DK1976516T3 - Behandling af viral hepatitis - Google Patents

Behandling af viral hepatitis

Info

Publication number
DK1976516T3
DK1976516T3 DK07717773.1T DK07717773T DK1976516T3 DK 1976516 T3 DK1976516 T3 DK 1976516T3 DK 07717773 T DK07717773 T DK 07717773T DK 1976516 T3 DK1976516 T3 DK 1976516T3
Authority
DK
Denmark
Prior art keywords
treatment
viral hepatitis
hepatitis
viral
Prior art date
Application number
DK07717773.1T
Other languages
Danish (da)
English (en)
Inventor
Jean-Francois Rossignol
Original Assignee
Romark Lab Lc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Romark Lab Lc filed Critical Romark Lab Lc
Application granted granted Critical
Publication of DK1976516T3 publication Critical patent/DK1976516T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicinal Preparation (AREA)
DK07717773.1T 2006-01-09 2007-01-09 Behandling af viral hepatitis DK1976516T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75703606P 2006-01-09 2006-01-09
PCT/US2007/000574 WO2007081974A2 (en) 2006-01-09 2007-01-09 Viral hepatitis treatment

Publications (1)

Publication Number Publication Date
DK1976516T3 true DK1976516T3 (da) 2013-07-15

Family

ID=38257004

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07717773.1T DK1976516T3 (da) 2006-01-09 2007-01-09 Behandling af viral hepatitis

Country Status (17)

Country Link
US (3) US8633230B2 (enExample)
EP (1) EP1976516B9 (enExample)
JP (2) JP5185826B2 (enExample)
CN (1) CN101448497B (enExample)
AP (1) AP2907A (enExample)
AU (1) AU2007204963B2 (enExample)
BR (1) BRPI0706379A2 (enExample)
CA (1) CA2636527C (enExample)
DK (1) DK1976516T3 (enExample)
EA (1) EA015560B1 (enExample)
ES (1) ES2422556T3 (enExample)
IL (1) IL192548A (enExample)
MX (1) MX2008008723A (enExample)
NZ (1) NZ569507A (enExample)
UA (1) UA100840C2 (enExample)
WO (1) WO2007081974A2 (enExample)
ZA (1) ZA200806310B (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006235490A1 (en) * 2005-04-12 2006-10-19 Romark Laboratories, L.C. Methods for treating diseases through the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents
EP1976516B9 (en) 2006-01-09 2013-10-30 Romark Laboratories, L.C. Viral hepatitis treatment
CN101820887A (zh) * 2007-07-25 2010-09-01 拜奥雷克斯治疗公司 干扰素控释药品以及使用相同药品治疗hcv感染
HUE049501T2 (hu) 2009-02-13 2020-09-28 Romark Laboratories Lc Nitazoxanidot tartalmazó szabályozott felszabadulású gyógyszerkészítmény
EP2408770B1 (en) 2009-03-20 2014-11-05 University Of Virginia Patent Foundation Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials
PE20121118A1 (es) 2009-05-12 2012-09-05 Romark Lab Lc Compuestos de haloalquil heteroaril benzamida
US9023877B2 (en) 2009-06-26 2015-05-05 Romark Laboratories L.C. Compounds and methods for treating influenza
EP2632460B1 (en) 2010-09-20 2018-02-28 University of Virginia Patent Foundation Thiophene derivatives for use in the treatment of tuberculosis
MX378726B (es) * 2011-05-16 2025-03-11 Romark Laboratories Lc Uso de compuestos de tiazolida para la prevencion y tratamiento de enfermedades virales, cancer y enfermedades causadas por infecciones intracelulares.
CN102805747B (zh) * 2011-06-01 2013-09-18 漳州片仔癀药业股份有限公司 2-(4-吗啉苯胺)-6-环己基氨基嘌呤及其药学上可接受的盐在制药中的用途
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
ES2529143B1 (es) 2011-10-21 2015-10-26 Abbvie Inc. Combinación de al menos dos agentes antivirales de acción directa, ribavirina pero no interferón para uso de tratamiento del vhc
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
CH707030B1 (de) 2011-10-21 2015-03-13 Abbvie Inc Kombinationsbehandlung von DAAs zur Verwendung in der Behandlung von HCV
EP2808019B1 (en) 2012-01-27 2019-09-25 Siegfried Rhein S.A. De C.V. Improved nitazoxanide composition and preparation method thereof
MX2017006083A (es) 2014-11-11 2017-11-08 Romark Laboratories Lc Composicones y metodos de tratamiento con profarmacos de tizoxanida, un analogo o sal de la misma.
US20180098972A1 (en) 2015-01-26 2018-04-12 Children's Medical Center Corporation Treatment of infectious diseases
EP3436074B1 (en) 2016-03-31 2020-06-10 Romark Laboratories, L.C. Thiazolide compounds for treating viral infections
WO2017178174A1 (en) * 2016-04-11 2017-10-19 Genfit Methods of treatment of cholestasis and fibrosis
ES2928408T3 (es) 2016-04-11 2022-11-17 Genfit Métodos para el tratamiento de enfermedades fibróticas
EP3448392A4 (en) 2016-04-28 2020-01-15 Emory University ALKYNOUS THERAPEUTIC NUCLEOTIDE AND NUCLEOSIDE COMPOSITIONS AND RELATED APPLICATIONS
WO2018140504A1 (en) 2017-01-24 2018-08-02 Patel Manoj K Compositions and methods for blocking sodium channels
US11033534B2 (en) * 2017-01-27 2021-06-15 Genfit Pharmaceutical compositions for combination therapy
US11191749B2 (en) * 2017-03-13 2021-12-07 Genfit Pharmaceutical compositions for combination therapy
US11173149B2 (en) 2017-04-18 2021-11-16 Romark Laboratories L.C. Inhibition of protein disulfide-isomerase A3
WO2019097050A1 (en) * 2017-11-17 2019-05-23 Köster [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl]ethanoate for use in lymphangioleiomyomatosis and other diseases
CN109364067B (zh) * 2018-11-17 2020-07-28 王海玲 一种化合物在制备提高血脑屏障通透性药物中的用途
WO2020208044A1 (en) * 2019-04-09 2020-10-15 Genfit Combination of nitazoxanide and elafibranor for the treatment of immune diseases or inflammation
WO2021016543A1 (en) * 2019-07-25 2021-01-28 Romark Laboratories L.C. Antiviral combinations of thiazolide compounds
CN111012788B (zh) * 2019-12-12 2021-01-15 武汉职业技术学院 硝唑尼特和替唑尼特在制备抗猪繁殖与呼吸综合征病毒药物中的应用
US20230303504A1 (en) 2020-07-20 2023-09-28 Romark Laboratories, L.C. Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine
KR20230098780A (ko) 2020-08-24 2023-07-04 로마크 레버러토리즈, 엘.씨. 코로나바이러스에 대한 티아졸리드의 용도
CN114259492A (zh) * 2021-12-21 2022-04-01 中以海德人工智能药物研发股份有限公司 硝唑尼特在治疗乙肝中的应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1437800A (en) * 1973-08-08 1976-06-03 Phavic Sprl Derivatives of 2-benzamido-5-nitro-thiazoles
GB1440212A (en) * 1973-08-29 1976-06-23 Phavic Sprl Derivatives of 2-phenoxyacetamido-5-nitrothiazoles
US4315018A (en) * 1978-12-07 1982-02-09 Rossignol Jean F Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives
US5387598A (en) * 1994-04-13 1995-02-07 Rossignol; Jean-Francois Composition and galenic formulation suitable for combatting affections of the lower abdomen
CN1072654C (zh) * 1994-04-13 2001-10-10 让-弗兰克伊斯·罗西格诺尔 苯甲酰胺衍生物,含所述衍生物的组合物及它们的用途
US5578621A (en) * 1994-09-08 1996-11-26 Romark Lab Lc Benzamide derivatives
US5968961A (en) * 1997-05-07 1999-10-19 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
US5856348A (en) * 1994-09-08 1999-01-05 Romark Laboratories, L.C. Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide
US5965590A (en) * 1994-09-08 1999-10-12 Romark Lab Lc Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide
US5859038A (en) * 1994-09-08 1999-01-12 Romark Laboratories, L.C. Method for treatment of helicobacter pylori infections
MX9604483A (es) * 1994-09-08 1998-02-28 Jean-Francois Rossignol Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
GEP20032970B (en) 1997-05-07 2003-05-27 Romark Laboratories Lc Pharmaceutical Compositions of Tizoxanide and Nitazoxanide
US5935591A (en) * 1998-01-15 1999-08-10 Romark Laboratories, L.C. Method for treatment of equine protozoal myeloencephalitis with thiazolides
AU766597B2 (en) 1998-05-15 2003-10-16 Schering Corporation Combination therapy comprising ribavirin and interferon alpha in antiviral treatment naive patients having chronic hepatitis C infection
US5925622A (en) * 1998-07-13 1999-07-20 Romark Laboratories, L.C. Synthesis of aryl glucuronide of 2-hydroxy-N- (5-nitro-2-thiazolyl) benzamide, and pharmaceutical compositions comprising same
US6180136B1 (en) * 1998-11-10 2001-01-30 Idexx Laboratories, Inc. Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use
US6340696B1 (en) * 1999-03-31 2002-01-22 The Procter & Gamble Company Viral treatment
US7125568B2 (en) * 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
AU2002343159A1 (en) 2002-10-29 2004-06-07 Council Of Scientific And Industrial Research New alpha-glucosidase inhibitors from a natural source
US7081260B2 (en) * 2002-10-29 2006-07-25 Council Of Scientific And Industrial Research α-Glucosidase inhibitors from a natural source
KR20060054174A (ko) * 2003-03-28 2006-05-22 센토코 인코포레이티드 항-아밀로이드 항체, 조성물, 방법 및 용도
WO2005049065A2 (en) * 2003-11-19 2005-06-02 Rigel Pharmaceuticals, Inc. Synergistic combinations of dihaloacetamide with interferon or ribavirin for treatment hcv infections
UA90864C2 (en) * 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives
US20060194853A1 (en) * 2004-10-08 2006-08-31 Rossignol Jean F Alkyl benzamides
AU2006235490A1 (en) 2005-04-12 2006-10-19 Romark Laboratories, L.C. Methods for treating diseases through the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents
EP1976516B9 (en) 2006-01-09 2013-10-30 Romark Laboratories, L.C. Viral hepatitis treatment
HUE049501T2 (hu) * 2009-02-13 2020-09-28 Romark Laboratories Lc Nitazoxanidot tartalmazó szabályozott felszabadulású gyógyszerkészítmény

Also Published As

Publication number Publication date
EP1976516B1 (en) 2013-04-24
AP2907A (en) 2014-05-31
EP1976516B9 (en) 2013-10-30
CN101448497A (zh) 2009-06-03
MX2008008723A (es) 2008-09-26
AU2007204963A1 (en) 2007-07-19
BRPI0706379A2 (pt) 2011-03-22
US20140112888A1 (en) 2014-04-24
ES2422556T3 (es) 2013-09-12
UA100840C2 (ru) 2013-02-11
US9107913B2 (en) 2015-08-18
IL192548A (en) 2015-08-31
WO2007081974A3 (en) 2008-01-17
EA015560B1 (ru) 2011-08-30
EP1976516A2 (en) 2008-10-08
JP2010070566A (ja) 2010-04-02
AU2007204963B2 (en) 2012-09-27
US20070167504A1 (en) 2007-07-19
CA2636527C (en) 2016-05-17
CN101448497B (zh) 2013-07-10
EP1976516A4 (en) 2009-11-11
CA2636527A1 (en) 2007-07-19
AP2008004550A0 (en) 2008-08-31
HK1123733A1 (en) 2009-06-26
JP5185826B2 (ja) 2013-04-17
WO2007081974A2 (en) 2007-07-19
EA200870164A1 (ru) 2008-12-30
NZ569507A (en) 2011-11-25
USRE47404E1 (en) 2019-05-28
ZA200806310B (en) 2009-12-30
US8633230B2 (en) 2014-01-21
JP2009522371A (ja) 2009-06-11
IL192548A0 (en) 2009-02-11

Similar Documents

Publication Publication Date Title
DK1976516T3 (da) Behandling af viral hepatitis
DK1912999T3 (da) Makrocykliske inhibitorer af hepatitis-c-virus
DK1912997T3 (da) Makrocycliske inhibitorer af hepatitis C virus
DK1919898T3 (da) Makrocykliske inhibitorer af hepatitis-C-virus
DK1912996T3 (da) Makrocykliske inhibitorer af hepatitis C-virus
DK1912981T3 (da) Makrocykliske inhibitorer af Hepatitis C-virus
DK1912995T3 (da) Makrocykliske inhibitorer af hepatitis C virus
DK1919899T3 (da) Makrocykliske inhibitorer af hepatitis C virus
DK1913014T3 (da) Makrocykliske inhibitorer af hepatitis-c-virus
CY2015004I1 (el) Αναστολεις του ιου της ηπατιτιδας c
DK1986633T3 (da) Behandling af duchennes muskeldystrofi
DK2084174T3 (da) Fremstilling af ribofuranosylpyrimidinnukleotider
DK2398794T3 (da) Hæmmere af hepatitis C-virus
DK2097402T3 (da) Makrocykliske inhibitorer af hepatitis c-virus
ATE555109T1 (de) Hepatitis-c-virus-hemmer
DK2019825T3 (da) Inhibitorer af human immundefektvirus-replikation
BRPI1010506A2 (pt) "inibidores do vírus da hepatite c"
DK1981506T6 (da) Langtidsbehandling af hiv-infektion med tcm278
EP2475254A4 (en) HEPATITIS C-VIRUS HEMMER
DK2091673T3 (da) Elektromagnetisk behandling af kontaminerede materialer
DK2111555T3 (da) Diagnosticering af præeklampsi
DK2209784T3 (da) Forbindelser til behandling af hepatitis C
DK2162238T3 (da) Overfladebehandling af termisk modificeret træ
DK1744781T3 (da) Behandling af infektionssygdomme
BRPI0818844A2 (pt) Métodos de inibição de infecção viral.