CA1182444A - Method of accelerating the dissolution of a hard- soluble lyophilized medicament using a magnetic stirrer - Google Patents
Method of accelerating the dissolution of a hard- soluble lyophilized medicament using a magnetic stirrerInfo
- Publication number
- CA1182444A CA1182444A CA000383132A CA383132A CA1182444A CA 1182444 A CA1182444 A CA 1182444A CA 000383132 A CA000383132 A CA 000383132A CA 383132 A CA383132 A CA 383132A CA 1182444 A CA1182444 A CA 1182444A
- Authority
- CA
- Canada
- Prior art keywords
- container
- lyophilized
- magnetic body
- magnetic
- dissolution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims abstract description 14
- 238000004090 dissolution Methods 0.000 title claims abstract description 11
- 239000002904 solvent Substances 0.000 claims abstract description 3
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 5
- 102000003839 Human Proteins Human genes 0.000 claims description 4
- 108090000144 Human Proteins Proteins 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 108010071289 Factor XIII Proteins 0.000 claims description 2
- 108010049003 Fibrinogen Proteins 0.000 claims description 2
- 102000008946 Fibrinogen Human genes 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- 229940012444 factor xiii Drugs 0.000 claims description 2
- 229940012952 fibrinogen Drugs 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 230000004308 accommodation Effects 0.000 abstract description 10
- 108090000623 proteins and genes Proteins 0.000 abstract description 7
- 102000004169 proteins and genes Human genes 0.000 abstract description 7
- 238000004108 freeze drying Methods 0.000 abstract 1
- 239000000696 magnetic material Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 8
- 239000006260 foam Substances 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000012738 dissolution medium Substances 0.000 description 2
- 229940090044 injection Drugs 0.000 description 2
- 229940070376 protein Drugs 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000002226 simultaneous effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F21/00—Dissolving
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
- B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/90—Heating or cooling systems
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ATA4289/80 | 1980-08-25 | ||
| AT0428980A AT371719B (de) | 1980-08-25 | 1980-08-25 | Verfahren und vorrichtung zur beschleunigung des aufloesens von schwerloeslichen lyophilisierten arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1182444A true CA1182444A (en) | 1985-02-12 |
Family
ID=3562079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000383132A Expired CA1182444A (en) | 1980-08-25 | 1981-08-04 | Method of accelerating the dissolution of a hard- soluble lyophilized medicament using a magnetic stirrer |
Country Status (14)
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4735616A (en) * | 1985-06-20 | 1988-04-05 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Arrangement for applying a tissue adhesive |
| US4909251A (en) * | 1988-05-31 | 1990-03-20 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Tissue adhesive |
| WO2008117746A1 (ja) | 2007-03-22 | 2008-10-02 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | 固体状フィブリノゲン製剤 |
| US10618950B2 (en) | 2011-12-29 | 2020-04-14 | Omrix Biopharmaceuticals Ltd. | Method and device for fast dissolution of solid protein composition |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3308892A1 (de) * | 1983-03-12 | 1984-09-13 | Vereinigte Aluminium-Werke AG, 1000 Berlin und 5300 Bonn | Heizbarer magnetruehrer fuer hochtemperaturaufschluesse |
| DE3439654C2 (de) * | 1984-10-30 | 1987-02-26 | Brauerei Beck GmbH & Co, 2800 Bremen | Vorrichtung zum gleichmäßigen Verteilen von Hefeteilchen in hefehaltigem Bier |
| DE4017868A1 (de) * | 1990-06-02 | 1990-10-31 | Siegfried Dipl Phys Stiller | Mischkammer zur verduennung und haemolyse von blut |
| JPH06312009A (ja) * | 1993-04-28 | 1994-11-08 | Daiichi Rajio Isotope Kenkyusho:Kk | 放射性医薬品加熱装置 |
| DE4406217C2 (de) * | 1994-02-25 | 1997-04-17 | Janke & Kunkel Kg | Magnetrührer mit einem Gehäuse |
| US5529391A (en) * | 1994-09-22 | 1996-06-25 | Duke University | Magnetic stirring and heating/cooling apparatus |
| US5549382A (en) * | 1995-04-27 | 1996-08-27 | Correia, Ii; Bernard A. | Stirrer for food preparation |
| DE19617369A1 (de) * | 1996-04-30 | 1997-11-06 | Immuno Ag | Lagerstabile Fibrinogen-Präparate |
| US5899567A (en) * | 1997-09-23 | 1999-05-04 | Morris, Jr.; Joseph E. | Magnetic synchronized stirring and heating test apparatus |
| US6382827B1 (en) * | 2000-11-01 | 2002-05-07 | Dade Behring Inc. | Method and apparatus for mixing liquid solutions using a rotating magnet to generate a stirring vortex action |
| US6467946B1 (en) * | 2001-04-24 | 2002-10-22 | Dade Microscan Inc. | Method and apparatus for mixing liquid samples in a container using rotating magnetic fields |
| JP2005502861A (ja) | 2001-08-10 | 2005-01-27 | サイミックス テクノロジーズ， インコーポレイテッド | 事前処方物を作製および試験するための装置および方法ならびにそのためのシステム |
| TWI590817B (zh) * | 2015-10-14 | 2017-07-11 | 鈺邦科技股份有限公司 | 含浸設備及含浸方法 |
| CN113576756A (zh) * | 2021-07-15 | 2021-11-02 | 伊索曼(中山)医疗器械有限公司 | 提升冻干敷料结构均匀性的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE498056A (enrdf_load_stackoverflow) * | 1949-03-25 | |||
| FR1200467A (fr) * | 1958-06-25 | 1959-12-22 | Rech S Et De Controle Du Caout | Dispositif d'agitation et de régulation thermique, applicable notamment dans les laboratoires |
| GB921719A (en) * | 1960-05-06 | 1963-03-20 | Nat Res Dev | Improvement in magnetic stirrers |
| US3356346A (en) * | 1966-01-03 | 1967-12-05 | Landsberger Kurt | Test tube stirring support |
| CA1072538A (en) * | 1975-07-03 | 1980-02-26 | Leonard E. Brown | Bottom supported magnetic stirring element |
| US3997272A (en) * | 1975-12-15 | 1976-12-14 | Varian Associates | Magnetic stirrer improvement |
| SE397637B (sv) * | 1976-03-09 | 1977-11-14 | Wik G | Magnetomrorare |
-
1980
- 1980-08-25 AT AT0428980A patent/AT371719B/de not_active IP Right Cessation
-
1981
- 1981-07-24 SE SE8104544A patent/SE8104544L/xx unknown
- 1981-07-29 DE DE3129995A patent/DE3129995C2/de not_active Expired
- 1981-08-04 CA CA000383132A patent/CA1182444A/en not_active Expired
- 1981-08-05 NL NLAANVRAGE8103695,A patent/NL189799C/xx not_active IP Right Cessation
- 1981-08-07 DK DK351481A patent/DK157331C/da not_active IP Right Cessation
- 1981-08-12 GB GB8124601A patent/GB2082929B/en not_active Expired
- 1981-08-18 BE BE0/205701A patent/BE890002A/fr not_active IP Right Cessation
- 1981-08-20 FR FR8116002A patent/FR2488802A1/fr active Granted
- 1981-08-20 ES ES504858A patent/ES504858A0/es active Granted
- 1981-08-24 IT IT23609/81A patent/IT1137641B/it active
- 1981-08-24 AR AR286518A patent/AR224086A1/es active
- 1981-08-24 CH CH5442/81A patent/CH659394A5/de not_active IP Right Cessation
- 1981-08-24 JP JP56133224A patent/JPS5789863A/ja active Granted
-
1991
- 1991-11-14 SE SE9103372A patent/SE510742C2/sv not_active IP Right Cessation
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4735616A (en) * | 1985-06-20 | 1988-04-05 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Arrangement for applying a tissue adhesive |
| US4909251A (en) * | 1988-05-31 | 1990-03-20 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Tissue adhesive |
| WO2008117746A1 (ja) | 2007-03-22 | 2008-10-02 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | 固体状フィブリノゲン製剤 |
| US9775884B2 (en) | 2007-03-22 | 2017-10-03 | The Chemo-Sero-Therapeutic Research Institute | Solid fibrinogen preparation |
| US10618950B2 (en) | 2011-12-29 | 2020-04-14 | Omrix Biopharmaceuticals Ltd. | Method and device for fast dissolution of solid protein composition |
| US11634473B2 (en) | 2011-12-29 | 2023-04-25 | Omrix Biopharmaceuticals Ltd. | Method and device for fast dissolution of solid protein composition |
Also Published As
| Publication number | Publication date |
|---|---|
| NL8103695A (nl) | 1982-03-16 |
| NL189799B (nl) | 1993-03-01 |
| IT1137641B (it) | 1986-09-10 |
| FR2488802B1 (enrdf_load_stackoverflow) | 1985-01-04 |
| AT371719B (de) | 1983-07-25 |
| NL189799C (nl) | 1993-08-02 |
| IT8123609A0 (it) | 1981-08-24 |
| GB2082929A (en) | 1982-03-17 |
| ATA428980A (de) | 1982-12-15 |
| AR224086A1 (es) | 1981-10-15 |
| DK157331C (da) | 1990-05-14 |
| BE890002A (fr) | 1981-12-16 |
| FR2488802A1 (fr) | 1982-02-26 |
| SE510742C2 (sv) | 1999-06-21 |
| DK351481A (da) | 1982-02-26 |
| DE3129995A1 (de) | 1982-05-27 |
| SE8104544L (sv) | 1982-02-26 |
| ES8303111A1 (es) | 1983-02-01 |
| GB2082929B (en) | 1985-02-27 |
| SE9103372D0 (sv) | 1991-11-14 |
| CH659394A5 (de) | 1987-01-30 |
| JPS5789863A (en) | 1982-06-04 |
| DE3129995C2 (de) | 1987-01-15 |
| ES504858A0 (es) | 1983-02-01 |
| DK157331B (da) | 1989-12-18 |
| SE9103372L (sv) | 1991-11-14 |
| JPS6353823B2 (enrdf_load_stackoverflow) | 1988-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |