ZA200903429B - Genetic ablation of the PrP gene cells using a targeted promoter trap strategy for production of serum-free recombinant proteins as therapeuticals - Google Patents
Genetic ablation of the PrP gene cells using a targeted promoter trap strategy for production of serum-free recombinant proteins as therapeuticalsInfo
- Publication number
- ZA200903429B ZA200903429B ZA200903429A ZA200903429A ZA200903429B ZA 200903429 B ZA200903429 B ZA 200903429B ZA 200903429 A ZA200903429 A ZA 200903429A ZA 200903429 A ZA200903429 A ZA 200903429A ZA 200903429 B ZA200903429 B ZA 200903429B
- Authority
- ZA
- South Africa
- Prior art keywords
- therapeuticals
- serum
- production
- recombinant proteins
- prp gene
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0686—Kidney cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C12N2500/92—Medium free of human- or animal-derived components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C12N2500/95—Protein-free medium and culture conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06124427 | 2006-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200903429B true ZA200903429B (en) | 2010-04-28 |
Family
ID=37685785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200903429A ZA200903429B (en) | 2006-11-20 | 2009-05-19 | Genetic ablation of the PrP gene cells using a targeted promoter trap strategy for production of serum-free recombinant proteins as therapeuticals |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2084269A2 (en) |
| KR (1) | KR20090106474A (en) |
| CN (1) | CN101605891A (en) |
| AU (1) | AU2007324530A1 (en) |
| BR (1) | BRPI0718989A2 (en) |
| CA (1) | CA2670003A1 (en) |
| IL (1) | IL198770A0 (en) |
| MX (1) | MX2009005277A (en) |
| NO (1) | NO20091875L (en) |
| RU (1) | RU2009123458A (en) |
| WO (1) | WO2008061995A2 (en) |
| ZA (1) | ZA200903429B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011143299A2 (en) * | 2010-05-12 | 2011-11-17 | Centocor Ortho Biotech Inc. | Differentiation of human embryonic stem cells |
| CN102277379B (en) * | 2011-08-18 | 2013-07-24 | 中国科学院遗传与发育生物学研究所 | Expression vector for expressing coagulation factor VIII and application thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| EP0613495B1 (en) * | 1991-11-14 | 2005-02-02 | WEISSMANN, Charles | Transgenic non-human animals lacking prion proteins |
| NZ512309A (en) * | 1998-12-22 | 2003-05-30 | Univ California | Prion-free therapeutic formulations produced from somatic cells with an artificially altered prion protein (PrP) gene |
| NZ521426A (en) * | 2000-03-24 | 2004-07-30 | Univ Massachusetts | Prion-free transgenic ungulates that bear a homozygous deletion or disruption of the prion gene |
| WO2002074935A2 (en) * | 2001-03-21 | 2002-09-26 | Geron Corporation | Use of telomerase reverse transcriptase to create homozygous knockout animals |
-
2007
- 2007-11-20 CA CA002670003A patent/CA2670003A1/en not_active Abandoned
- 2007-11-20 CN CNA2007800466531A patent/CN101605891A/en active Pending
- 2007-11-20 AU AU2007324530A patent/AU2007324530A1/en not_active Abandoned
- 2007-11-20 MX MX2009005277A patent/MX2009005277A/en not_active Application Discontinuation
- 2007-11-20 BR BRPI0718989-3A2A patent/BRPI0718989A2/en not_active Application Discontinuation
- 2007-11-20 WO PCT/EP2007/062597 patent/WO2008061995A2/en active Search and Examination
- 2007-11-20 EP EP07847234A patent/EP2084269A2/en not_active Withdrawn
- 2007-11-20 KR KR1020097012589A patent/KR20090106474A/en not_active Application Discontinuation
- 2007-11-20 RU RU2009123458/10A patent/RU2009123458A/en not_active Application Discontinuation
-
2009
- 2009-05-13 NO NO20091875A patent/NO20091875L/en not_active Application Discontinuation
- 2009-05-14 IL IL198770A patent/IL198770A0/en unknown
- 2009-05-19 ZA ZA200903429A patent/ZA200903429B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0718989A2 (en) | 2014-02-11 |
| AU2007324530A1 (en) | 2008-05-29 |
| WO2008061995A2 (en) | 2008-05-29 |
| CA2670003A1 (en) | 2008-05-29 |
| NO20091875L (en) | 2009-07-28 |
| EP2084269A2 (en) | 2009-08-05 |
| IL198770A0 (en) | 2011-08-01 |
| CN101605891A (en) | 2009-12-16 |
| RU2009123458A (en) | 2010-12-27 |
| MX2009005277A (en) | 2009-05-28 |
| KR20090106474A (en) | 2009-10-09 |
| WO2008061995A3 (en) | 2008-07-10 |
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