BRPI0911991B8 - derivados de 5-hidroximetil-oxazolidin-2-ona para o tratamento de doenças intestinais bacterianas - Google Patents

derivados de 5-hidroximetil-oxazolidin-2-ona para o tratamento de doenças intestinais bacterianas

Info

Publication number
BRPI0911991B8
BRPI0911991B8 BRPI0911991A BRPI0911991A BRPI0911991B8 BR PI0911991 B8 BRPI0911991 B8 BR PI0911991B8 BR PI0911991 A BRPI0911991 A BR PI0911991A BR PI0911991 A BRPI0911991 A BR PI0911991A BR PI0911991 B8 BRPI0911991 B8 BR PI0911991B8
Authority
BR
Brazil
Prior art keywords
treatment
oxazolidin
hydroxymethyl
derivatives
intestinal diseases
Prior art date
Application number
BRPI0911991A
Other languages
English (en)
Inventor
Hubschwerlen Christian
Locher Hans
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40955145&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0911991(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BRPI0911991A2 publication Critical patent/BRPI0911991A2/pt
Publication of BRPI0911991B1 publication Critical patent/BRPI0911991B1/pt
Publication of BRPI0911991B8 publication Critical patent/BRPI0911991B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

derivados de 5-hidroximetil-oxazolidin-2-ona para o tratamento de doenças intestinais bacterianas. a presente invenção se refere a compostos da fórmula i (i) em que a é n ou ch; e n é 0 ou 1; u aos sais famaceuticamente aceitáveis, para a prevenção ou tratamento de doenças intestinais que são causadas por bactérias selecionadas de clostridium difficile, clostridium perfringens, ou staphylococcus aureus.
BRPI0911991A 2008-05-09 2009-05-08 derivados de 5-hidroximetil-oxazolidin-2-ona para o tratamento de doenças intestinais bacterianas BRPI0911991B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IBPCT/IB2008/051854 2008-05-09
IBIB2008/051854 2008-05-09
PCT/IB2009/051896 WO2009136379A1 (en) 2008-05-09 2009-05-08 5-hydroxymethyl-oxazolidin-2-one derivatives for treating bacterial intestinal diseases

Publications (3)

Publication Number Publication Date
BRPI0911991A2 BRPI0911991A2 (pt) 2018-02-27
BRPI0911991B1 BRPI0911991B1 (pt) 2020-09-15
BRPI0911991B8 true BRPI0911991B8 (pt) 2021-05-25

Family

ID=40955145

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0911991A BRPI0911991B8 (pt) 2008-05-09 2009-05-08 derivados de 5-hidroximetil-oxazolidin-2-ona para o tratamento de doenças intestinais bacterianas

Country Status (25)

Country Link
EP (1) EP2296651B1 (pt)
JP (1) JP4819980B2 (pt)
KR (1) KR101283222B1 (pt)
CN (1) CN102014903B (pt)
AR (1) AR071762A1 (pt)
AU (1) AU2009245351B2 (pt)
BR (1) BRPI0911991B8 (pt)
CA (1) CA2723232C (pt)
CY (1) CY1113197T1 (pt)
DK (1) DK2296651T3 (pt)
ES (1) ES2390405T3 (pt)
HK (1) HK1155086A1 (pt)
HR (1) HRP20120791T1 (pt)
IL (1) IL209105A0 (pt)
MA (1) MA32375B1 (pt)
MX (1) MX2010011918A (pt)
MY (1) MY156304A (pt)
NZ (1) NZ589734A (pt)
PL (1) PL2296651T3 (pt)
PT (1) PT2296651E (pt)
RU (1) RU2527769C2 (pt)
SI (1) SI2296651T1 (pt)
TW (1) TWI447115B (pt)
WO (1) WO2009136379A1 (pt)
ZA (1) ZA201008841B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
MXPA05011654A (es) 2003-04-30 2005-12-15 Morphochem Ag Komb Chemie Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones.
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
CN1898238A (zh) 2003-12-18 2007-01-17 莫弗凯姆联合化学股份公司 噁唑烷酮－喹诺酮杂化物抗生素
MX363678B (es) * 2013-05-28 2019-03-29 Morphochem Aktiengesellschaft Fuer Komb Torische Chemie Terapia de combinación que comprende oxazolidinona-quinolonas para usarse en el tratamiento de infecciones bacterianas.
AU2014273510B2 (en) * 2013-05-28 2019-10-10 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibacterials for the parenteral treatment or prophylaxis of bacterial diseases
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1156597A3 (ru) * 1982-04-28 1985-05-15 Е.И.Дюпон Де Немур Энд Компани (Фирма) Способ получени производных 3-( @ -алкилсульфонилфенил)оксазолидинона или их фармацевтически приемлемых кислотно-аддитивных солей
US4461773A (en) * 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
ES2256331T3 (es) * 2000-12-21 2006-07-16 PHARMACIA & UPJOHN COMPANY LLC Derivados de quinolina antimicrobianos y uso de los mismos para tratar infecciones bacterianas.
ES2186550B2 (es) * 2001-06-27 2003-11-16 Vita Lab Nuevos derivados de oxazolidinonas como antibacterianos.
WO2003031443A1 (en) * 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
MXPA05011654A (es) * 2003-04-30 2005-12-15 Morphochem Ag Komb Chemie Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones.
KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
TWI374138B (en) * 2006-11-10 2012-10-11 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-one derivatives

Also Published As

Publication number Publication date
ES2390405T3 (es) 2012-11-12
KR101283222B1 (ko) 2013-07-11
RU2010149994A (ru) 2012-06-20
CA2723232C (en) 2016-08-02
CA2723232A1 (en) 2009-11-12
EP2296651B1 (en) 2012-07-18
TW200948808A (en) 2009-12-01
MY156304A (en) 2016-01-29
JP4819980B2 (ja) 2011-11-24
NZ589734A (en) 2012-11-30
TWI447115B (zh) 2014-08-01
EP2296651A1 (en) 2011-03-23
AU2009245351A1 (en) 2009-11-12
KR20100137569A (ko) 2010-12-30
WO2009136379A1 (en) 2009-11-12
PL2296651T3 (pl) 2012-12-31
BRPI0911991A2 (pt) 2018-02-27
CN102014903A (zh) 2011-04-13
JP2011519914A (ja) 2011-07-14
SI2296651T1 (sl) 2012-10-30
BRPI0911991B1 (pt) 2020-09-15
IL209105A0 (en) 2016-09-29
MA32375B1 (fr) 2011-06-01
CN102014903B (zh) 2013-07-10
MX2010011918A (es) 2010-11-26
AR071762A1 (es) 2010-07-14
ZA201008841B (en) 2012-05-30
PT2296651E (pt) 2012-10-01
HRP20120791T1 (hr) 2012-11-30
HK1155086A1 (en) 2012-05-11
CY1113197T1 (el) 2016-04-13
RU2527769C2 (ru) 2014-09-10
DK2296651T3 (da) 2012-09-24
AU2009245351B2 (en) 2015-01-22

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/09/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/05/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF