CA1115266A - PROCEDE DE PREPARATION DE NOUVEAUX DERIVES STEROIDES 4,9-DIENIQUES 11.beta.-SUBSTITUES - Google Patents
PROCEDE DE PREPARATION DE NOUVEAUX DERIVES STEROIDES 4,9-DIENIQUES 11.beta.-SUBSTITUESInfo
- Publication number
- CA1115266A CA1115266A CA294,879A CA294879A CA1115266A CA 1115266 A CA1115266 A CA 1115266A CA 294879 A CA294879 A CA 294879A CA 1115266 A CA1115266 A CA 1115266A
- Authority
- CA
- Canada
- Prior art keywords
- beta
- alpha
- hydroxy
- diene
- estra
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0085—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7700858A FR2377418A1 (fr) | 1977-01-13 | 1977-01-13 | Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments |
FR7700858 | 1977-01-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1115266A true CA1115266A (fr) | 1981-12-29 |
Family
ID=9185437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA294,879A Expired CA1115266A (fr) | 1977-01-13 | 1978-01-12 | PROCEDE DE PREPARATION DE NOUVEAUX DERIVES STEROIDES 4,9-DIENIQUES 11.beta.-SUBSTITUES |
Country Status (14)
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2801452C2 (de) * | 1978-01-13 | 1985-03-28 | Agfa-Gevaert Ag, 5090 Leverkusen | Magnetisches Aufzeichnungsmaterial |
FR2495621A1 (fr) * | 1980-12-05 | 1982-06-11 | Roussel Uclaf | Nouveaux derives de l'estra 4,9-diene, leur procede de preparation et leur application comme medicaments |
FR2625505B2 (fr) * | 1981-01-09 | 1991-05-10 | Roussel Uclaf | Nouveaux derives steroides substitues en 11beta leur procede de preparation et leur application comme medicaments et les compositions pharmaceutiques les renfermant |
ZA8231B (en) * | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
FR2528434B1 (fr) | 1982-06-11 | 1985-07-19 | Roussel Uclaf | Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament |
US5182381A (en) * | 1982-03-01 | 1993-01-26 | Roussel Ulcaf | Intermediates for 3-keto-19-nor-Δ4,9 -steroids |
FR2522328B1 (fr) * | 1982-03-01 | 1986-02-14 | Roussel Uclaf | Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments |
FR2639045B2 (fr) * | 1982-03-01 | 1994-07-29 | Roussel Uclaf | Nouveaux produits derives de la structure 3-ceto-delta-4,9-19-nor steroides et leur application comme medicaments |
FR2640977A2 (en) * | 1982-06-11 | 1990-06-29 | Roussel Uclaf | New position-11 substituted 19-norsteroids and their application as medicinal products. |
DE3231827A1 (de) * | 1982-08-24 | 1984-03-01 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11ss-aryl-17(alpha)-alkinyl-17ss-hydroxy-4,9(10)- estradien-3-on-derivate, deren herstellung und diese enthaltende pharmazeutische praeparate |
DE3461090D1 (en) * | 1983-02-18 | 1986-12-04 | Schering Ag | 11-beta-aryl-estradienes, process for their preparation and pharmaceutical compositions containing them |
US4780461A (en) * | 1983-06-15 | 1988-10-25 | Schering Aktiengesellschaft | 13α-alkyl-gonanes, their production, and pharmaceutical preparations containing same |
ES533260A0 (es) * | 1983-06-15 | 1985-02-01 | Schering Ag | Procedimiento para la preparacion de 13a-alquilgonanos |
AU572589B2 (en) | 1983-12-14 | 1988-05-12 | Upjohn Company, The | 11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids |
DE3347126A1 (de) * | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
DE3410880A1 (de) | 1984-03-21 | 1985-10-03 | Schering AG, Berlin und Bergkamen, 1000 Berlin | 17-substituierte estradiene und estratriene |
FR2566779B2 (fr) * | 1984-06-29 | 1987-03-06 | Roussel Uclaf | Nouveaux derives steroides substitues en 11b, leur procede de preparation et leur application comme medicaments |
DE3438500C1 (de) * | 1984-10-18 | 1986-05-28 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verfahren zur Herstellung 11ß-substituierter Δ↑9↑-19-Norsteroide |
DE3504421A1 (de) * | 1985-02-07 | 1986-08-07 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate |
AU580843B2 (en) * | 1985-02-07 | 1989-02-02 | Schering Aktiengesellschaft | 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them |
GB8513723D0 (en) * | 1985-05-31 | 1985-07-03 | Erba Farmitalia | 11-beta substituted steroids |
FR2598421B1 (fr) * | 1986-05-06 | 1988-08-19 | Roussel Uclaf | Nouveaux produits 19-nor ou 19-nor d-homo steroides substitues en position 11b par un radical phenyle portant un radical alkynyle, leur procede de preparation, leur application comme medicaments et les compositions les renfermant |
DE3625315A1 (de) * | 1986-07-25 | 1988-01-28 | Schering Ag | 11ss-(4-isopropenylphenyl)-estra-4,9-diene, deren herstellung und diese enthaltende pharmazeutische praeparate |
US4774236A (en) * | 1986-09-17 | 1988-09-27 | Research Triangle Institute | 17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them |
US4861763A (en) * | 1986-09-17 | 1989-08-29 | Research Triangle Institute | 17 α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and their progestational use |
US5272140A (en) * | 1987-01-23 | 1993-12-21 | Akzo N.V. | 11-aryl steroid derivatives |
DE3702383A1 (de) * | 1987-01-23 | 1988-08-04 | Schering Ag | 11ss-alkinylestrene und -estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
FR2618783B1 (fr) * | 1987-07-30 | 1991-02-01 | Roussel Uclaf | Nouveaux 17-aryle steroides, leurs procedes et des intermediaires de preparation comme medicaments et les compositions pharmaceutiques les renfermant |
FR2620707B1 (fr) * | 1987-09-18 | 1989-12-08 | Roussel Uclaf | Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
JP2785023B2 (ja) * | 1987-12-30 | 1998-08-13 | ルセル―ユクラフ | 17α位置を置換された17β―OH―19―ノルステロイドの新誘導体、その製造方法、その薬剤としての使用及びそれを含有する製薬組成物 |
US4954490A (en) * | 1988-06-23 | 1990-09-04 | Research Triangle Institute | 11 β-substituted progesterone analogs |
EP0369881A1 (fr) * | 1988-11-16 | 1990-05-23 | Roussel-Uclaf | Nouveaux produits dérivés de la structure 3-céto delta-4,9 19-nor stéroides et leur application comme médicaments |
DE4413184A1 (de) * | 1994-04-12 | 1995-10-19 | Schering Ag | 10,11-C¶3¶-überbrückte Steroide |
US5929262A (en) * | 1995-03-30 | 1999-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Method for preparing 17α-acetoxy-11β-(4-N, N-dimethylaminophyl)-19-Norpregna-4,9-diene-3, 20-dione, intermediates useful in the method, and methods for the preparation of such intermediates |
US5581233A (en) * | 1995-06-06 | 1996-12-03 | Barr; William A. | Vehicle door lock, shift lever interlock system |
FR2826004B1 (fr) | 2001-06-13 | 2008-03-28 | Aventis Pharma Sa | Procede de preparation de derives estrogenes |
US7323591B2 (en) * | 2006-01-10 | 2008-01-29 | Allergan, Inc. | Substituted cyclopentanes or cyclopentanones as therapeutic agents |
TWI477276B (zh) * | 2008-04-28 | 2015-03-21 | Repros Therapeutics Inc | 抗黃體素給藥方案 |
TWI539953B (zh) * | 2008-04-28 | 2016-07-01 | 瑞波若斯治療學公司 | 用於治療乳癌之組成物和方法 |
CA2793712A1 (en) * | 2010-03-22 | 2011-09-29 | Repros Therapeutics Inc. | Compositions and methods for non-toxic delivery of antiprogestins |
MX363640B (es) | 2012-05-31 | 2019-03-28 | Repros Therapeutics Inc | Formulaciones y metodos para la administracion vaginal de antiprogestinas. |
EP2914268B1 (en) | 2012-11-02 | 2018-07-04 | Repros Therapeutics Inc. | Methods and compositions for treating progesterone-dependent conditions |
HU230397B1 (hu) * | 2013-11-25 | 2016-04-28 | Richter Gedeon Nyrt. | Eljárás (11b,17a)-17-acetoxi-11-metil-19-norpregn-4-én-3,20-dion előállítására |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3325520A (en) * | 1965-12-08 | 1967-06-13 | Searle & Co | (optionally 17-hydrocarbon-substituted) 11, 13beta-dialkylgon-4-en-3-ones and esters corresponding |
US3465010A (en) * | 1966-11-22 | 1969-09-02 | Searle & Co | 17 - (unsaturated hydrocarbon - substituted) 11,13beta - dialkylgon -4 - ene - 3,17beta-diols and esters thereof |
US3527778A (en) * | 1969-02-27 | 1970-09-08 | Searle & Co | 3,17 - bisoxygenated 11betamethyl - 19 - norpregn - 4 - en - 20 - ones and derivatives thereof |
FI54128C (fi) * | 1972-12-09 | 1978-10-10 | Akzo Nv | Foerfarande foer framstaellning av nya 11,11-alkylidensteroider ur oestran- och 19-norpregnanserien med foerbaettrad hormonell verkan |
FR2235949B1 (US07943777-20110517-C00090.png) * | 1973-06-18 | 1978-03-17 | Roussel Uclaf | |
FR2237906A1 (en) * | 1973-06-26 | 1975-02-14 | Roussel Uclaf | 11-oxo estr-9-ene derivs. - intermediates in the synthesis of steroids |
US3978048A (en) * | 1973-07-13 | 1976-08-31 | Sandoz, Inc. | 17β-SUBSTITUTED-ALLENE-BEARING STEROIDS |
-
1977
- 1977-01-13 FR FR7700858A patent/FR2377418A1/fr active Granted
- 1977-12-21 SE SE7714613A patent/SE435515B/sv not_active IP Right Cessation
-
1978
- 1978-01-06 US US05/867,485 patent/US4233296A/en not_active Expired - Lifetime
- 1978-01-12 NL NL7800363A patent/NL7800363A/xx not_active Application Discontinuation
- 1978-01-12 DK DK013878A patent/DK161333C/da not_active IP Right Cessation
- 1978-01-12 HU HU78RO954A patent/HU176006B/hu not_active IP Right Cessation
- 1978-01-12 CA CA294,879A patent/CA1115266A/fr not_active Expired
- 1978-01-12 LU LU78861A patent/LU78861A1/xx unknown
- 1978-01-12 BE BE184284A patent/BE862869A/xx not_active IP Right Cessation
- 1978-01-13 DE DE19782801416 patent/DE2801416A1/de active Granted
- 1978-01-13 DE DE2858797A patent/DE2858797C2/de not_active Expired - Fee Related
- 1978-01-13 JP JP206678A patent/JPS5392752A/ja active Granted
- 1978-01-13 CH CH39078A patent/CH633811A5/fr not_active IP Right Cessation
- 1978-01-13 IE IE78/78A patent/IE46301B1/en not_active IP Right Cessation
- 1978-01-13 GB GB1376/78A patent/GB1595132A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE2801416A1 (de) | 1978-07-20 |
DE2858797C2 (US07943777-20110517-C00090.png) | 1993-06-03 |
LU78861A1 (fr) | 1978-09-18 |
IE780078L (en) | 1978-07-13 |
CH633811A5 (fr) | 1982-12-31 |
SE7714613L (sv) | 1978-07-14 |
DK161333B (da) | 1991-06-24 |
IE46301B1 (en) | 1983-04-20 |
SE435515B (sv) | 1984-10-01 |
JPS5392752A (en) | 1978-08-15 |
NL7800363A (nl) | 1978-07-17 |
FR2377418B1 (US07943777-20110517-C00090.png) | 1979-04-20 |
DK13878A (da) | 1978-07-14 |
US4233296A (en) | 1980-11-11 |
DK161333C (da) | 1991-12-09 |
JPS6247878B2 (US07943777-20110517-C00090.png) | 1987-10-09 |
GB1595132A (en) | 1981-08-05 |
FR2377418A1 (fr) | 1978-08-11 |
HU176006B (en) | 1980-11-28 |
BE862869A (fr) | 1978-07-12 |
DE2801416C2 (US07943777-20110517-C00090.png) | 1992-09-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MKEX | Expiry |