BRPI0606170A2 - purificação diastereomérica de rosuvastatina - Google Patents
purificação diastereomérica de rosuvastatinaInfo
- Publication number
- BRPI0606170A2 BRPI0606170A2 BRPI0606170-2A BRPI0606170A BRPI0606170A2 BR PI0606170 A2 BRPI0606170 A2 BR PI0606170A2 BR PI0606170 A BRPI0606170 A BR PI0606170A BR PI0606170 A2 BRPI0606170 A2 BR PI0606170A2
- Authority
- BR
- Brazil
- Prior art keywords
- rosuvastatin
- purification
- diastereomeric
- diastereomeric purification
- diastereomerically pure
- Prior art date
Links
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 title abstract 4
- 229960000672 rosuvastatin Drugs 0.000 title abstract 4
- 238000000746 purification Methods 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72349105P | 2005-10-03 | 2005-10-03 | |
| US73297905P | 2005-11-02 | 2005-11-02 | |
| PCT/US2006/035711 WO2007040940A1 (en) | 2005-10-03 | 2006-09-12 | Diastereomeric purification of rosuvastatin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0606170A2 true BRPI0606170A2 (pt) | 2009-06-02 |
Family
ID=37731511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0606170-2A BRPI0606170A2 (pt) | 2005-10-03 | 2006-09-12 | purificação diastereomérica de rosuvastatina |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20090187026A1 (https=) |
| EP (1) | EP1817293A1 (https=) |
| JP (1) | JP2008526897A (https=) |
| KR (2) | KR101019450B1 (https=) |
| BR (1) | BRPI0606170A2 (https=) |
| CA (1) | CA2624801A1 (https=) |
| IL (1) | IL187949A0 (https=) |
| TW (1) | TW200804305A (https=) |
| WO (1) | WO2007040940A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7851624B2 (en) | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
| EP2024341B1 (en) | 2006-05-03 | 2015-12-02 | MSN Laboratories Private Limited | Novel process for statins and its pharmaceutically acceptable salts thereof |
| US8404841B2 (en) | 2006-10-09 | 2013-03-26 | Msn Laboratories Limited | Process for the preparation of statins and their pharmaceutically acceptable salts thereof |
| US8318933B2 (en) * | 2006-10-31 | 2012-11-27 | Aurobindo Pharma Ltd | Process for preparing rosuvastatin calcium |
| WO2008096257A1 (en) * | 2007-02-08 | 2008-08-14 | Aurobindo Pharma Limited | An improved process for preparation of rosuvastatin calcium |
| JP2010501643A (ja) | 2007-07-12 | 2010-01-21 | テバ ファーマシューティカル インダストリーズ リミティド | 薄膜蒸発及び化学的手法によるロスバスタチン中間体の精製 |
| EP2022784A1 (en) * | 2007-08-08 | 2009-02-11 | LEK Pharmaceuticals D.D. | Process for the preparation of methyl ester of rosuvastatin |
| EP2298745B1 (en) * | 2008-05-27 | 2014-09-03 | Changzhou Pharmaceutical Factory | Preparation method of rosuvastatin calcium and its intermediates |
| WO2010035284A2 (en) * | 2008-09-26 | 2010-04-01 | Matrix Laboratories Ltd | An improved process for the preparation of rosuvastatin calcium |
| WO2010089770A2 (en) | 2009-01-19 | 2010-08-12 | Msn Laboratories Limited | Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof |
| US8846915B2 (en) | 2009-08-17 | 2014-09-30 | Aurobindo Pharma Ltd. | Process for the manufacture of rosuvastatin calcium using crystalline rosuvastatin ethyl ester |
| US8987444B2 (en) | 2010-01-18 | 2015-03-24 | Msn Laboratories Private Limited | Process for the preparation of amide intermediates and their use thereof |
| EP2383260A3 (en) * | 2010-04-30 | 2011-12-28 | Dipharma Francis S.r.l. | Process for the preparation of statins |
| ITMI20100753A1 (it) * | 2010-04-30 | 2011-10-31 | Dipharma Francis Srl | Procedimento per la preparazione di statine |
| HU230987B1 (hu) * | 2010-11-29 | 2019-08-28 | Egis Gyógyszergyár Nyrt. | Eljárás nagy tisztaságú gyógyszeripari intermedierek előállítására |
| CN104230817B (zh) * | 2013-06-19 | 2016-09-14 | 南京欧信医药技术有限公司 | 3，5-二羟基庚-6-烯酸衍生物的制备方法 |
| CN109580789B (zh) * | 2017-09-28 | 2021-06-22 | 安徽省庆云医药股份有限公司 | 一种液相色谱法分离测定瑞舒伐他汀叔丁酯及其光学异构体的方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5189164A (en) * | 1989-05-22 | 1993-02-23 | Sandoz Ltd. | Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof |
| JP2648897B2 (ja) * | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
| US5218138A (en) * | 1992-09-02 | 1993-06-08 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Stereoselective reduction of 3-hydroxyket-1-ones to 1,3-syn-dihydroxylated compounds |
| JPH08301864A (ja) * | 1995-05-09 | 1996-11-19 | Toyobo Co Ltd | α−オキシ酸の分子間環状ジエステルの精製方法 |
| US5741934A (en) * | 1996-04-10 | 1998-04-21 | Sandler; Stanley R. | Preparation of primary mercaptans |
| DE19841342A1 (de) * | 1998-09-10 | 2000-04-20 | Merck Patent Gmbh | Neue Reaktivsysteme aus polymerisierbaren Monomeren , die Peroxide und stabilisierten Boralkylverbindungen enthalten |
| JP4565208B2 (ja) * | 2000-03-31 | 2010-10-20 | 株式会社クレハ | グリコリドの精製方法 |
| KR100511533B1 (ko) * | 2002-04-09 | 2005-08-31 | 임광민 | 키랄 중간체, 그의 제조방법 및 그를 이용한 HMG-CoA환원저해제의 제조방법 |
| EA200401533A1 (ru) * | 2002-05-21 | 2005-06-30 | Ранбакси Лабораторис Лимитед | Способ получения росувастатина |
| JP2004277396A (ja) * | 2003-01-23 | 2004-10-07 | Teijin Chem Ltd | 芳香族ポリカーボネートから芳香族ジヒドロキシ化合物と炭酸ジアルキルを得る方法 |
| WO2004103977A2 (en) * | 2003-05-21 | 2004-12-02 | Ciba Specialty Chemicals Holding Inc. | Process for the preparation of pyrimidine derivatives |
| CA2537271A1 (en) | 2003-08-28 | 2005-03-17 | Teva Pharmaceutical Industries, Ltd. | Process for preparation of rosuvastatin calcium |
| EP1678148A1 (en) * | 2003-10-22 | 2006-07-12 | Ranbaxy Laboratories Limited | Process for the preparation of amorphous rosuvastatin calcium |
| CA2550742A1 (en) * | 2003-12-24 | 2005-07-14 | Teva Pharmaceutical Industries Ltd. | Process for preparation of statins with high syn to anti ratio |
| US7851624B2 (en) * | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
| US20070179166A1 (en) * | 2003-12-24 | 2007-08-02 | Valerie Niddam-Hildesheim | Process for preparation of statins with high syn to anti ratio |
| JP2007508379A (ja) * | 2004-07-13 | 2007-04-05 | テバ ファーマシューティカル インダストリーズ リミティド | Ｔｅｍｐｏ媒介型酸化段階を包含するロスバスタチンの調製方法 |
-
2006
- 2006-09-12 WO PCT/US2006/035711 patent/WO2007040940A1/en not_active Ceased
- 2006-09-12 TW TW095133788A patent/TW200804305A/zh unknown
- 2006-09-12 JP JP2007550593A patent/JP2008526897A/ja not_active Withdrawn
- 2006-09-12 CA CA002624801A patent/CA2624801A1/en not_active Abandoned
- 2006-09-12 EP EP06790220A patent/EP1817293A1/en not_active Withdrawn
- 2006-09-12 KR KR1020077012477A patent/KR101019450B1/ko not_active Expired - Fee Related
- 2006-09-12 KR KR1020097020950A patent/KR20090113920A/ko not_active Abandoned
- 2006-09-12 BR BRPI0606170-2A patent/BRPI0606170A2/pt not_active IP Right Cessation
-
2007
- 2007-12-06 IL IL187949A patent/IL187949A0/en unknown
-
2009
- 2009-02-26 US US12/380,419 patent/US20090187026A1/en not_active Abandoned
-
2010
- 2010-02-02 US US12/698,871 patent/US20100197916A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW200804305A (en) | 2008-01-16 |
| KR20070085667A (ko) | 2007-08-27 |
| EP1817293A1 (en) | 2007-08-15 |
| KR101019450B1 (ko) | 2011-03-07 |
| US20100197916A1 (en) | 2010-08-05 |
| US20090187026A1 (en) | 2009-07-23 |
| WO2007040940A1 (en) | 2007-04-12 |
| IL187949A0 (en) | 2008-03-20 |
| KR20090113920A (ko) | 2009-11-02 |
| JP2008526897A (ja) | 2008-07-24 |
| CA2624801A1 (en) | 2007-04-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0606170A2 (pt) | purificação diastereomérica de rosuvastatina | |
| SV2009002865A (es) | Uso de oxazolidinonas para el tratamiento y profilaxis de microangiopatias | |
| NO20080129L (no) | Fremgangsmate for fremstilling av dihydrokinazoliner | |
| UA102251C2 (ru) | Производные аминодигидротиазина как ингибиторы васе для лечения болезни альцгеймера | |
| MX388468B (es) | Compuestos multicíclicos y métodos de uso de los mismos. | |
| EA201270149A1 (ru) | Ингибиторы bace | |
| CY1111733T1 (el) | Παραγωγα 2-(1η-ινδολυλοσουλφανυλ)-βενζυλαμινης ως ssri | |
| EA201000329A1 (ru) | Циклические депсипептиды | |
| CR10955A (es) | Nuevo procedimiento de sintesis de la agomelatina | |
| MX2012007341A (es) | Inhibidores de proteasoma y procesos para su preparacion, purificacion y uso. | |
| ATE517869T1 (de) | Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon | |
| MX2011012533A (es) | Espiro-epoxidos como productos intermedios. | |
| BRPI0720050A2 (pt) | 6-oxo-1,6-diidropirimidin-2-ilas no tratamento de doenças proliferativas | |
| NO20080265L (no) | 2-(1H-indolylsulfanyl)-arylaminderivater | |
| GB0508318D0 (en) | Organic compounds | |
| MX2010010597A (es) | Procesos para la preparacion de derivados de dioxina benzofusionados. | |
| MX2008001428A (es) | Compuestos de imidazolil-pirimidina para uso en el tratamiento de trastornos proliferativos. | |
| DE602006009789D1 (de) | Acetylenderivate | |
| ATE517900T1 (de) | Heptarylen-und octarylentetracarbonsäurediimide und deren herstellung | |
| NI200700175A (es) | Procesos para la preparación de alcoholes de aminoetoxibencilo | |
| CR10934A (es) | Nuevo procedimiento de sintesis de la agomelatina | |
| IL189286A0 (en) | Novel cysteine protease inhibitors and their therapeutic applications | |
| MX2009000198A (es) | Formas cristalinas de profarmaco amida de gemcitabina, composiciones y usos del mismo. | |
| TW200716564A (en) | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | |
| TNSN06260A1 (en) | Process for the preparation of tryptase inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 4A E 5A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012. |