BRPI0607026A2 - processos para redução do teor de proteìna e preservação do teror de polissacarìdeo capsular em caldo de lisato de streptococcus pneumonial celular complexo antes da purificação - Google Patents
processos para redução do teor de proteìna e preservação do teror de polissacarìdeo capsular em caldo de lisato de streptococcus pneumonial celular complexo antes da purificaçãoInfo
- Publication number
- BRPI0607026A2 BRPI0607026A2 BRPI0607026-4A BRPI0607026A BRPI0607026A2 BR PI0607026 A2 BRPI0607026 A2 BR PI0607026A2 BR PI0607026 A BRPI0607026 A BR PI0607026A BR PI0607026 A2 BRPI0607026 A2 BR PI0607026A2
- Authority
- BR
- Brazil
- Prior art keywords
- purification
- protein content
- preserving
- complex cellular
- reducing protein
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/06—Lysis of microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Sustainable Development (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
PROCESSOS PARA REDUçãO DO TEOR DE PROTEìNA E PRESERVAçãO DO TEROR DE POLISSACARìDEO CAPSULAR EM CALDO DE LISATO DE STREPTOCOCCUS PNEUMONIAL CELULAR COMPLEXO ANTES DA PURIFICAçãO. A presente invenção refere-se a um processo para redução do teor de proteína e preservação do teor de polissacarídeo capsular em um caldo de lisato de Streptococcus pneumoniae celular complexo antes de purificação. Utilização de redução de pH após lise celular resultou em um polissacarídeo purificado que vai de encontro consistentemente à especificação para proteína e maiores rendimentos de recuperação do polissacarídeo durante o processo de purificação.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66954605P | 2005-04-08 | 2005-04-08 | |
| US60/669,546 | 2005-04-08 | ||
| PCT/US2006/012134 WO2006110352A2 (en) | 2005-04-08 | 2006-03-31 | Separation of contaminants from streptococcus pneumoniae polysaccharide by ph manipulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0607026A2 true BRPI0607026A2 (pt) | 2009-07-28 |
| BRPI0607026B1 BRPI0607026B1 (pt) | 2022-02-15 |
Family
ID=36660782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0607026-4A BRPI0607026B1 (pt) | 2005-04-08 | 2006-03-31 | Processos para redução do teor de proteína e preservação do teor de polissacarídeo capsular em um caldo de lisado celular de streptococcus pneumoniae complexo antes da purificação |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7718791B2 (pt) |
| EP (2) | EP1866342B1 (pt) |
| JP (1) | JP5049264B2 (pt) |
| KR (1) | KR101317256B1 (pt) |
| CN (1) | CN101155833B (pt) |
| AR (1) | AR053843A1 (pt) |
| AU (1) | AU2006234984B2 (pt) |
| BR (1) | BRPI0607026B1 (pt) |
| CA (1) | CA2604362C (pt) |
| DK (2) | DK3466982T3 (pt) |
| ES (2) | ES2707202T3 (pt) |
| HU (1) | HUE050049T2 (pt) |
| IL (1) | IL186366A (pt) |
| MX (1) | MX2007012337A (pt) |
| NZ (1) | NZ562719A (pt) |
| PL (2) | PL1866342T3 (pt) |
| PT (2) | PT3466982T (pt) |
| SI (2) | SI3466982T1 (pt) |
| TR (1) | TR201820018T4 (pt) |
| WO (1) | WO2006110352A2 (pt) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013201631C1 (en) * | 2006-10-10 | 2015-06-04 | Wyeth Llc | Purification of Streptococcus pneumoniae type 3 polysaccharides |
| RU2460539C2 (ru) * | 2006-10-10 | 2012-09-10 | Вайет | СПОСОБ ОЧИСТКИ ПОЛИСАХАРИДОВ Streptococcus pneumoniae 3 ТИПА (ВАРИАНТЫ) |
| PL2129693T3 (pl) | 2007-03-23 | 2017-07-31 | Wyeth Llc | Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniae |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| PT2385981T (pt) * | 2008-12-18 | 2019-10-28 | Wyeth Llc | Método para controlar peso molecular de polissacárido de streptococcus pneumoniae com a utilização de carbono. |
| US8795689B2 (en) * | 2008-12-18 | 2014-08-05 | Wyeth Llc | Method for controlling Streptococcus pneumoniae serotype 19A polysaccharide molecular weight |
| EP2411048B1 (en) | 2009-03-24 | 2020-05-06 | GlaxoSmithKline Biologicals SA | Adjuvanting meningococcal factor h binding protein |
| JP5668049B2 (ja) | 2009-03-24 | 2015-02-12 | ノバルティス アーゲー | 髄膜炎菌ｈ因子結合タンパク質および肺炎球菌糖結合体の組み合わせ |
| BRPI1014494A2 (pt) | 2009-04-30 | 2016-08-02 | Coley Pharm Group Inc | vacina pneumocócica e usos da mesma |
| WO2011145108A2 (en) * | 2010-05-15 | 2011-11-24 | Serum Institute Of India Ltd. | Purification of capsular polysaccharides |
| EP2585106A1 (en) | 2010-06-25 | 2013-05-01 | Novartis AG | Combinations of meningococcal factor h binding proteins |
| CN102093963B (zh) * | 2010-11-26 | 2012-11-14 | 兰州生物制品研究所有限责任公司 | 富含磷壁酸的肺炎链球菌的培养方法 |
| CN102094053B (zh) * | 2010-11-26 | 2013-01-16 | 兰州生物制品研究所有限责任公司 | 肺炎链球菌c多糖的纯化方法 |
| JP6191082B2 (ja) | 2011-03-02 | 2017-09-06 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | より低用量の抗原および／またはアジュバントを有する混合ワクチン |
| EP2797624A1 (en) | 2011-12-29 | 2014-11-05 | Novartis AG | Adjuvanted combinations of meningococcal factor h binding proteins |
| JP2015510872A (ja) | 2012-03-07 | 2015-04-13 | ノバルティス アーゲー | Ｓｔｒｅｐｔｏｃｏｃｃｕｓｐｎｅｕｍｏｎｉａｅ抗原の増強された製剤 |
| EP2822584A1 (en) | 2012-03-08 | 2015-01-14 | Novartis AG | Combination vaccines with tlr4 agonists |
| CN102660601B (zh) * | 2012-04-17 | 2015-10-28 | 江苏康泰生物医学技术有限公司 | 快速纯化细菌荚膜多糖的方法 |
| CN102660603B (zh) * | 2012-04-17 | 2015-03-25 | 江苏康泰生物医学技术有限公司 | 一种快速纯化细菌荚膜多糖的方法 |
| CN102660602B (zh) * | 2012-04-17 | 2015-03-25 | 江苏康泰生物医学技术有限公司 | 快速纯化细菌荚膜多糖的方法 |
| JP6324961B2 (ja) | 2012-09-06 | 2018-05-16 | ノバルティス アーゲー | 血清群ｂ髄膜炎菌とｄ／ｔ／ｐとの組み合わせワクチン |
| EP2894225B1 (en) * | 2012-09-07 | 2017-11-22 | SK Chemicals Co., Ltd. | Production method for capsular polysaccharide having pneumococcal serotype |
| WO2014095771A1 (en) | 2012-12-18 | 2014-06-26 | Novartis Ag | Conjugates for protecting against diphtheria and/or tetanus |
| JP6612260B2 (ja) | 2014-01-21 | 2019-11-27 | ファイザー・インク | 肺炎連鎖球菌（Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｐｎｅｕｍｏｎｉａｅ）莢膜多糖およびそのコンジュゲート |
| EP3616716A3 (en) | 2014-01-21 | 2020-05-06 | Pfizer Inc | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| SI3096786T1 (sl) | 2014-01-21 | 2021-09-30 | Pfizer Inc. | Kapsularni polisaharidi streptococcus pneumoniae in njihovi konjugati |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| CN107427568B (zh) | 2015-01-15 | 2021-12-14 | 辉瑞公司 | 用于肺炎球菌疫苗中的免疫原性组合物 |
| EP3292146A1 (en) | 2015-05-04 | 2018-03-14 | Pfizer Inc | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof |
| PE20240927A1 (es) | 2015-07-21 | 2024-04-30 | Pfizer | Composiciones inmunogenas que comprenden antigenos de sacarido capsular conjugados, kits que las comprenden y sus usos |
| CA3005524C (en) | 2015-11-20 | 2023-10-10 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
| IL264553B2 (en) | 2016-08-05 | 2023-04-01 | Sanofi Pasteur Inc | A multivalent pneumococcal protein-polysaccharide conjugate preparation |
| TWI789357B (zh) | 2016-08-05 | 2023-01-11 | 南韓商Ｓｋ生物科技股份有限公司 | 多價肺炎球菌多醣-蛋白質共軛物組成物(二) |
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| WO2018144439A1 (en) | 2017-01-31 | 2018-08-09 | Merck Sharp & Dohme Corp. | Methods for making polysaccharide-protein conjugates |
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| JP7369123B2 (ja) | 2017-12-06 | 2023-10-25 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎球菌多糖類－タンパク質コンジュゲートを含む組成物およびその使用方法 |
| KR20210005158A (ko) | 2018-04-30 | 2021-01-13 | 머크 샤프 앤드 돔 코포레이션 | 스트렙토코쿠스 뉴모니아에 피막 폴리사카라이드 담체 단백질 접합체를 제조하는 방법 |
| KR20210002641A (ko) | 2018-04-30 | 2021-01-08 | 머크 샤프 앤드 돔 코포레이션 | 디메틸술폭시드 중의 동결건조된 돌연변이체 디프테리아 독소의 균질 용액을 제공하는 방법 |
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| CN112543649A (zh) | 2018-07-04 | 2021-03-23 | Vaxcyte公司 | 免疫原性缀合物的改进 |
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| JP2022512345A (ja) | 2018-12-12 | 2022-02-03 | ファイザー・インク | 免疫原性多重ヘテロ抗原多糖－タンパク質コンジュゲートおよびその使用 |
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| JP2024517780A (ja) | 2021-05-03 | 2024-04-23 | ファイザー・インク | 細菌およびベータコロナウイルス感染症に対するワクチン接種 |
| WO2022234416A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| MX2023013434A (es) | 2021-05-28 | 2023-12-12 | Pfizer Inc | Composiciones inmunogenas que comprenden antigenos de sacarido capsular conjugados y sus usos. |
| US20220387576A1 (en) | 2021-05-28 | 2022-12-08 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2023135515A1 (en) | 2022-01-13 | 2023-07-20 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| GB2614916A (en) | 2022-01-25 | 2023-07-26 | Optivalent Ltd | Intradermal vaccine complement |
| WO2023161817A1 (en) | 2022-02-25 | 2023-08-31 | Pfizer Inc. | Methods for incorporating azido groups in bacterial capsular polysaccharides |
| CN114853917A (zh) * | 2022-04-22 | 2022-08-05 | 兰州生物制品研究所有限责任公司 | 制备肺炎球菌荚膜多糖和肺炎球菌疫苗的方法 |
| WO2024084397A1 (en) | 2022-10-19 | 2024-04-25 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| WO2024110827A1 (en) | 2022-11-21 | 2024-05-30 | Pfizer Inc. | Methods for preparing conjugated capsular saccharide antigens and uses thereof |
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Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1115210A (en) * | 1977-11-28 | 1981-12-29 | Dennis J. Carlo | Pneumococcal vaccine |
| US4242501A (en) * | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
| FR2495939B1 (fr) * | 1980-12-11 | 1985-10-11 | Merieux Inst | Procede de purification de polyosides de streptococcus pneumoniae et vaccin a base de polyosides ainsi purifies |
| BE889979A (fr) * | 1981-08-14 | 1982-02-15 | Smith Kline Rit | Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation |
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| WO2000006738A2 (en) * | 1998-07-27 | 2000-02-10 | Microbial Technics Limited | NUCLEIC ACIDS AND PROTEINS FROM $i(STREPTOCOCCUS PNEUMONIAE) |
| WO2001068903A1 (en) * | 2000-03-16 | 2001-09-20 | The Children's Hospital Of Philadelphia | Modulating production of pneumococcal capsular polysaccharide |
-
2006
- 2006-03-31 NZ NZ562719A patent/NZ562719A/en unknown
- 2006-03-31 TR TR2018/20018T patent/TR201820018T4/tr unknown
- 2006-03-31 SI SI200632381T patent/SI3466982T1/sl unknown
- 2006-03-31 ES ES06740302T patent/ES2707202T3/es active Active
- 2006-03-31 HU HUE18199835A patent/HUE050049T2/hu unknown
- 2006-03-31 PT PT181998352T patent/PT3466982T/pt unknown
- 2006-03-31 AU AU2006234984A patent/AU2006234984B2/en active Active
- 2006-03-31 WO PCT/US2006/012134 patent/WO2006110352A2/en active Application Filing
- 2006-03-31 CN CN200680011379XA patent/CN101155833B/zh active Active
- 2006-03-31 DK DK18199835.2T patent/DK3466982T3/da active
- 2006-03-31 PL PL06740302T patent/PL1866342T3/pl unknown
- 2006-03-31 US US11/396,108 patent/US7718791B2/en active Active
- 2006-03-31 PL PL18199835T patent/PL3466982T3/pl unknown
- 2006-03-31 ES ES18199835T patent/ES2808126T3/es active Active
- 2006-03-31 PT PT06740302T patent/PT1866342T/pt unknown
- 2006-03-31 SI SI200632310T patent/SI1866342T1/sl unknown
- 2006-03-31 KR KR1020077025986A patent/KR101317256B1/ko active IP Right Grant
- 2006-03-31 DK DK06740302.2T patent/DK1866342T3/en active
- 2006-03-31 CA CA2604362A patent/CA2604362C/en active Active
- 2006-03-31 EP EP06740302.2A patent/EP1866342B1/en active Active
- 2006-03-31 BR BRPI0607026-4A patent/BRPI0607026B1/pt active IP Right Grant
- 2006-03-31 JP JP2008505399A patent/JP5049264B2/ja active Active
- 2006-03-31 EP EP18199835.2A patent/EP3466982B1/en active Active
- 2006-03-31 MX MX2007012337A patent/MX2007012337A/es active IP Right Grant
- 2006-04-07 AR ARP060101391A patent/AR053843A1/es unknown
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2007
- 2007-10-07 IL IL186366A patent/IL186366A/en active IP Right Grant
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