BRPI0923359A2 - Anticorpos anti-igf - Google Patents

Anticorpos anti-igf

Info

Publication number
BRPI0923359A2
BRPI0923359A2 BRPI0923359-8A BRPI0923359A BRPI0923359A2 BR PI0923359 A2 BRPI0923359 A2 BR PI0923359A2 BR PI0923359 A BRPI0923359 A BR PI0923359A BR PI0923359 A2 BRPI0923359 A2 BR PI0923359A2
Authority
BR
Brazil
Prior art keywords
igf antibodies
igf
antibodies
Prior art date
Application number
BRPI0923359-8A
Other languages
English (en)
Inventor
Eric Borges
Paul Adam
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40512371&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0923359(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BRPI0923359A2 publication Critical patent/BRPI0923359A2/pt
Publication of BRPI0923359B1 publication Critical patent/BRPI0923359B1/pt
Publication of BRPI0923359B8 publication Critical patent/BRPI0923359B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
BRPI0923359A 2008-12-12 2009-12-11 molécula de anticorpo anti-igf, método para a produção da mesma, molécula de dna, vetor de expressão, e composição farmacêutica e método in vitro para inibir a ligação do igf-1 e do igf-2 ao receptor de igf-1 e ao receptor de insulina ir-a BRPI0923359B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08171554.2 2008-12-12
EP08171554 2008-12-12
PCT/EP2009/066894 WO2010066868A2 (en) 2008-12-12 2009-12-11 Anti-igf antibodies

Publications (3)

Publication Number Publication Date
BRPI0923359A2 true BRPI0923359A2 (pt) 2015-07-21
BRPI0923359B1 BRPI0923359B1 (pt) 2020-09-15
BRPI0923359B8 BRPI0923359B8 (pt) 2021-05-25

Family

ID=40512371

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0923359A BRPI0923359B8 (pt) 2008-12-12 2009-12-11 molécula de anticorpo anti-igf, método para a produção da mesma, molécula de dna, vetor de expressão, e composição farmacêutica e método in vitro para inibir a ligação do igf-1 e do igf-2 ao receptor de igf-1 e ao receptor de insulina ir-a

Country Status (39)

Country Link
US (4) US8318159B2 (pt)
EP (2) EP2376116B1 (pt)
JP (2) JP5694184B2 (pt)
KR (1) KR101827332B1 (pt)
CN (3) CN103396488A (pt)
AP (1) AP3371A (pt)
AR (1) AR074726A1 (pt)
AU (1) AU2009324296B2 (pt)
BR (1) BRPI0923359B8 (pt)
CA (1) CA2740341C (pt)
CL (1) CL2011001431A1 (pt)
CO (1) CO6390042A2 (pt)
CY (1) CY1117241T1 (pt)
DK (1) DK2376116T3 (pt)
EA (1) EA029178B1 (pt)
EC (1) ECSP11011126A (pt)
ES (1) ES2561045T3 (pt)
GE (1) GEP20146119B (pt)
HK (1) HK1158933A1 (pt)
HR (1) HRP20160190T1 (pt)
HU (1) HUE026374T2 (pt)
IL (1) IL212047A (pt)
MA (1) MA32888B1 (pt)
ME (1) ME02377B (pt)
MX (1) MX2011006055A (pt)
MY (1) MY150984A (pt)
NZ (3) NZ597692A (pt)
PE (1) PE20120415A1 (pt)
PL (1) PL2376116T3 (pt)
PT (1) PT2376116E (pt)
RS (1) RS54423B1 (pt)
SG (2) SG172107A1 (pt)
SI (1) SI2376116T1 (pt)
TN (1) TN2011000299A1 (pt)
TW (1) TWI471139B (pt)
UA (1) UA105198C2 (pt)
UY (1) UY32317A (pt)
WO (1) WO2010066868A2 (pt)
ZA (1) ZA201102308B (pt)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2664738C (en) * 2006-09-29 2017-03-07 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
PE20090368A1 (es) 2007-06-19 2009-04-28 Boehringer Ingelheim Int Anticuerpos anti-igf
DK2769729T3 (en) 2007-09-04 2019-04-23 Compugen Ltd POLYPEPTIDES AND POLYNUCLEOTIDES AND APPLICATIONS THEREOF AS A PHARMACEUTICAL OBJECTIVE FOR THE PRODUCTION OF MEDICINAL PRODUCTS AND BIOTECHNOLOGICAL PRODUCTS
CN102232087A (zh) 2008-11-10 2011-11-02 诺瓦提斯公司 修饰的人igf-1/e肽的抗体
DK2376116T3 (en) 2008-12-12 2016-02-29 Boehringer Ingelheim Int The anti-IGF antibodies.
ES2575152T3 (es) 2009-10-16 2016-06-24 Oncomed Pharmaceuticals, Inc. Combinación terapéutica y uso de anticuerpos antagonistas de DLL4 y agentes antihipertensores
EP2494070A2 (en) * 2009-10-30 2012-09-05 Bristol-Myers Squibb Company Methods for treating cancer in patients having igf-1r inhibitor resistance
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
US20130330353A1 (en) * 2010-11-16 2013-12-12 Medimmune, Llc Regimens for treatments using anti-igf antibodies
US9150644B2 (en) 2011-04-12 2015-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
AU2012277376B2 (en) 2011-06-30 2016-11-24 Compugen Ltd. Polypeptides and uses thereof for treatment of autoimmune disorders and infection
MX361712B (es) 2011-09-23 2018-12-14 Oncomed Pharm Inc Agentes de ligacion al factor de crecimiento endotelial vascular/ligando 4 similar a delta (vegf/dell4) y usos de los mismos.
US20130122005A1 (en) 2011-10-27 2013-05-16 Paul Adam Anticancer combination therapy
IN2014KN00848A (pt) 2012-02-01 2015-10-02 Compugen Ltd
TW201427685A (zh) 2012-09-25 2014-07-16 Biogen Idec Inc Ｆｉｘ多肽的應用
CN102863530A (zh) * 2012-09-26 2013-01-09 李彬 一种脂肪细胞分化代谢产物igf-1抗体及包含该抗体的芯片以及应用
JP6371294B2 (ja) 2012-10-31 2018-08-08 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｄｌｌ４アンタゴニストによる処置の方法およびモニタリング
US20140255413A1 (en) * 2013-03-07 2014-09-11 Boehringer Ingelheim International Gmbh Combination therapy for neoplasia treatment
AU2014261630B2 (en) 2013-04-29 2019-05-09 F. Hoffmann-La Roche Ag Human FcRn-binding modified antibodies and methods of use
CN106029690B (zh) * 2013-10-18 2021-08-31 诺瓦塞浦加工有限公司 蛋白质纯化
EP3082859A4 (en) * 2013-12-19 2017-07-19 Medlmmune, LLC Compositions and methods for treating sarcoma
MX2016008782A (es) 2014-01-15 2016-09-08 Hoffmann La Roche Variantes de region fc con union mejorada de la proteina a.
LT3096792T (lt) * 2014-01-24 2019-12-27 Boehringer Ingelheim International Gmbh Vėžio gydymas, naudojant į insuliną panašaus augimo faktoriaus (igf) receptoriaus antagonistą kartu su egzemestanu ir everolimuzu
JO3663B1 (ar) * 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
PT3212233T (pt) 2014-10-31 2020-07-16 Oncomed Pharm Inc Terapia combinada para o tratamento de doenças
WO2016113572A1 (en) * 2015-01-16 2016-07-21 The University Of Liverpool Insulin-like growth factor inhibitor and chemotherapeutic agent for use in cancer therapy
US11091559B2 (en) 2015-08-27 2021-08-17 Celldex Therapeutics, Inc. Anti-ALK antibodies and methods for use thereof
CA2999160A1 (en) 2015-09-23 2017-03-30 Oncomed Pharmaceuticals, Inc. Methods and compositions for treatment of cancer
US20170088609A1 (en) 2015-09-28 2017-03-30 Boehringer Ingelheim International Gmbh Anticancer combination therapy
CN105622730B (zh) * 2016-02-18 2020-06-26 深圳华尔康生物科技有限公司 一种特异性结合igf-1的多肽及其应用
EP3558979B1 (en) 2016-12-22 2021-02-17 Boehringer Ingelheim International GmbH Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors
EP3687573A1 (en) 2017-09-29 2020-08-05 Boehringer Ingelheim International GmbH Anti igf, anti pd-1 anti-cancer combination therapy
AR114164A1 (es) 2017-12-21 2020-07-29 Boehringer Ingelheim Int Piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1
KR102404684B1 (ko) * 2019-01-15 2022-06-07 서울대학교산학협력단 인슐린 유사 성장인자 2 억제제를 포함하는 만성 폐질환의 예방 또는 치료용 조성물
US11945812B2 (en) 2020-06-02 2024-04-02 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
EP4267250A1 (en) 2020-12-22 2023-11-01 Qilu Regor Therapeutics Inc. Sos1 inhibitors and uses thereof
EP4328219A1 (en) 2021-04-23 2024-02-28 Shanghai Leadingtac Pharmaceutical Co. Ltd. Sos1 degrading agent and preparation method therefor and application thereof
TW202337432A (zh) 2021-12-01 2023-10-01 德商百靈佳殷格翰國際股份有限公司 用於治療癌症之環狀2-胺基-3-氰基噻吩及衍生物
TW202337431A (zh) 2021-12-01 2023-10-01 德商百靈佳殷格翰國際股份有限公司 用於治療癌症之環狀2-胺基-3-氰基噻吩及衍生物
WO2023099592A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
WO2023099620A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Kras degrading compounds comprising annulated 2-amino-3-cyano thiophenes
TW202340209A (zh) 2021-12-01 2023-10-16 德商百靈佳殷格翰國際股份有限公司 用於治療癌症之環狀2-胺基-3-氰基噻吩及衍生物
TW202340208A (zh) 2021-12-01 2023-10-16 德商百靈佳殷格翰國際股份有限公司 用於治療癌症之環狀2-胺基-3-氰基噻吩及衍生物
CN114671949B (zh) * 2022-04-20 2023-04-28 山西农业大学 一种igf1纳米抗体及其应用
WO2023225657A2 (en) * 2022-05-20 2023-11-23 Rezolute, Inc. Formulations for anti-insulin receptor antibody and uses thereof

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4342566A (en) * 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
ATE95236T1 (de) 1983-04-25 1993-10-15 Chiron Corp Hybrid-dns-synthesis von reifen insulinaehnlichen wachstumsfaktoren.
WO1985000831A1 (en) 1983-08-10 1985-02-28 Amgen Microbial expression of insulin-like growth factor
AU1232188A (en) 1987-05-29 1988-12-01 Mallinckrodt, Inc. Novel pair of monoclonal antibodies to insulin-like growth factor i permits immunometric assay for igf-i
EP0417193B1 (en) 1988-05-27 1993-08-04 Centocor, Inc. Freeze-dried formulation for antibody products
DE68927854T2 (de) 1988-06-30 1997-10-16 Hope City Insulinomimetrische eigenschaften und insulin-rezeptor-bindestellen-peptide
CA2058041A1 (en) 1990-06-27 1991-12-28 Katsuichi Sakano Anti-igf-ii monoclonal antibody
WO1994029347A1 (en) 1993-06-03 1994-12-22 Therapeutic Antibodies Inc. Antibody fragments in therapy
WO1995025794A1 (fr) 1994-03-23 1995-09-28 Japan Clinical Laboratories Anticorps monoclonal anti-igf-i
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US6991790B1 (en) 1997-06-13 2006-01-31 Genentech, Inc. Antibody formulation
GB9722131D0 (en) * 1997-10-20 1997-12-17 Medical Res Council Method
WO1999028347A1 (en) 1997-11-27 1999-06-10 Commonwealth Scientific And Industrial Research Organisation Method of designing agonists and antagonists to igf receptor
US6416758B1 (en) * 1999-04-28 2002-07-09 Board Of Regents, The University Of Texax System Antibody conjugate kits for selectively inhibiting VEGF
ME00502B (me) 2001-01-05 2011-10-10 Amgen Fremont Inc Antitjela za insulinu sličan receptor faktora i rasta
NZ527591A (en) 2001-01-17 2006-04-28 Trubion Pharmaceuticals Inc Binding domain-immunoglobulin fusion proteins
ATE477280T1 (de) 2001-06-28 2010-08-15 Domantis Ltd Doppelspezifischer ligand und dessen verwendung
EP1456410A2 (en) 2001-12-11 2004-09-15 AlgoNomics N.V. Method for displaying loops from immunoglobulin domains in different contexts
DE60312639T2 (de) 2002-01-18 2007-11-29 Pierre Fabre Médicament Antikörper gegen igf-ir und ihre verwendungen
JP2003310275A (ja) 2002-04-30 2003-11-05 Kyowa Hakko Kogyo Co Ltd ヒトインスリン様成長因子に対する遺伝子組換え抗体
CA2483848C (en) 2002-04-30 2012-08-21 Kyowa Hakko Kogyo Co., Ltd. Antibody against human insulin-like growth factor
NZ554740A (en) 2002-05-24 2009-01-31 Schering Corp Neutralizing human anti-IGFR antibody
US8034904B2 (en) 2002-06-14 2011-10-11 Immunogen Inc. Anti-IGF-I receptor antibody
US7538195B2 (en) 2002-06-14 2009-05-26 Immunogen Inc. Anti-IGF-I receptor antibody
PT1517921E (pt) 2002-06-28 2006-09-29 Domantis Ltd Ligandos duplamente especificos com semi-vida no soro aumentada
US20030138430A1 (en) * 2002-09-20 2003-07-24 Stimmel Julie Beth Pharmaceutical comprising an agent that blocks the cell cycle and an antibody
JP2006523090A (ja) 2002-12-27 2006-10-12 ドマンティス リミテッド リガンドに、そしてリガンド受容体に特異的な二重特異性単一ドメイン抗体
CN101164616A (zh) 2003-02-13 2008-04-23 辉瑞产品公司 抗-胰岛素样生长因子i受体抗体的用途
CA2518980A1 (en) 2003-03-14 2004-09-30 Pharmacia Corporation Antibodies to igf-i receptor for the treatment of cancers
EP1622942B1 (en) 2003-05-01 2014-11-19 ImClone LLC Fully human antibodies directed against the human insulin-like growth factor-1 receptor
AR046071A1 (es) 2003-07-10 2005-11-23 Hoffmann La Roche Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos
WO2005018671A1 (ja) 2003-08-21 2005-03-03 Kyowa Hakko Kogyo Co., Ltd. 癌転移阻害剤
CA2540138C (en) 2003-09-24 2013-07-30 Kyowa Hakko Kogyo Co., Ltd. Recombinant antibody against human insulin-like growth factor
CA2540133A1 (en) 2003-09-24 2005-03-31 Kyowa Hakko Kogyo Co., Ltd. Drugs for treating cancer
WO2005058967A2 (en) 2003-12-16 2005-06-30 Pierre Fabre Medicament Novel anti-insulin/igf-i hybrid receptor or anti-insulin/igf-i hybrid receptor and igf-ir antibodies and uses thereof
KR20070036130A (ko) 2004-07-16 2007-04-02 화이자 프로덕츠 인코포레이티드 항-아이지에프-1알 항체를 사용하는 비-혈액학적악성종양에 대한 조합 치료
MY146381A (en) 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
AR053489A1 (es) 2005-05-24 2007-05-09 Morphosys Ag Generacion perfilado de anticuerpos terapeuticos totalmente derivados de hucal gold humanos especificos para cd38 humano
FR2888850B1 (fr) 2005-07-22 2013-01-11 Pf Medicament Nouveaux anticorps anti-igf-ir et leurs applications
US8088896B2 (en) 2005-10-12 2012-01-03 Morphosys Ag Generation and profiling of fully human gold-derived therapeutic antibodies specific for human CD38
RS52357B (en) * 2005-12-13 2012-12-31 Medimmune Limited BINDING PROTEINS SPECIFIC TO INSULIN SIMILAR GROWTH FACTORS AND THEIR USE
CN101484587B (zh) 2006-02-03 2014-02-12 英克隆有限责任公司 Igf-ir拮抗剂作为辅药用于前列腺癌的治疗
WO2007126876A2 (en) * 2006-03-28 2007-11-08 Biogen Idec Ma Inc. Anti-igf-ir antibodies and uses thereof
CA2648846A1 (en) * 2006-04-07 2007-10-18 The Government Of The United States Of America As Represented By The Sec Retary, Department Of Health And Human Services Antibody compositions and methods for treatment of neoplastic disease
US20080014203A1 (en) 2006-04-11 2008-01-17 Silke Hansen Antibodies against insulin-like growth factor I receptor and uses thereof
WO2007141626A1 (en) 2006-06-02 2007-12-13 Pfizer Products Inc. Circulating tumor cell assay
ES2427924T3 (es) 2006-06-30 2013-11-04 Merck Sharp & Dohme Corp. Biomarcador IGFBP2
US7749966B2 (en) * 2006-12-21 2010-07-06 Boston Biomedical Research Institute Immunological modulation of insulin-like growth factor 1 for cancer prevention/treatment and prolonging longevity
TW200833711A (en) 2006-12-22 2008-08-16 Genentech Inc Antibodies to insulin-like growth factor receptor
GB0702888D0 (en) 2007-02-14 2007-03-28 Glaxo Group Ltd Novel Antibodies
JP2010520204A (ja) 2007-03-02 2010-06-10 アムジェン インコーポレイテッド 腫瘍疾患を治療するための方法および組成物
WO2008115470A2 (en) 2007-03-16 2008-09-25 East Carolina University Hox-gene expression as a biomarker for igf-1r therapeutics
BRPI0809112A2 (pt) 2007-03-22 2014-08-26 Imclone Llc Formulações estáveis de anticorpos
EP2145021A2 (en) 2007-05-17 2010-01-20 Bristol-Myers Squibb Company Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators
WO2008144720A2 (en) 2007-05-21 2008-11-27 University Of Washington Inhibitors of igf-1r signaling for the treatment of respiratory disorders
WO2008152422A2 (en) 2007-06-12 2008-12-18 Astrazeneca Ab Binding proteins specific for insulin-like growth factors and uses thereof-909
PE20090368A1 (es) * 2007-06-19 2009-04-28 Boehringer Ingelheim Int Anticuerpos anti-igf
WO2009005673A1 (en) 2007-06-28 2009-01-08 Schering Corporation Anti-igf1r
WO2009006336A1 (en) 2007-06-28 2009-01-08 Sylgen Laboratories, Inc. Compositions and methods for inhibiting angiogenesis and tumorigenesis
JP2010535710A (ja) 2007-07-31 2010-11-25 メルク・シャープ・エンド・ドーム・コーポレイション 細胞増殖性疾患の検出及び診断に有用なｉｇｆ−１ｒ特異抗体
CN101855244A (zh) 2007-08-01 2010-10-06 葛兰素集团有限公司 新型抗体
WO2009019117A1 (en) 2007-08-03 2009-02-12 Affibody Ab Igf-1r binding polypeptides and their use
EP2952588A1 (en) 2007-08-06 2015-12-09 Orion Genomics, LLC Single nucleotide polymorphism in igf2 for determining the allele-specific expression of the igf2 gene
CN101842116A (zh) 2007-08-28 2010-09-22 比奥根艾迪克Ma公司 结合igf-1r多个表位的组合物
JP2010537985A (ja) 2007-08-28 2010-12-09 バイオジェン アイデック マサチューセッツ インコーポレイテッド 抗ｉｇｆ−１ｒ抗体およびその使用
AU2008302076B2 (en) 2007-09-19 2015-06-11 The Trustees Of Boston University Identification of novel pathways for drug development for lung disease
US8048621B2 (en) 2007-10-03 2011-11-01 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
US7939272B2 (en) 2007-10-03 2011-05-10 Osi Pharmaceuticals, Inc. Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
TWI468417B (zh) 2007-11-30 2015-01-11 Genentech Inc 抗－ｖｅｇｆ抗體
MX2010006854A (es) 2007-12-18 2010-09-09 Schering Corp Biomarcadores para sensibilidad a terapia anti-receptor-1 del factor de crecimiento tipo insulina.
US20090258365A1 (en) 2008-03-25 2009-10-15 Terstappen Leon W M M METHOD FOR DETECTING IGF1R/Chr 15 in CIRCULATING TUMOR CELLS USING FISH
EP2274010A1 (en) 2008-04-11 2011-01-19 Biogen Idec MA Inc. Therapeutic combinations of anti-igf-1r antibodies and other compounds
MX2010012064A (es) 2008-05-05 2010-12-06 Schering Corp Uso secuencial de agentes quimioterapeuticos citotoxicos para el tratamiento de cancer.
JP5734180B2 (ja) 2008-05-09 2015-06-17 ダイアックス コーポレーション Ｉｇｆ−ｉｉ／ｉｇｆ−ｉｉｅ結合タンパク質
US9109026B2 (en) 2008-06-03 2015-08-18 Abbvie, Inc. Dual variable domain immunoglobulins and uses thereof
MX2011003133A (es) 2008-09-26 2011-04-21 Roche Glycart Ag Anticuerpos biespecificos anti-egfr/anti-igf-1r.
US20110229933A1 (en) 2008-09-26 2011-09-22 SAchering Corporaton High titer antibody production
AU2009303453B2 (en) 2008-10-14 2015-02-26 Dyax Corp. Use of IGF-II/IGF-IIE binding for the treatment and prevention of systemic sclerosis associated pulmonary fibrosis
JP2012506238A (ja) 2008-10-20 2012-03-15 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイト インスリン様増殖因子−１受容体キナーゼ阻害剤に対する抗がん反応を予測する生物学的マーカー
CN102232087A (zh) 2008-11-10 2011-11-02 诺瓦提斯公司 修饰的人igf-1/e肽的抗体
NZ606283A (en) 2008-11-28 2014-08-29 Abbvie Inc Stable antibody compositions and methods for stabilizing same
DK2376116T3 (en) 2008-12-12 2016-02-29 Boehringer Ingelheim Int The anti-IGF antibodies.
WO2010069858A1 (en) 2008-12-19 2010-06-24 F. Hoffmann-La Roche Ag Pharmaceutical composition
JP2012513477A (ja) 2008-12-23 2012-06-14 ソーク インスティチュート フォー バイオロジカル スタディーズ 神経変性疾患の治療方法
AU2010236818B2 (en) 2009-04-16 2014-03-13 Merck Sharp & Dohme Corp. Combination therapy using an anti-EGFR agent(s) and IGF-1R specific inhibitors
WO2011057064A1 (en) 2009-11-05 2011-05-12 Brian Long Igf1r inhibitor based treatment of prostate cancer
WO2013148568A1 (en) 2012-03-30 2013-10-03 Merck Sharp & Dohme Corp. Igf1 biomarker for igf1r inhibitor therapy
WO2013169611A1 (en) 2012-05-09 2013-11-14 Merck Sharp & Dohme Corp. Compositions and methods for treating breast cancer
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
US20140255413A1 (en) 2013-03-07 2014-09-11 Boehringer Ingelheim International Gmbh Combination therapy for neoplasia treatment
LT3096792T (lt) 2014-01-24 2019-12-27 Boehringer Ingelheim International Gmbh Vėžio gydymas, naudojant į insuliną panašaus augimo faktoriaus (igf) receptoriaus antagonistą kartu su egzemestanu ir everolimuzu
US20170088609A1 (en) 2015-09-28 2017-03-30 Boehringer Ingelheim International Gmbh Anticancer combination therapy

Also Published As

Publication number Publication date
US20190225681A1 (en) 2019-07-25
JP5694184B2 (ja) 2015-04-01
HUE026374T2 (en) 2016-05-30
IL212047A0 (en) 2011-06-30
AP2011005719A0 (en) 2011-06-30
PE20120415A1 (es) 2012-05-09
JP2015131812A (ja) 2015-07-23
WO2010066868A3 (en) 2010-09-10
MY150984A (en) 2014-03-31
SG2014013841A (en) 2014-07-30
SG172107A1 (en) 2011-07-28
IL212047A (en) 2016-03-31
HK1158933A1 (en) 2012-07-27
AR074726A1 (es) 2011-02-09
WO2010066868A2 (en) 2010-06-17
PT2376116E (pt) 2016-02-24
BRPI0923359B1 (pt) 2020-09-15
CA2740341A1 (en) 2010-06-17
CN103396488A (zh) 2013-11-20
BRPI0923359B8 (pt) 2021-05-25
US20130230541A1 (en) 2013-09-05
US11299538B2 (en) 2022-04-12
AP3371A (en) 2015-07-31
CN102227226B (zh) 2015-05-13
TWI471139B (zh) 2015-02-01
HRP20160190T1 (hr) 2016-03-25
TN2011000299A1 (en) 2012-12-17
CL2011001431A1 (es) 2012-02-17
AU2009324296A1 (en) 2010-06-17
NZ597694A (en) 2013-08-30
ECSP11011126A (es) 2011-07-29
MX2011006055A (es) 2011-07-04
US20150010574A1 (en) 2015-01-08
CA2740341C (en) 2019-05-07
EA029178B1 (ru) 2018-02-28
US20100150940A1 (en) 2010-06-17
CY1117241T1 (el) 2017-04-05
AU2009324296B2 (en) 2016-07-28
MA32888B1 (fr) 2011-12-01
CN103396487A (zh) 2013-11-20
EP3064219A3 (en) 2016-09-28
NZ592151A (en) 2012-10-26
ZA201102308B (en) 2011-12-28
CN102227226A (zh) 2011-10-26
US8318159B2 (en) 2012-11-27
TW201026327A (en) 2010-07-16
RS54423B1 (en) 2016-04-28
DK2376116T3 (en) 2016-02-29
CO6390042A2 (es) 2012-02-29
UY32317A (es) 2010-07-30
PL2376116T3 (pl) 2016-07-29
SI2376116T1 (sl) 2016-03-31
ME02377B (me) 2016-06-20
EP3064219A2 (en) 2016-09-07
EP2376116A2 (en) 2011-10-19
UA105198C2 (ru) 2014-04-25
EP2376116B1 (en) 2015-12-09
NZ597692A (en) 2013-08-30
JP2012511315A (ja) 2012-05-24
KR101827332B1 (ko) 2018-02-09
GEP20146119B (en) 2014-07-25
US10179810B2 (en) 2019-01-15
KR20110094034A (ko) 2011-08-19
EA201100918A1 (ru) 2012-01-30
ES2561045T3 (es) 2016-02-24

Similar Documents

Publication Publication Date Title
CY2019004I2 (el) Τροποποιημενα αντισωματα αντι-ιl-23ρ19
BRPI0923359A2 (pt) Anticorpos anti-igf
SMT201700083B (it) Anticorpi monoclonali
BRPI0907532A2 (pt) Anticorpos anti-c5ar humanizados
BRPI0906877A2 (pt) Anticorpos anti-trkb aperfeiçoados
BRPI0907237A2 (pt) Anticorpo anti-cldn6
BRPI0819165A2 (pt) Anticorpos anti-vegf
DK2131860T3 (da) Anti-sclerostin-antistoffer
DK2344537T3 (da) Bispecifikke anti-vegf/anti-ang-2-antistoffer
BRPI1011005A2 (pt) anticorpos anti-epcam
CR20170001A (es) Anticuerpos anti factor d humanizados
DK2443154T3 (da) Bispecifikke antigenbindingsproteiner
BRPI1011145A2 (pt) anticorpo anti-axl
BRPI0922800A2 (pt) anticorpos c-met
BRPI0912173A2 (pt) anticorpos anti-flt3
BRPI0917148A2 (pt) anticorpos anti-cd5
BR112012030311A2 (pt) anticorpo
DK2459167T3 (da) SUBKUTAN ANTI-HER2-antistofformulering
DK2521736T3 (da) Humaniserede antistoffer
BRPI0820073A2 (pt) Anticorpos anti-axl
BRPI0821777A2 (pt) Anticorpos biespecíficos bivalentes
DK3072906T3 (da) Antistofformulering
BRPI0909633A2 (pt) anticorpos anti-tyrp1
CO6791565A2 (es) Anticuerpos anti-notch1
DK3514173T3 (da) DKK-1-antistoffer

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/09/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 11/12/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF