CA1304369C - Azoniaspironortropanol esters and processes for the preparation thereof - Google Patents

Azoniaspironortropanol esters and processes for the preparation thereof

Info

Publication number
CA1304369C
CA1304369C CA000526376A CA526376A CA1304369C CA 1304369 C CA1304369 C CA 1304369C CA 000526376 A CA000526376 A CA 000526376A CA 526376 A CA526376 A CA 526376A CA 1304369 C CA1304369 C CA 1304369C
Authority
CA
Canada
Prior art keywords
radical
general formula
chloride
alpha
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000526376A
Other languages
English (en)
French (fr)
Inventor
Wolf Grimminger
Klaus Gorler
Karl Peter Odenthal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Madaus Holding GmbH
Original Assignee
Madaus AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19853546165 external-priority patent/DE3546165A1/de
Priority claimed from DE19853546218 external-priority patent/DE3546218A1/de
Application filed by Madaus AG filed Critical Madaus AG
Application granted granted Critical
Publication of CA1304369C publication Critical patent/CA1304369C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA000526376A 1985-12-27 1986-12-29 Azoniaspironortropanol esters and processes for the preparation thereof Expired - Fee Related CA1304369C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DEP3546165.9-41 1985-12-27
DE19853546165 DE3546165A1 (de) 1985-12-27 1985-12-27 Verwendung von azoniaspironortropanolestern als asthmatherapeutikum und als broncholytikum
DE19853546218 DE3546218A1 (de) 1985-12-27 1985-12-27 Azoniaspironortropanolester, verfahren zu deren herstellung und pharmazeutisches mittel
DEP3546218.3-44 1985-12-27

Publications (1)

Publication Number Publication Date
CA1304369C true CA1304369C (en) 1992-06-30

Family

ID=25839393

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000526376A Expired - Fee Related CA1304369C (en) 1985-12-27 1986-12-29 Azoniaspironortropanol esters and processes for the preparation thereof

Country Status (18)

Country Link
KR (1) KR930000113B1 (cs)
AT (1) AT397962B (cs)
AU (1) AU584266B2 (cs)
BE (1) BE906054A (cs)
CA (1) CA1304369C (cs)
CH (1) CH677793A5 (cs)
ES (1) ES2004177A6 (cs)
FI (1) FI865295A7 (cs)
FR (1) FR2598417B1 (cs)
GB (1) GB2184726B (cs)
HU (1) HU201930B (cs)
IT (1) IT1198263B (cs)
NL (1) NL193184C (cs)
PL (1) PL150843B1 (cs)
PT (1) PT84022B (cs)
SE (1) SE8605531L (cs)
SU (1) SU1711674A3 (cs)
YU (1) YU46038B (cs)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA49801C2 (uk) * 1994-04-19 2002-10-15 Нейросерч А/С Похідні тропан-2-альдоксиму, спосіб їх отримання, фармацевтична композиція, спосіб лікування
AU2004289221B2 (en) * 2003-11-04 2009-12-17 Supernus Pharmaceuticals, Inc Sustained release of positively charged pharmacologically active molecules from a matrix containing polymers with polarized oxygen atoms
US8709476B2 (en) * 2003-11-04 2014-04-29 Supernus Pharmaceuticals, Inc. Compositions of quaternary ammonium compounds containing bioavailability enhancers
CN101684117B (zh) * 2008-09-27 2013-06-12 宁波市医药技术研究有限公司 去甲托品醇的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1194422B (de) * 1963-03-05 1965-06-10 Robert Pfleger Chem Fab Dr Verfahren zur Herstellung von Azoniaspironortropanderivaten
US3480626A (en) * 1967-05-18 1969-11-25 Chem Fab Dr R Pfleger Certain azoniaspironortropine derivatives
DE1670257A1 (de) * 1967-08-04 1972-03-02 Boehringer Sohn Ingelheim Cyclische Aminoverbindungen und Verfahren zu ihrer Herstellung
IT1140998B (it) * 1980-06-18 1986-10-10 Valeas Ind Chimica E Farmaceut Sali di endo-8-metil-8-sin-alchil-8-azoniabiciclo aperta par. quadrata 3.2.1. chiusa par. quadrata-ottan-3-alchilcarbossilati, processo per la loro preparazione e composizioni terapeutiche che li contengono come principio attivo

Also Published As

Publication number Publication date
AT397962B (de) 1994-08-25
PL150843B1 (en) 1990-07-31
IT1198263B (it) 1988-12-21
FI865295L (fi) 1987-06-28
CH677793A5 (cs) 1991-06-28
KR930000113B1 (ko) 1993-01-09
PT84022A (en) 1987-01-01
SU1711674A3 (ru) 1992-02-07
AU6698586A (en) 1987-07-02
GB2184726A (en) 1987-07-01
ES2004177A6 (es) 1988-12-16
IT8622877A0 (it) 1986-12-24
GB8630809D0 (en) 1987-02-04
ATA339286A (de) 1993-12-15
NL193184B (nl) 1998-10-01
SE8605531D0 (sv) 1986-12-22
IT8622877A1 (it) 1988-06-24
NL193184C (nl) 1999-02-02
PT84022B (pt) 1989-07-31
AU584266B2 (en) 1989-05-18
YU46038B (sh) 1992-12-21
HU201930B (en) 1991-01-28
GB2184726B (en) 1990-10-03
BE906054A (fr) 1987-06-29
NL8603303A (nl) 1987-07-16
FI865295A0 (fi) 1986-12-23
FI865295A7 (fi) 1987-06-28
FR2598417A1 (fr) 1987-11-13
PL263216A1 (en) 1988-04-14
YU224986A (en) 1988-04-30
FR2598417B1 (fr) 1993-10-29
HUT43060A (en) 1987-09-28
KR870005998A (ko) 1987-07-08
SE8605531L (sv) 1987-06-28

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