CA1109461A - Cephalosporin derivatives and processes for their manufacture - Google Patents

Cephalosporin derivatives and processes for their manufacture

Info

Publication number
CA1109461A
CA1109461A CA318,496A CA318496A CA1109461A CA 1109461 A CA1109461 A CA 1109461A CA 318496 A CA318496 A CA 318496A CA 1109461 A CA1109461 A CA 1109461A
Authority
CA
Canada
Prior art keywords
syn
amino
acid
thiazol
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA318,496A
Other languages
English (en)
French (fr)
Inventor
Jurgen Blumbach
Walter Durckheimer
Elmar Schrinner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of CA1109461A publication Critical patent/CA1109461A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA318,496A 1977-12-24 1978-12-22 Cephalosporin derivatives and processes for their manufacture Expired CA1109461A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19772758001 DE2758001A1 (de) 1977-12-24 1977-12-24 Cephalosporinderivate und verfahren zu ihrer herstellung
DEP2758001.4 1977-12-24

Publications (1)

Publication Number Publication Date
CA1109461A true CA1109461A (en) 1981-09-22

Family

ID=6027279

Family Applications (1)

Application Number Title Priority Date Filing Date
CA318,496A Expired CA1109461A (en) 1977-12-24 1978-12-22 Cephalosporin derivatives and processes for their manufacture

Country Status (20)

Country Link
US (1) US4293550A (cg-RX-API-DMAC7.html)
EP (1) EP0002765B1 (cg-RX-API-DMAC7.html)
JP (1) JPS5495592A (cg-RX-API-DMAC7.html)
AT (1) AT365599B (cg-RX-API-DMAC7.html)
AU (1) AU534258B2 (cg-RX-API-DMAC7.html)
CA (1) CA1109461A (cg-RX-API-DMAC7.html)
DE (2) DE2758001A1 (cg-RX-API-DMAC7.html)
DK (1) DK578978A (cg-RX-API-DMAC7.html)
EG (1) EG13762A (cg-RX-API-DMAC7.html)
ES (1) ES476109A1 (cg-RX-API-DMAC7.html)
FI (1) FI66007C (cg-RX-API-DMAC7.html)
GR (1) GR65234B (cg-RX-API-DMAC7.html)
HU (1) HU184140B (cg-RX-API-DMAC7.html)
IE (1) IE48147B1 (cg-RX-API-DMAC7.html)
IL (1) IL56284A (cg-RX-API-DMAC7.html)
NO (1) NO784366L (cg-RX-API-DMAC7.html)
NZ (1) NZ189266A (cg-RX-API-DMAC7.html)
PH (1) PH15925A (cg-RX-API-DMAC7.html)
PT (1) PT68964A (cg-RX-API-DMAC7.html)
ZA (1) ZA787209B (cg-RX-API-DMAC7.html)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703046A (en) * 1978-09-08 1987-10-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and processes for preparation thereof
NL8005440A (nl) * 1979-10-02 1981-04-06 Glaxo Group Ltd Cefalosporinen met antibiotische werking.
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
DE3006888A1 (de) * 1980-02-23 1981-09-10 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
JPS57131794A (en) * 1980-12-31 1982-08-14 Fujisawa Pharmaceut Co Ltd Novel cephem compound or salt thereof, preparation of the same and preventing agent and remedy for microbism containing the same as active constituent
US4427677A (en) * 1980-12-31 1984-01-24 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
EP0055465B1 (en) * 1980-12-31 1989-08-23 Fujisawa Pharmaceutical Co., Ltd. 7-acylaminocephalosporanic acid derivatives and processes for the preparation thereof
US4618606A (en) * 1982-11-17 1986-10-21 Toyama Chemical Co., Ltd. Antibiotic 7-(thiazolyl)-3-(pyrazinylmethyl) or (pyridazinylmethyl) cephalosporins
EP1059293A1 (en) * 1995-10-12 2000-12-13 Microcide Pharmaceuticals, Inc. Novel amino chlorothiazole compounds
IT1295935B1 (it) * 1997-10-30 1999-05-28 Acs Dobfar Spa Derivati aminotiazolici utili nella preparazione di antibiotici b -lattamici
TWI335332B (en) * 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
CN102015591B (zh) 2008-03-04 2014-01-29 艾尼纳制药公司 制备与5-ht2c激动剂(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓相关的中间体的方法
WO2011153206A1 (en) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
KR20180094131A (ko) 2010-09-01 2018-08-22 에자이 알앤드디 매니지먼트 가부시키가이샤 신장 손상을 갖는 개체에 대한 로카세린의 투여
CN103189360A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 5-ht2c激动剂的非吸湿性盐
SG188362A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Modified-release dosage forms of 5-ht2c agonists useful for weight management
SG10201506870PA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Salts of lorcaserin with optically active acids
WO2014058441A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5168589A (cg-RX-API-DMAC7.html) * 1974-12-06 1976-06-14 Shionogi Seiyaku Kk
GB1536281A (en) * 1975-06-09 1978-12-20 Takeda Chemical Industries Ltd Cephem compounds
DK154939C (da) 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen

Also Published As

Publication number Publication date
IE782546L (en) 1979-06-24
DE2758001A1 (de) 1979-07-12
IE48147B1 (en) 1984-10-17
AT365599B (de) 1982-01-25
NO784366L (no) 1979-06-26
HU184140B (en) 1984-07-30
FI783960A7 (fi) 1979-06-25
AU534258B2 (en) 1984-01-12
ZA787209B (en) 1979-12-27
PH15925A (en) 1983-04-26
US4293550A (en) 1981-10-06
JPS5495592A (en) 1979-07-28
EG13762A (en) 1982-09-30
NZ189266A (en) 1981-12-15
AU4284878A (en) 1979-06-28
EP0002765A1 (de) 1979-07-11
IL56284A (en) 1983-03-31
FI66007C (fi) 1984-08-10
ATA924178A (de) 1981-06-15
EP0002765B1 (de) 1981-09-02
GR65234B (en) 1980-07-30
ES476109A1 (es) 1979-10-16
PT68964A (de) 1979-01-01
IL56284A0 (en) 1979-03-12
DK578978A (da) 1979-06-25
DE2861043D1 (en) 1981-11-26
FI66007B (fi) 1984-04-30
JPH0132226B2 (cg-RX-API-DMAC7.html) 1989-06-29

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Legal Events

Date Code Title Description
MKEX Expiry