BRPI0917000A2 - proteínas conjugadas com eficácia in vivo prolongada - Google Patents
proteínas conjugadas com eficácia in vivo prolongadaInfo
- Publication number
- BRPI0917000A2 BRPI0917000A2 BRPI0917000A BRPI0917000A BRPI0917000A2 BR PI0917000 A2 BRPI0917000 A2 BR PI0917000A2 BR PI0917000 A BRPI0917000 A BR PI0917000A BR PI0917000 A BRPI0917000 A BR PI0917000A BR PI0917000 A2 BRPI0917000 A2 BR PI0917000A2
- Authority
- BR
- Brazil
- Prior art keywords
- prolonged
- vivo efficacy
- protein conjugates
- conjugates
- protein
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08161905 | 2008-08-06 | ||
| PCT/EP2009/060186 WO2010015668A1 (en) | 2008-08-06 | 2009-08-06 | Conjugated proteins with prolonged in vivo efficacy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0917000A2 true BRPI0917000A2 (pt) | 2016-02-16 |
Family
ID=41334423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0917000A BRPI0917000A2 (pt) | 2008-08-06 | 2009-08-06 | proteínas conjugadas com eficácia in vivo prolongada |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8865868B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2323694A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5977945B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20110039348A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102112157B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009279090A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0917000A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2733200A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2011000847A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2526804C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010015668A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US8759292B2 (en) | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
| US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| KR20110039348A (ko) | 2008-08-06 | 2011-04-15 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 연장된 생체내 효능을 가지는 콘쥬게이트된 단백질 |
| CN104984319B (zh) | 2008-12-19 | 2025-05-09 | 武田药品工业株式会社 | Tfpi抑制剂和使用方法 |
| JP5816097B2 (ja) | 2009-01-22 | 2015-11-18 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 安定な成長ホルモン化合物 |
| US12203113B2 (en) | 2009-07-09 | 2025-01-21 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
| CN105963710A (zh) * | 2009-08-06 | 2016-09-28 | 诺沃—诺迪斯克保健股份有限公司 | 具有延长的体内功效的生长激素 |
| RU2605627C2 (ru) | 2010-01-22 | 2016-12-27 | Ново Нордиск Хелс Кеа Аг | Гормоны роста с пролонгированной эффективностью in vivo |
| BR112012018162A2 (pt) | 2010-01-22 | 2017-10-03 | Novo Nordisk Healthcare Ag | Compostos de hormônio do crescimento estáveis |
| WO2011101261A2 (en) * | 2010-02-16 | 2011-08-25 | Novo Nordisk A/S | Purification method |
| EP3146977B1 (en) | 2010-03-19 | 2024-05-08 | Takeda Pharmaceutical Company Limited | Tfpi inhibitors and methods of use |
| CN103269720A (zh) * | 2010-07-22 | 2013-08-28 | 诺沃—诺迪斯克保健股份有限公司 | 生长激素缀合物 |
| BR112013021661A2 (pt) | 2011-03-02 | 2016-11-22 | Novo Nordisk As | objetivação de fator de coagulação a tlt-1 sobre plaquetas ativadas |
| US9480751B2 (en) | 2011-04-11 | 2016-11-01 | Yeda Research And Development Co. Ltd. | Albumin binding probes and drug conjugates thereof |
| CN109535245A (zh) * | 2012-02-14 | 2019-03-29 | 奥普科生物制品有限公司 | 长效凝血因子和生产它们的方法 |
| KR102263685B1 (ko) | 2012-03-21 | 2021-06-11 | 다케다 야쿠힌 고교 가부시키가이샤 | Tfpi 저해제 및 사용 방법 |
| SG11201406671RA (en) | 2012-04-19 | 2014-11-27 | Opko Biolog Ltd | Long-acting oxyntomodulin variants and methods of producing same |
| WO2013167455A1 (en) * | 2012-05-08 | 2013-11-14 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| CA2891393A1 (en) | 2012-11-20 | 2014-05-30 | Opko Biologics Ltd. | Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides |
| US11045523B2 (en) | 2013-04-05 | 2021-06-29 | Novo Nordisk Healthcare Ag | Formulation of growth hormone albumin-binder conjugate |
| FR3006315B1 (fr) * | 2013-05-31 | 2015-10-02 | Centre Nat Rech Scient | Microparticules et nanoparticules auto-associatives composees de proteines |
| FR3011470B1 (fr) | 2013-10-09 | 2017-01-06 | Centre Nat De La Rech Scient (Cnrs) | Composition antifongique comprenant un agent antifongique et du chitosane hydrophobise |
| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US10583104B2 (en) | 2014-08-06 | 2020-03-10 | Indiana University Research And Technology Corporation | Tuneable delivery of nanoparticle bound active plasmin for the treatment of thrombosis |
| ES2943359T3 (es) | 2014-12-10 | 2023-06-12 | Opko Biologics Ltd | Métodos de producción de polipéptidos de hormona de crecimiento modificados con CTP de acción prolongada |
| PE20171328A1 (es) * | 2015-01-23 | 2017-09-12 | Novartis Ag | Conjugados de acidos grasos y apelina sintetica con mayor vida media |
| EP3310347B1 (en) | 2015-06-19 | 2021-08-04 | OPKO Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US11976106B2 (en) | 2016-07-11 | 2024-05-07 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| EP4378926A4 (en) * | 2021-07-29 | 2025-05-28 | Novocodex Biopharmaceuticals Co., Ltd. | Unnatural amino acid and use thereof, recombinant protein therewith and recombinant protein conjugate |
| CN113698468B (zh) * | 2021-09-01 | 2022-10-11 | 浙江新码生物医药有限公司 | 人白细胞介素2-聚乙二醇偶联物及其应用 |
Family Cites Families (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| GB8610551D0 (en) | 1986-04-30 | 1986-06-04 | Hoffmann La Roche | Polypeptide & protein derivatives |
| JPH0665280B2 (ja) | 1987-03-04 | 1994-08-24 | 味の素株式会社 | タンパクゲル化剤及びそれを用いるタンパクのゲル化方法 |
| DE68929273T2 (de) | 1988-08-24 | 2001-07-05 | American Cyanamid Co., Wayne | Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung |
| CA2345497A1 (en) | 1988-10-28 | 1990-04-28 | Genentech, Inc. | Growth hormone variants and method for forming growth hormone variants |
| US5534617A (en) | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
| US6780613B1 (en) | 1988-10-28 | 2004-08-24 | Genentech, Inc. | Growth hormone variants |
| WO1990011296A1 (en) | 1989-03-20 | 1990-10-04 | The General Hospital Corporation | Insulinotropic hormone |
| DE3930696A1 (de) | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
| CA2073856C (en) | 1990-01-24 | 2002-12-03 | Douglas I. Buckley | Glp-1 analogs useful for diabetes treatment |
| US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
| US5951972A (en) | 1990-05-04 | 1999-09-14 | American Cyanamid Company | Stabilization of somatotropins and other proteins by modification of cysteine residues |
| JP2849773B2 (ja) | 1990-08-27 | 1999-01-27 | 天野製薬株式会社 | ストレプトミセス属由来のトランスグルタミナーゼの製造法 |
| DK220890D0 (da) | 1990-09-14 | 1990-09-14 | Ole Buchardt | Fremgangsmaade til fremstilling af c-terminalt amiderede peptider |
| DK0564531T3 (da) | 1990-12-03 | 1998-09-28 | Genentech Inc | Berigelsesfremgangsmåde for variantproteiner med ændrede bindingsegenskaber |
| IT1251895B (it) | 1991-09-27 | 1995-05-26 | Eniricerche Spa | Mutanti dell'ormone della crescita umano e loro impiego |
| EP0555649B1 (en) | 1992-01-14 | 2004-12-08 | Ajinomoto Co., Inc. | Gene encoding transglutaminase derived from fish |
| ZA936811B (en) | 1992-10-28 | 1995-03-15 | Upjohn Co | Somatotropin modifications |
| US5359030A (en) | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| JP3758187B2 (ja) | 1994-01-28 | 2006-03-22 | 味の素株式会社 | マガキ由来のトランスグルタミナーゼ |
| ES2267103T3 (es) | 1994-08-26 | 2007-03-01 | Novozymes A/S | Transglutaminasas microbianas, su produccion y uso. |
| EP0785276A4 (en) | 1994-09-29 | 2002-01-09 | Ajinomoto Kk | MODIFICATION OF A PEPTIDE AND A PROTEIN |
| DE4437604A1 (de) | 1994-10-21 | 1996-04-25 | Basf Ag | Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung |
| NZ298746A (en) | 1995-01-19 | 1998-07-28 | Novo Nordisk As | Transglutaminases from oomcyetes |
| JP3669390B2 (ja) | 1995-02-09 | 2005-07-06 | 味の素株式会社 | バチルス属細菌由来のトランスグルタミナーゼ |
| US5869602A (en) | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
| JP3628333B2 (ja) | 1995-09-21 | 2005-03-09 | ジェネンテック インコーポレーテッド | ヒト成長ホルモン変異体 |
| IL128332A0 (en) | 1996-08-30 | 2000-01-31 | Novo Nordisk As | GLP-1 derivatives |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| WO1998008872A1 (en) | 1996-08-30 | 1998-03-05 | Novo Nordisk A/S | Glp-2 derivatives |
| WO1998013381A1 (fr) | 1996-09-26 | 1998-04-02 | Ajinomoto Co., Inc. | Proteines modifiees physiologiquement actives et compositions medicamenteuses les contenant |
| US5985627A (en) | 1997-02-28 | 1999-11-16 | Carlsberg Laboratory | Modified carboxypeptidase |
| US6608183B1 (en) | 1997-07-14 | 2003-08-19 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
| US6310183B1 (en) * | 1997-09-10 | 2001-10-30 | Novo Nordisk A/S | Coagulation factor VIIa composition |
| US6136536A (en) | 1997-10-29 | 2000-10-24 | Genetics Institute, Inc. | Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins |
| EP1056774A1 (en) | 1998-02-27 | 2000-12-06 | Novo Nordisk A/S | N-terminally truncated glp-1 derivatives |
| DE69942307D1 (de) | 1998-02-27 | 2010-06-10 | Novo Nordisk As | N-terminal veränderte glp-1 abkömmlinge |
| ATE265224T1 (de) | 1998-02-27 | 2004-05-15 | Novo Nordisk As | Glp-1 derivate mit einem helix-gehalt über 25 , die partiell strukturierte mizellenartige aggregate bilden |
| WO1999043708A1 (en) | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
| EP1060192A2 (en) | 1998-02-27 | 2000-12-20 | Novo Nordisk A/S | Glp-2 derivatives with helix-content exceeding 25 %, forming partially structured micellar-like aggregates |
| US6656922B2 (en) | 1998-05-28 | 2003-12-02 | Mediplex Corporation, Korea | Oral delivery of macromolecules |
| US6358705B1 (en) | 1998-07-16 | 2002-03-19 | Novo Nordisk A/S | Method of making proteins in transformed yeast cells |
| PL202367B1 (pl) | 1998-12-07 | 2009-06-30 | Sod Conseils Rech Applic | Związki stanowiące analogi GLP-1, kompozycje zawierające te związki oraz zastosowanie tych związków |
| DE60006100T2 (de) | 1999-05-17 | 2004-07-01 | Conjuchem, Inc., Montreal | Lang wirkende insulinotrope peptide |
| US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
| WO2001004287A1 (en) | 1999-07-07 | 2001-01-18 | Maxygen Aps | A method for preparing modified polypeptides |
| US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
| EP1076066A1 (en) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides for lowering blood glucose levels |
| GB2355009A (en) | 1999-07-30 | 2001-04-11 | Univ Glasgow | Peptides conjugated to bile acids/salts |
| US20040001827A1 (en) | 2002-06-28 | 2004-01-01 | Dennis Mark S. | Serum albumin binding peptides for tumor targeting |
| AU2353701A (en) | 2000-01-11 | 2001-07-24 | Novo Nordisk A/S | Transepithelial delivery of glp-1 derivatives |
| EP2319541A1 (en) | 2000-02-11 | 2011-05-11 | Bayer HealthCare LLC | Factor VII or VIIA-like conjugates |
| US20020142964A1 (en) | 2000-11-02 | 2002-10-03 | Nissen Torben Lauesgaard | Single-chain polypeptides |
| ATE406384T1 (de) | 2000-12-07 | 2008-09-15 | Lilly Co Eli | Glp-1 fusion proteine |
| AU2002219021A1 (en) | 2001-01-11 | 2002-07-24 | Maxygen Aps | Variant growth hormone molecules conjugated with macromolecular compounds |
| US20060183197A1 (en) | 2001-01-11 | 2006-08-17 | Andersen Kim V | Variant growth hormone molecules conjugated with macromolecules compounds |
| FR2819810B1 (fr) | 2001-01-23 | 2004-05-28 | Pf Medicament | Peptides non glycosyles derives de la proteine g du vrs et leur utilisation dans un vaccin |
| US6858580B2 (en) | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| JP5562510B2 (ja) | 2001-06-28 | 2014-07-30 | ノヴォ ノルディスク アー／エス | 修飾ｇｌｐ−１の安定な処方剤 |
| EP1423136A4 (en) | 2001-08-10 | 2007-07-25 | Epix Pharm Inc | POLYPEPTIDE CONJUGATES HAVING INCREASED CIRCULATION HALF-VIES |
| AR036711A1 (es) | 2001-10-05 | 2004-09-29 | Bayer Corp | Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico |
| OA13063A (en) | 2001-11-20 | 2006-11-10 | Pharmacia Corp | Chemically-modified human growth hormone conjugates. |
| JP2003199569A (ja) | 2001-12-17 | 2003-07-15 | Food Industry Research & Development Inst | ストレプトベルティシリウム・ラダカヌムのトランスグルタミナーゼ遺伝子及び該遺伝子によってコードされるトランスグルタミナーゼ |
| WO2004065621A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| WO2003087139A2 (en) | 2002-04-10 | 2003-10-23 | Eli Lilly And Company | Treatment of gastroparesis |
| BR0309576A (pt) | 2002-04-30 | 2005-02-09 | Maxygen Holdings Ltd | Variante de polipeptìdeo do fator vii (fvii) ou fator viia (fviia), sequência de nucleotìdeo, vetor de expressão, célula hospedeira, composição farmacêutica, uso de uma variante, e, método para tratar um mamìfero que tenha uma doença ou um distúrbio em que a formação de coágulo é desejável |
| EP1539960B1 (en) | 2002-09-09 | 2010-04-28 | Hanall Pharmaceutical Co., Ltd. | Protease-resistant modified interferon alpha polypeptides |
| NZ541659A (en) | 2003-01-14 | 2007-05-31 | Teva Pharma | Pharmaceutical composition comprising with a pH between 4 and 9 to treat SLE comprising an aqueous carrier, a pharmaceutically acceptable salt of a peptide and a substituted beta-cyclodextrin |
| ATE455555T1 (de) | 2003-02-19 | 2010-02-15 | Ipsen Pharma | Glp-1-analoga |
| AU2004235872A1 (en) | 2003-05-09 | 2004-11-18 | Novo Nordisk A/S | Peptides for use in treating obesity |
| WO2005014035A2 (en) | 2003-08-08 | 2005-02-17 | Novo Nordisk Health Care Ag | Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest |
| EP1667724A2 (en) | 2003-09-19 | 2006-06-14 | Novo Nordisk A/S | Albumin-binding derivatives of therapeutic peptides |
| RU2401276C2 (ru) | 2003-09-19 | 2010-10-10 | Ново Нордиск А/С | Производные глюкагон-подобного пептида-1 (glp-1) |
| AU2004273573B2 (en) | 2003-09-19 | 2010-04-22 | Novo Nordisk A/S | Albumin-binding derivatives of therapeutic peptides |
| JP2007508250A (ja) | 2003-10-10 | 2007-04-05 | ノボ ノルディスク アクティーゼルスカブ | 持続性放出製剤における長期作用性分子 |
| MXPA06006746A (es) | 2003-12-18 | 2006-08-18 | Novo Nordisk As | Analogos de glp-1 novedosos ligados a agentes similares a albumina. |
| WO2005058954A1 (en) | 2003-12-18 | 2005-06-30 | Novo Nordisk A/S | Novel glp-1 compounds |
| ES2642214T3 (es) | 2004-01-21 | 2017-11-15 | Novo Nordisk Health Care Ag | Conjugación de péptidos mediante transglutaminasa |
| US7906137B2 (en) | 2004-05-21 | 2011-03-15 | Mediplex Corporation, Korea | Delivery agents for enhancing mucosal absorption of therapeutic agents |
| JP2006273834A (ja) * | 2004-06-28 | 2006-10-12 | Kao Corp | Ａｍｐｋ活性化剤 |
| US20070244202A1 (en) | 2004-06-28 | 2007-10-18 | Kao Corporation | Ampk Activator |
| AU2005261740A1 (en) | 2004-07-08 | 2006-01-19 | Novo Nordisk A/S | Polypeptide protracting tags comprising a tetrazole moiety |
| EP1778838A2 (en) | 2004-08-02 | 2007-05-02 | Novo Nordisk Health Care AG | Conjugation of fvii |
| WO2006037810A2 (en) | 2004-10-07 | 2006-04-13 | Novo Nordisk A/S | Protracted glp-1 compounds |
| US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
| AU2006224537A1 (en) | 2005-03-18 | 2006-09-21 | Novo Nordisk A/S | Extended GLP-1 compounds |
| EP1863537A2 (en) | 2005-03-18 | 2007-12-12 | Novo Nordisk A/S | Dimeric peptide agonists of the glp-1 receptor |
| TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
| WO2006122982A1 (en) | 2005-05-20 | 2006-11-23 | Novo Nordisk Health Care Ag | New poly(ethylene glycol) derivatives and process for their coupling to proteins |
| EP1893632B1 (en) | 2005-06-17 | 2015-08-12 | Novo Nordisk Health Care AG | Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine |
| JP5290753B2 (ja) | 2005-06-17 | 2013-09-18 | ノボ ノルディスク ヘルス ケア アーゲー | 二量体及び多量体ＦＶＩＩａ化合物 |
| CN101263225A (zh) | 2005-08-18 | 2008-09-10 | 诺沃-诺迪斯克保健股份有限公司 | 改进转谷氨酰胺酶的底物特异性 |
| US20090082254A1 (en) | 2006-02-14 | 2009-03-26 | Novo Nordisk A/S | Coupling of Polypeptides at the C-Terminus |
| JP5252458B2 (ja) * | 2006-07-07 | 2013-07-31 | ノボ ノルディスク ヘルス ケア アーゲー | 新規タンパク質コンジュゲート及びその製造方法 |
| CA2672267C (en) | 2006-07-27 | 2016-05-31 | Emisphere Technologies, Inc. | Arylsulfanyl compounds and compositions for delivering active agents |
| JP2010500886A (ja) | 2006-08-18 | 2010-01-14 | ノボ ノルディスク ヘルス ケア アーゲー | 改善された特異性を有するトランスグルタミナーゼ変異体 |
| US20080095837A1 (en) | 2006-08-31 | 2008-04-24 | Emisphere Technologies, Inc. | Human growth hormone formulations |
| BRPI0716261A2 (pt) | 2006-08-31 | 2013-08-06 | Novartis Ag | composiÇÕes farmacÊuticas compreendendo hch para distribuiÇço oral |
| JP5390404B2 (ja) | 2007-02-16 | 2014-01-15 | エミスフェアー・テクノロジーズ・インク | 活性薬剤を送達するための環状部分を有する化合物及び組成物 |
| WO2009030771A1 (en) | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Peptides derivatized with a-b-c-d- and their therapeutical use |
| KR20110039348A (ko) | 2008-08-06 | 2011-04-15 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 연장된 생체내 효능을 가지는 콘쥬게이트된 단백질 |
| ES2561208T3 (es) | 2008-09-12 | 2016-02-25 | Novo Nordisk A/S | Método de acilación de un péptido o una proteína |
| JP5816097B2 (ja) | 2009-01-22 | 2015-11-18 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 安定な成長ホルモン化合物 |
| CN102333788A (zh) * | 2009-02-19 | 2012-01-25 | 诺沃—诺迪斯克有限公司 | 因子viii的修饰 |
-
2009
- 2009-08-06 KR KR1020117003464A patent/KR20110039348A/ko not_active Withdrawn
- 2009-08-06 WO PCT/EP2009/060186 patent/WO2010015668A1/en not_active Ceased
- 2009-08-06 CN CN2009801309611A patent/CN102112157B/zh not_active Expired - Fee Related
- 2009-08-06 MX MX2011000847A patent/MX2011000847A/es active IP Right Grant
- 2009-08-06 JP JP2011521577A patent/JP5977945B2/ja not_active Expired - Fee Related
- 2009-08-06 RU RU2011106573/15A patent/RU2526804C2/ru not_active IP Right Cessation
- 2009-08-06 BR BRPI0917000A patent/BRPI0917000A2/pt not_active IP Right Cessation
- 2009-08-06 AU AU2009279090A patent/AU2009279090A1/en not_active Withdrawn
- 2009-08-06 US US13/055,871 patent/US8865868B2/en not_active Expired - Fee Related
- 2009-08-06 EP EP09781544A patent/EP2323694A1/en not_active Withdrawn
- 2009-08-06 CA CA2733200A patent/CA2733200A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010015668A1 (en) | 2010-02-11 |
| US8865868B2 (en) | 2014-10-21 |
| JP5977945B2 (ja) | 2016-08-24 |
| RU2011106573A (ru) | 2012-09-20 |
| JP2011529948A (ja) | 2011-12-15 |
| CA2733200A1 (en) | 2010-02-11 |
| US20110223151A1 (en) | 2011-09-15 |
| AU2009279090A1 (en) | 2010-02-11 |
| RU2526804C2 (ru) | 2014-08-27 |
| CN102112157B (zh) | 2013-05-29 |
| MX2011000847A (es) | 2011-02-25 |
| KR20110039348A (ko) | 2011-04-15 |
| EP2323694A1 (en) | 2011-05-25 |
| CN102112157A (zh) | 2011-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0917000A2 (pt) | proteínas conjugadas com eficácia in vivo prolongada | |
| SMT201500082B (it) | Coniugati di oligosaccaride-proteina | |
| DK2240595T4 (da) | Glykosyleret proteinekspression i prokaryoter | |
| SI2126093T1 (sl) | Izboljšanje priprave proteinov | |
| BRPI0922989A2 (pt) | Liberação sustentada de nutrientes in vivo | |
| HRP20150485T1 (xx) | ANTITIJELA ZA PROTEIN U KORELACIJI SA OSTEOPLASTOM Siglec | |
| DK3118220T3 (da) | Protein | |
| BRPI0907231A2 (pt) | pirrolpirimidinas e pirrolpiridinas | |
| BRPI1009829A2 (pt) | combinações de proteína de ligação de fator h meningocócico e conjugados de sacarídeos pneumocócicos | |
| EP2487146A4 (en) | hONEYCOMB STRUCTURE | |
| BRPI0916931A2 (pt) | agentes terapêuticos | |
| BRPI0807908A2 (pt) | Melhoramentos em composições medicinais. | |
| DK2280734T3 (da) | Faktor-ix-konjugater med forlængede halveringstider | |
| ATE522136T1 (de) | Wirkstoffsuspensionen in glycerin | |
| EP2165609A4 (en) | MEANS FOR IMPROVED PANSEN FERMENTATION | |
| BRPI0814971A2 (pt) | Proteína | |
| BR112013014115A2 (pt) | conjugados de fornecimento de polinucleotídeos in vivo apresentando ligações enzimáticas sensíveis | |
| BRPI0921947A2 (pt) | formulações de proteína terapêutica | |
| BRPI0721216A2 (pt) | Composições de acetaminofen com efeitos colaterais minimizados e hepatotoxidez reduzida | |
| EP2340271A4 (en) | CONJUGATES OF POLYMER-BIOACTIVE SUBSTANCES | |
| EP2293815A4 (en) | SYNERGISTIC IMMUNOGENIC FUSION PROTEIN POLYSACCHARIDE CONJUGATE | |
| GB2462761B (en) | Protein formulation | |
| GB0816976D0 (en) | Protein | |
| BRPI0909096A2 (pt) | uso de conjugados de interleicna-1 no tratamento de diabetes | |
| BRPI0909302A2 (pt) | redução de plasmídeos de conjugação em bactérias |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25G | Requested change of headquarter approved |
Owner name: NOVO NORDISK HEALTH CARE AG (CH) |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Ipc: A61K 47/54 (2017.01), A61K 47/64 (2017.01), A61P 7 |