BRPI0809446B8 - Método de determinação da presença ou quantidade de glifosato, n-acetilglifosato, ácido n-acetilaminometifosfônico (n-acetil ampa), ou ácido de fosfônico aminometil (ampa) em uma amostra de teste e método de purificação de pelo menos glifosato, n-acetil ampa ou n-acetilglifosato do ampa - Google Patents
Método de determinação da presença ou quantidade de glifosato, n-acetilglifosato, ácido n-acetilaminometifosfônico (n-acetil ampa), ou ácido de fosfônico aminometil (ampa) em uma amostra de teste e método de purificação de pelo menos glifosato, n-acetil ampa ou n-acetilglifosato do ampaInfo
- Publication number
- BRPI0809446B8 BRPI0809446B8 BRPI0809446A BRPI0809446A BRPI0809446B8 BR PI0809446 B8 BRPI0809446 B8 BR PI0809446B8 BR PI0809446 A BRPI0809446 A BR PI0809446A BR PI0809446 A BRPI0809446 A BR PI0809446A BR PI0809446 B8 BRPI0809446 B8 BR PI0809446B8
- Authority
- BR
- Brazil
- Prior art keywords
- ampa
- acetylglyphosate
- glyphosate
- acetyl
- test sample
- Prior art date
Links
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 title abstract 16
- BFECXRMSKVFCNB-UHFFFAOYSA-N 2-[acetyl(phosphonomethyl)amino]acetic acid Chemical compound OC(=O)CN(C(=O)C)CP(O)(O)=O BFECXRMSKVFCNB-UHFFFAOYSA-N 0.000 title abstract 15
- 239000005562 Glyphosate Substances 0.000 title abstract 11
- XDDAORKBJWWYJS-UHFFFAOYSA-N glyphosate Chemical compound OC(=O)CNCP(O)(O)=O XDDAORKBJWWYJS-UHFFFAOYSA-N 0.000 title abstract 11
- 229940097068 glyphosate Drugs 0.000 title abstract 11
- 238000000034 method Methods 0.000 title abstract 8
- 239000002253 acid Substances 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- -1 N-acetyl AMPA Chemical compound 0.000 abstract 10
- 239000002207 metabolite Substances 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 3
- 238000001514 detection method Methods 0.000 abstract 2
- 125000003047 N-acetyl group Chemical group 0.000 abstract 1
- IAANMKMHMYZVOC-UHFFFAOYSA-N aminomethyl dihydrogen phosphate Chemical compound NCOP(O)(O)=O IAANMKMHMYZVOC-UHFFFAOYSA-N 0.000 abstract 1
- 238000001212 derivatisation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C07F9/3813—N-Phosphonomethylglycine; Salts or complexes thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/16—Phosphorus containing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/16—Phosphorus containing
- Y10T436/163333—Organic [e.g., chemical warfare agents, insecticides, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
MÉTODO DE DETERMINAÇÃO DA PRESENÇA OU QUANTIDADE DE GLIFOSATO, N-ACETILGLIFOSATO, ÁCIDO N-ACETILAMINOMETIFOSFÔNICO (N-ACETIL AMPA), OU ÁCIDO DE FOSFÔNICO AMINOMETIL (AMPA) EM UMA AMOSTRA DE TESTE E MÉTODO DE PURIFICAÇÃO DE PELO MENOS GLIFOSATO, N-ACETIL AMPA OU N-ACETILGLIFOSATO DO AMPA A presente invenção fornece vários métodos e composições que permitem a determinação da presença ou da quantidade de glifosato, N-acetilglifosato, N-acetil ou AMPA ou ácido fosfórico aminometil (AMPA) e seus metabólitos em uma variedade de matrizes de teste. Em um método, que determina a presença ou quantidade de N-acetilglifosato e/ou Nacetil AMPA em uma amostra de teste que consiste em fornecer a amostra de teste que contém N-acetilglifosato e/ou N-acetil AMPA; a extração de uma composição que consiste de N-acetilglifosato e/ou N-acetil AMPA da amostra de teste; e, a detecção de N-acetilglifosato e/ou N-acetil AMPA no extrato. Em outros métodos, é determinada a presença ou quantidade de pelo menos um glifosato, N-acetilglifosato, N-acetil AMPA ou ácido fosfônico aminometil (AMPA) ou um de seus metabólitos em uma amostra de teste. O método consiste em fornecer a amostra de teste que contém pelo menos um glifosato, N-acetilglifosato, N-acetil AMPA ou AMPA ou um dos seus metabólitos; em extrair da amostra de uma composição que consiste de pelo menos um glifosato, N-acetilglifosato, N-acetil AMPA ou AMPA ou um dos seus metabólitos, e, em detectar ao menos, um glifosato, N-acetilglifosato, N-acetil AMPA ou AMPA ou um dos seus metabólitos na amostra de teste, onde a detecção do glifosato, N-acetilglifosato, N-acetil AMPA e/ou AMPA ocorre sem derivatização do glifosato, N-acetilglifosato, N-acetil AMPA ou AMPA.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90833607P | 2007-03-27 | 2007-03-27 | |
| US60/908,336 | 2007-03-27 | ||
| US12/051,220 | 2008-03-19 | ||
| US12/051,220 US8003398B2 (en) | 2007-03-27 | 2008-03-19 | Methods and compositions for detecting glyphosate and metabolites thereof |
| PCT/US2008/058104 WO2008118899A1 (en) | 2007-03-27 | 2008-03-25 | Methods and compositions for detecting glyphosate and metabolites thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0809446A2 BRPI0809446A2 (pt) | 2014-09-09 |
| BRPI0809446B1 BRPI0809446B1 (pt) | 2018-12-04 |
| BRPI0809446B8 true BRPI0809446B8 (pt) | 2022-12-06 |
Family
ID=39618945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0809446A BRPI0809446B8 (pt) | 2007-03-27 | 2008-03-25 | Método de determinação da presença ou quantidade de glifosato, n-acetilglifosato, ácido n-acetilaminometifosfônico (n-acetil ampa), ou ácido de fosfônico aminometil (ampa) em uma amostra de teste e método de purificação de pelo menos glifosato, n-acetil ampa ou n-acetilglifosato do ampa |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8003398B2 (pt) |
| EP (1) | EP2124570B1 (pt) |
| CN (1) | CN101646348B (pt) |
| BR (1) | BRPI0809446B8 (pt) |
| CA (1) | CA2679820C (pt) |
| MX (1) | MX2009010256A (pt) |
| WO (1) | WO2008118899A1 (pt) |
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| US20080237458A1 (en) * | 2007-04-02 | 2008-10-02 | Yongdong Wang | Automated mass spectral identification |
| CN101839897B (zh) * | 2009-12-02 | 2013-05-22 | 天津市农业科学院中心实验室 | 大豆和土壤中氯酯磺草胺残留的测定方法 |
| BR112016008489A2 (pt) | 2013-10-18 | 2017-10-03 | Pioneer Hi Bred Int | Sequências de glifosato-n-acetiltransferase (glyat) e métodos de uso |
| CN103529148B (zh) * | 2013-10-21 | 2014-11-05 | 福建出入境检验检疫局检验检疫技术中心 | 食品中草甘膦及其代谢物氨甲基膦酸残留量的检测方法 |
| CN104730186B (zh) * | 2013-12-19 | 2017-01-11 | 勐海茶业有限责任公司 | 茶叶中草甘膦和草铵膦农药残留量的柱前衍生-uplc-esi+-ms/ms检测方法 |
| CN103869028B (zh) * | 2014-03-31 | 2015-04-22 | 中国农业科学院茶叶研究所 | 一种测定茶叶中草甘膦和草胺膦农药的前处理方法 |
| CN105044224B (zh) * | 2015-05-11 | 2017-03-15 | 石家庄瑞凯化工有限公司 | 一种3‑(1‑甲基乙氧基亚磷酰基)‑丙醛的检测方法 |
| CN104977389B (zh) * | 2015-06-29 | 2017-06-13 | 中国科学院东北地理与农业生态研究所 | 基于线虫趋避行为的草甘膦农药检测方法 |
| US10155675B2 (en) | 2015-12-21 | 2018-12-18 | International Business Machines Corporation | Method for removing glyphosate from a solution |
| CN105372353B (zh) * | 2015-12-22 | 2017-09-05 | 厦门出入境检验检疫局检验检疫技术中心 | 一种食品中草甘膦及其代谢物氨甲基膦酸残留量的测定方法 |
| CN107525698A (zh) * | 2016-06-21 | 2017-12-29 | 广州禾信仪器股份有限公司 | 用于单颗粒气溶胶质谱仪性能调试的标准样品及其应用 |
| CN108445133A (zh) * | 2018-04-02 | 2018-08-24 | 杨梅 | 一种检测茶叶中草铵膦和草甘膦药物残留量的方法 |
| CN108680663B (zh) * | 2018-04-26 | 2020-10-30 | 广东省生物工程研究所（广州甘蔗糖业研究所） | 一种甘蔗中草甘膦及其代谢物的检测方法 |
| CN108918709B (zh) * | 2018-07-12 | 2021-05-18 | 河北医科大学 | 一种血液中常见除草剂的筛查、定量检测方法及应用 |
| DE102018130134A1 (de) | 2018-11-28 | 2020-05-28 | Technische Universität Dresden | Verfahren zum Nachweis von Analyten in Proben |
| DE102018130133A1 (de) | 2018-11-28 | 2020-05-28 | Technische Universität Dresden | Verfahren zur Detektion von Analyten auf Basis immobilisierter Proteine |
| CN111487330B (zh) * | 2019-01-29 | 2022-11-18 | 上海安谱实验科技股份有限公司 | 用于多种基质草甘膦及其代谢物的检测方法 |
| ES2787703B2 (es) * | 2019-04-15 | 2022-12-22 | Agrofresh Inc | Aparato y procedimientos para medir, monitorizar y controlar concentraciones quimicas de ingredientes activos en soluciones de tratamiento de plantas y de cultivos de plantas |
| JP7156154B2 (ja) * | 2019-04-18 | 2022-10-19 | 株式会社島津製作所 | 培地処理システム及び培地処理方法 |
| CN110361477B (zh) * | 2019-08-13 | 2021-12-28 | 深圳市深大检测有限公司 | 蔬菜和水果中有机磷农药多残留的测定 |
| CN110646538A (zh) * | 2019-09-29 | 2020-01-03 | 单莉 | 一种基于hplc和spss分析技术的木瓜药材质量评价方法 |
| CN112129857A (zh) * | 2020-09-24 | 2020-12-25 | 上海烟草集团有限责任公司 | 一种全二维液相色谱分析烟草指纹图谱的方法及全二维液相色谱装置和系统 |
| CN114720614B (zh) * | 2020-12-22 | 2024-04-26 | 桂林三金药业股份有限公司 | 一种hplc-cad法检测积雪草苷-b和/或羟基积雪草苷含量的方法 |
| CN113030339B (zh) * | 2021-04-02 | 2022-05-03 | 厦门大学 | 一种适用于不同盐度水体中常见膦酸酯的检测方法 |
| CN114324655B (zh) * | 2021-12-29 | 2024-09-13 | 武汉市农业科学院 | 农产品中草甘膦、草铵膦及氨甲基膦酸残留量的测定方法 |
| CN114740112A (zh) * | 2022-04-06 | 2022-07-12 | 浙江省林业科学研究院 | 一种植物油中草甘膦残留量的提取净化方法 |
| CN115322137B (zh) * | 2022-08-19 | 2024-06-25 | 广电计量检测(福州)有限公司 | 一种用于农残检测的衍生化试剂及其制备方法和应用 |
| CN117783408B (zh) * | 2023-12-28 | 2024-05-14 | 浙江景岳堂药业有限公司 | 一种无花果配方颗粒质量控制方法 |
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| US4517303A (en) * | 1982-10-20 | 1985-05-14 | E. I. Du Pont De Nemours And Company | Specific binding assays utilizing analyte-cytolysin conjugates |
| BR9915435A (pt) * | 1998-11-17 | 2002-02-13 | Monsanto Co | Plantas de metabolização de fosfonato |
| US20030083480A1 (en) * | 2000-10-30 | 2003-05-01 | Maxygen, Inc. | Novel glyphosate N-acetyl transferase (GAT) genes |
| US7462481B2 (en) | 2000-10-30 | 2008-12-09 | Verdia, Inc. | Glyphosate N-acetyltransferase (GAT) genes |
| US20040158526A1 (en) * | 2003-02-06 | 2004-08-12 | David Bogart Dort | Contingency network access for accounts or information |
| EP1620557A2 (en) | 2003-04-29 | 2006-02-01 | Pioneer Hi-Bred International, Inc. | Novel glyphosate-n-acetyltransferase (gat) genes |
| EP1664068A2 (en) | 2003-08-22 | 2006-06-07 | Monsanto Technology, LLC | Process for the preparation of n-phosphono-methylglycine and derivatives thereof |
-
2008
- 2008-03-19 US US12/051,220 patent/US8003398B2/en active Active
- 2008-03-25 BR BRPI0809446A patent/BRPI0809446B8/pt active IP Right Grant
- 2008-03-25 CN CN200880010069.5A patent/CN101646348B/zh active Active
- 2008-03-25 MX MX2009010256A patent/MX2009010256A/es active IP Right Grant
- 2008-03-25 EP EP08744298.4A patent/EP2124570B1/en active Active
- 2008-03-25 CA CA2679820A patent/CA2679820C/en active Active
- 2008-03-25 WO PCT/US2008/058104 patent/WO2008118899A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP2124570A1 (en) | 2009-12-02 |
| EP2124570B1 (en) | 2016-11-16 |
| US20080280370A1 (en) | 2008-11-13 |
| BRPI0809446A2 (pt) | 2014-09-09 |
| CN101646348A (zh) | 2010-02-10 |
| BRPI0809446B1 (pt) | 2018-12-04 |
| US8003398B2 (en) | 2011-08-23 |
| MX2009010256A (es) | 2009-10-19 |
| CN101646348B (zh) | 2014-07-23 |
| CA2679820A1 (en) | 2008-10-02 |
| WO2008118899A1 (en) | 2008-10-02 |
| CA2679820C (en) | 2015-07-14 |
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