BRPI0718989A2 - Ablação genética de células com gene prp usando uma estratégia de captura de promotor direcionada para a produção de proteínas recombinantes isentas de soro como produtos terapêuticos. - Google Patents
Ablação genética de células com gene prp usando uma estratégia de captura de promotor direcionada para a produção de proteínas recombinantes isentas de soro como produtos terapêuticos. Download PDFInfo
- Publication number
- BRPI0718989A2 BRPI0718989A2 BRPI0718989-3A2A BRPI0718989A BRPI0718989A2 BR PI0718989 A2 BRPI0718989 A2 BR PI0718989A2 BR PI0718989 A BRPI0718989 A BR PI0718989A BR PI0718989 A2 BRPI0718989 A2 BR PI0718989A2
- Authority
- BR
- Brazil
- Prior art keywords
- prp
- cells
- human
- cell line
- free
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0686—Kidney cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C12N2500/92—Medium free of human- or animal-derived components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C12N2500/95—Protein-free medium and culture conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06124427.3 | 2006-11-20 | ||
| EP06124427 | 2006-11-20 | ||
| PCT/EP2007/062597 WO2008061995A2 (en) | 2006-11-20 | 2007-11-20 | Genetic ablation of the prp gene cells using a targeted promoter trap strategy for production of serum-free recombinant proteins as therapeuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0718989A2 true BRPI0718989A2 (pt) | 2014-02-11 |
Family
ID=37685785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0718989-3A2A BRPI0718989A2 (pt) | 2006-11-20 | 2007-11-20 | Ablação genética de células com gene prp usando uma estratégia de captura de promotor direcionada para a produção de proteínas recombinantes isentas de soro como produtos terapêuticos. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2084269A2 (no) |
| KR (1) | KR20090106474A (no) |
| CN (1) | CN101605891A (no) |
| AU (1) | AU2007324530A1 (no) |
| BR (1) | BRPI0718989A2 (no) |
| CA (1) | CA2670003A1 (no) |
| IL (1) | IL198770A0 (no) |
| MX (1) | MX2009005277A (no) |
| NO (1) | NO20091875L (no) |
| RU (1) | RU2009123458A (no) |
| WO (1) | WO2008061995A2 (no) |
| ZA (1) | ZA200903429B (no) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2800610C (en) * | 2010-05-12 | 2019-09-24 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| CN102277379B (zh) * | 2011-08-18 | 2013-07-24 | 中国科学院遗传与发育生物学研究所 | 表达凝血因子viii的表达载体及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| SG47979A1 (en) * | 1991-11-14 | 1998-04-17 | Charles Weissman | Transgenic animals lacking prion proteins |
| ES2253000T3 (es) * | 1998-12-22 | 2006-05-16 | The Regents Of The University Of California | Celulas somaticas con gen prp alterado y sus metodos de utilizacion. |
| JP2003528620A (ja) * | 2000-03-24 | 2003-09-30 | ユニバシティ オブ マサチューセッツ、ア パブリック インスチチユーション オブ ハイアー エデュケイション オブ ザ コモンウエルス オブ マサチューセッツ、アズ リプリゼンテッド バイ イッツ アマースト キャンパス | プリオンのないトランスジェニック有蹄類 |
| AU2002242854A1 (en) * | 2001-03-21 | 2002-10-03 | Geron Corporation | Use of telomerase reverse transcriptase to create homozygous knockout animals |
-
2007
- 2007-11-20 EP EP07847234A patent/EP2084269A2/en not_active Withdrawn
- 2007-11-20 CA CA002670003A patent/CA2670003A1/en not_active Abandoned
- 2007-11-20 RU RU2009123458/10A patent/RU2009123458A/ru not_active Application Discontinuation
- 2007-11-20 CN CNA2007800466531A patent/CN101605891A/zh active Pending
- 2007-11-20 BR BRPI0718989-3A2A patent/BRPI0718989A2/pt not_active Application Discontinuation
- 2007-11-20 MX MX2009005277A patent/MX2009005277A/es not_active Application Discontinuation
- 2007-11-20 KR KR1020097012589A patent/KR20090106474A/ko not_active Application Discontinuation
- 2007-11-20 AU AU2007324530A patent/AU2007324530A1/en not_active Abandoned
- 2007-11-20 WO PCT/EP2007/062597 patent/WO2008061995A2/en active Search and Examination
-
2009
- 2009-05-13 NO NO20091875A patent/NO20091875L/no not_active Application Discontinuation
- 2009-05-14 IL IL198770A patent/IL198770A0/en unknown
- 2009-05-19 ZA ZA200903429A patent/ZA200903429B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008061995A2 (en) | 2008-05-29 |
| AU2007324530A1 (en) | 2008-05-29 |
| KR20090106474A (ko) | 2009-10-09 |
| NO20091875L (no) | 2009-07-28 |
| ZA200903429B (en) | 2010-04-28 |
| CA2670003A1 (en) | 2008-05-29 |
| WO2008061995A3 (en) | 2008-07-10 |
| RU2009123458A (ru) | 2010-12-27 |
| MX2009005277A (es) | 2009-05-28 |
| CN101605891A (zh) | 2009-12-16 |
| IL198770A0 (en) | 2011-08-01 |
| EP2084269A2 (en) | 2009-08-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101320489B1 (ko) | 인간 세포주에서 재조합 인간 단백질의 무혈청의 안정한형질감염 및 생산 | |
| KR20230091894A (ko) | 부위 특이적 표적화 요소를 통한 프로그램 가능한 첨가(paste)를 사용하는 부위 특이적 유전 공학을 위한 시스템, 방법, 및 조성물 | |
| KR20210056329A (ko) | 신규 cas12b 효소 및 시스템 | |
| KR102516697B1 (ko) | 조작된 캐스케이드 구성성분 및 캐스케이드 복합체 | |
| KR20090122465A (ko) | 염증성 질환의 치료 | |
| KR102652494B1 (ko) | 전장 t-세포 수용체 오픈 리딩 프레임의 신속한 조립 및 다양화를 위한 2-성분 벡터 라이브러리 시스템 | |
| EA030440B1 (ru) | Сопровождающая диагностика для терапии антигиалуронановым агентом и способы ее применения | |
| KR102614328B1 (ko) | T-세포 수용체 합성 및 tcr-제시 세포에 대한 안정적인 게놈 통합을 위한 2-부분 디바이스 | |
| KR101921698B1 (ko) | 재조합에 의해 제조된 인간 인자 ⅷ 및 ⅸ | |
| CN110684804B (zh) | 递送外源rnp的慢病毒载体及其制备方法 | |
| KR20100049084A (ko) | 질병 진단을 위한 방법 및 조성물 | |
| KR20220047623A (ko) | 세포 유형 운명 특정화의 조절인자를 확인하기 위한 조성물 및 방법 | |
| KR20160002880A (ko) | 엔도솜 포집을 극복하기 위해 설계된 인공 전사 인자 | |
| JP2024037917A (ja) | 組換えｔ細胞受容体遺伝子を用いて細胞ベースの治療薬を製造するための技法 | |
| CN110042124A (zh) | 基因组碱基编辑增加人红细胞中胎儿血红蛋白水平的试剂盒及应用 | |
| CN111094569A (zh) | 光控性病毒蛋白质、其基因及包含该基因的病毒载体 | |
| CN101657097A (zh) | 以炎症为特征的疾病的治疗 | |
| CN113474453B (zh) | 用于治疗iv a型粘多糖的腺相关病毒载体 | |
| KR20160003691A (ko) | Opa1 단상부족에 의해 원인이 되는 질병 치료를 위한 인공전사인자 | |
| BRPI0718989A2 (pt) | Ablação genética de células com gene prp usando uma estratégia de captura de promotor direcionada para a produção de proteínas recombinantes isentas de soro como produtos terapêuticos. | |
| US11814412B2 (en) | Artificial proteins and compositions and methods thereof | |
| KR20240022571A (ko) | Rna-가이드된 이펙터 동원을 위한 시스템, 방법 및 성분 | |
| KR20240029020A (ko) | Dna 변형을 위한 crispr-트랜스포손 시스템 | |
| CN116670157A (zh) | 用于抗淋病奈瑟球菌的疫苗接种的组合物和方法 | |
| CN114058607B (zh) | 一种用于c到u碱基编辑的融合蛋白及其制备方法和应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |