BR112015009022A2 - métodos para determinação da abundância de um analito em uma pluralidade de amostras - Google Patents
métodos para determinação da abundância de um analito em uma pluralidade de amostrasInfo
- Publication number
- BR112015009022A2 BR112015009022A2 BR112015009022A BR112015009022A BR112015009022A2 BR 112015009022 A2 BR112015009022 A2 BR 112015009022A2 BR 112015009022 A BR112015009022 A BR 112015009022A BR 112015009022 A BR112015009022 A BR 112015009022A BR 112015009022 A2 BR112015009022 A2 BR 112015009022A2
- Authority
- BR
- Brazil
- Prior art keywords
- analyte
- mass spectrometry
- methods
- quantification
- systems
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
abstract the invention provides mass spectrometry methods, compositions and systems which enable a unique platform for analyte quantitation accessing very high degrees of multiplexing and accurate quantification, particularly well-suited for a range of quantitative analysis for proteomics applications. embodiments of the present methods and systems combine isotopic coding agents characterized by very small differences in molecular mass with mass spectrometry methods providing large resolving power to provide relative or absolute analyte quantification in a large number of samples. ______________________________________________________________________________ resumo patente de invenção: "marcadores de massa codificados por neutron para quantificação de analito". a invenção fornece métodos de espectrometria de massa, composições e sistemas que possibilitam uma plataforma única para a quantificação de analito que acessa graus muito elevados de multiplexação e quantificação acurada, particularmente bem adequados para uma gama de análise quantitativa para aplicações em proteômica. modalidades dos presentes métodos e sistemas combinam agentes que codificadores isotópicos caracterizados por diferenças muito pequenas na massa molecular com métodos de espectrometria de massa que fornecem um grande poder de resolução para fornecer uma quantificação relativa ou absoluta do analito em um grande número de amostras.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/660,677 US9366678B2 (en) | 2012-10-25 | 2012-10-25 | Neutron encoded mass tags for analyte quantification |
US13/660,677 | 2012-10-25 | ||
PCT/US2013/065311 WO2014066117A2 (en) | 2012-10-25 | 2013-10-16 | Neutron encoded mass tags for analyte quantification |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112015009022A2 true BR112015009022A2 (pt) | 2017-11-14 |
BR112015009022B1 BR112015009022B1 (pt) | 2023-03-07 |
Family
ID=49486734
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015009022-2A BR112015009022B1 (pt) | 2012-10-25 | 2013-10-16 | Métodos para determinação da abundância de um analito em uma pluralidade de amostras |
Country Status (8)
Country | Link |
---|---|
US (2) | US9366678B2 (pt) |
EP (1) | EP2912470B1 (pt) |
JP (1) | JP6238375B2 (pt) |
CN (1) | CN107250797B (pt) |
AU (1) | AU2013335048B2 (pt) |
BR (1) | BR112015009022B1 (pt) |
CA (1) | CA2889411C (pt) |
WO (1) | WO2014066117A2 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7939331B2 (en) | 2005-03-07 | 2011-05-10 | Life Technologies Corporation | Isotopically-labeled proteome standards |
GB201901818D0 (en) * | 2010-07-07 | 2019-04-03 | Thermo Fisher Scient Gmbh | Analyte mass spectrometry quantitation using a universal reporter |
US10247711B2 (en) * | 2013-02-13 | 2019-04-02 | Promega Corporation | Quality control reagents and methods |
WO2014197754A1 (en) * | 2013-06-07 | 2014-12-11 | Pierce Biotechnology, Inc. | Absolute quantitation of proteins and protein modifications by mass spectrometry with multiplexed internal standards |
WO2016011355A1 (en) | 2014-07-18 | 2016-01-21 | Thermo Finnigan Llc | Methods for mass spectrometry of mixtures of proteins of polypeptides using proton transfer reaction |
EP3268978A1 (en) * | 2015-03-12 | 2018-01-17 | Thermo Finnigan LLC | Methods for data-dependent mass spectrometry of mixed biomolecular analytes |
EP3347718A4 (en) * | 2015-09-08 | 2019-01-16 | Kinemed, Inc. | MEASUREMENT OF MOLECULAR FLOWS BY QUANTIFICATION OF ISOTOPOLOGIST ABUNDANCES BY HIGH RESOLUTION MASS SPECTROMETRY |
US20170076054A1 (en) * | 2015-09-10 | 2017-03-16 | Iris International, Inc. | Particle analysis systems and methods |
CA2999331A1 (en) * | 2015-10-14 | 2017-04-20 | Wisconsin Alumni Research Foundation | Mass defect-based multiplex dimethyl pyrimidinyl ornithine (dipyro) tags for high-throughput quantitative proteomics and peptidomics |
EP3460481B1 (en) | 2016-01-14 | 2020-09-02 | Thermo Finnigan LLC | Methods for top-down multiplexed mass spectral analysis of mixtures of proteins or polypeptides |
EP3193352A1 (en) | 2016-01-14 | 2017-07-19 | Thermo Finnigan LLC | Methods for mass spectrometric based characterization of biological molecules |
WO2018042454A2 (en) * | 2016-09-01 | 2018-03-08 | Translational Health Science And Technology Institute (Thsti) | Method of hyperplexing in mass spectrometry to elucidate temporal dynamics of proteome |
US10048213B2 (en) * | 2016-10-27 | 2018-08-14 | Raytheon Company | Systems and methods for component identification |
CN108878253B (zh) * | 2017-05-15 | 2020-06-23 | 株式会社岛津制作所 | 质谱数据采集方法 |
WO2020041042A1 (en) * | 2018-08-21 | 2020-02-27 | The Board Of Trustees Of The Leland Stanford Junior University | Isotopically-encoded nanoparticles for multimodal high-order multiplexed detection and imaging |
US11232936B2 (en) * | 2020-05-28 | 2022-01-25 | Thermo Finnigan Llc | Absolute quantitation of a target analyte using a mass spectrometer |
EP4334714A1 (en) * | 2021-05-07 | 2024-03-13 | Donald Danforth Plant Science Center | Amplification and detection of compound signals |
CN113252818B (zh) * | 2021-07-07 | 2021-10-26 | 裕菁科技(上海)有限公司 | 一种采用基准样品对同系列化合物进行定量和评价的方法 |
CN115662500B (zh) * | 2022-10-21 | 2023-06-20 | 清华大学 | 通过计算机模拟替换相近质量同位素区分聚糖结构异构体的方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0006141D0 (en) | 2000-03-14 | 2000-05-03 | Brax Group Ltd | Mass labels |
US20020090652A1 (en) * | 2000-12-22 | 2002-07-11 | Fu Emil Wei-Ming | Inverse labeling method for the rapid identification of marker/target proteins |
WO2003053910A1 (fr) * | 2001-12-19 | 2003-07-03 | Japan Science And Technology Agency | Amino acide marque par isotope stable, technique d'integration de cet amino acide dans une proteine cible, technique d'analyse structurelle par irm de proteine et technique de production d'acide fumarique et d'acide tartrique marques par isotope stable a selection de site |
EP1546364A4 (en) * | 2002-07-30 | 2006-09-06 | Univ California | METHOD FOR THE LARGE-SCALE AUTOMATIC MEASUREMENT OF PROTEOMIC OR ORGANOMOMIC MOLECULAR FLOW RATES BY MASS SPECTROMETRY |
EP2186879B1 (en) * | 2002-10-03 | 2016-11-23 | Norman Leigh Anderson | High sensitivity quantitation of peptides by mass spectrometry |
US7799576B2 (en) | 2003-01-30 | 2010-09-21 | Dh Technologies Development Pte. Ltd. | Isobaric labels for mass spectrometric analysis of peptides and method thereof |
EP1636822A2 (en) | 2003-05-15 | 2006-03-22 | Electrophoretics Limited | Mass spectrometry |
US20050147982A1 (en) | 2004-01-05 | 2005-07-07 | Applera Corporation | Mixtures of isobarically labeled analytes and fragments ions derived therefrom |
US20050148087A1 (en) | 2004-01-05 | 2005-07-07 | Applera Corporation | Isobarically labeled analytes and fragment ions derived therefrom |
US20050147985A1 (en) | 2004-01-05 | 2005-07-07 | Applera Corporation | Mixtures of isobarically labeled analytes and fragments ions derived therefrom |
US20070048752A1 (en) | 2004-07-12 | 2007-03-01 | Applera Corporation | Mass tags for quantitative analyses |
EP1776588A1 (en) | 2004-07-12 | 2007-04-25 | Applera Corporation | Mass tags for quantitative analyses |
US7939331B2 (en) | 2005-03-07 | 2011-05-10 | Life Technologies Corporation | Isotopically-labeled proteome standards |
GB0515323D0 (en) | 2005-07-26 | 2005-08-31 | Electrophoretics Ltd | Mass labels |
GB0518585D0 (en) | 2005-09-12 | 2005-10-19 | Electrophoretics Ltd | Mass labels |
US8975404B2 (en) | 2006-01-24 | 2015-03-10 | Dh Technologies Development Pte. Ltd. | Labeling reagents for analyte determination and methods and compounds used in making the same |
US8362242B2 (en) | 2006-06-30 | 2013-01-29 | Dh Technologies Development Pte. Ltd. | Analyte determination utilizing mass tagging reagents comprising a non-encoded detectable label |
US7906341B2 (en) | 2006-06-30 | 2011-03-15 | Dh Technologies Development Pte, Ltd. | Methods, mixtures, kits and compositions pertaining to analyte determination |
US20080113441A1 (en) | 2006-11-14 | 2008-05-15 | Ron Orlando | Isobaric labeling and methods of use thereof |
GB0704764D0 (en) | 2007-03-12 | 2007-04-18 | Electrophoretics Ltd | Isobarically labelled reagents and methods of their use |
CN101910841A (zh) * | 2007-10-29 | 2010-12-08 | 佐治亚大学研究基金会 | 用于定量糖组学的体内同位素标记方法 |
GB0809488D0 (en) | 2008-05-23 | 2008-07-02 | Electrophoretics Ltd | Mass spectrometric analysis |
CA2750076A1 (en) | 2009-01-26 | 2010-07-29 | Electrophoretics Limited | Methods |
WO2010086697A1 (en) | 2009-01-30 | 2010-08-05 | Bio-Rad Pasteur | Method for the in vitro diagnosis of stroke |
-
2012
- 2012-10-25 US US13/660,677 patent/US9366678B2/en active Active
-
2013
- 2013-10-16 JP JP2015539662A patent/JP6238375B2/ja active Active
- 2013-10-16 BR BR112015009022-2A patent/BR112015009022B1/pt active IP Right Grant
- 2013-10-16 CN CN201380068114.3A patent/CN107250797B/zh active Active
- 2013-10-16 AU AU2013335048A patent/AU2013335048B2/en active Active
- 2013-10-16 EP EP13783212.7A patent/EP2912470B1/en active Active
- 2013-10-16 CA CA2889411A patent/CA2889411C/en active Active
- 2013-10-16 WO PCT/US2013/065311 patent/WO2014066117A2/en active Application Filing
-
2016
- 2016-05-13 US US15/154,514 patent/US11333669B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN107250797B (zh) | 2019-08-06 |
US20140120565A1 (en) | 2014-05-01 |
BR112015009022B1 (pt) | 2023-03-07 |
US9366678B2 (en) | 2016-06-14 |
WO2014066117A3 (en) | 2014-07-03 |
AU2013335048A1 (en) | 2015-04-30 |
CN107250797A (zh) | 2017-10-13 |
JP6238375B2 (ja) | 2017-11-29 |
US20160305953A1 (en) | 2016-10-20 |
US11333669B2 (en) | 2022-05-17 |
CA2889411C (en) | 2022-05-03 |
AU2013335048B2 (en) | 2019-05-30 |
EP2912470A2 (en) | 2015-09-02 |
EP2912470B1 (en) | 2018-11-21 |
WO2014066117A2 (en) | 2014-05-01 |
CA2889411A1 (en) | 2014-05-01 |
JP2016501009A (ja) | 2016-01-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112015009022A2 (pt) | métodos para determinação da abundância de um analito em uma pluralidade de amostras | |
BR112014025246A8 (pt) | método para classificação de uma amostra em uma de pelo menos duas classes com base em dados espectrais, método para criar um banco de dados para uso na classificação de uma amostra em uma de pelo menos duas classes com base em dados espectrais, programa de computador, meio de armazenagem de dados, e sistema para classificar uma amostra com base em dados espectrais | |
BR112019006196A2 (pt) | filtros de interpolação melhorados para intrapredição em codificação de vídeo | |
BR112017025097A2 (pt) | método para quantificação espectrométrica de massa de analitos extraídos de um dispositivo de microamostragem | |
BR112015032123A8 (pt) | método, um ou mais meios de armazenamento não-transitório legível por computador e sistema | |
BR112012008347A2 (pt) | posição ótica e/ou percepção de formato | |
BR112015023894A2 (pt) | sistema e método para determinação de propriedades de uma amostra | |
BR112016005064A2 (pt) | método para avaliar os efeitos de uma composição compreendendo microrganismos em microbiota intestinal | |
BR112014030298A2 (pt) | ensaios multiplexados baseados em aptâmero | |
BR112014026503A2 (pt) | método e sistema de monitorar mancais | |
BR112015022788A2 (pt) | sistema de determinação de emoção de contexto | |
BR112012008537A2 (pt) | processo de caracterização de pelo menos um micro-organismo por espectrometria de massa | |
AR092929A1 (es) | Codificador, decodificador y metodos para la transformacion de ampliacion por acercamiento dependiente de señales en la codificacion espacial de objetos de audio | |
BRPI0509068A (pt) | métodos para determinar quantitativamente heparinas de constituição especìfica ou heparinas de baixo peso molecular usando hplc | |
BR112016010510A2 (pt) | método, arranjo e uso do mesmo | |
BR112014019168A2 (pt) | ensaio capaz de detectar de forma não degenerada presença ou ausência de analitos em um único volume de amostra, bem como método de detecção da presença ou ausência de analito dentre uma pluralidade dos mesmos | |
BR112012031860A8 (pt) | Método para detecção de um alvo biológico em um ensaio de afinidade, disposição de detecção para um alvo biológico e porção de captura para uso em um método | |
BR112016004324A2 (pt) | anticorpos | |
BR112015024780A2 (pt) | metodo para determinar radiosensibilidade | |
ATE551055T1 (de) | Nachweis von succinylaceton | |
BR112013007871A2 (pt) | quantificação e caracterização de alérgenos | |
BR112014012366A2 (pt) | processos para a detecção de triiodotironina inversa por espectrometria de massa | |
BR112018013298A2 (pt) | método para a detecção e quantificação de oxigênio em compostos oxidáveis | |
BR112012010273A2 (pt) | composição, dispositivo, método e artigo para detecção de um analito em uma amostra por leitura óptica colorimétrica, e, uso da composição | |
BR112013032808A2 (pt) | método e sistema de mensuração de superfície |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/10/2013, OBSERVADAS AS CONDICOES LEGAIS |