CA1303978C - Injectable opacifying composition containing liposomes of high encapsulation capacity for x-ray examinations - Google Patents

Injectable opacifying composition containing liposomes of high encapsulation capacity for x-ray examinations

Info

Publication number
CA1303978C
CA1303978C CA000567314A CA567314A CA1303978C CA 1303978 C CA1303978 C CA 1303978C CA 000567314 A CA000567314 A CA 000567314A CA 567314 A CA567314 A CA 567314A CA 1303978 C CA1303978 C CA 1303978C
Authority
CA
Canada
Prior art keywords
vesicles
liposomes
iodine
encapsulated
suspension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000567314A
Other languages
English (en)
French (fr)
Inventor
Bernard Lamy
Herve Tournier
Michel Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco SpA
Original Assignee
Bracco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4223355&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA1303978(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco SpA filed Critical Bracco SpA
Application granted granted Critical
Publication of CA1303978C publication Critical patent/CA1303978C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA000567314A 1987-05-22 1988-05-20 Injectable opacifying composition containing liposomes of high encapsulation capacity for x-ray examinations Expired - Fee Related CA1303978C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1991/87-3 1987-05-22
CH1991/87A CH672733A5 (enExample) 1987-05-22 1987-05-22

Publications (1)

Publication Number Publication Date
CA1303978C true CA1303978C (en) 1992-06-23

Family

ID=4223355

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000567314A Expired - Fee Related CA1303978C (en) 1987-05-22 1988-05-20 Injectable opacifying composition containing liposomes of high encapsulation capacity for x-ray examinations

Country Status (13)

Country Link
US (3) US5312615A (enExample)
EP (1) EP0314764B2 (enExample)
JP (1) JP2619037B2 (enExample)
AT (1) ATE80294T1 (enExample)
AU (1) AU612371B2 (enExample)
CA (1) CA1303978C (enExample)
CH (1) CH672733A5 (enExample)
DE (1) DE3874485T3 (enExample)
ES (1) ES2009917A6 (enExample)
IL (1) IL86409A (enExample)
MX (1) MX9203271A (enExample)
WO (1) WO1988009165A1 (enExample)
ZA (1) ZA883449B (enExample)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH672733A5 (enExample) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa
MX9203504A (es) * 1988-04-20 1992-07-01 Liposome Co Inc Complejo agente: lipido activo de alta proporcion.
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5820848A (en) * 1990-01-12 1998-10-13 The Liposome Company, Inc. Methods of preparing interdigitation-fusion liposomes and gels which encapsulate a bioactive agent
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6613306B1 (en) * 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IN172208B (enExample) * 1990-04-02 1993-05-01 Sint Sa
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IS1685B (is) * 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
US5447635A (en) * 1991-02-26 1995-09-05 Bracco International B.V. Process of concentration and purification of organic compounds
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
SE470086B (sv) * 1991-04-23 1993-11-08 Kabi Pharmacia Ab Organspecifik emulsion
SE9101709L (sv) * 1991-06-03 1992-12-04 Karlshamns Lipidteknik Ab Lipidderivat som diagnostikum eller kontrastmedel
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
CA2146963A1 (en) * 1992-10-16 1994-04-28 Andreas Sachse Process and device for producing liquid, dispersed systems
CA2160118A1 (en) * 1993-05-21 1994-12-08 Patrick L. Ahl Reduction of liposome-induced adverse physiological reactions
US6217849B1 (en) 1993-09-29 2001-04-17 Bracco Research S.A. Liposome suspensions as blood pool imaging contrast agents
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
PL182223B1 (pl) * 1993-12-15 2001-11-30 Bracco Research Sa Biokompatybilna faza rozproszona do otrzymywania srodka kontrastowego do badan ultradzwiekowych, srodek kontrastowy do badan ultradzwiekowych, suchy preparat srodka kontrastowego oraz dwuskladnikowy zestaw do otrzymywania srodka kontrastowego do badan ultradzwiekowych PL PL PL
CN1148812A (zh) * 1994-03-28 1997-04-30 尼科梅德成像有限公司 “脂质体”
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
AU4546996A (en) * 1995-02-24 1996-09-11 Bracco Research S.A. Liposome suspensions as blood pool imaging contrast agents
DE19518221A1 (de) * 1995-05-10 1996-11-14 Schering Ag Verwendung nichtsteroidaler Entzündungshemmer zur Verbesserung der physiologischen Verträglichkeit partikulärer pharmazeutischer Zubereitungen
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
AU736301B2 (en) 1996-05-01 2001-07-26 Imarx Therapeutics, Inc. Methods for delivering compounds into a cell
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
JP4109780B2 (ja) 1998-03-06 2008-07-02 株式会社東海理化電機製作所 ギヤ機構及びウエビング巻取装置
CA2326348C (en) * 1998-03-31 2009-10-06 Yissum Research Development Company Of The Hebrew University In Jerusalem Liposomal bupivacaine compositions and methods of preparation
US6706280B2 (en) * 1998-08-19 2004-03-16 Bracco Research S.A. Carboxylated phosphatidic acid esters
JP3980777B2 (ja) 1998-11-02 2007-09-26 株式会社東海理化電機製作所 ウエビング巻取装置
US6426145B1 (en) 1999-05-20 2002-07-30 Scimed Life Systems, Inc. Radiopaque compositions for visualization of medical devices
ES2274372T3 (es) 1999-05-27 2007-05-16 Euro-Celtique S.A. Uso de antisepticos en la fabricacion de un preparado farmaceutico para la prevencion o el tratamiento de inflamaciones en el interior del cuerpo humano.
US7297344B1 (en) 1999-05-27 2007-11-20 Euro-Celtique, S.A. Preparations for the promotion of wound healing in the upper respiratory tract and/or ear
US7300667B1 (en) 1999-05-27 2007-11-27 Euro-Celtique, S.A. Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract
JP5078212B2 (ja) 2000-06-02 2012-11-21 ブラッコ・スイス・ソシエテ・アノニム 内皮細胞を標的とするための化合物、それを含む組成物およびその使用方法
JP2005170928A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP2005170923A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP4654590B2 (ja) * 2004-03-31 2011-03-23 コニカミノルタエムジー株式会社 Ｘ線ｃｔ用造影組成物およびその製造方法
US8357351B2 (en) 2004-04-21 2013-01-22 Ananth Annapragada Nano-scale contrast agents and methods of use
US7713517B2 (en) * 2004-04-21 2010-05-11 Marval Biosciences, Inc. Compositions and methods for enhancing contrast in imaging
WO2006009022A1 (ja) * 2004-07-21 2006-01-26 Konica Minolta Medical & Graphic, Inc. リポソーム含有ｘ線造影剤およびその製造方法
JP5176320B2 (ja) * 2004-08-11 2013-04-03 コニカミノルタエムジー株式会社 リポソーム含有製剤の製造方法
WO2006047409A2 (en) * 2004-10-22 2006-05-04 Dynamis Therapeutics, Inc. Dermal delivery of n-methyl-glucamine and n-methyl-glucamine compounds
WO2007129311A2 (en) * 2006-05-04 2007-11-15 Pan Sci Tech S.A. Nano-particles with contrast agents for diagnostic delivery system for x-ray and ct
CA2708028A1 (en) * 2007-12-05 2009-06-11 Marval Biosciences, Inc. Nano-scale contrast agents and methods of use
WO2009152445A1 (en) * 2008-06-13 2009-12-17 Marval Biosciences, Inc. Imaging of atherosclerotic plaques using liposomal imaging agents
JP2012520898A (ja) * 2009-03-19 2012-09-10 マーヴァル バイオサイエンシーズ，インコーポレイテッド 画像化におけるコントラスト強調のための組成物および方法
US10894098B2 (en) 2012-04-09 2021-01-19 Signablok, Inc. Methods and compositions for targeted imaging
IT1404011B1 (it) 2010-12-03 2013-11-08 Uni Degli Studi Magna Graecia Di Catanzaro Nanovettore coniugato con tsh per il trattamento del cancro della tiroide
FR3017295B1 (fr) * 2014-02-07 2018-01-12 Guerbet Composition destinee a vectoriser un agent anticancereux
IL296875A (en) 2014-12-31 2022-12-01 Lantheus Medical Imaging Inc Fat-wrapped gas microsphere preparations and related methods
FR3039767B1 (fr) 2015-08-04 2017-09-08 Guerbet Sa Composition destinee a vectoriser un agent anticancereux
CA3022698A1 (en) 2016-05-04 2017-11-09 Lantheus Medical Imaging, Inc. Methods and devices for preparation of ultrasound contrast agents
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957971A (en) * 1974-07-29 1976-05-18 Lever Brothers Company Moisturizing units and moisturizing compositions containing the same
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4529561A (en) * 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers
CH641682A5 (en) * 1978-10-05 1984-03-15 Daeniker Felix X-ray contrast medium
US4241046A (en) * 1978-11-30 1980-12-23 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4519024A (en) * 1983-09-02 1985-05-21 At&T Bell Laboratories Two-terminal transistor rectifier circuit arrangement
US4599227A (en) * 1983-11-07 1986-07-08 Wisconsin Alumni Research Foundation Injectable pharmaceutical preparation for the induction of multiple follicular growth
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
US4567034A (en) * 1984-09-07 1986-01-28 E. R. Squibb & Sons, Inc. Esters of diatrizoic acid as X-ray contrast agents
CH672733A5 (enExample) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa

Also Published As

Publication number Publication date
JP2619037B2 (ja) 1997-06-11
US5445810A (en) 1995-08-29
DE3874485T2 (de) 1993-03-11
MX9203271A (es) 1992-07-01
DE3874485T3 (de) 2000-09-14
WO1988009165A1 (en) 1988-12-01
IL86409A (en) 1991-12-12
DE3874485D1 (de) 1992-10-15
US5626832A (en) 1997-05-06
IL86409A0 (en) 1988-11-15
EP0314764A1 (en) 1989-05-10
ES2009917A6 (es) 1989-10-16
JPH02500192A (ja) 1990-01-25
CH672733A5 (enExample) 1989-12-29
EP0314764B2 (en) 2000-02-02
US5312615A (en) 1994-05-17
ATE80294T1 (de) 1992-09-15
AU1805488A (en) 1988-12-21
AU612371B2 (en) 1991-07-11
EP0314764B1 (en) 1992-09-09
ZA883449B (en) 1988-11-16

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