BRPI0706379A2 - tratamento de hepatite viral - Google Patents
tratamento de hepatite viral Download PDFInfo
- Publication number
- BRPI0706379A2 BRPI0706379A2 BRPI0706379-2A BRPI0706379A BRPI0706379A2 BR PI0706379 A2 BRPI0706379 A2 BR PI0706379A2 BR PI0706379 A BRPI0706379 A BR PI0706379A BR PI0706379 A2 BRPI0706379 A2 BR PI0706379A2
- Authority
- BR
- Brazil
- Prior art keywords
- interferon
- patient
- compound
- nitazoxanide
- treatment
- Prior art date
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- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/US2007/000574 WO2007081974A2 (en) | 2006-01-09 | 2007-01-09 | Viral hepatitis treatment |
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| EP1976516B9 (en) | 2006-01-09 | 2013-10-30 | Romark Laboratories, L.C. | Viral hepatitis treatment |
| CN101820887A (zh) * | 2007-07-25 | 2010-09-01 | 拜奥雷克斯治疗公司 | 干扰素控释药品以及使用相同药品治疗hcv感染 |
| HUE049501T2 (hu) | 2009-02-13 | 2020-09-28 | Romark Laboratories Lc | Nitazoxanidot tartalmazó szabályozott felszabadulású gyógyszerkészítmény |
| EP2408770B1 (en) | 2009-03-20 | 2014-11-05 | University Of Virginia Patent Foundation | Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials |
| PE20121118A1 (es) | 2009-05-12 | 2012-09-05 | Romark Lab Lc | Compuestos de haloalquil heteroaril benzamida |
| US9023877B2 (en) | 2009-06-26 | 2015-05-05 | Romark Laboratories L.C. | Compounds and methods for treating influenza |
| EP2632460B1 (en) | 2010-09-20 | 2018-02-28 | University of Virginia Patent Foundation | Thiophene derivatives for use in the treatment of tuberculosis |
| MX378726B (es) * | 2011-05-16 | 2025-03-11 | Romark Laboratories Lc | Uso de compuestos de tiazolida para la prevencion y tratamiento de enfermedades virales, cancer y enfermedades causadas por infecciones intracelulares. |
| CN102805747B (zh) * | 2011-06-01 | 2013-09-18 | 漳州片仔癀药业股份有限公司 | 2-(4-吗啉苯胺)-6-环己基氨基嘌呤及其药学上可接受的盐在制药中的用途 |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| ES2529143B1 (es) | 2011-10-21 | 2015-10-26 | Abbvie Inc. | Combinación de al menos dos agentes antivirales de acción directa, ribavirina pero no interferón para uso de tratamiento del vhc |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| CH707030B1 (de) | 2011-10-21 | 2015-03-13 | Abbvie Inc | Kombinationsbehandlung von DAAs zur Verwendung in der Behandlung von HCV |
| EP2808019B1 (en) | 2012-01-27 | 2019-09-25 | Siegfried Rhein S.A. De C.V. | Improved nitazoxanide composition and preparation method thereof |
| MX2017006083A (es) | 2014-11-11 | 2017-11-08 | Romark Laboratories Lc | Composicones y metodos de tratamiento con profarmacos de tizoxanida, un analogo o sal de la misma. |
| US20180098972A1 (en) | 2015-01-26 | 2018-04-12 | Children's Medical Center Corporation | Treatment of infectious diseases |
| EP3436074B1 (en) | 2016-03-31 | 2020-06-10 | Romark Laboratories, L.C. | Thiazolide compounds for treating viral infections |
| WO2017178174A1 (en) * | 2016-04-11 | 2017-10-19 | Genfit | Methods of treatment of cholestasis and fibrosis |
| ES2928408T3 (es) | 2016-04-11 | 2022-11-17 | Genfit | Métodos para el tratamiento de enfermedades fibróticas |
| EP3448392A4 (en) | 2016-04-28 | 2020-01-15 | Emory University | ALKYNOUS THERAPEUTIC NUCLEOTIDE AND NUCLEOSIDE COMPOSITIONS AND RELATED APPLICATIONS |
| WO2018140504A1 (en) | 2017-01-24 | 2018-08-02 | Patel Manoj K | Compositions and methods for blocking sodium channels |
| US11033534B2 (en) * | 2017-01-27 | 2021-06-15 | Genfit | Pharmaceutical compositions for combination therapy |
| US11191749B2 (en) * | 2017-03-13 | 2021-12-07 | Genfit | Pharmaceutical compositions for combination therapy |
| US11173149B2 (en) | 2017-04-18 | 2021-11-16 | Romark Laboratories L.C. | Inhibition of protein disulfide-isomerase A3 |
| WO2019097050A1 (en) * | 2017-11-17 | 2019-05-23 | Köster | [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl]ethanoate for use in lymphangioleiomyomatosis and other diseases |
| CN109364067B (zh) * | 2018-11-17 | 2020-07-28 | 王海玲 | 一种化合物在制备提高血脑屏障通透性药物中的用途 |
| WO2020208044A1 (en) * | 2019-04-09 | 2020-10-15 | Genfit | Combination of nitazoxanide and elafibranor for the treatment of immune diseases or inflammation |
| WO2021016543A1 (en) * | 2019-07-25 | 2021-01-28 | Romark Laboratories L.C. | Antiviral combinations of thiazolide compounds |
| CN111012788B (zh) * | 2019-12-12 | 2021-01-15 | 武汉职业技术学院 | 硝唑尼特和替唑尼特在制备抗猪繁殖与呼吸综合征病毒药物中的应用 |
| US20230303504A1 (en) | 2020-07-20 | 2023-09-28 | Romark Laboratories, L.C. | Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine |
| KR20230098780A (ko) | 2020-08-24 | 2023-07-04 | 로마크 레버러토리즈, 엘.씨. | 코로나바이러스에 대한 티아졸리드의 용도 |
| CN114259492A (zh) * | 2021-12-21 | 2022-04-01 | 中以海德人工智能药物研发股份有限公司 | 硝唑尼特在治疗乙肝中的应用 |
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| GB1440212A (en) * | 1973-08-29 | 1976-06-23 | Phavic Sprl | Derivatives of 2-phenoxyacetamido-5-nitrothiazoles |
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| US5387598A (en) * | 1994-04-13 | 1995-02-07 | Rossignol; Jean-Francois | Composition and galenic formulation suitable for combatting affections of the lower abdomen |
| CN1072654C (zh) * | 1994-04-13 | 2001-10-10 | 让-弗兰克伊斯·罗西格诺尔 | 苯甲酰胺衍生物,含所述衍生物的组合物及它们的用途 |
| US5578621A (en) * | 1994-09-08 | 1996-11-26 | Romark Lab Lc | Benzamide derivatives |
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| US5859038A (en) * | 1994-09-08 | 1999-01-12 | Romark Laboratories, L.C. | Method for treatment of helicobacter pylori infections |
| MX9604483A (es) * | 1994-09-08 | 1998-02-28 | Jean-Francois Rossignol | Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas. |
| US6576636B2 (en) * | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| GEP20032970B (en) | 1997-05-07 | 2003-05-27 | Romark Laboratories Lc | Pharmaceutical Compositions of Tizoxanide and Nitazoxanide |
| US5935591A (en) * | 1998-01-15 | 1999-08-10 | Romark Laboratories, L.C. | Method for treatment of equine protozoal myeloencephalitis with thiazolides |
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| US7125568B2 (en) * | 2001-08-23 | 2006-10-24 | Sung Michael T | Lipophilic drug compositions |
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| US7081260B2 (en) * | 2002-10-29 | 2006-07-25 | Council Of Scientific And Industrial Research | α-Glucosidase inhibitors from a natural source |
| KR20060054174A (ko) * | 2003-03-28 | 2006-05-22 | 센토코 인코포레이티드 | 항-아밀로이드 항체, 조성물, 방법 및 용도 |
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| UA90864C2 (en) * | 2004-09-09 | 2010-06-10 | Ромарк Лебораториз, Л.К. | Halogenated benzamide derivatives |
| US20060194853A1 (en) * | 2004-10-08 | 2006-08-31 | Rossignol Jean F | Alkyl benzamides |
| AU2006235490A1 (en) | 2005-04-12 | 2006-10-19 | Romark Laboratories, L.C. | Methods for treating diseases through the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents |
| EP1976516B9 (en) | 2006-01-09 | 2013-10-30 | Romark Laboratories, L.C. | Viral hepatitis treatment |
| HUE049501T2 (hu) * | 2009-02-13 | 2020-09-28 | Romark Laboratories Lc | Nitazoxanidot tartalmazó szabályozott felszabadulású gyógyszerkészítmény |
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| AP2907A (en) | 2014-05-31 |
| EP1976516B9 (en) | 2013-10-30 |
| CN101448497A (zh) | 2009-06-03 |
| DK1976516T3 (da) | 2013-07-15 |
| MX2008008723A (es) | 2008-09-26 |
| AU2007204963A1 (en) | 2007-07-19 |
| US20140112888A1 (en) | 2014-04-24 |
| ES2422556T3 (es) | 2013-09-12 |
| UA100840C2 (ru) | 2013-02-11 |
| US9107913B2 (en) | 2015-08-18 |
| IL192548A (en) | 2015-08-31 |
| WO2007081974A3 (en) | 2008-01-17 |
| EA015560B1 (ru) | 2011-08-30 |
| EP1976516A2 (en) | 2008-10-08 |
| JP2010070566A (ja) | 2010-04-02 |
| AU2007204963B2 (en) | 2012-09-27 |
| US20070167504A1 (en) | 2007-07-19 |
| CA2636527C (en) | 2016-05-17 |
| CN101448497B (zh) | 2013-07-10 |
| EP1976516A4 (en) | 2009-11-11 |
| CA2636527A1 (en) | 2007-07-19 |
| AP2008004550A0 (en) | 2008-08-31 |
| HK1123733A1 (en) | 2009-06-26 |
| JP5185826B2 (ja) | 2013-04-17 |
| WO2007081974A2 (en) | 2007-07-19 |
| EA200870164A1 (ru) | 2008-12-30 |
| NZ569507A (en) | 2011-11-25 |
| USRE47404E1 (en) | 2019-05-28 |
| ZA200806310B (en) | 2009-12-30 |
| US8633230B2 (en) | 2014-01-21 |
| JP2009522371A (ja) | 2009-06-11 |
| IL192548A0 (en) | 2009-02-11 |
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