NO20091875L - Genetisk ablasjon av PRP genceller ved anvendelse av en malsokt strategi for produksjon av serum - Google Patents
Genetisk ablasjon av PRP genceller ved anvendelse av en malsokt strategi for produksjon av serumInfo
- Publication number
- NO20091875L NO20091875L NO20091875A NO20091875A NO20091875L NO 20091875 L NO20091875 L NO 20091875L NO 20091875 A NO20091875 A NO 20091875A NO 20091875 A NO20091875 A NO 20091875A NO 20091875 L NO20091875 L NO 20091875L
- Authority
- NO
- Norway
- Prior art keywords
- smelly
- prp gene
- genetic ablation
- production strategy
- gene cells
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0686—Kidney cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C12N2500/92—Medium free of human- or animal-derived components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C12N2500/95—Protein-free medium and culture conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Foreliggende oppfinnelse tilveiebringer en prionprotein (PrP)-fri immortalisert somatisk human cellelinje hvor begge allelene av PrP-genet har blitt fullstendig deletert ved homolog rekombinasjon. Oppfinnelsen tilveiebringer videre en fremgangsmåte for fremstilling av nevnte cellelinje og anvendelse derav for fremstilling av humane rekombinante proteiner som er egnet som biofarmasøytiske midler.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06124427 | 2006-11-20 | ||
PCT/EP2007/062597 WO2008061995A2 (en) | 2006-11-20 | 2007-11-20 | Genetic ablation of the prp gene cells using a targeted promoter trap strategy for production of serum-free recombinant proteins as therapeuticals |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20091875L true NO20091875L (no) | 2009-07-28 |
Family
ID=37685785
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20091875A NO20091875L (no) | 2006-11-20 | 2009-05-13 | Genetisk ablasjon av PRP genceller ved anvendelse av en malsokt strategi for produksjon av serum |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP2084269A2 (no) |
KR (1) | KR20090106474A (no) |
CN (1) | CN101605891A (no) |
AU (1) | AU2007324530A1 (no) |
BR (1) | BRPI0718989A2 (no) |
CA (1) | CA2670003A1 (no) |
IL (1) | IL198770A0 (no) |
MX (1) | MX2009005277A (no) |
NO (1) | NO20091875L (no) |
RU (1) | RU2009123458A (no) |
WO (1) | WO2008061995A2 (no) |
ZA (1) | ZA200903429B (no) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2728900T3 (es) * | 2010-05-12 | 2019-10-29 | Janssen Biotech Inc | Diferenciación de células madre embrionarias humanas |
CN102277379B (zh) * | 2011-08-18 | 2013-07-24 | 中国科学院遗传与发育生物学研究所 | 表达凝血因子viii的表达载体及其应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
ATE288484T1 (de) * | 1991-11-14 | 2005-02-15 | Charles Weissmann | Transgene nicht-menschliche tiere ohne prionprotein |
NZ512309A (en) * | 1998-12-22 | 2003-05-30 | Univ California | Prion-free therapeutic formulations produced from somatic cells with an artificially altered prion protein (PrP) gene |
AU2001247773A1 (en) * | 2000-03-24 | 2001-10-08 | University Of Massachusetts, As Represented By Its Amherst Campus | Prion-free transgenic ungulates |
AU2002242854A1 (en) * | 2001-03-21 | 2002-10-03 | Geron Corporation | Use of telomerase reverse transcriptase to create homozygous knockout animals |
-
2007
- 2007-11-20 BR BRPI0718989-3A2A patent/BRPI0718989A2/pt not_active Application Discontinuation
- 2007-11-20 WO PCT/EP2007/062597 patent/WO2008061995A2/en active Search and Examination
- 2007-11-20 CN CNA2007800466531A patent/CN101605891A/zh active Pending
- 2007-11-20 AU AU2007324530A patent/AU2007324530A1/en not_active Abandoned
- 2007-11-20 RU RU2009123458/10A patent/RU2009123458A/ru not_active Application Discontinuation
- 2007-11-20 KR KR1020097012589A patent/KR20090106474A/ko not_active Application Discontinuation
- 2007-11-20 EP EP07847234A patent/EP2084269A2/en not_active Withdrawn
- 2007-11-20 MX MX2009005277A patent/MX2009005277A/es not_active Application Discontinuation
- 2007-11-20 CA CA002670003A patent/CA2670003A1/en not_active Abandoned
-
2009
- 2009-05-13 NO NO20091875A patent/NO20091875L/no not_active Application Discontinuation
- 2009-05-14 IL IL198770A patent/IL198770A0/en unknown
- 2009-05-19 ZA ZA200903429A patent/ZA200903429B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
WO2008061995A2 (en) | 2008-05-29 |
CA2670003A1 (en) | 2008-05-29 |
RU2009123458A (ru) | 2010-12-27 |
EP2084269A2 (en) | 2009-08-05 |
KR20090106474A (ko) | 2009-10-09 |
IL198770A0 (en) | 2011-08-01 |
WO2008061995A3 (en) | 2008-07-10 |
AU2007324530A1 (en) | 2008-05-29 |
MX2009005277A (es) | 2009-05-28 |
CN101605891A (zh) | 2009-12-16 |
BRPI0718989A2 (pt) | 2014-02-11 |
ZA200903429B (en) | 2010-04-28 |
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