le systeme nerveux central |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued | ||
FZDE | Discontinued |
Effective date: 20010716 |