CA1055413A - Separation of sialic acid from whey - Google Patents
Separation of sialic acid from wheyInfo
- Publication number
- CA1055413A CA1055413A CA238,023A CA238023A CA1055413A CA 1055413 A CA1055413 A CA 1055413A CA 238023 A CA238023 A CA 238023A CA 1055413 A CA1055413 A CA 1055413A
- Authority
- CA
- Canada
- Prior art keywords
- supernatent
- precipitate
- acid
- whey
- retentate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000005862 Whey Substances 0.000 title claims abstract description 31
- 102000007544 Whey Proteins Human genes 0.000 title claims abstract description 31
- 108010046377 Whey Proteins Proteins 0.000 title claims abstract description 31
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 title claims abstract description 19
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 title claims abstract description 17
- 238000000926 separation method Methods 0.000 title claims description 5
- 238000000034 method Methods 0.000 claims abstract description 53
- 239000002244 precipitate Substances 0.000 claims abstract description 29
- 235000018102 proteins Nutrition 0.000 claims abstract description 27
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 27
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 27
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 claims abstract description 24
- 238000011282 treatment Methods 0.000 claims abstract description 23
- 239000012465 retentate Substances 0.000 claims abstract description 21
- 230000007062 hydrolysis Effects 0.000 claims abstract description 13
- 238000006460 hydrolysis reaction Methods 0.000 claims abstract description 13
- 102000002068 Glycopeptides Human genes 0.000 claims abstract description 12
- 108010015899 Glycopeptides Proteins 0.000 claims abstract description 12
- 235000013365 dairy product Nutrition 0.000 claims abstract description 11
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 10
- 239000005018 casein Substances 0.000 claims abstract description 8
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000021240 caseins Nutrition 0.000 claims abstract description 8
- 238000005903 acid hydrolysis reaction Methods 0.000 claims abstract description 5
- 238000005189 flocculation Methods 0.000 claims abstract 5
- 230000016615 flocculation Effects 0.000 claims abstract 5
- 239000012528 membrane Substances 0.000 claims description 23
- 239000000047 product Substances 0.000 claims description 13
- 239000011347 resin Substances 0.000 claims description 13
- 229920005989 resin Polymers 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 12
- 235000013336 milk Nutrition 0.000 claims description 8
- 239000008267 milk Substances 0.000 claims description 8
- 210000004080 milk Anatomy 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 125000000129 anionic group Chemical group 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 7
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 6
- 239000008101 lactose Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- BDAGIHXWWSANSR-UHFFFAOYSA-N Formic acid Chemical group OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 5
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 5
- 239000011707 mineral Chemical class 0.000 claims description 5
- IYDGMDWEHDFVQI-UHFFFAOYSA-N phosphoric acid;trioxotungsten Chemical compound O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.OP(O)(O)=O IYDGMDWEHDFVQI-UHFFFAOYSA-N 0.000 claims description 5
- 239000001117 sulphuric acid Substances 0.000 claims description 5
- 235000011149 sulphuric acid Nutrition 0.000 claims description 5
- RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical compound [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 claims description 4
- 229910001863 barium hydroxide Inorganic materials 0.000 claims description 4
- 125000002091 cationic group Chemical group 0.000 claims description 4
- 150000002500 ions Chemical class 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 238000001556 precipitation Methods 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 108091005804 Peptidases Proteins 0.000 claims description 3
- 102000035195 Peptidases Human genes 0.000 claims description 3
- 239000001888 Peptone Substances 0.000 claims description 3
- 108010080698 Peptones Proteins 0.000 claims description 3
- 239000004365 Protease Substances 0.000 claims description 3
- 230000002378 acidificating effect Effects 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 235000019319 peptone Nutrition 0.000 claims description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 2
- 241000282849 Ruminantia Species 0.000 claims description 2
- 102000007365 Sialoglycoproteins Human genes 0.000 claims description 2
- 108010032838 Sialoglycoproteins Proteins 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- 239000000919 ceramic Substances 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims description 2
- 230000036425 denaturation Effects 0.000 claims description 2
- 238000004925 denaturation Methods 0.000 claims description 2
- 238000010828 elution Methods 0.000 claims description 2
- 230000003311 flocculating effect Effects 0.000 claims description 2
- 235000019253 formic acid Nutrition 0.000 claims description 2
- 230000003301 hydrolyzing effect Effects 0.000 claims description 2
- 238000007669 thermal treatment Methods 0.000 claims description 2
- 230000007071 enzymatic hydrolysis Effects 0.000 claims 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 claims 1
- 239000000706 filtrate Substances 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical group O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 238000000605 extraction Methods 0.000 abstract description 6
- 102000003886 Glycoproteins Human genes 0.000 abstract description 5
- 108090000288 Glycoproteins Proteins 0.000 abstract description 5
- CERZMXAJYMMUDR-QBTAGHCHSA-N 5-amino-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic acid Chemical compound N[C@@H]1[C@@H](O)CC(O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO CERZMXAJYMMUDR-QBTAGHCHSA-N 0.000 abstract 2
- CERZMXAJYMMUDR-UHFFFAOYSA-N neuraminic acid Natural products NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO CERZMXAJYMMUDR-UHFFFAOYSA-N 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 5
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 229910021653 sulphate ion Inorganic materials 0.000 description 3
- 241000518994 Conta Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 206010065042 Immune reconstitution inflammatory syndrome Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 2
- 230000001376 precipitating effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 229940108461 rennet Drugs 0.000 description 2
- 108010058314 rennet Proteins 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- -1 sulphate ions Chemical class 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 241000283707 Capra Species 0.000 description 1
- 241000237074 Centris Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
- 241000282596 Hylobatidae Species 0.000 description 1
- 241000353097 Molva molva Species 0.000 description 1
- 101100270435 Mus musculus Arhgef12 gene Proteins 0.000 description 1
- 102000005348 Neuraminidase Human genes 0.000 description 1
- 108010006232 Neuraminidase Proteins 0.000 description 1
- 241001387976 Pera Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- KBGAYAKRZNYFFG-BOHATCBPSA-N aceneuramic acid Chemical compound OC(=O)C(=O)C[C@H](O)[C@@H](NC(=O)C)[C@@H](O)[C@H](O)[C@H](O)CO KBGAYAKRZNYFFG-BOHATCBPSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000012154 double-distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- ZMRUPTIKESYGQW-UHFFFAOYSA-N propranolol hydrochloride Chemical compound [H+].[Cl-].C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 ZMRUPTIKESYGQW-UHFFFAOYSA-N 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000001913 submandibular gland Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
- A23C9/142—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
- A23C9/1425—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration by ultrafiltration, microfiltration or diafiltration of whey, e.g. treatment of the UF permeate
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
- A23J1/205—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey from whey, e.g. lactalbumine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/986—Milk; Derivatives thereof, e.g. butter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/832—Milk; colostrum
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/833—Whey; cheese
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Water Supply & Treatment (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Dairy Products (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Fodder In General (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7435495A FR2288473A1 (fr) | 1974-10-22 | 1974-10-22 | Procede de traitement du lactoserum de fromagerie, notamment en vue de l'extraction de glycoproteides et d'acide sialique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1055413A true CA1055413A (en) | 1979-05-29 |
Family
ID=9144365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA238,023A Expired CA1055413A (en) | 1974-10-22 | 1975-10-21 | Separation of sialic acid from whey |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4042575A (OSRAM) |
| JP (1) | JPS5823400B2 (OSRAM) |
| AU (1) | AU498773B2 (OSRAM) |
| BE (1) | BE834542A (OSRAM) |
| CA (1) | CA1055413A (OSRAM) |
| CH (1) | CH610729A5 (OSRAM) |
| DE (1) | DE2547349C2 (OSRAM) |
| DK (1) | DK148357C (OSRAM) |
| FI (1) | FI59701C (OSRAM) |
| FR (1) | FR2288473A1 (OSRAM) |
| GB (1) | GB1519815A (OSRAM) |
| IT (1) | IT1048074B (OSRAM) |
| LU (1) | LU73609A1 (OSRAM) |
| NL (1) | NL7512339A (OSRAM) |
| NO (1) | NO145009C (OSRAM) |
| NZ (1) | NZ179009A (OSRAM) |
| SE (1) | SE441832B (OSRAM) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH630243A5 (fr) * | 1978-05-11 | 1982-06-15 | Nestle Sa | Procede de recuperation des proteines du lactoserum. |
| FR2459619B1 (fr) * | 1979-06-26 | 1983-07-29 | Agronomique Inst Nat Rech | Procede pour l'obtention a partir de lactoserum, d'un produit enrichi en alpha-lactalbumine et applications dudit procede |
| GB2138664A (en) * | 1982-09-14 | 1984-10-31 | Igi Biotechnology Inc | Conversion of clarified dairy whey lactose permeates to culture media and other commercially useful products |
| US5198213A (en) * | 1985-04-15 | 1993-03-30 | Protein Technology, Inc. | Method of disease treatment utilizing an immunologically whey fraction |
| US4816252A (en) * | 1985-04-15 | 1989-03-28 | Protein Technology, Inc. | Product and process for transferring passive immunity to newborn domestic animals using ultrafiltered whey containing immunoglobulins |
| CH671879A5 (OSRAM) * | 1987-02-26 | 1989-10-13 | Nestle Sa | |
| JP2631470B2 (ja) * | 1987-05-15 | 1997-07-16 | 雪印乳業株式会社 | 感染防御剤 |
| US5344820A (en) * | 1987-05-15 | 1994-09-06 | Snow Brand Milk Products Co., Ltd. | Infection protectant |
| DD273543A3 (de) * | 1987-09-14 | 1989-11-22 | Univ Rostock | Verfahren zur herstellung von saeuglings- und diaetnahrungen mit hypoantigener, bifidogener wirkung |
| JP2684179B2 (ja) * | 1987-12-21 | 1997-12-03 | 雪印乳業株式会社 | 抗炎症剤 |
| DE3743440A1 (de) * | 1987-12-21 | 1989-06-29 | Gauri Kailash Kumar | Verfahren zum trennen der geloesten und ungeloesten bestandteile von milch |
| JPH0631286B2 (ja) * | 1987-12-24 | 1994-04-27 | 雪印乳業株式会社 | シアル酸類含有組成物の製造法 |
| US4954361A (en) * | 1989-01-13 | 1990-09-04 | Immunopath Profile, Inc. | Hypoallergenic milk products and process of making |
| US5186971A (en) * | 1989-01-13 | 1993-02-16 | Immunopath Profile, Inc. | Hypoallergenic milk products and process of making |
| US5204134A (en) * | 1989-01-13 | 1993-04-20 | Immuno Path Profile, Inc. | Hypoallergenic milk products from natural and/or synthetic components and process of making |
| US5064674A (en) * | 1989-01-13 | 1991-11-12 | Immunopath Profile, Inc. | Hypoallergenic milk products and process of making |
| US5112636A (en) * | 1989-01-13 | 1992-05-12 | Immunopath Profile, Inc. | Hypoallergenic butter and process of making |
| CH681543A5 (OSRAM) * | 1990-04-27 | 1993-04-15 | Nestle Sa | |
| JP3035833B2 (ja) * | 1991-01-21 | 2000-04-24 | 雪印乳業株式会社 | シアル酸類含有組成物の製造方法 |
| US5248418A (en) * | 1991-02-20 | 1993-09-28 | Eastman Kodak Company | 2-stage ultrafiltration system for photographic emulsions |
| DK170035B1 (da) * | 1992-05-04 | 1995-05-08 | Md Foods Amba | Fremgangsmåde til regulering af mælketørstofbestanddele i koncentrerede mælkeprodukter i forbindelse med ultrafiltrering |
| US5707678A (en) * | 1995-04-12 | 1998-01-13 | Galagen Inc. | Method for microfiltration of milk or colostral whey |
| US5670196A (en) * | 1995-04-12 | 1997-09-23 | Galagen Inc. | Method for microfiltration of milk or colostral whey |
| EP0963163A4 (en) | 1996-10-01 | 2004-09-08 | Univ Massey | Process for isolating glycomacropeptide from dairy products with a phenylalanine impurity of 0.5 %w/w |
| NZ507335A (en) * | 2000-10-05 | 2004-10-29 | New Zealand Dairy Board | Bone health compositions derived from milk comprising an acidic protein fraction but that does not contain CGMP |
| EP1798237A1 (en) * | 2005-12-16 | 2007-06-20 | Pharmatex Italia Srl | Process for the purification of macrolide antibiotics |
| NZ581390A (en) * | 2007-06-25 | 2012-09-28 | Dsm Ip Assets Bv | Prebiotics comprising an oligosaccharide, sialyloligosaccharide and free sialic acid |
| CN108997450A (zh) * | 2018-06-28 | 2018-12-14 | 燕生（福建）生物工程有限公司 | 一种结晶方式从燕窝中提取燕窝酸的方法 |
| CN116998555A (zh) * | 2023-08-02 | 2023-11-07 | 安徽天凯生物科技有限公司 | 一种同时制备零糖乳蛋白、唾液酸及脱盐乳清粉的方法和装置 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1536183A (fr) * | 1966-06-27 | 1968-08-27 | Genvrain S A | Amélioration à l'extraction des protéines du lactosérum |
| FR2232999B1 (OSRAM) * | 1973-06-18 | 1976-11-12 | Claudel Sa |
-
1974
- 1974-10-22 FR FR7435495A patent/FR2288473A1/fr active Granted
-
1975
- 1975-10-16 CH CH1344875A patent/CH610729A5/xx not_active IP Right Cessation
- 1975-10-17 SE SE7511694A patent/SE441832B/xx unknown
- 1975-10-20 US US05/624,305 patent/US4042575A/en not_active Expired - Lifetime
- 1975-10-20 LU LU73609A patent/LU73609A1/xx unknown
- 1975-10-21 IT IT51867/75A patent/IT1048074B/it active
- 1975-10-21 NO NO753531A patent/NO145009C/no unknown
- 1975-10-21 NL NL7512339A patent/NL7512339A/xx not_active Application Discontinuation
- 1975-10-21 FI FI752934A patent/FI59701C/fi not_active IP Right Cessation
- 1975-10-21 NZ NZ179009A patent/NZ179009A/xx unknown
- 1975-10-21 CA CA238,023A patent/CA1055413A/en not_active Expired
- 1975-10-21 DK DK472875A patent/DK148357C/da not_active IP Right Cessation
- 1975-10-21 GB GB43089/75A patent/GB1519815A/en not_active Expired
- 1975-10-21 AU AU85905/75A patent/AU498773B2/en not_active Expired
- 1975-10-22 DE DE2547349A patent/DE2547349C2/de not_active Expired
- 1975-10-22 JP JP50126449A patent/JPS5823400B2/ja not_active Expired
-
1976
- 1976-04-15 BE BE160964A patent/BE834542A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU498773B2 (en) | 1979-03-22 |
| NO145009B (no) | 1981-09-14 |
| US4042575A (en) | 1977-08-16 |
| FR2288473A1 (fr) | 1976-05-21 |
| IT1048074B (it) | 1980-11-20 |
| DK148357B (da) | 1985-06-17 |
| LU73609A1 (OSRAM) | 1977-05-24 |
| CH610729A5 (OSRAM) | 1979-05-15 |
| NO753531L (OSRAM) | 1976-04-23 |
| AU8590575A (en) | 1977-04-28 |
| SE441832B (sv) | 1985-11-11 |
| NZ179009A (en) | 1978-04-03 |
| DK472875A (da) | 1976-04-23 |
| FI59701C (fi) | 1981-10-12 |
| JPS5823400B2 (ja) | 1983-05-14 |
| BE834542A (fr) | 1976-04-15 |
| FI59701B (fi) | 1981-06-30 |
| GB1519815A (en) | 1978-08-02 |
| NO145009C (no) | 1981-12-28 |
| FI752934A7 (OSRAM) | 1976-04-23 |
| SE7511694L (sv) | 1976-04-23 |
| JPS5191358A (OSRAM) | 1976-08-10 |
| DE2547349C2 (de) | 1983-09-15 |
| DE2547349A1 (de) | 1976-05-06 |
| FR2288473B1 (OSRAM) | 1977-03-18 |
| NL7512339A (nl) | 1976-04-26 |
| DK148357C (da) | 1985-12-09 |
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