CA1125761A - Process for the manufacture of novel oxothia compounds - Google Patents

Process for the manufacture of novel oxothia compounds

Info

Publication number
CA1125761A
CA1125761A CA330,705A CA330705A CA1125761A CA 1125761 A CA1125761 A CA 1125761A CA 330705 A CA330705 A CA 330705A CA 1125761 A CA1125761 A CA 1125761A
Authority
CA
Canada
Prior art keywords
formula
compound
salt
oxo
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA330,705A
Other languages
English (en)
French (fr)
Inventor
Raymond Bernasconi
Jacques Gosteli
Richard Goschke
Pier G. Ferrini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy Investments Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Investments Ltd filed Critical Ciba Geigy Investments Ltd
Application granted granted Critical
Publication of CA1125761A publication Critical patent/CA1125761A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA330,705A 1978-06-29 1979-06-27 Process for the manufacture of novel oxothia compounds Expired CA1125761A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH7103/78-5 1978-06-29
CH710378A CH634840A5 (de) 1978-06-29 1978-06-29 2-oxo-2,3-dihydro-benzo(b)thiophen-verbindung und daraus hergestellte pharmazeutische praeparate.

Publications (1)

Publication Number Publication Date
CA1125761A true CA1125761A (en) 1982-06-15

Family

ID=4320005

Family Applications (1)

Application Number Title Priority Date Filing Date
CA330,705A Expired CA1125761A (en) 1978-06-29 1979-06-27 Process for the manufacture of novel oxothia compounds

Country Status (26)

Country Link
JP (1) JPS559075A (xx)
AR (1) AR231540A1 (xx)
AT (3) AT373597B (xx)
AU (1) AU531535B2 (xx)
BE (1) BE877339R (xx)
CA (1) CA1125761A (xx)
CH (1) CH634840A5 (xx)
CY (1) CY1288A (xx)
DD (1) DD144544A6 (xx)
DE (1) DE2924496A1 (xx)
DK (1) DK152047C (xx)
ES (1) ES481936A2 (xx)
FI (1) FI792011A (xx)
FR (1) FR2429792A2 (xx)
GB (1) GB2024220B (xx)
GR (1) GR82335B (xx)
HK (1) HK42585A (xx)
HU (1) HU181663B (xx)
IE (1) IE48767B1 (xx)
MY (1) MY8500212A (xx)
NL (1) NL7905084A (xx)
NO (1) NO151323C (xx)
PL (3) PL216377A3 (xx)
SE (1) SE445737B (xx)
SG (1) SG15985G (xx)
ZA (1) ZA793230B (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4800211A (en) * 1986-08-18 1989-01-24 Merck & Co., Inc. 5-methylthio-3-hydroxybenzo [b]thiophene-2-carboxamide derivatives as cyclooxygenase and lipoxygenase inhibitors
US6713505B2 (en) 2000-06-28 2004-03-30 Eli Lilly And Company spla2 inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2713584C2 (de) * 1976-04-09 1986-09-04 Ciba-Geigy Ag, Basel Benzo[b]thiophencarboxamide, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
JPS6218556A (ja) * 1985-07-18 1987-01-27 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料

Also Published As

Publication number Publication date
AT373598B (de) 1984-02-10
DE2924496A1 (de) 1980-01-17
AT374199B (de) 1984-03-26
HK42585A (en) 1985-06-07
NL7905084A (nl) 1980-01-03
PL216376A3 (xx) 1980-03-24
NO792178L (no) 1980-01-03
ATA451579A (de) 1983-08-15
IE48767B1 (en) 1985-05-15
DD144544A6 (de) 1980-10-22
AU4850979A (en) 1980-02-07
SE7905631L (sv) 1979-12-30
ATA451779A (de) 1983-06-15
NO151323C (no) 1985-03-20
BE877339R (fr) 1979-12-28
AT373597B (de) 1984-02-10
DK152047B (da) 1988-01-25
GB2024220B (en) 1982-12-01
ZA793230B (en) 1980-06-25
DE2924496C2 (xx) 1989-12-21
ATA451679A (de) 1983-06-15
GR82335B (xx) 1984-12-13
GB2024220A (en) 1980-01-09
FR2429792B2 (xx) 1983-02-04
AU531535B2 (en) 1983-08-25
DK152047C (da) 1988-08-08
SG15985G (en) 1985-08-16
CY1288A (en) 1985-07-05
MY8500212A (en) 1985-12-31
SE445737B (sv) 1986-07-14
PL216378A3 (xx) 1980-03-24
FI792011A (fi) 1979-12-30
JPS559075A (en) 1980-01-22
JPH0215549B2 (xx) 1990-04-12
ES481936A2 (es) 1980-06-16
PL216377A3 (xx) 1980-03-24
IE791205L (en) 1979-12-29
NO151323B (no) 1984-12-10
FR2429792A2 (fr) 1980-01-25
DK274279A (da) 1979-12-30
HU181663B (en) 1983-10-28
CH634840A5 (de) 1983-02-28
AR231540A1 (es) 1984-12-28

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Legal Events

Date Code Title Description
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