BRPI0619252A2 - inibidores de c-met e seus usos - Google Patents

inibidores de c-met e seus usos Download PDF

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Publication number
BRPI0619252A2
BRPI0619252A2 BRPI0619252-1A BRPI0619252A BRPI0619252A2 BR PI0619252 A2 BRPI0619252 A2 BR PI0619252A2 BR PI0619252 A BRPI0619252 A BR PI0619252A BR PI0619252 A2 BRPI0619252 A2 BR PI0619252A2
Authority
BR
Brazil
Prior art keywords
formula
aliphatic
optionally substituted
original document
document page
Prior art date
Application number
BRPI0619252-1A
Other languages
English (en)
Portuguese (pt)
Inventor
Alex Aronov
Pan Li
David D Deininger
Kira Mcginty
Dean Stamos
Jon Come
Michelle Stewart
David Lauffer
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of BRPI0619252A2 publication Critical patent/BRPI0619252A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BRPI0619252-1A 2005-11-30 2006-11-30 inibidores de c-met e seus usos BRPI0619252A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US74085905P 2005-11-30 2005-11-30
US74073705P 2005-11-30 2005-11-30
US74074105P 2005-11-30 2005-11-30
US60/740,741 2005-11-30
US60/740,859 2005-11-30
US60/740,737 2005-11-30
PCT/US2006/045847 WO2007064797A2 (en) 2005-11-30 2006-11-30 Inhibitors of c-met and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0619252A2 true BRPI0619252A2 (pt) 2011-09-20

Family

ID=37998312

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0619252-1A BRPI0619252A2 (pt) 2005-11-30 2006-11-30 inibidores de c-met e seus usos

Country Status (12)

Country Link
US (2) US7728017B2 (enExample)
EP (1) EP1963329B1 (enExample)
JP (1) JP5144532B2 (enExample)
KR (1) KR20080080584A (enExample)
AU (1) AU2006320580B2 (enExample)
BR (1) BRPI0619252A2 (enExample)
CA (1) CA2630884A1 (enExample)
IL (1) IL191623A0 (enExample)
MX (1) MX2008007049A (enExample)
NO (1) NO20082880L (enExample)
NZ (1) NZ568666A (enExample)
WO (1) WO2007064797A2 (enExample)

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Publication number Publication date
WO2007064797A3 (en) 2007-12-13
KR20080080584A (ko) 2008-09-04
AU2006320580A1 (en) 2007-06-07
IL191623A0 (en) 2008-12-29
NO20082880L (no) 2008-09-01
US20070191369A1 (en) 2007-08-16
WO2007064797A2 (en) 2007-06-07
US7728017B2 (en) 2010-06-01
US20100190774A1 (en) 2010-07-29
AU2006320580B2 (en) 2011-06-23
MX2008007049A (es) 2008-10-23
NZ568666A (en) 2011-09-30
EP1963329A2 (en) 2008-09-03
US7998987B2 (en) 2011-08-16
JP2009518296A (ja) 2009-05-07
CA2630884A1 (en) 2007-06-07
EP1963329B1 (en) 2013-01-23
JP5144532B2 (ja) 2013-02-13

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