BRPI0508232A - sìntese de epotilonas, intermediários das mesmas, análogos e usos das mesmas - Google Patents

sìntese de epotilonas, intermediários das mesmas, análogos e usos das mesmas

Info

Publication number
BRPI0508232A
BRPI0508232A BRPI0508232-3A BRPI0508232A BRPI0508232A BR PI0508232 A BRPI0508232 A BR PI0508232A BR PI0508232 A BRPI0508232 A BR PI0508232A BR PI0508232 A BRPI0508232 A BR PI0508232A
Authority
BR
Brazil
Prior art keywords
formula
epothilones
analogues
intermediates
synthesis
Prior art date
Application number
BRPI0508232-3A
Other languages
English (en)
Inventor
Samuel J Danishefsky
Alexey Rivkin
Fumihiko Yoshimura
Ting-Chao Chou
Ana Esther Gabarda Ortega
Huajin Dong
Kaida Wu
Malcolm A S Moore
David Dorn
Original Assignee
Sloan Kettering Insitute For C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Insitute For C filed Critical Sloan Kettering Insitute For C
Publication of BRPI0508232A publication Critical patent/BRPI0508232A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SìNTESE DE EPOTILONAS, INTERMEDIáRIOS DAS MESMAS, ANáLOGOS E USOS DAS MESMAS. A presente invenção refere-se compostos da fórmula (l): como descrito de forma geral e nas classes e nas subclasses contidas aqui. A presente invenção fornece adicionalmente composições farmacêuticas que compreendem compostos da fórmula (l) e fornece processos de tratamento de câncer que compreendem a administração de um composto da fórmula (l).
BRPI0508232-3A 2004-02-27 2005-02-28 sìntese de epotilonas, intermediários das mesmas, análogos e usos das mesmas BRPI0508232A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54840204P 2004-02-27 2004-02-27
US10/921,109 US7384964B2 (en) 2002-08-23 2004-08-18 Synthesis of epothilones, intermediates thereto, analogues and uses thereof
PCT/US2005/006051 WO2005084222A2 (en) 2004-02-27 2005-02-28 Synthesis of epothilones, intermediates thereto, analogues and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0508232A true BRPI0508232A (pt) 2007-07-17

Family

ID=34922686

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508232-3A BRPI0508232A (pt) 2004-02-27 2005-02-28 sìntese de epotilonas, intermediários das mesmas, análogos e usos das mesmas

Country Status (9)

Country Link
US (1) US7384964B2 (pt)
EP (1) EP1722791A4 (pt)
JP (1) JP2007525519A (pt)
KR (1) KR20070100626A (pt)
AU (1) AU2005218308A1 (pt)
BR (1) BRPI0508232A (pt)
CA (1) CA2556692A1 (pt)
RU (1) RU2006134290A (pt)
WO (1) WO2005084222A2 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7649006B2 (en) * 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
CA2628227A1 (en) * 2005-11-22 2007-05-31 The Scripps Research Institute Chemical synthesis of a highly potent epothilone
CN102675357B (zh) * 2012-01-20 2015-04-29 中国科学院上海有机化学研究所 一种合成埃坡霉素碳7-19片段的中间体、合成方法和用途
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
US10201623B2 (en) 2013-03-15 2019-02-12 Memorial Sloan Kettering Cancer Center HSP90-targeted cardiac imaging and therapy
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
WO2020247054A1 (en) 2019-06-05 2020-12-10 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
WO2022182415A1 (en) 2021-02-24 2022-09-01 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4579351B2 (ja) * 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US6380394B1 (en) * 1996-12-13 2002-04-30 The Scripps Research Institute Epothilone analogs
DE19826988A1 (de) * 1998-06-18 1999-12-23 Biotechnolog Forschung Gmbh Epothilon-Nebenkomponenten
US6596875B2 (en) * 2000-02-07 2003-07-22 James David White Method for synthesizing epothilones and epothilone analogs
AU2001243372A1 (en) * 2000-03-01 2001-09-12 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6589968B2 (en) * 2001-02-13 2003-07-08 Kosan Biosciences, Inc. Epothilone compounds and methods for making and using the same
WO2001092255A2 (en) * 2000-05-26 2001-12-06 Kosan Biosciences, Inc. Epothilone derivatives and methods for making and using the same
WO2002024712A1 (de) * 2000-09-22 2002-03-28 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Triazolo-epothilone
JP2004522771A (ja) * 2001-02-20 2004-07-29 ブリストル−マイヤーズ　スクイブ　カンパニー 治療抵抗性腫瘍の処置用エポチロン誘導体
WO2002080846A2 (en) * 2001-04-03 2002-10-17 Kosan Biosciences, Inc. Epothilone derivatives and methods for making and using the same
WO2003018002A2 (en) * 2001-08-23 2003-03-06 Novartis Ag Cyclopropyl and cyclobutyl epothilone analogs
US20030176368A1 (en) * 2001-09-06 2003-09-18 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
US7649006B2 (en) * 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
PT1506203E (pt) * 2002-08-23 2007-04-30 Sloan Kettering Inst Cancer Síntese de epotilonas, seus intermediários, seus análogos e suas utilizações
DE60330703D1 (de) * 2002-11-07 2010-02-04 Kosan Biosciences Inc Trans-9,10-dehydroepothilon c und d, analoga davon und verfahren zu deren herstellung

Also Published As

Publication number Publication date
CA2556692A1 (en) 2005-09-15
RU2006134290A (ru) 2008-04-10
EP1722791A2 (en) 2006-11-22
KR20070100626A (ko) 2007-10-11
US7384964B2 (en) 2008-06-10
US20050143429A1 (en) 2005-06-30
JP2007525519A (ja) 2007-09-06
WO2005084222A3 (en) 2005-11-24
AU2005218308A1 (en) 2005-09-15
EP1722791A4 (en) 2010-06-09
WO2005084222A2 (en) 2005-09-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 12A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]