SI1866342T1 - Ločevanje onesnaževalcev od polisaharida streptococcus pneumoniae s postopkom manipulacije pH - Google Patents

Ločevanje onesnaževalcev od polisaharida streptococcus pneumoniae s postopkom manipulacije pH

Info

Publication number
SI1866342T1
SI1866342T1 SI200632310T SI200632310T SI1866342T1 SI 1866342 T1 SI1866342 T1 SI 1866342T1 SI 200632310 T SI200632310 T SI 200632310T SI 200632310 T SI200632310 T SI 200632310T SI 1866342 T1 SI1866342 T1 SI 1866342T1
Authority
SI
Slovenia
Prior art keywords
contaminants
manipulation
separation
streptococcus pneumoniae
pneumoniae polysaccharide
Prior art date
Application number
SI200632310T
Other languages
English (en)
Inventor
Brian Bahler
Tsu-Shun Lee
Jason Arnold Lotvin
Mark Edward Ruppen
Pamela Sue Fink Charbonneau
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36660782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1866342(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of SI1866342T1 publication Critical patent/SI1866342T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Sustainable Development (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SI200632310T 2005-04-08 2006-03-31 Ločevanje onesnaževalcev od polisaharida streptococcus pneumoniae s postopkom manipulacije pH SI1866342T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66954605P 2005-04-08 2005-04-08
PCT/US2006/012134 WO2006110352A2 (en) 2005-04-08 2006-03-31 Separation of contaminants from streptococcus pneumoniae polysaccharide by ph manipulation
EP06740302.2A EP1866342B1 (en) 2005-04-08 2006-03-31 Separation of contaminants from streptococcus pneumoniae polysaccharide by ph manipulation

Publications (1)

Publication Number Publication Date
SI1866342T1 true SI1866342T1 (sl) 2019-02-28

Family

ID=36660782

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200632381T SI3466982T1 (sl) 2005-04-08 2006-03-31 Ločevanje onesnaževalcev od polisaharida streptococcus pneumoniae s postopkom manipulacije pH
SI200632310T SI1866342T1 (sl) 2005-04-08 2006-03-31 Ločevanje onesnaževalcev od polisaharida streptococcus pneumoniae s postopkom manipulacije pH

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI200632381T SI3466982T1 (sl) 2005-04-08 2006-03-31 Ločevanje onesnaževalcev od polisaharida streptococcus pneumoniae s postopkom manipulacije pH

Country Status (20)

Country Link
US (1) US7718791B2 (sl)
EP (2) EP3466982B1 (sl)
JP (1) JP5049264B2 (sl)
KR (1) KR101317256B1 (sl)
CN (1) CN101155833B (sl)
AR (1) AR053843A1 (sl)
AU (1) AU2006234984B2 (sl)
BR (1) BRPI0607026B1 (sl)
CA (1) CA2604362C (sl)
DK (2) DK3466982T3 (sl)
ES (2) ES2808126T3 (sl)
HU (1) HUE050049T2 (sl)
IL (1) IL186366A (sl)
MX (1) MX2007012337A (sl)
NZ (1) NZ562719A (sl)
PL (2) PL1866342T3 (sl)
PT (2) PT3466982T (sl)
SI (2) SI3466982T1 (sl)
TR (1) TR201820018T4 (sl)
WO (1) WO2006110352A2 (sl)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013201631C1 (en) * 2006-10-10 2015-06-04 Wyeth Llc Purification of Streptococcus pneumoniae type 3 polysaccharides
MX2009003730A (es) * 2006-10-10 2009-04-22 Wyeth Corp Purificacion de polisacaridos de streptococcus pneumoniae tipo 3.
SI2436700T1 (sl) 2007-03-23 2018-09-28 Wyeth Llc Skrajšan postopek čiščenja za proizvodnjo kapsularnih polisaharidov streptococcusa pneumoniae
GB0822634D0 (en) 2008-12-11 2009-01-21 Novartis Ag Meningitis vaccines
RU2524436C2 (ru) * 2008-12-18 2014-07-27 УАЙТ ЭлЭлСи Способ получения жидкой фракции, содержащей изолированные высокомолекулярные капсульные полисахариды streptococcus pneumoniae, и жидкая фракция, полученная таким способом
RU2511404C2 (ru) * 2008-12-18 2014-04-10 УАЙТ ЭлЭлСи Способ получения раствора, содержащего высокомолекулярные изолированные капсульные полисахариды streptococcus pneumoniae серотипа 19а (варианты)
RU2555757C2 (ru) 2009-03-24 2015-07-10 Новартис Аг Комбинации менингококкового фактор н-связывающего белка и пневмококковых сахаридных конъюгатов
EP2411048B1 (en) 2009-03-24 2020-05-06 GlaxoSmithKline Biologicals SA Adjuvanting meningococcal factor h binding protein
KR101450958B1 (ko) 2009-04-30 2014-10-15 콜레이 파마시티컬 그룹, 인코포레이티드 폐렴구균 백신 및 그의 용도
WO2011145108A2 (en) * 2010-05-15 2011-11-24 Serum Institute Of India Ltd. Purification of capsular polysaccharides
WO2011161653A1 (en) 2010-06-25 2011-12-29 Novartis Ag Combinations of meningococcal factor h binding proteins
CN102093963B (zh) * 2010-11-26 2012-11-14 兰州生物制品研究所有限责任公司 富含磷壁酸的肺炎链球菌的培养方法
CN102094053B (zh) * 2010-11-26 2013-01-16 兰州生物制品研究所有限责任公司 肺炎链球菌c多糖的纯化方法
CA2828844C (en) 2011-03-02 2020-07-14 Novartis Ag Combination vaccines with lower doses of antigen and/or adjuvant
BR112014016223A8 (pt) 2011-12-29 2017-07-04 Novartis Ag combinações adjuvantes de proteínas de ligação de fator h meningocócico
US20150132339A1 (en) 2012-03-07 2015-05-14 Novartis Ag Adjuvanted formulations of streptococcus pneumoniae antigens
JP2015509963A (ja) 2012-03-08 2015-04-02 ノバルティス アーゲー Ｔｌｒ４アゴニストを含む混合ワクチン
CN102660601B (zh) * 2012-04-17 2015-10-28 江苏康泰生物医学技术有限公司 快速纯化细菌荚膜多糖的方法
CN102660602B (zh) * 2012-04-17 2015-03-25 江苏康泰生物医学技术有限公司 快速纯化细菌荚膜多糖的方法
CN102660603B (zh) * 2012-04-17 2015-03-25 江苏康泰生物医学技术有限公司 一种快速纯化细菌荚膜多糖的方法
AU2013311702A1 (en) 2012-09-06 2015-02-19 Novartis Ag Combination vaccines with serogroup B meningococcus and D/T/P
BR112015005081B1 (pt) * 2012-09-07 2021-10-26 Sk Bioscience Co., Ltd. Método para produzir um polissacarídeo capsular tendo um sorotipo de pneumococo
JP2016502994A (ja) 2012-12-18 2016-02-01 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ジフテリア及び／又は破傷風から防御するためのコンジュゲート
AU2015208821B2 (en) 2014-01-21 2017-11-02 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
MX371453B (es) 2014-01-21 2020-01-29 Pfizer Polisacaridos capsulares de streptococcus pneumoniae y conjugados de los mismos.
US11160855B2 (en) 2014-01-21 2021-11-02 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
CN105934251A (zh) 2014-01-21 2016-09-07 辉瑞大药厂 肺炎链球菌荚膜多糖及其缀合物
FI3244917T3 (fi) 2015-01-15 2023-05-25 Pfizer Immunogeenisiä koostumuksia pneumokokkirokotteissa käytettäväksi
IL297740A (en) 2015-05-04 2022-12-01 Pfizer Protein-polysaccharide conjugates of group b streptococcus, methods for preparing the conjugates, immunogenic preparations containing conjugates and their uses
TWI756893B (zh) 2015-07-21 2022-03-01 美商輝瑞股份有限公司 包含經共軛之莢膜糖抗原的致免疫性組成物、包含該致免疫性組成物之套組及彼等之用途
CA3005524C (en) 2015-11-20 2023-10-10 Pfizer Inc. Immunogenic compositions for use in pneumococcal vaccines
EP3493840B1 (en) 2016-08-05 2022-08-24 Sanofi Pasteur Inc. Multivalent pneumococcal polysaccharide-protein conjugate composition
MX2019001342A (es) 2016-08-05 2019-07-04 Sanofi Pasteur Inc Composicion de conjugado de proteina-polisacarido de neumococo multivalente.
US10751402B2 (en) 2016-11-09 2020-08-25 Pfizer Inc. Immunogenic compositions and uses thereof
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
KR20190103256A (ko) 2016-12-30 2019-09-04 수트로박스, 인코포레이티드 비자연 아미노산을 갖는 폴리펩타이드-항원 접합체
DK3570879T3 (da) 2017-01-20 2022-04-11 Pfizer Immunogene sammensætninger til anvendelse i pneumokokvacciner
EP3576784A4 (en) 2017-01-31 2020-11-11 Merck Sharp & Dohme Corp. PROCESS FOR THE PRODUCTION OF POLYSACCHARIDE PROTEIN CONJUGATES
CN107043431B (zh) * 2017-02-23 2020-06-30 上海瑞宙生物科技有限公司 细菌性荚膜多糖的纯化方法
JP2020514326A (ja) 2017-02-24 2020-05-21 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 肺炎連鎖球菌多糖−タンパク質コンジュゲートの免疫原性の増強
AU2018328035B2 (en) 2017-09-07 2024-03-07 Chitrananda Abeygunawardana Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
KR20200051005A (ko) 2017-09-07 2020-05-12 머크 샤프 앤드 돔 코포레이션 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도
EP3720483A2 (en) 2017-12-06 2020-10-14 Merck Sharp&Dohme Corp. Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof
KR20210002641A (ko) 2018-04-30 2021-01-08 머크 샤프 앤드 돔 코포레이션 디메틸술폭시드 중의 동결건조된 돌연변이체 디프테리아 독소의 균질 용액을 제공하는 방법
WO2019212846A1 (en) 2018-04-30 2019-11-07 Merck Sharp & Dohme Corp. Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates
WO2020010016A1 (en) 2018-07-04 2020-01-09 Sutrovax, Inc. Self-adjuvanted immunogenic conjugates
WO2020010000A1 (en) 2018-07-04 2020-01-09 Sutrovax, Inc. Improved methods for the preparation of immunogenic conjugates
AU2019299836A1 (en) 2018-07-04 2021-02-25 Vaxcyte, Inc. Improvements in immunogenic conjugates
JP2022512345A (ja) 2018-12-12 2022-02-03 ファイザー・インク 免疫原性多重ヘテロ抗原多糖－タンパク質コンジュゲートおよびその使用
CR20210333A (es) 2018-12-19 2021-08-18 Merck Sharp & Dohme Composiciones que comprenden conjugados de polisacárido de streptococcus pneumoniae con proteína y sus métodos de uso
JP7239509B6 (ja) * 2019-02-22 2023-03-28 ファイザー・インク 細菌多糖類を精製するための方法
JP2022528158A (ja) 2019-04-10 2022-06-08 ファイザー・インク コンジュゲート化莢膜糖抗原を含む免疫原性組成物、それを含むキットおよびその使用
EP4003410A1 (en) 2019-07-31 2022-06-01 Sanofi Pasteur, Inc. Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same
US20210070890A1 (en) * 2019-09-06 2021-03-11 Serum Institute Of India Private Limited Method for obtaining purified bacterial polysaccharides
CA3192786A1 (en) 2020-08-26 2022-03-03 Pfizer Inc. Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof
GB202016165D0 (en) 2020-10-12 2020-11-25 Optivalent Ltd Vaccine
KR20230097160A (ko) 2020-11-04 2023-06-30 화이자 인코포레이티드 폐렴구균 백신에 사용하기 위한 면역원성 조성물
JP2023549736A (ja) 2020-11-10 2023-11-29 ファイザー・インク コンジュゲートさせた莢膜糖抗原を含む免疫原性組成物およびその使用
JP2024517780A (ja) 2021-05-03 2024-04-23 ファイザー・インク 細菌およびベータコロナウイルス感染症に対するワクチン接種
WO2022234416A1 (en) 2021-05-03 2022-11-10 Pfizer Inc. Vaccination against pneumoccocal and covid-19 infections
PE20240090A1 (es) 2021-05-28 2024-01-16 Pfizer Composiciones inmunogenas que comprenden antigenos de sacarido capsular conjugados y sus usos
TW202306969A (zh) 2021-05-28 2023-02-16 美商輝瑞大藥廠 包含結合之莢膜醣抗原的免疫原組合物及其用途
WO2023135515A1 (en) 2022-01-13 2023-07-20 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
GB2614916A (en) 2022-01-25 2023-07-26 Optivalent Ltd Intradermal vaccine complement
WO2023161817A1 (en) 2022-02-25 2023-08-31 Pfizer Inc. Methods for incorporating azido groups in bacterial capsular polysaccharides
CN114853917A (zh) * 2022-04-22 2022-08-05 兰州生物制品研究所有限责任公司 制备肺炎球菌荚膜多糖和肺炎球菌疫苗的方法
WO2024084397A1 (en) 2022-10-19 2024-04-25 Pfizer Inc. Vaccination against pneumoccocal and covid-19 infections

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1115210A (en) * 1977-11-28 1981-12-29 Dennis J. Carlo Pneumococcal vaccine
US4242501A (en) * 1979-08-08 1980-12-30 American Cyanamid Company Purification of pneumococcal capsular polysaccharides
FR2495939B1 (fr) * 1980-12-11 1985-10-11 Merieux Inst Procede de purification de polyosides de streptococcus pneumoniae et vaccin a base de polyosides ainsi purifies
BE889979A (fr) * 1981-08-14 1982-02-15 Smith Kline Rit Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation
US5714354A (en) * 1995-06-06 1998-02-03 American Home Products Corporation Alcohol-free pneumococcal polysaccharide purification process
JP2002521058A (ja) * 1998-07-27 2002-07-16 マイクロビアル テクニクス リミティッド 肺炎連鎖球菌由来の核酸及びタンパク質
BRPI0109293B8 (pt) * 2000-03-16 2021-05-25 Childrens Hospital Philadelphia métodos para produzir polissacarídeo capsular a partir de um pneumococo, para produzir uma preparação imunogênica para a administração a um animal em risco de desenvolver uma infecção pneumocócica, e para produzir polissacarídeo pneumocócico

Also Published As

Publication number Publication date
IL186366A0 (en) 2008-01-20
IL186366A (en) 2012-10-31
CA2604362A1 (en) 2006-10-19
NZ562719A (en) 2008-12-24
MX2007012337A (es) 2007-11-21
SI3466982T1 (sl) 2020-08-31
CN101155833A (zh) 2008-04-02
HUE050049T2 (hu) 2020-11-30
KR20080005414A (ko) 2008-01-11
AR053843A1 (es) 2007-05-23
DK3466982T3 (da) 2020-08-03
US7718791B2 (en) 2010-05-18
KR101317256B1 (ko) 2013-10-14
BRPI0607026A2 (pt) 2009-07-28
WO2006110352A3 (en) 2007-03-29
BRPI0607026B1 (pt) 2022-02-15
PT3466982T (pt) 2020-07-24
TR201820018T4 (tr) 2019-01-21
JP5049264B2 (ja) 2012-10-17
AU2006234984A1 (en) 2006-10-19
EP3466982B1 (en) 2020-06-17
ES2808126T3 (es) 2021-02-25
US20060228381A1 (en) 2006-10-12
EP1866342B1 (en) 2018-11-21
CN101155833B (zh) 2011-04-20
JP2008535490A (ja) 2008-09-04
PT1866342T (pt) 2019-01-30
EP3466982A1 (en) 2019-04-10
WO2006110352A2 (en) 2006-10-19
PL3466982T3 (pl) 2020-11-02
ES2707202T3 (es) 2019-04-02
DK1866342T3 (en) 2019-01-28
PL1866342T3 (pl) 2019-04-30
EP1866342A2 (en) 2007-12-19
CA2604362C (en) 2013-11-12
AU2006234984B2 (en) 2011-10-13

Similar Documents

Publication Publication Date Title
IL186366A0 (en) SEPARATION OF CONTAMINANTS FROM STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE BY pH MANIPULATION
IL184980A0 (en) Purification of streptococcal capsular polysaccharide
GB2425620B (en) Production system
TWI368611B (en) Improving product recovery from simulated-moving-bed adsorption
JP2010505963A5 (ja) 肺炎連鎖球菌3型多糖体の精製
ZA200803317B (en) Separation process
GB2429993B (en) Production system
ZA200808372B (en) Antibody purification
EP1961239A4 (en) SELECTIVE THROTTLE OF PRESENCE UPDATES
EP1885410A4 (en) SWIVEL CATHETERISM SYSTEM FOR ADVANCING
EP1937503A4 (en) DIFFERENTIAL
EP1872189A4 (en) GENERIC CLASSIFICATION SYSTEM
GB0503942D0 (en) Purification process
ZA200709326B (en) Dairy production information system
GB0523257D0 (en) Purification process
GB0624555D0 (en) Filtering signals
GB0510127D0 (en) Signal processing systems
EP1971202A4 (en) SERUM PRODUCTION SYSTEM
PL2074221T3 (pl) Ulepszone sposoby oddzielania polisacharydów Streptococcus pneumoniae typu 3
GB0505247D0 (en) Teaching aid
GB0500855D0 (en) Cadesorb PH buffer
AU2005906908A0 (en) Mineral separating means
ZA201100565B (en) Antibody purification
AU308097S (en) Teaspoon
GB0523058D0 (en) Separation system