MX2008008723A - Tratamiento de la hepatitis viral. - Google Patents

Tratamiento de la hepatitis viral.

Info

Publication number
MX2008008723A
MX2008008723A MX2008008723A MX2008008723A MX2008008723A MX 2008008723 A MX2008008723 A MX 2008008723A MX 2008008723 A MX2008008723 A MX 2008008723A MX 2008008723 A MX2008008723 A MX 2008008723A MX 2008008723 A MX2008008723 A MX 2008008723A
Authority
MX
Mexico
Prior art keywords
interferon
patient
compound
nitazoxanide
treatment
Prior art date
Application number
MX2008008723A
Other languages
English (en)
Spanish (es)
Inventor
Jean-Francois Rossignol
Original Assignee
Romark Lab Lc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Romark Lab Lc filed Critical Romark Lab Lc
Publication of MX2008008723A publication Critical patent/MX2008008723A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/212IFN-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicinal Preparation (AREA)
MX2008008723A 2006-01-09 2007-01-09 Tratamiento de la hepatitis viral. MX2008008723A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75703606P 2006-01-09 2006-01-09
PCT/US2007/000574 WO2007081974A2 (en) 2006-01-09 2007-01-09 Viral hepatitis treatment

Publications (1)

Publication Number Publication Date
MX2008008723A true MX2008008723A (es) 2008-09-26

Family

ID=38257004

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008008723A MX2008008723A (es) 2006-01-09 2007-01-09 Tratamiento de la hepatitis viral.

Country Status (17)

Country Link
US (3) US8633230B2 (enExample)
EP (1) EP1976516B9 (enExample)
JP (2) JP5185826B2 (enExample)
CN (1) CN101448497B (enExample)
AP (1) AP2907A (enExample)
AU (1) AU2007204963B2 (enExample)
BR (1) BRPI0706379A2 (enExample)
CA (1) CA2636527C (enExample)
DK (1) DK1976516T3 (enExample)
EA (1) EA015560B1 (enExample)
ES (1) ES2422556T3 (enExample)
IL (1) IL192548A (enExample)
MX (1) MX2008008723A (enExample)
NZ (1) NZ569507A (enExample)
UA (1) UA100840C2 (enExample)
WO (1) WO2007081974A2 (enExample)
ZA (1) ZA200806310B (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006110814A2 (en) * 2005-04-12 2006-10-19 Romark Laboratories, L.C. Methods for treating diseases through inhibition the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents
CN101448497B (zh) * 2006-01-09 2013-07-10 罗马克实验室有限公司 包含硝唑尼特、替唑尼特、或其混合物的组合物在制备治疗丙型肝炎药物中的应用
BRPI0814363A2 (pt) * 2007-07-25 2015-01-27 Biolex Therapeutics Inc Produtos fármacos de interferon de liberação controlada e tratamento de infecção por hcv usando os mesmos
LT2395840T (lt) * 2009-02-13 2020-07-10 Romark Laboratories, L.C. Nitazoksanido kontroliuojamo atpalaidavimo farmacinės kompozicijos
US8835644B2 (en) 2009-03-20 2014-09-16 University Of Virginia Patent Foundation Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials
KR101760956B1 (ko) * 2009-05-12 2017-07-24 로마크 레버러토리즈, 엘.씨. 할로알킬 헤테로아릴 벤즈아미드 화합물
KR20180032689A (ko) 2009-06-26 2018-03-30 로마크 레버러토리즈, 엘.씨. 인플루엔자를 치료하기 위한 화합물 및 방법
EP2632460B1 (en) 2010-09-20 2018-02-28 University of Virginia Patent Foundation Thiophene derivatives for use in the treatment of tuberculosis
MX2013013115A (es) 2011-05-16 2014-02-27 Romark Lab Lc Uso de compuestos de tiazolida para la prevencion y tratamiento de enfermedades virales, cancer y enfermedades causadas por infecciones intracelulares.
CN102805747B (zh) * 2011-06-01 2013-09-18 漳州片仔癀药业股份有限公司 2-(4-吗啉苯胺)-6-环己基氨基嘌呤及其药学上可接受的盐在制药中的用途
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
AU2013201406B2 (en) 2011-10-21 2014-10-02 Abbvie Ireland Unlimited Company Methods for treating HCV
EP2583680A3 (en) 2011-10-21 2013-06-12 Abbvie Inc. Mono (PSI-7977) or combination treatment of DAAs for use in treating HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
WO2013110975A1 (es) 2012-01-27 2013-08-01 Siegfried Rhein S.A. De C.V. Composición de nitazoxanida mejorada y proceso para prepararla
KR20170081228A (ko) 2014-11-11 2017-07-11 로마크 레버러토리즈, 엘.씨. 티족사나이드, 그의 유사체 또는 염의 전구 약물을 이용한 치료 조성물 및 방법
US20180098972A1 (en) 2015-01-26 2018-04-12 Children's Medical Center Corporation Treatment of infectious diseases
HUE050601T2 (hu) 2016-03-31 2020-12-28 Romark Laboratories Lc Tiazolidvegyületek vírusfertõzések kezelésére
PH12018502142B1 (en) * 2016-04-11 2023-08-11 Genfit Methods of treatment for cholestatic and fibrotic diseases
US20170290814A1 (en) * 2016-04-11 2017-10-12 Genfit Methods of treatment of cholestasis and fibrosis
WO2017189978A1 (en) 2016-04-28 2017-11-02 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
EP3573957B1 (en) 2017-01-24 2023-04-26 Rivara, Mirko Compositions and methods for blocking sodium channels
KR102537043B1 (ko) * 2017-01-27 2023-05-25 장피트 조합 치료요법용 약학 조성물
EP3595656A1 (en) * 2017-03-13 2020-01-22 Genfit Pharmaceutical compositions for combination therapy
US11173149B2 (en) 2017-04-18 2021-11-16 Romark Laboratories L.C. Inhibition of protein disulfide-isomerase A3
AU2018368611B2 (en) * 2017-11-17 2023-12-14 KÖSTER, Hubert (2-((5-nitro-1,3-thiazol-2-yl)carbamoyl)phenyl)ethanoate for use in lymphangioleiomyomatosis and other diseases
CN109364067B (zh) * 2018-11-17 2020-07-28 王海玲 一种化合物在制备提高血脑屏障通透性药物中的用途
JP2022527840A (ja) 2019-04-09 2022-06-06 ジェンフィット 免疫疾患又は炎症を治療するためのニタゾキサニド及びエラフィブラノールの組合せ
WO2021016543A1 (en) * 2019-07-25 2021-01-28 Romark Laboratories L.C. Antiviral combinations of thiazolide compounds
CN111012788B (zh) * 2019-12-12 2021-01-15 武汉职业技术学院 硝唑尼特和替唑尼特在制备抗猪繁殖与呼吸综合征病毒药物中的应用
EP4182304A1 (en) 2020-07-20 2023-05-24 Romark Laboratories, L.C. Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine
CN116367892A (zh) 2020-08-24 2023-06-30 罗马克实验室有限公司 噻唑化物抗冠状病毒的用途
CN114259492A (zh) * 2021-12-21 2022-04-01 中以海德人工智能药物研发股份有限公司 硝唑尼特在治疗乙肝中的应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1437800A (en) * 1973-08-08 1976-06-03 Phavic Sprl Derivatives of 2-benzamido-5-nitro-thiazoles
GB1440212A (en) * 1973-08-29 1976-06-23 Phavic Sprl Derivatives of 2-phenoxyacetamido-5-nitrothiazoles
US4315018A (en) * 1978-12-07 1982-02-09 Rossignol Jean F Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives
US5578621A (en) * 1994-09-08 1996-11-26 Romark Lab Lc Benzamide derivatives
CN1072654C (zh) * 1994-04-13 2001-10-10 让-弗兰克伊斯·罗西格诺尔 苯甲酰胺衍生物,含所述衍生物的组合物及它们的用途
US5387598A (en) * 1994-04-13 1995-02-07 Rossignol; Jean-Francois Composition and galenic formulation suitable for combatting affections of the lower abdomen
US5965590A (en) * 1994-09-08 1999-10-12 Romark Lab Lc Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide
MX9604483A (es) * 1994-09-08 1998-02-28 Jean-Francois Rossignol Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
US5859038A (en) * 1994-09-08 1999-01-12 Romark Laboratories, L.C. Method for treatment of helicobacter pylori infections
US5856348A (en) * 1994-09-08 1999-01-05 Romark Laboratories, L.C. Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide
US5968961A (en) * 1997-05-07 1999-10-19 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
TR199902733T2 (xx) * 1997-05-07 2000-03-21 Romark Laboratories, L.C. Tizoksanit ve nitazoksanitten olu�an farmas�tik kompozisyonlar.
US5935591A (en) * 1998-01-15 1999-08-10 Romark Laboratories, L.C. Method for treatment of equine protozoal myeloencephalitis with thiazolides
CN1230198C (zh) * 1998-05-15 2005-12-07 先灵公司 给首次接受抗病毒疗法的G慢性丙型肝炎感染患者施用包括利巴韦林和α干扰素的联合疗法
US5925622A (en) * 1998-07-13 1999-07-20 Romark Laboratories, L.C. Synthesis of aryl glucuronide of 2-hydroxy-N- (5-nitro-2-thiazolyl) benzamide, and pharmaceutical compositions comprising same
US6180136B1 (en) * 1998-11-10 2001-01-30 Idexx Laboratories, Inc. Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use
US6340696B1 (en) * 1999-03-31 2002-01-22 The Procter & Gamble Company Viral treatment
US7125568B2 (en) * 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
CN100438868C (zh) 2002-10-29 2008-12-03 科学与工业研究委员会 天然来源的葡萄糖苷酶抑制剂
US7081260B2 (en) * 2002-10-29 2006-07-25 Council Of Scientific And Industrial Research α-Glucosidase inhibitors from a natural source
CA2520853A1 (en) * 2003-03-28 2005-03-31 Centocor, Inc. Anti-amyloid antibodies, compositions, methods and uses
US7410979B2 (en) 2003-11-19 2008-08-12 Rigel Pharmaceuticals, Inc. Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections
UA90864C2 (en) * 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives
US20060194853A1 (en) * 2004-10-08 2006-08-31 Rossignol Jean F Alkyl benzamides
WO2006110814A2 (en) 2005-04-12 2006-10-19 Romark Laboratories, L.C. Methods for treating diseases through inhibition the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents
CN101448497B (zh) 2006-01-09 2013-07-10 罗马克实验室有限公司 包含硝唑尼特、替唑尼特、或其混合物的组合物在制备治疗丙型肝炎药物中的应用
LT2395840T (lt) * 2009-02-13 2020-07-10 Romark Laboratories, L.C. Nitazoksanido kontroliuojamo atpalaidavimo farmacinės kompozicijos

Also Published As

Publication number Publication date
HK1123733A1 (en) 2009-06-26
WO2007081974A3 (en) 2008-01-17
JP2010070566A (ja) 2010-04-02
WO2007081974A2 (en) 2007-07-19
AU2007204963B2 (en) 2012-09-27
UA100840C2 (ru) 2013-02-11
CN101448497B (zh) 2013-07-10
ES2422556T3 (es) 2013-09-12
DK1976516T3 (da) 2013-07-15
EP1976516A2 (en) 2008-10-08
BRPI0706379A2 (pt) 2011-03-22
NZ569507A (en) 2011-11-25
US20070167504A1 (en) 2007-07-19
AP2008004550A0 (en) 2008-08-31
USRE47404E1 (en) 2019-05-28
IL192548A0 (en) 2009-02-11
EA200870164A1 (ru) 2008-12-30
CA2636527A1 (en) 2007-07-19
EP1976516B1 (en) 2013-04-24
AU2007204963A1 (en) 2007-07-19
JP2009522371A (ja) 2009-06-11
US20140112888A1 (en) 2014-04-24
EP1976516B9 (en) 2013-10-30
US9107913B2 (en) 2015-08-18
CN101448497A (zh) 2009-06-03
JP5185826B2 (ja) 2013-04-17
CA2636527C (en) 2016-05-17
US8633230B2 (en) 2014-01-21
AP2907A (en) 2014-05-31
ZA200806310B (en) 2009-12-30
IL192548A (en) 2015-08-31
EP1976516A4 (en) 2009-11-11
EA015560B1 (ru) 2011-08-30

Similar Documents

Publication Publication Date Title
USRE47404E1 (en) Viral hepatitis treatment
JP2009522371A5 (enExample)
EP1484059B1 (en) Antiviral compositions comprising phenylacetic acid derivatives
SE513082C2 (sv) Användning av taxol i infusionspreparat
EP2651414A1 (en) Combination therapy comprising vemurafenib and an interferon for use in the treatment of cancer
RU2730998C2 (ru) Композиции форболовых эфиров и способы их применения для лечения или уменьшения продолжительности цитопении
CN120284929A (zh) 用于在已经经历造血干细胞移植的患者中抑制血液恶性肿瘤复发的活性剂
CN111956649A (zh) 用于联合治疗间质性肺疾病的喹啉衍生物或其药学上可接受的盐
AU2009240908B2 (en) Methods of administering antitumor agent comprising deoxycytidine derivative
CA2742030A1 (en) Compositions and methods for treating myelodysplastic syndrome
EP2392329B1 (en) Compositions for use in treating myelodysplastic syndrome
HK1123733B (en) Viral hepatitis treatment
WO2005027910A1 (en) Method of treating mixed lineage leukemia gene-rearranged acute lymphoblastic leukemias
KR20220082862A (ko) 혈액 악성 종양을 치료하기 위한 병용 요법
WO2025208443A1 (en) Methods of treatment warm autoimmune hemolytic anemia using sovleplenib
WO2020139300A2 (en) A combination comprising granulocyte colony stimulating factor
EP2500029A1 (en) Therapeutic agent for gastrointestinal diseases
EP1656941A1 (en) Compositions for the treatment of diabetic nephropathy
EP2450051A1 (en) Medicinal agent and method for treatment of intractable chronic hepatitis c
HK1185808B (en) Combination therapy comprising vemurafenib and an interferon for use in the treatment of cancer
HK1067551B (en) Antiviral compositions comprising phenylacetic acid derivatives
HK1162310A (en) Compositions for use in treating myelodysplastic syndrome

Legal Events

Date Code Title Description
FG Grant or registration