BRPI0508232A - sìntese de epotilonas, intermediários das mesmas, análogos e usos das mesmas - Google Patents

sìntese de epotilonas, intermediários das mesmas, análogos e usos das mesmas

Info

Publication number
BRPI0508232A
BRPI0508232A BRPI0508232-3A BRPI0508232A BRPI0508232A BR PI0508232 A BRPI0508232 A BR PI0508232A BR PI0508232 A BRPI0508232 A BR PI0508232A BR PI0508232 A BRPI0508232 A BR PI0508232A
Authority
BR
Brazil
Prior art keywords
formula
epothilones
analogues
intermediates
synthesis
Prior art date
Application number
BRPI0508232-3A
Other languages
English (en)
Inventor
Samuel J Danishefsky
Alexey Rivkin
Fumihiko Yoshimura
Ting-Chao Chou
Ana Esther Gabarda Ortega
Huajin Dong
Kaida Wu
Malcolm A S Moore
David Dorn
Original Assignee
Sloan Kettering Insitute For C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Insitute For C filed Critical Sloan Kettering Insitute For C
Publication of BRPI0508232A publication Critical patent/BRPI0508232A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SìNTESE DE EPOTILONAS, INTERMEDIáRIOS DAS MESMAS, ANáLOGOS E USOS DAS MESMAS. A presente invenção refere-se compostos da fórmula (l): como descrito de forma geral e nas classes e nas subclasses contidas aqui. A presente invenção fornece adicionalmente composições farmacêuticas que compreendem compostos da fórmula (l) e fornece processos de tratamento de câncer que compreendem a administração de um composto da fórmula (l).
BRPI0508232-3A 2004-02-27 2005-02-28 sìntese de epotilonas, intermediários das mesmas, análogos e usos das mesmas BRPI0508232A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54840204P 2004-02-27 2004-02-27
US10/921,109 US7384964B2 (en) 2002-08-23 2004-08-18 Synthesis of epothilones, intermediates thereto, analogues and uses thereof
PCT/US2005/006051 WO2005084222A2 (en) 2004-02-27 2005-02-28 Synthesis of epothilones, intermediates thereto, analogues and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0508232A true BRPI0508232A (pt) 2007-07-17

Family

ID=34922686

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508232-3A BRPI0508232A (pt) 2004-02-27 2005-02-28 sìntese de epotilonas, intermediários das mesmas, análogos e usos das mesmas

Country Status (9)

Country Link
US (1) US7384964B2 (pt)
EP (1) EP1722791A4 (pt)
JP (1) JP2007525519A (pt)
KR (1) KR20070100626A (pt)
AU (1) AU2005218308A1 (pt)
BR (1) BRPI0508232A (pt)
CA (1) CA2556692A1 (pt)
RU (1) RU2006134290A (pt)
WO (1) WO2005084222A2 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7649006B2 (en) * 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
AU2006318284A1 (en) * 2005-11-22 2007-05-31 The Scripps Research Institute Chemical synthesis of a highly potent epothilone
CN102675357B (zh) * 2012-01-20 2015-04-29 中国科学院上海有机化学研究所 一种合成埃坡霉素碳7-19片段的中间体、合成方法和用途
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
CA2905509A1 (en) 2013-03-15 2014-09-18 Memorial Sloan-Kettering Cancer Center Hsp90-targeted cardiac imaging and therapy
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1386922B1 (en) * 1996-12-03 2012-04-11 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereof, analogues and uses thereof
US6380394B1 (en) * 1996-12-13 2002-04-30 The Scripps Research Institute Epothilone analogs
DE19826988A1 (de) * 1998-06-18 1999-12-23 Biotechnolog Forschung Gmbh Epothilon-Nebenkomponenten
US6596875B2 (en) * 2000-02-07 2003-07-22 James David White Method for synthesizing epothilones and epothilone analogs
WO2001064650A2 (en) * 2000-03-01 2001-09-07 Sloan-Kettering Institute For Cancer Research Center Synthesis of epothilones, intermediates thereto and analogues thereof
US6589968B2 (en) * 2001-02-13 2003-07-08 Kosan Biosciences, Inc. Epothilone compounds and methods for making and using the same
AU2001266583A1 (en) * 2000-05-26 2001-12-11 Kosan Biosciences, Inc. Epothilone derivatives and methods for making and using the same
MXPA03002521A (es) * 2000-09-22 2004-02-12 Biotechnolog Forschung Gmbh Triazol-epotilona.
BR0207316A (pt) * 2001-02-20 2004-02-10 Bristol Myers Squibb Co Derivados de epotilona para o tratamento de tumores refratários
WO2002080846A2 (en) * 2001-04-03 2002-10-17 Kosan Biosciences, Inc. Epothilone derivatives and methods for making and using the same
EP2070534A3 (en) * 2001-08-23 2009-08-26 Novartis Ag Cyclopropyl and cyclobutyl epothilone analogs
WO2003022844A2 (en) * 2001-09-06 2003-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones intermediates thereto and analogues thereof
US7649006B2 (en) * 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
WO2004018478A2 (en) * 2002-08-23 2004-03-04 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
EP2135867B1 (en) * 2002-11-07 2013-09-25 Kosan Biosciences Incorporated Trans-9, 10-dehydroepothilone C and trans-9, 10-dehydroepothilone D, analogs thereof and methods of making the same

Also Published As

Publication number Publication date
RU2006134290A (ru) 2008-04-10
CA2556692A1 (en) 2005-09-15
AU2005218308A1 (en) 2005-09-15
JP2007525519A (ja) 2007-09-06
US7384964B2 (en) 2008-06-10
EP1722791A4 (en) 2010-06-09
EP1722791A2 (en) 2006-11-22
KR20070100626A (ko) 2007-10-11
US20050143429A1 (en) 2005-06-30
WO2005084222A2 (en) 2005-09-15
WO2005084222A3 (en) 2005-11-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 12A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]