BRPI1006435A8 - Molécula de ácido nucleico recombinante e célula hospedeira microbiana - Google Patents

Molécula de ácido nucleico recombinante e célula hospedeira microbiana

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Publication number
BRPI1006435A8
BRPI1006435A8 BRPI1006435A BRPI1006435A BRPI1006435A8 BR PI1006435 A8 BRPI1006435 A8 BR PI1006435A8 BR PI1006435 A BRPI1006435 A BR PI1006435A BR PI1006435 A BRPI1006435 A BR PI1006435A BR PI1006435 A8 BRPI1006435 A8 BR PI1006435A8
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Brazil
Prior art keywords
nucleic acid
host cell
acid molecule
recombinant nucleic
microbial host
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BRPI1006435A
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English (en)
Inventor
E Apt Kirk
Simpson David
Richter Leslie
Zirkle Ross
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Martek Biosciences Corp
Dsm Ip Assets Bv
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Publication date
Application filed by Martek Biosciences Corp, Dsm Ip Assets Bv filed Critical Martek Biosciences Corp
Publication of BRPI1006435A2 publication Critical patent/BRPI1006435A2/pt
Publication of BRPI1006435A8 publication Critical patent/BRPI1006435A8/pt
Publication of BRPI1006435B1 publication Critical patent/BRPI1006435B1/pt

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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
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    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
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    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
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    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
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    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01039—[Acyl-carrier-protein] S-malonyltransferase (2.3.1.39)
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    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01041—Beta-ketoacyl-acyl-carrier-protein synthase I (2.3.1.41)
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    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01059—3-Hydroxyacyl-[acyl-carrier-protein] dehydratase (4.2.1.59)
    • A—HUMAN NECESSITIES
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    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
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Abstract

MOLÉCULA DE ÁCIDO NUCLEICO RECOMBINANTE E CÉLULA HOSPEDEIRA MICROBIANA. A presente invenção se refere a moléculas de ácido nucleico isoladas e polipeptídeos das sintases de ácidos graxos poli-insaturados (AGPl) de traustocitridios envolvidas na produção de AGPls, incluindo AGPls enriquecidos com ácido docosaexaenoico (DHA), ácido eicosapentaenoico (EPA), ou uma combinação destes. A presente invenção está direcionada para vetores e células hospedeiras compreendendo as moléculas de ácido nucleico, polipeptídeos codificados pelas moléculas de ácido nucleico, composições compreendendo as moléculas de ácido nucleico ou polipeptídeos, e métodos de produção e uso dos mesmos.
BRPI1006435-4A 2009-03-19 2010-03-19 molécula de ácido nucleico recombinante e célula hospedeira microbiana BRPI1006435B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16174209P 2009-03-19 2009-03-19
US61/161,742 2009-03-19
US29646010P 2010-01-19 2010-01-19
US61/296,460 2010-01-19
PCT/US2010/028009 WO2010108114A2 (en) 2009-03-19 2010-03-19 Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof

Publications (3)

Publication Number Publication Date
BRPI1006435A2 BRPI1006435A2 (pt) 2016-10-04
BRPI1006435A8 true BRPI1006435A8 (pt) 2017-09-26
BRPI1006435B1 BRPI1006435B1 (pt) 2021-01-19

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BRPI1006435-4A BRPI1006435B1 (pt) 2009-03-19 2010-03-19 molécula de ácido nucleico recombinante e célula hospedeira microbiana

Country Status (11)

Country Link
US (4) US8940884B2 (pt)
EP (2) EP2408797B1 (pt)
JP (3) JP2012521195A (pt)
CN (1) CN102741267B (pt)
AR (1) AR075897A1 (pt)
AU (1) AU2010226440B2 (pt)
BR (1) BRPI1006435B1 (pt)
CA (2) CA2755639C (pt)
ES (2) ES2623610T3 (pt)
TW (1) TWI600762B (pt)
WO (1) WO2010108114A2 (pt)

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