BRPI0607271A2 - sais de valnemulina com ácidos orgánicos - Google Patents

sais de valnemulina com ácidos orgánicos

Info

Publication number
BRPI0607271A2
BRPI0607271A2 BRPI0607271-2A BRPI0607271A BRPI0607271A2 BR PI0607271 A2 BRPI0607271 A2 BR PI0607271A2 BR PI0607271 A BRPI0607271 A BR PI0607271A BR PI0607271 A2 BRPI0607271 A2 BR PI0607271A2
Authority
BR
Brazil
Prior art keywords
organic acids
valnemulin
salts
valnemulin salts
vaínemulin
Prior art date
Application number
BRPI0607271-2A
Other languages
English (en)
Inventor
Ingolf Macher
Annett Geissler
Susanne Christine Wieland-Berghausen
Ferenc Jozsef Rakoczi
Uwe Thomas Schote
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0607271A2 publication Critical patent/BRPI0607271A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/24—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/80—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings
    • C07C2603/82—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings having three condensed rings with in total fourteen carbon atoms and having a having a [5.4.3.0(1,8)] ring structure, e.g. pleuromutiline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Fodder In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SAIS DE VALNEMULINA COM áCIDOS ORGáNICOS. A presente invenção refere-se à produção de uma nova forma de sal de vaínemulina, um composto de fórmula 1, que é notável por sua boa cristalinidade em maior pureza, seu uso técnico simples e estabilidade de armazenamento melhorada.
BRPI0607271-2A 2005-01-26 2006-01-26 sais de valnemulina com ácidos orgánicos BRPI0607271A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05001498A EP1686115A1 (de) 2005-01-26 2005-01-26 Organische Säureadditionssalze von Valnemulin
PCT/EP2006/000680 WO2006079535A1 (en) 2005-01-26 2006-01-26 Valnemulin salts with organic acids

Publications (1)

Publication Number Publication Date
BRPI0607271A2 true BRPI0607271A2 (pt) 2009-08-25

Family

ID=34933446

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607271-2A BRPI0607271A2 (pt) 2005-01-26 2006-01-26 sais de valnemulina com ácidos orgánicos

Country Status (21)

Country Link
US (1) US20090156674A1 (pt)
EP (2) EP1686115A1 (pt)
JP (1) JP4922948B2 (pt)
KR (1) KR101354738B1 (pt)
CN (1) CN101107224B (pt)
AR (1) AR052468A1 (pt)
AT (1) ATE476415T1 (pt)
AU (1) AU2006208642B2 (pt)
BR (1) BRPI0607271A2 (pt)
CA (1) CA2594582C (pt)
DE (1) DE602006015909D1 (pt)
DK (1) DK1844008T3 (pt)
ES (1) ES2349757T3 (pt)
MX (1) MX2007008975A (pt)
NZ (1) NZ555895A (pt)
PL (1) PL1844008T3 (pt)
PT (1) PT1844008E (pt)
RU (1) RU2401256C2 (pt)
TW (1) TWI370115B (pt)
WO (1) WO2006079535A1 (pt)
ZA (1) ZA200704733B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2411747C2 (ru) * 2008-12-25 2011-02-20 Сергей Петрович Воронин Биодоступная форма микроэлементных добавок в кормовые смеси для животных и птиц
CN101874785A (zh) * 2010-04-30 2010-11-03 广东大华农动物食品保健品股份有限公司 盐酸沃尼妙林肠溶微丸的配方及其制备方法
CN102180818A (zh) * 2011-03-10 2011-09-14 青岛科技大学 一种延胡索酸沃尼妙林的制备方法
CN102225906B (zh) * 2011-05-12 2014-07-30 浙江国邦药业有限公司 一种沃尼妙林盐酸盐的结晶方法
CN102344397B (zh) * 2011-08-23 2013-09-04 浙江升华拜克生物股份有限公司 一种伐奈莫林盐酸盐的提纯方法
CN102813644A (zh) * 2012-08-07 2012-12-12 湖北龙翔药业有限公司 一种酒石酸沃尼妙林在兽药中的用途
CN102813629A (zh) * 2012-08-29 2012-12-12 湖北龙翔药业有限公司 一种酒石酸沃尼妙林预混剂的制备方法
CN102813625A (zh) * 2012-08-29 2012-12-12 湖北龙翔药业有限公司 一种酒石酸沃尼妙林预混剂的制备方法
CN103073464B (zh) * 2013-02-04 2014-11-26 中国兽医药品监察所 一种富马酸沃尼妙林的制备方法
CN103483232B (zh) * 2013-09-25 2015-05-13 宁夏泰瑞制药股份有限公司 一种盐酸沃尼妙林的精制方法
CN103755609B (zh) * 2014-01-17 2016-01-20 天津大学 酒石酸沃尼妙林的晶型及其制备方法
CN104004055A (zh) * 2014-06-06 2014-08-27 海南建邦制药科技有限公司 胸腺五肽的有机酸盐及其制剂
CN104130168B (zh) * 2014-07-08 2016-01-20 天津大学 一种草酸沃尼妙林晶体及其制备方法
CN104230774B (zh) * 2014-08-26 2016-08-17 浙江汇能生物股份有限公司 一种沃尼妙林盐的纯化方法
CN105061273B (zh) * 2015-07-20 2017-04-26 中国兽医药品监察所 酒石酸沃尼妙林多晶型及其制备方法
CN105878228B (zh) * 2016-06-27 2018-05-18 河北天元药业有限公司 一种延胡索酸泰妙菌素可溶性粉及其制备方法
KR101978364B1 (ko) * 2017-06-15 2019-05-14 크리스탈지노믹스(주) 알킬카바모일 나프탈렌일옥시 옥테노일 하이드록시아마이드 또는 그 유도체의 약학적으로 허용 가능한 염 및 그 제조방법
KR102098289B1 (ko) * 2018-04-11 2020-04-07 경북대학교 산학협력단 발네물린을 유효성분으로 함유하는 골 질환 예방 또는 치료용 조성물
KR102678356B1 (ko) * 2018-10-29 2024-06-26 씨지인바이츠 주식회사 알킬카바모일 나프탈렌일옥시 옥테노일 하이드록시아마이드 인산염, 타르타르산염 또는 이들의 조합을 포함하는 약제학적 조성물 및 그 제조방법
CN115645390A (zh) * 2022-11-04 2023-01-31 中国兽医药品监察所 沃尼妙林有机酸盐类兽药的制备及其在制备治疗家禽气囊炎及猪胸膜肺炎药物中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4032530A (en) * 1971-10-05 1977-06-28 Sandoz Ltd. Certain pleuromutilins
US3919290A (en) * 1972-10-03 1975-11-11 Sandoz Ltd Substituted 14-desoxy-mutilins
US4086359A (en) * 1975-09-30 1978-04-25 E. R. Squibb & Sons, Inc. Derivatives of pleuromutilin and compositions
EP0153277B1 (de) * 1984-02-17 1987-08-26 Sandoz Ag Neue Pleuromutilinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
AT400674B (de) * 1991-07-24 1996-02-26 Biochemie Gmbh Pharmazeutische pleuromutilin-zubereitung
AT397654B (de) * 1992-05-04 1994-06-27 Biochemie Gmbh Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung
GB9614017D0 (en) * 1996-07-04 1996-09-04 Biochemie Gmbh Organic compounds
GB0207495D0 (en) * 2002-03-28 2002-05-08 Biochemie Gmbh Organic compounds
GB0218578D0 (en) * 2002-08-09 2002-09-18 Glaxo Group Ltd Novel method

Also Published As

Publication number Publication date
MX2007008975A (es) 2007-09-18
CA2594582C (en) 2013-10-08
RU2401256C2 (ru) 2010-10-10
EP1844008A1 (en) 2007-10-17
EP1844008B1 (en) 2010-08-04
ZA200704733B (en) 2008-09-25
ES2349757T3 (es) 2011-01-11
JP4922948B2 (ja) 2012-04-25
RU2007132258A (ru) 2009-03-10
CN101107224B (zh) 2011-12-28
JP2008528530A (ja) 2008-07-31
AR052468A1 (es) 2007-03-21
NZ555895A (en) 2010-11-26
CA2594582A1 (en) 2006-08-03
PT1844008E (pt) 2010-08-31
EP1686115A1 (de) 2006-08-02
KR20070101284A (ko) 2007-10-16
TW200637811A (en) 2006-11-01
DE602006015909D1 (de) 2010-09-16
KR101354738B1 (ko) 2014-01-22
TWI370115B (en) 2012-08-11
ATE476415T1 (de) 2010-08-15
PL1844008T3 (pl) 2011-01-31
CN101107224A (zh) 2008-01-16
US20090156674A1 (en) 2009-06-18
WO2006079535A1 (en) 2006-08-03
AU2006208642A1 (en) 2006-08-03
DK1844008T3 (da) 2010-11-15
AU2006208642B2 (en) 2009-11-26

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B25B Requested transfer of rights rejected

Owner name: NOVARTIS AG (CH)

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25C Requirement related to requested transfer of rights

Owner name: NOVARTIS AG (CH)

B25A Requested transfer of rights approved

Owner name: NOVARTIS TIERGESUNDHEIT AG (CH)

B25D Requested change of name of applicant approved

Owner name: ELANCO TIERGESUNDHEIT AG (CH)

B25G Requested change of headquarter approved

Owner name: ELANCO TIERGESUNDHEIT AG (CH)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time