CA1210405A - Analogs of mevalolactone and derivatives thereof - Google Patents

Analogs of mevalolactone and derivatives thereof

Info

Publication number
CA1210405A
CA1210405A CA000441684A CA441684A CA1210405A CA 1210405 A CA1210405 A CA 1210405A CA 000441684 A CA000441684 A CA 000441684A CA 441684 A CA441684 A CA 441684A CA 1210405 A CA1210405 A CA 1210405A
Authority
CA
Canada
Prior art keywords
hydrogen
3alkyl
fluoro
chloro
benzyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000441684A
Other languages
English (en)
French (fr)
Inventor
Faizulla G. Kathawala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of CA1210405A publication Critical patent/CA1210405A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA000441684A 1982-11-22 1983-11-22 Analogs of mevalolactone and derivatives thereof Expired CA1210405A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US44366882A 1982-11-22 1982-11-22
US443,668 1982-11-22
US54885083A 1983-11-04 1983-11-04
US548,850 1983-11-04

Publications (1)

Publication Number Publication Date
CA1210405A true CA1210405A (en) 1986-08-26

Family

ID=27033614

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000441684A Expired CA1210405A (en) 1982-11-22 1983-11-22 Analogs of mevalolactone and derivatives thereof

Country Status (18)

Country Link
EP (1) EP0114027B1 (cg-RX-API-DMAC10.html)
JP (1) JPH0347167A (cg-RX-API-DMAC10.html)
AT (1) ATE31718T1 (cg-RX-API-DMAC10.html)
AU (1) AU570021B2 (cg-RX-API-DMAC10.html)
CA (1) CA1210405A (cg-RX-API-DMAC10.html)
CY (1) CY1579A (cg-RX-API-DMAC10.html)
DE (2) DE3375137D1 (cg-RX-API-DMAC10.html)
DK (2) DK359284D0 (cg-RX-API-DMAC10.html)
FI (1) FI77228C (cg-RX-API-DMAC10.html)
GR (1) GR79042B (cg-RX-API-DMAC10.html)
HK (1) HK11191A (cg-RX-API-DMAC10.html)
HU (1) HU204253B (cg-RX-API-DMAC10.html)
IE (1) IE56262B1 (cg-RX-API-DMAC10.html)
IL (1) IL70286A (cg-RX-API-DMAC10.html)
LU (1) LU88670I2 (cg-RX-API-DMAC10.html)
NL (1) NL950022I2 (cg-RX-API-DMAC10.html)
NZ (1) NZ206338A (cg-RX-API-DMAC10.html)
WO (1) WO1984002131A1 (cg-RX-API-DMAC10.html)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
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US5091378A (en) * 1987-05-22 1992-02-25 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method
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CA1336714C (en) * 1987-08-20 1995-08-15 Yoshihiro Fujikawa Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis
US5185328A (en) * 1987-08-20 1993-02-09 Nissan Chemical Industries Ltd. Quinoline type mevalonolactones useful for treating hyperlipidemia, hyperlipoproteinemia or atherosclerosis
DE3739882A1 (de) * 1987-11-25 1989-06-08 Bayer Ag Substituierte hydroxylamine
US4868185A (en) * 1987-12-10 1989-09-19 Warner-Lambert Company 6-[[Substituted)pyrimidinyl)ethyl]- and ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
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Also Published As

Publication number Publication date
CY1579A (en) 1991-12-20
AU570021B2 (en) 1988-03-03
DE3375137D1 (en) 1988-02-11
FI77228B (fi) 1988-10-31
HUT35642A (en) 1985-07-29
IE832713L (en) 1984-05-22
DE19475017I2 (de) 2003-02-20
EP0114027A1 (en) 1984-07-25
DK359284A (da) 1984-07-20
EP0114027B1 (en) 1988-01-07
JPH0347167A (ja) 1991-02-28
WO1984002131A1 (fr) 1984-06-07
NZ206338A (en) 1987-08-31
DK165244B (da) 1992-10-26
NL950022I2 (nl) 1996-12-02
HU204253B (en) 1991-12-30
GR79042B (cg-RX-API-DMAC10.html) 1984-10-02
DK97890D0 (da) 1990-04-19
IL70286A (en) 1987-08-31
AU2261283A (en) 1984-06-18
FI77228C (fi) 1989-02-10
FI842615A7 (fi) 1984-06-28
LU88670I2 (fr) 1996-04-29
FI842615A0 (fi) 1984-06-28
JPH0440343B2 (cg-RX-API-DMAC10.html) 1992-07-02
NL950022I1 (cg-RX-API-DMAC10.html) 1996-01-02
IL70286A0 (en) 1984-02-29
DK359284D0 (da) 1984-07-20
IE56262B1 (en) 1991-06-05
DK97890A (da) 1990-04-19
ATE31718T1 (de) 1988-01-15
DK165244C (da) 1993-03-22
HK11191A (en) 1991-02-13

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