BRPI0519803A2 - métodos para purificar trans-(-)-delta9-tetraidrocanabinol e trans-(+)-delta9-tetraidrocanabinol - Google Patents

métodos para purificar trans-(-)-delta9-tetraidrocanabinol e trans-(+)-delta9-tetraidrocanabinol

Info

Publication number
BRPI0519803A2
BRPI0519803A2 BRPI0519803-8A BRPI0519803A BRPI0519803A2 BR PI0519803 A2 BRPI0519803 A2 BR PI0519803A2 BR PI0519803 A BRPI0519803 A BR PI0519803A BR PI0519803 A2 BRPI0519803 A2 BR PI0519803A2
Authority
BR
Brazil
Prior art keywords
trans
tetrahydrocannabinol
delta9
methods
purifying
Prior art date
Application number
BRPI0519803-8A
Other languages
English (en)
Inventor
Ariel Gutman
L Nisnevich
A Gennady
Igor Rukhman
Boris Tishin
Marina Etinger
Irina Fedotev
Boris Pertsikov
Ram Khanolkar
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35789123&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0519803(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of BRPI0519803A2 publication Critical patent/BRPI0519803A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

MéTODOS PARA PURIFICAR TRANS- (-) - <30>^ 9^ - TETRAIDROCANABINOL E TRANS - (+) - <30>)^ 9^ - TETRAIDROCANABINOL. Métodos para fazer trans-(-) ^ 9^-tetraidrocanabinol e trans- (+) - ^ 9^-tetraidrocanabinol são revelados aqui. Em uma configuração, uma composição de trans-(-)- ^ 9^-tetraidrocanabinol é preparada permitindo que uma composição compreendendo (±)- ^ 9^-tetraidrocanabinol seja separada em uma fase fixa quiral para prover uma composição de trans-(-)- ^ 9^- tetraidrocanabinol compreendendo pelo menos aproximadamente 99% em peso de trans-(-)- ^ 9^-tetraidrocanabinol com base na quantidade total de trans-(->- ^ 9^-tetraidrocanabinol e trans- (+)- ^ 9^- tetraidrocanabinol. A invenção também se refere a métodos para tratamento ou prevenção de uma condição tal como dor, compreendendo a administração, a um paciente em necessidade do tratamento, de uma quantidade efetiva de um trans-(-)- ^ 9^- tetraidrocanabinol tendo uma pureza de pelo menos aproximadamente 98% com base no peso total de canabinóides.
BRPI0519803-8A 2004-11-22 2005-11-18 métodos para purificar trans-(-)-delta9-tetraidrocanabinol e trans-(+)-delta9-tetraidrocanabinol BRPI0519803A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63055604P 2004-11-22 2004-11-22
PCT/EP2005/012378 WO2006053766A1 (en) 2004-11-22 2005-11-18 Methods for purifying trans-(-)-δ9-tetrahydrocannabinol and trans-(+)-δ9-tetrahydrocannabinol

Publications (1)

Publication Number Publication Date
BRPI0519803A2 true BRPI0519803A2 (pt) 2009-03-17

Family

ID=35789123

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519803-8A BRPI0519803A2 (pt) 2004-11-22 2005-11-18 métodos para purificar trans-(-)-delta9-tetraidrocanabinol e trans-(+)-delta9-tetraidrocanabinol

Country Status (31)

Country Link
US (6) US8383842B2 (pt)
EP (3) EP2356987B1 (pt)
JP (3) JP4995728B2 (pt)
KR (1) KR100919719B1 (pt)
CN (2) CN102151259A (pt)
AR (1) AR054989A1 (pt)
AT (1) ATE500824T1 (pt)
AU (2) AU2005305944B2 (pt)
BR (1) BRPI0519803A2 (pt)
CA (2) CA2921590C (pt)
CY (1) CY1111471T1 (pt)
DE (1) DE602005026852D1 (pt)
DK (3) DK2289509T3 (pt)
EA (1) EA012299B1 (pt)
ES (3) ES2556802T3 (pt)
HK (3) HK1109058A1 (pt)
HR (3) HRP20110385T1 (pt)
HU (2) HUE027197T2 (pt)
IL (1) IL183306A (pt)
ME (2) ME02306B (pt)
MX (1) MX2007006104A (pt)
NO (1) NO331831B1 (pt)
NZ (1) NZ556038A (pt)
PL (3) PL2289509T3 (pt)
PT (2) PT2289509E (pt)
RS (3) RS54338B1 (pt)
SI (3) SI2356987T1 (pt)
TW (2) TWI436991B (pt)
UA (1) UA88491C2 (pt)
WO (1) WO2006053766A1 (pt)
ZA (1) ZA200706837B (pt)

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MX2007006104A (es) 2007-07-11
US9278083B2 (en) 2016-03-08
HK1109058A1 (en) 2008-05-30
CY1111471T1 (el) 2015-08-05
AU2010200227A1 (en) 2010-02-11
CN102151259A (zh) 2011-08-17
UA88491C2 (ru) 2009-10-26
HK1159500A1 (en) 2012-08-03
AR054989A1 (es) 2007-08-01
EA012299B1 (ru) 2009-08-28
US20150126596A1 (en) 2015-05-07
SI2356987T1 (sl) 2016-04-29
ES2566480T3 (es) 2016-04-13
NO20072964L (no) 2007-08-17
PT2289509E (pt) 2015-12-23
KR20070086529A (ko) 2007-08-27
JP5048448B2 (ja) 2012-10-17
ES2556802T3 (es) 2016-01-20
WO2006053766A1 (en) 2006-05-26
NO331831B1 (no) 2012-04-16
JP4995728B2 (ja) 2012-08-08
PL2289509T3 (pl) 2016-04-29
ZA200706837B (en) 2008-04-30
PT1824475E (pt) 2011-06-01
NZ556038A (en) 2009-12-24
RS51706B (en) 2011-10-31
DE602005026852D1 (de) 2011-04-21
HRP20160300T1 (hr) 2016-04-22
WO2006053766A8 (en) 2006-12-14
US8383842B2 (en) 2013-02-26
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DK2289509T3 (en) 2015-11-23
TWI369203B (en) 2012-08-01
US9675581B2 (en) 2017-06-13
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SI2289509T1 (sl) 2016-01-29
EA200701123A1 (ru) 2007-12-28
DK2356987T3 (en) 2016-03-21
IL183306A0 (en) 2007-09-20
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US20160199344A1 (en) 2016-07-14
DK1824475T3 (da) 2011-06-06
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US20160184261A1 (en) 2016-06-30
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US9744151B2 (en) 2017-08-29
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US8937097B2 (en) 2015-01-20
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US20090298930A1 (en) 2009-12-03
ME02403B (me) 2016-09-20
HUE025904T2 (en) 2016-05-30
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